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Birthweight for gestational age

Mohammad L Rahman, Liming Liang, Linda Valeri, Li Su, Zhaozhong Zhu, Shangzhi Gao, Golam Mostofa, Qazi Qamruzzaman, Russ Hauser, Andrea Baccarelli, David C Christiani
Altered expression of microRNAs (miRNAs) is implicated in fetal growth. However, the mechanisms by which placenta-derived miRNAs regulate birthweight are not well understood. In Phase 1, we compared the expression of 754 miRNAs in the placenta of mothers from two extreme birthweight groups (0.8-2.2 kg vs. 3.3-3.9 kg, n = 77 each) selected from an arsenic-exposed Bangladeshi birth cohort (n = 1,141). We identified 49 miRNAs associated with the extreme birthweight groups and/or gestational age in Phase 1, which were further analyzed in Phase 2 among 364 randomly selected mother-infant pairs...
August 13, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Yael Baumfeld, Asnat Walfisch, Tamar Wainstock, Idit Segal, Ruslan Sergienko, Daniella Landau, Eyal Sheiner
Maternal morbidity is associated with cesarean deliveries. However, new evidence suggests that short- and long-term neonatal morbidity is also associated. This includes respiratory morbidity with conflicting results. To determine whether mode of delivery has an impact on the long-term risk for respiratory morbidity in the offspring, a population-based cohort analysis was conducted including all singleton term deliveries occurring between 1991 and 2014 at a single tertiary medical center. A comparison was performed between children delivered via elective cesarean delivery (CD) and those delivered vaginally...
August 8, 2018: European Journal of Pediatrics
Alex Y Wang, Nadom Safi, Fathalla Ali, Kei Lui, Zhuoyang Li, Mark P Umstad, Elizabeth A Sullivan
BACKGROUND: While their incidence is on the rise, twin pregnancies are associated with risks to the mothers and their babies. This study aims to investigate the likelihood of adverse neonatal outcomes of twins following assisted reproductive technology (ART) compared to non-ART twins. METHODS: A retrospective population study using the Australian National Perinatal Data Collections (NPDC) which included 19,662 twins of ≥20 weeks gestational age or ≥ 400 g birthweight in Australia...
August 8, 2018: BMC Pregnancy and Childbirth
Paul Cullis, Frith Cull, Gordon Bruce, Allan Johnston, Hetal Patel, Lesley Jackson, Peter John Galloway, Gregor Walker
BACKGROUND: Infants with gastrointestinal conditions and poor weight gain are administered sodium supplementation based upon urinary sodium levels. However, the reference range of urinary electrolytes is unknown. The aim of this study was to ascertain the normal values of urinary electrolytes in heatlhy, term infants. Secondary aims were to establish the relationship between urinary electrolytes with weight velocity and feeding practices. METHODS: Healthy, term (≥ 37 weeks gestation) infants were recruited...
August 8, 2018: Annals of Clinical Biochemistry
Natasha Pritchard, Anthea Lindquist, Richard Hiscock, Prerna Diksha, Susan P Walker, Michael Permezel
BACKGROUND AND AIM: Large-for-gestational-age (LGA) infants are at increased risk of intrapartum complications. However, some infants classified as LGA may be appropriate-for-gestational-age (AGA) if adjusted for maternal stature. We determined whether customisation of birthweight centiles by maternal height, or height and weight, improves the detection of LGA infants at risk of complications. METHODS: We conducted a retrospective analysis of 38 246 term, singleton nulliparous women...
August 8, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Emily S Barrett, Wendy Vitek, Omar Mbowe, Sally W Thurston, Richard S Legro, Ruben Alvero, Valerie Baker, G Wright Bates, Peter Casson, Christos Coutifaris, Esther Eisenberg, Karl Hansen, Stephen Krawetz, Randal Robinson, Mitchell Rosen, Rebecca Usadi, Heping Zhang, Nanette Santoro, Michael Diamond
STUDY QUESTION: Among infertile women undergoing ovarian stimulation, is allostatic load (AL), a measure of chronic physiological stress, associated with subsequent fertility and pregnancy outcomes? SUMMARY ANSWER: AL at baseline was not associated with conception, spontaneous abortion or live birth, however, it was significantly associated with increased odds of pre-eclampsia and preterm birth among women who had a live birth in the study. WHAT IS KNOWN ALREADY: Several studies have linked AL during pregnancy to adverse outcomes including preterm birth and pre-eclampsia, hypothesizing that it may contribute to well-documented disparities in pregnancy and birth outcomes...
August 1, 2018: Human Reproduction
Paul Stephen Cullis, Emily Mullan, Allan Jackson, Gregor Walker
BACKGROUND: Between 20% and 50% neonates with bilious vomiting are diagnosed with surgical pathology. Distinguishing neonates requiring surgery remains challenging. Our aim was to conduct an audit of term neonates with bilious vomiting referred for assessment to identify characteristics of this cohort and management. Secondary aims were to identify factors predictive of surgical pathology. METHODS: Infants <28 days referred for bilious vomiting from 2011 to 2015 were identified through cross-referencing multiple patient databases...
July 26, 2018: Journal of Pediatric Surgery
Xiaolin Hua, Minxue Shen, Uma M Reddy, Germaine Buck Louis, Joao Paulo Souza, A Metin Gülmezoglu, Jun Zhang
OBJECTIVE: To compare the ability of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards to identify fetuses at risk of adverse perinatal outcomes. METHODS: A retrospective analysis was performed among women enrolled in a multicenter randomized controlled trial (Routine Antenatal Diagnostic Imaging with Ultrasound) that was conducted in six states in the USA between November 1987 and May 1991. The predictive capability of various biometric indicators (biparietal diameter, femur length, abdominal circumference, head circumference, estimated fetal weight, and birthweight) was evaluated...
August 3, 2018: International Journal of Gynaecology and Obstetrics
M J Silva, N M Kilpatrick, J M Craig, D J Manton, P Leong, D Burgner, K J Scurrah
The etiology of hypomineralized second primary molars (HSPM) is unclear, but genetic and environmental factors have been proposed. The aim of this study was to investigate the relative contribution of genes and environment to the etiology of HSPM and to identify potential environmental risk factors in a longitudinal twin cohort. Children from twin pregnancies ( N = 250) were recruited antenatally, and detailed demographic, health, and phenotypic data were collected at recruitment, 24- and 36-wk gestation, birth, and 18 mo of age...
August 3, 2018: Journal of Dental Research
B D Garg, H Balasubramanian, N S Kabra, A Bansal
BACKGROUND: Necrotising enterocolitis (NEC) is one of the most common life-threatening emergencies of the gastrointestinal tract in preterm neonates. The present study aimed to determine the efficacy of oropharyngeal colostrum with respect to reducing NEC in preterm neonates. METHODS: A literature search was conducted for various randomised control trials by searching the Cochrane Central Register of Controlled Trials, PubMed, EMBASE and ongoing clinical trials...
August 2, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Samantha M McDonald, SeonAe Yeo, Jihong Liu, Sara Wilcox, Xuemei Sui, Russell R Pate
Prenatal physical activity (PA) reduces the risk of delivering infants with a birthweight ≥4000 g among normal-weight pregnant women, but evidence on the impact of maternal cardiorespiratory fitness (CRF) on birthweight remains equivocal among overweight or obese (OW/OB) pregnant women. The purpose of this study was to evaluate the relationship between maternal prenatal PA and CRF and birthweight in OW/OB pregnant women. Data from a randomized controlled exercise intervention trial in sedentary, OW/OB pregnant women were used...
September 2018: Preventive Medicine Reports
Paul N Morison, Montserrat Bacardi-Gascon, Manuel Lopez-Corrales, Arturo Jimenez-Cruz
BACKGROUND AND OBJECTIVES: Excessive gestational weight gain has been associated with higher risk for large for gestational age newborns. This systematic review and meta-analysis aims to assess whether an intensive diet and exercise intervention has an effect in reducing gestational weight gain and large for gestational age newborns. METHODS AND STUDY DESIGN: The search was conducted on PubMed and Cochrane database. Through PRISMA flow diagram, clinical trials which met the inclusion criteria were selected...
2018: Asia Pacific Journal of Clinical Nutrition
Jodie M Dodd, Rosalie M Grivell, Andrea R Deussen, William M Hague
BACKGROUND: There has been considerable interest in providing antenatal dietary and lifestyle advice for women with obesity or who are overweight during pregnancy, as a strategy to limit gestational weight gain and improve maternal and infant health. However, such antenatal interventions appear to have a modest effect on gestational weight gain and other clinical pregnancy and birth outcomes and additional strategies are required.Metformin is an oral insulin-sensitising medication that acts to decrease blood glucose concentrations...
July 24, 2018: Cochrane Database of Systematic Reviews
Vidya Seshan, Esra Alkhasawneh, Salam Al Kindi, Fayez Abdel-Majid Al Simadi, Judie Arulappan
Objectives: We conducted this study to assess the risk factors of gestational anemia and evaluate the effectiveness of a culturally-tailored nutrition educational intervention on hemoglobin (Hb) status among pregnant Omani women. Newborn birthweight was used as a birth outcome. Methods: The study was conducted in two phases. The first phase investigated the risk factors associated with gestational anemia in 206 Omani women who were 3 20 years old and had at least completed 12 weeks of gestation...
July 2018: Oman Medical Journal
S Amrane, M B Morton, R A Lobo, B Luke
PURPOSE: To evaluate factors associated with interpregnancy interval (IPI) among women treated with in vitro fertilization (IVF). METHODS: Women with at least two cycles of IVF between 2004 and 2013 were identified from the SART CORS database and grouped by age at first cycle, infertility diagnosis, IVF treatment parameters, and cycle 1 outcome (singleton or multiple live birth or no live birth, length of gestation, and birthweight). The distributions of IPIs (in months, 0-5, 6-11, 12-17, 18-23, and ≥ 24) were compared across these factors...
July 20, 2018: Journal of Assisted Reproduction and Genetics
Junshun Fang, Lihua Zhu, Dong Li, Zhipeng Xu, Guijun Yan, Haixiang Sun, Ningyuan Zhang, Linjun Chen
PURPOSE: To evaluate the effect of culture duration (embryo (day 3) transfer vs. blastocyst (day 5-6) transfer) on the birthweight of singletons from frozen embryo transfer (FET) cycles. METHODS: A total of 1092 singletons were analyzed in this retrospective study. The distribution of large for gestational age (LGA) infants, the mean birthweight, and z scores of singletons were compared between the day 3 and day 5-6 transfer groups. Multiple linear regression analysis was performed to evaluate the relationships between confounding factors and singleton birthweight...
July 20, 2018: Journal of Assisted Reproduction and Genetics
Daniela K Schlüter, Rowena Griffiths, Abdulfatah Adam, Ashley Akbari, Martin L Heaven, Shantini Paranjothy, Anne-Marie Nybo Andersen, Siobhán B Carr, Tania Pressler, Peter J Diggle, David Taylor-Robinson
BACKGROUND: Poor growth during infancy and childhood is a characteristic feature of cystic fibrosis (CF). However, the impact of CF on intrauterine growth is unclear. We studied the effect of CF on birth weight in Denmark and Wales, and assessed whether any associations are due to differences in gestational age at birth. METHODS: We conducted national registry linkage studies in two countries, using data for 2.2 million singletons born in Denmark (between 1980 and 2010) and Wales (between 1998 and 2015)...
July 19, 2018: Thorax
Parag K Thaware, Sonia McKenna, Christopher C Patterson, Claire Casey, David R McCance
Context: Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention. Objective: We aimed to prospectively examine the association of maternal fasting lipids with adiposity in 5-7-year old offspring in a large observational study. Design: 1612 pregnant women were recruited to the Belfast centre of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study in a large tertiary maternity hospital at an average of 28 weeks gestation...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Xiujuan Zhu, Luyun Wei, Dehao Cao, Chaoqun Liu, Jiarong Tian, Yu Long, Shengzhu Huang, Liqian Ou, Xiaobo Yang, Zengnan Mo
AIM: This study aimed to explore the influence of maternal folate and vitamin B12 (B12) status during pregnancy on the incidence of low birthweight (LBW) infants. METHODS: A total of 6203 eligible women registered in seven hospitals in southern China, and 230 cases with singleton live births and 382 controls were matched for further analyses. The concentrations of serum folate and B12 were detected with chemiluminescence microparticle immunoassay on ARCHITECT i2000-1...
July 18, 2018: Journal of Obstetrics and Gynaecology Research
James G Huang, Shi Hua Chan, Le Ye Lee
INTRODUCTION: We studied the effects of ethnicity on early infant growth patterns in exclusively breast-fed (EBF) infants from a Singaporean multiethnic population. This was a prospective cohort study conducted in National University Hospital, Singapore. MATERIALS AND METHODS: Healthy, EBF infants born at-term completing 37 weeks and above, and whose birthweight was appropriate for gestational age (>10th centile, <90th centile) were recruited. Infants were required to be EBF at least until the minimum age of weaning...
June 2018: Annals of the Academy of Medicine, Singapore
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