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https://www.readbyqxmd.com/read/30320665/a-novel-donkey-milk-derived-human-milk-fortifier-in-feeding-preterm-infants-a-randomized-controlled-trial
#1
Enrico Bertino, Laura Cavallarin, Francesco Cresi, Paola Tonetto, Chiara Peila, Giulia Ansaldi, Melissa Raia, Alessia Varalda, Marzia Giribaldi, Amedeo Conti, Sara Antoniazzi, Guido E Moro, Elena Spada, Silvano Milani, Alessandra Coscia
OBJECTIVES: The purpose of the present randomized controlled clinical trial was to compare the use of donkey milk-derived fortifier with commercial bovine milk-derived fortifier in very preterm or very low-birthweight newborns, in terms of feeding tolerance. METHODS: This trial included 156 newborns born at <32 weeks of gestational age and/or with a birthweight ≤1500 g. Newborns were randomized 1:1 to receive enteral feeding with either a bovine milk-based fortifier (BF-arm), or a new, donkey milk-derived fortifier (DF-arm) for 21 days...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30308685/obstetric-outcomes-among-syrian-refugees-a-comparative-study-at-a-tertiary-care-maternity-hospital-in-turkey
#2
Sule Ozel, Selen Yaman, Hatice Kansu-Celik, Necati Hancerliogullari, Nurgul Balci, Yaprak Engin-Ustun
OBJECTIVE:  The aim of this study was to analyze and compare obstetric and neonatal outcomes between Syrian refugees and ethnic Turkish women. METHODS:  Retrospective, observational study. A total of 576 Syrian refugees and 576 ethnic Turkish women were included in this study, which was conducted between January 2015 and December 2015 at a tertiary maternity training hospital in Ankara, Turkey. The demographic characteristics, obstetric and neonatal outcomes were compared...
October 11, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/30302841/teething-symptoms-in-children-with-congenital-zika-syndrome-a-2-year-follow-up
#3
Alidianne Fábia Cabral Cavalcanti, Yêska Paola Costa Aguiar, Adriana Suely de Oliveira Melo, Jeime Iara Bezerra de Freitas Leal, Alessandro Leite Cavalcanti, Sergio d'Ávila Lins Bezerra Cavalcanti
BACKGROUND: The eruption of primary teeth represents a stage of many challenges for parents. AIM: To investigate the occurrence of signs and symptoms related to the eruption of the primary dentition in children with congenital Zika syndrome. DESIGN: Longitudinal study developed with 79 children followed up for a period of 24 months. Data on sex, gestational age, low birthweight, microcephaly, signs and symptoms related to the dental eruption phase, and use and type of medication were collected...
October 9, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/30299319/clinical-significance-of-cerebroplacental-ratio
#4
Erkan Kalafat, Asma Khalil
PURPOSE OF REVIEW: Two-thirds of the pregnancies complicated by stillbirth demonstrate growth restriction. Identification of the foetus at risk of growth restriction is essential to reduce the risk of stillbirth. The aim of this review is to critically appraise the current evidence regarding clinical utility of cerebroplacental ratio (CPR) in antenatal surveillance. RECENT FINDINGS: The CPR has emerged as an assessment tool for foetuses at increased risk of growth disorders...
October 6, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30297334/risk-adjusted-mortality-of-vlbw-infants-in-high-volume-versus-low-volume-nicus
#5
Roland Hentschel, Kilian Guenther, Werner Vach, Ingo Bruder
OBJECTIVE: To examine whether the number of very low birthweight (VLBW) infants treated annually in neonatal intensive care units (NICUs) (hospital volume) has an effect on their in-hospital mortality under the regulatory conditions in Germany. SETTING: The study included VLBW infants with <33 weeks of gestational age and birth weight below 1500 g admitted to NICUs in the state of Baden-Wüerttemberg, Germany, from 2003 to 2008. Cases were extracted from the compulsory German neonatal quality assurance programme with variables essential for calculation of the Clinical Risk Index for Babies (CRIB) and PREM birth model (PREM(bm)) scores...
October 8, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30296771/ambient-air-pollution-and-fetal-growth-restriction-physician-diagnosis-of-fetal-growth-restriction-versus-population-based-small-for-gestational-age
#6
Carrie J Nobles, Katherine L Grantz, Danping Liu, Andrew Williams, Marion Ouidir, Indulaxmi Seeni, Seth Sherman, Pauline Mendola
BACKGROUND: Ambient air pollution may affect fetal growth restriction (FGR) through several mechanisms. However, prior studies of air pollution and small-for-gestational age (SGA), a common proxy for FGR, have reported inconsistent findings. OBJECTIVE: We assessed air pollution in relation to physician-diagnosed FGR and population-based SGA in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Consecutive Pregnancy Study (2002-2010)...
October 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30296639/placental-concentrations-of-essential-toxic-and-understudied-metals-and-relationships-with-birth-outcomes-in-chattanooga-tn
#7
Colleen K Mikelson, Jacopo Troisi, Amy LaLonde, Steven J K Symes, Sally W Thurston, Lauren M DiRe, C David Adair, Richard K Miller, Sean M Richards
BACKGROUND: Comprehensive examinations of placental metal concentrations and correlations with infant parameters are under-investigated. Chattanooga, Tennessee's consistently high incidence of low birth weight and potential for metal exposure provides an ideal opportunity to investigate potential correlations. OBJECTIVES: To investigate the associations between a wide variety of metals in placental tissue and multiple infant parameters. METHODS: A total of 31 elements were screened via ICP-MS in 374 individual placental samples...
September 7, 2018: Environmental Research
https://www.readbyqxmd.com/read/30291022/long-term-cardiovascular-morbidity-in-children-born-following-fertility-treatment
#8
Sivan Reut Shiloh, Eyal Sheiner, Tamar Wainstock, Asnat Walfisch, Idit Segal, Daniella Landau, Avi Harlev
OBJECTIVE: To determine the risk of long-term cardiovascular disease (CVD) among children born following in vitro fertilization (IVF) and compared with spontaneous pregnancies. STUDY DESIGN: A population-based cohort study including all singleton deliveries occurring between 1991and 2014 at a tertiary medical center was performed. Hospitalizations up to the age of 18 years involving CVD were evaluated in children delivered following IVF, ovulation induction, and spontaneous pregnancies...
October 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30288833/placental-histopathology-in-preterm-fetal-growth-restriction
#9
Arvind Sehgal, Jane E Dahlstrom, Yuen Chan, Beth J Allison, Suzanne L Miller, Graeme R Polglase
AIMS: Approximately 6-9% pregnancies are affected by fetal growth restriction (FGR). Placental alterations related to utero-placental insufficiency in FGR may induce placental vascular remodelling to the detriment of the fetus. The objective of this article was to study histopathological features of placentae in a cohort of preterm growth-restricted infants in comparison to a cohort of preterm appropriately grown infants. METHODS: In a cohort of 40 preterm infants of 28-32 weeks' gestation, placental histopathology was evaluated by a histopathologist, who was blinded to the identity of the grouping...
October 4, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30288823/the-baby-moves-smartphone-app-for-general-movements-assessment-engagement-amongst-extremely-preterm-and-term-born-infants-in-a-state-wide-geographical-study
#10
Amanda Kl Kwong, Abbey L Eeles, Joy E Olsen, Jeanie Ly Cheong, Lex W Doyle, Alicia J Spittle
AIM: The Baby Moves smartphone application is designed for parents to video their infants' spontaneous movement for remote General Movements Assessment (GMA). We aimed to assess the engagement with Baby Moves amongst high- and low-risk infants' families and the socio-demographic variables related to engagement. METHODS: Families of extremely preterm (EP; <28 weeks' gestational age) or extremely low-birthweight (ELBW; <1000 g) infants and term-born controls from a state-wide geographical cohort study were asked to download Baby Moves...
October 4, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30286782/maternal-breast-cancer-risk-in-relation-to-birthweight-and-gestation-of-her-offspring
#11
Anthony J Swerdlow, Lauren B Wright, Minouk J Schoemaker, Michael E Jones
BACKGROUND: Parity and age at first pregnancy are well-established risk factors for breast cancer, but the effects of other characteristics of pregnancies are uncertain and the literature is inconsistent. METHODS: In a cohort of 83,451 parous women from the general population of the UK, which collected detailed information on each pregnancy and a wide range of potential confounders, we investigated the associations of length of gestation and birthweight of offspring in a woman's pregnancies with her breast cancer risk, adjusting for a full range of non-reproductive as well as reproductive risk factors unlike in previous large studies...
October 5, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30285948/antecedents-of-red-cell-transfusion-in-a-large-contemporary-obstetric-cohort
#12
Siobhan Enright, Sonia Varadkar, Alison Demaio, Catherine Flynn, Fionnuala Ni Áinle, Mark P Hehir
Background Hemorrhage is a critical contributor to maternal morbidity but estimation of blood loss at delivery is frequently inaccurate. Due to this inaccuracy we sought to examine blood transfusion as a surrogate marker for morbidity in a large non-population based consecutive cohort. Methods A retrospective analysis of prospectively gathered data was carried out at two university institutions serving a heterogeneous urban obstetric population from January to December 2016. Data were analyzed to determine whether individual characteristics were associated with perinatal transfusion...
October 4, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/30284621/the-differences-in-placental-pathology-and-neonatal-outcome-in-singleton-vs-twin-gestation-complicated-by-small-for-gestational-age
#13
Elad Barber, Eran Weiner, Ohad Feldstein, Ann Dekalo, Yossi Mizrachi, Damla Celen Gonullu, Jacob Bar, Letizia Schreiber, Michal Kovo
OBJECTIVE: We aimed to compare placental histopathology and neonatal outcome between dichorionic diamniotic (DCDA) twins and singleton pregnancies complicated by small for gestational age (SGA). METHODS: Medical files and placental pathology reports from all deliveries between 2008 and 2017 of SGA neonates, (birthweight < 10th percentile), were reviewed. Comparison was made between singleton pregnancies complicated with SGA (singletons SGA group) and DCDA twin pregnancies (Twins SGA group), in which only one of the neonates was SGA...
October 4, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/30282685/protocol-for-the-lactoferrin-infant-feeding-trial-lift-a-randomised-trial-of-adding-lactoferrin-to-the-feeds-of-very-low-birthweight-babies-prior-to-hospital-discharge
#14
Andrew Martin, Alpana Ghadge, Paolo Manzoni, Kei Lui, Rebecca Brown, William Tarnow-Mordi
INTRODUCTION: Very-low birthweight (VLBW, <1500 g) infants comprise about 1%-1.4% of all births in high-income countries. Every year, about 3000 VLBW babies in Australia and New Zealand receive intensive care. Many die or else survive with severe brain injury, retinopathy, late-onset sepsis or necrotising enterocolitis (NEC), each of which carries substantial risk of disability. METHODS AND ANALYSIS: This trial tests whether adding bovine lactoferrin (bLF) to feeds in VLBW infants improves (1) survival to hospital discharge free from brain injury, late-onset sepsis, NEC and treated retinopathy of prematurity (primary composite end point); (2) each component of the primary composite end point and (3) time to reach full enteral feeds, number of blood transfusions, chronic lung disease and length of hospital stay...
October 2, 2018: BMJ Open
https://www.readbyqxmd.com/read/30281170/effects-of-maturation-and-size-on-population-pharmacokinetics-of-pentoxifylline-and-its-metabolites-in-very-preterm-infants-with-suspected-late-onset-sepsis-or-necrotising-enterocolitis-a-pilot-study-incorporating-clinical-outcomes
#15
Sam Salman, Julie Hibbert, Madhu Page-Sharp, Laurens Manning, Karen Simmer, Dorota A Doherty, Sanjay Patole, Kevin T Batty, Tobias Strunk
AIMS: Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotising enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterise the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. METHOD: An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation <32 weeks) with suspected LOS or NEC was undertaken...
October 3, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30280118/paternal-race-ethnicity-and-risk-of-adverse-birth-outcomes-in-the-united-states-1989-2013
#16
Yu Li, Zhehui Luo, Claudia Holzman, Hui Liu, Claire E Margerison
Objectives: Investigate adverse birth outcomes in the United States (US) from 1989-2013 in relation to paternal and maternal race/ethnicity. Design: We used US natality data for singleton births to women 15-44 with information on birthweight, gestational age, and covariates (n = 90,771,339). We calculated unadjusted and adjusted probabilities of preterm birth (PTB, < 37 weeks gestation) and small for gestational age (SGA, < 10th percentile) among all combinations of maternal and paternal race/ethnicity: non-Hispanic black (NHB), non-Hispanic white (NHW), Hispanic, and Asian, and where paternal race/ethnicity was missing...
2018: AIMS Public Health
https://www.readbyqxmd.com/read/30277426/serum-heme-oxygenase-1-ho-1-soluble-fms-like-tyrosine-kinase-sflt-1-level-and-neonatal-outcome-in-early-onset-late-onset-preeclampsia-and-normal-pregnancy
#17
Muhammad Ilham Aldika Akbar, Mita Herdiyantini, Rozi Aditya Aryananda, Nareswari CIninta, Manggala Pasca Wardhana, Khanisyah Erza Gumilar, Budi Wicaksono, Ernawati, Agus Sulistyono, Aditiawarman, Hermanto Tri Joewono, Nadir Abdullah, Gustaaf Dekker, Erry Gumilar Dachlan, Muhammad Dikman Angsar
OBJECTIVE: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). METHODS: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks)...
October 2, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30268404/long-term-neurodevelopment-of-low-birthweight-preterm-infants-with-patent-ductus-arteriosus
#18
R Thomas Collins, Robert E Lyle, Mallikarjuna Rettiganti, Jeffrey M Gossett, James M Robbins, Patrick H Casey
OBJECTIVE: To evaluate whether the presence of patent ductus arteriosus (PDA) in preterm infants worsens long-term neurodevelopmental outcomes. STUDY DESIGN: This was a secondary observational analysis of data from 1090 preterm low-birthweight infants in the Infant Health and Development Program (IHDP), a multicenter longitudinal cohort study of outcomes assessed from 3 to 18 years of age. Multivariable analysis was adjusted for IHDP treatment group (intervention or follow-up), birth weight, maternal race, maternal education, infant sex, maternal preconception weight, Home Observation Measurement of the Environment (HOME) total score at 12 months, neonatal health index, and gestational age...
September 26, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30260419/neonatal-outcomes-among-offspring-of-obese-women-diagnosed-with-gestational-diabetes-mellitus-in-early-versus-late-pregnancy
#19
N E Grotenfelt, K Rönö, J G Eriksson, A Valkama, J Meinilä, H Kautiainen, B Stach-Lempinen, S B Koivusalo
Background: Maternal metabolic derangements associated with early pregnancy gestational diabetes may affect the fetus differently compared with gestational diabetes diagnosed later in pregnancy. The aim of this observational study was to assess neonatal outcomes according to timing of gestational diabetes diagnosis in obese women. Methods: Women ≥18 years of age with a pre-pregnancy body mass index ≥30 kg/m2 were grouped according to the results of a 75 g 2-h oral glucose tolerance test performed at 13...
September 27, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/30255546/fetal-programming-and-wilms-tumor
#20
Julia E Heck, Di He, Carla Janzen, Noah Federman, Jorn Olsen, Beate Ritz, Johnni Hansen
BACKGROUND: The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns. METHODS: Cases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age...
September 25, 2018: Pediatric Blood & Cancer
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