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Birthweight for gestational age

Jennifer A Hutcheon, Olof Stephansson, Sven Cnattingius, Lisa M Bodnar, KariJ Johansson
BACKGROUND: Observational cohort studies have consistently shown that maternal weight gain in pregnancy is positively associated with fetal size, but it is unknown whether the association is causal. This study investigated the effect of pregnancy weight gain on fetal growth using a sibling comparison design to control for unmeasured confounding by genetic and shared environmental factors. METHODS: Our study population included 44,457 infants (21,680 women) with electronic medical records in the Stockholm-Gotland Obstetrical Database, 2008-2014...
December 3, 2018: Epidemiology
Namirembe J Kazibwe, Phani S Veeranki, Karen E Smith
OBJECTIVE: The objective of this study was to evaluate for decline in cognitive scores from 12 to 24 months of age for preterm infants ≤32 weeks gestational age for those with and without bronchopulmonary dysplasia. STUDY DESIGN: In an observational retrospective study, detailed medical data was collected from the electronic medical records of preterm infants born between January 2009 and December 2015 who had cognitive evaluations using Bayley Scales of Infant Development, 3rd ed (BISD-3) at 12 months corrected gestational age and 24 months chronological age...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Caroline Hartley, Fiona Moultrie, Amy Hoskin, Gabrielle Green, Vaneesha Monk, Jennifer L Bell, Andrew R King, Miranda Buckle, Marianne van der Vaart, Deniz Gursul, Sezgi Goksan, Edmund Juszczak, Jane E Norman, Richard Rogers, Chetan Patel, Eleri Adams, Rebeccah Slater
BACKGROUND: Infant pain has immediate and long-term effects but is undertreated because of a paucity of evidence-based analgesics. Although morphine is often used to sedate ventilated infants, its analgesic efficacy is unclear. We aimed to establish whether oral morphine could provide effective and safe analgesia in non-ventilated premature infants for acute procedural pain. METHODS: In this single-centre masked trial, 31 infants at the John Radcliffe Hospital, Oxford, UK, were randomly allocated using a web-based facility with a minimisation algorithm to either 100 μg/kg oral morphine sulphate or placebo 1 h before a clinically required heel lance and retinopathy of prematurity screening examination, on the same occasion...
November 30, 2018: Lancet
Anna-Veera Seppänen, Florence Bodeau-Livinec, Elaine M Boyle, Anna-Karin Edstedt-Bonamy, Marina Cuttini, Liis Toome, Rolf F Maier, Eva Cloet, Corine Koopman-Esseboom, Pernille Pedersen, Janusz Gadzinowski, Henrique Barros, Jennifer Zeitlin
AIM: Children born very preterm require additional specialist care because of the health and developmental risks associated with preterm birth, but information on their health service use is sparse. We sought to describe the use of specialist services by children born very preterm in Europe. METHOD: We analysed data from the multi-regional, population-based Effective Perinatal Intensive Care in Europe (EPICE) cohort of births before 32 weeks' gestation in 11 European countries...
December 3, 2018: Developmental Medicine and Child Neurology
Odessa P Hamidi, Avi Hameroff, Allen Kunselman, William M Curtin, Risha Sinha, Serdar H Ural
Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. The relationship between placental thickness and neonatal birthweight was assessed using Pearson's correlation coefficient (r) with 95% confidence interval (CI)...
December 3, 2018: Journal of Perinatal Medicine
Kelly A Kogut, Nicholas F Fiore
PURPOSE: We describe our series of giant omphalocele patients treated with a serial taping method for gradual reduction of the abdominal contents and early fascial closure. METHODS: Between 2010 and 2017 we cared for ten newborns with giant omphaloceles. The average gestational age was 35.5 weeks (range 29-38) and average birthweight was 2.84 kg. Seven infants had other major anomalies, including one with a variant of Pentology of Cantrell. Four had abnormal chromosomes...
December 2018: Journal of Pediatric Surgery
Paulina M Merino, Patricia Lopez, Abril Salinas, Carolina Pastene, Alex Muñoz, Fernando Cassorla, Ethel Codner
STUDY OBJECTIVE: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP). DESIGN: Multicenter study of ovarian function in AcART due to male or tubal infertility. SETTING: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. The participants were born at term (>37 weeks of gestation) with normal birthweights (>2500 g) from singleton pregnancies...
November 28, 2018: Journal of Pediatric and Adolescent Gynecology
Guo-Rui Dou, Man-Hong Li, Zi-Feng Zhang, Yi-Na Lu, Yan-Ni Zhu, Hai-Yan Wang, Jing Wang, Xiao-Jie Wang, Jing Fan, Yu-Sheng Wang
BACKGROUND: Severe retinopathy of prematurity (ROP) with extremely unfavorable prognosis among infants can do great damage to individuals and bring tremendous social-economic burden. The purpose of this study is to describe the demographic and ocular characteristics of infants who presented with stage 5 ROP in order to identify reasons why they have become blind, and to identify contributing factors in order to focus great attention on the current ROP program and to inspire more effort in ROP screening in middle income countries...
November 29, 2018: BMC Ophthalmology
S Nazzari, P Fearon, F Rice, N Dottori, F Ciceri, M Molteni, A Frigerio
Accumulating evidence suggests that antenatal maternal stress is associated with altered behavioral and physiological outcomes in the offspring, however, whether this association is causal and the underlying biological mechanisms remain largely unknown. While the most studied mediator of maternal stress influences on the fetus has generally been cortisol, alternative novel markers of stress or inflammation warrant further consideration. The current investigation explored the influence of variations in self-reported symptoms of distress, stress hormones and inflammatory markers on infant birth outcomes and early stress regulation...
November 14, 2018: Psychoneuroendocrinology
(no author information available yet)
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations. METHODS: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017...
November 10, 2018: Lancet
Julie M Petersen, Allen A Mitchell, Carla Van Bennekom, Martha M Werler
PURPOSE: To assess agreement between maternal recall and medical records for gestational age (GA) at birth as derived from dating information and birthweight. METHODS: In the case-control Slone Birth Defects Study, within 6 months of delivery, trained nurses conducted standardized telephone interviews with mothers of infants with and without major structural malformations. In a subset of approximately 5000 case and control mothers from five US centers (2008-2012), a research nurse abstracted subjects' medical records...
November 29, 2018: Pharmacoepidemiology and Drug Safety
Philippa Middleton, Judith C Gomersall, Jacqueline F Gould, Emily Shepherd, Sjurdur F Olsen, Maria Makrides
BACKGROUND: Higher intakes of foods containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA), such as fish, during pregnancy have been associated with longer gestations and improved perinatal outcomes. This is an update of a review that was first published in 2006. OBJECTIVES: To assess the effects of omega-3 LCPUFA, as supplements or as dietary additions, during pregnancy on maternal, perinatal, and neonatal outcomes and longer-term outcomes for mother and child...
November 15, 2018: Cochrane Database of Systematic Reviews
Eyal Krispin, Adi Borovich, Alyssa Hochberg, Lina Salman, Rony Chen, Arnon Wiznitzer, Eran Hadar
OBJECTIVE: To evaluate the association between antenatal corticosteroid treatment and neonatal outcome when delivery occurs at term. STUDY DESIGN: A retrospective cohort study of all women with singleton gestations who delivered at term (37 + 0 to 41 + 6 weeks) in a tertiary medical center (2012-2015). Women with diabetes, suspected fetal growth restriction, antepartum fetal death, and fetal structural or chromosomal anomalies were excluded. The cohort was divided according to prior preterm (24 + 0 to 33 + 6 weeks) antenatal corticosteroids treatment due to threatened preterm labor (study group), vs...
November 26, 2018: Archives of Gynecology and Obstetrics
Lisa McHugh, Helen S Marshall, Kirsten P Perrett, Terry Nolan, Nicholas Wood, Stephen B Lambert, Peter Richmond, Robert S Ware, Paula Binks, Michael J Binks, Ross M Andrews
Background: Inactivated influenza vaccine (IIV) and pertussis vaccination are recommended in pregnancy. Limited safety data exist for women who received IIV vaccine during the first trimester of pregnancy or received both vaccines in pregnancy. We assessed adverse birth outcomes between vaccinated and unvaccinated pregnancies. Methods: Among prospectively enrolled Australian "FluMum" participants (2012-2015), primary exposure was receipt and timing of IIV during pregnancy...
November 23, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Temilayo E Adeyeye, Edwina H Yeung, Alexander C McLain, Shao Lin, David A Lawrence, Erin M Bell
We examined whether cesarean delivery (CD) increased the risk of wheeze or food allergy in early childhood compared to vaginal delivery and whether these associations were mediated by breastfeeding. The study population was the Upstate KIDS cohort (2008-2010) of mothers and infants from New York State (excluding New York City). Infant's wheeze was reported by questionnaire every 4-6 months until 3 years as was food allergies beginning at 8 months. Modified Poisson regression was used to compare risks of the outcomes by mode of delivery (MOD)...
November 26, 2018: American Journal of Epidemiology
Klaudia Berk, Malgorzata Powirtowska, Adrianna Blahuszewska, Agata Korzeniecka-Kozerska
AIM: The etiology of micturition disorders in children is multifactorial and still unclear. The perinatal factors may play a role in the development of children's urinary incontinence. We compared each type of micturition disorders in terms of length of gestation, birthweight, family history of bed-wetting and delivery type. METHODS: Data were from 488 patients of the Department of Pediatrics and Nephrology, Children's Clinical Hospital of the Medical University of Bialystok, and included: age, sex, clinical diagnosis, perinatal history, constipation, history of vesicoureteral reflux, family history of nocturnal enuresis, urodynamic diagnosis, bladder capacity...
November 25, 2018: Acta Paediatrica
Neidin Bussmann, Afif El-Khuffash, Colm R Breatnach, Naomi McCallion, Orla Franklin, Gautam K Singh, Philip T Levy
INTRODUCTION: Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV-pulmonary vasculature (PV) coupling. RV-PV can be assessed with the RV length-force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association between LV diastolic function measured using tissue Doppler imaging (TDI) and TAPSE/PAAT. METHODS: A study of premature infants <29 weeks gestation...
November 19, 2018: Early Human Development
Jane E Hirst, Hannah Ellin Knight, Eric O Ohuma, Terence Dwyer, Benjamin D Hennig, Aris T Papageorghiou, Leila Cheikh Ismail, José Villar, Stephen H Kennedy
OBJECTIVE: To determine the socioeconomic gradient of birthweights in England with reference to the prescriptive INTERGROWTH-21st Birthweight Standard. DESIGN: National cross-sectional study using data from Hospital Episode Statistics. SETTING: National Health Service in England. PARTICIPANTS: All singleton babies, live born between 34 weeks' gestation and 42 weeks' gestation, between 1 April 2011 and 31 March 2012. MAIN OUTCOME MEASURES: Birthweight distribution of babies with a birthweight of <10th centile or >90th centile, that is, small for gestational age (SGA) or large for gestational age (LGA) using Index of Multiple Deprivation quintiles as a proxy for socioeconomic status...
November 21, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Ans C M Kluivers, Carly E Calabrese, Maarten J Koudstaal, Cory M Resnick
OBJECTIVE: The purpose of this study was to determine whether gestational amniotic fluid level abnormalities were associated with postnatal syndromic status in a series of patients with Robin sequence (RS). DESIGN: Retrospective study of participants with RS at Boston Children's Hospital from 1967 to 2017. Participants were divided into syndromic and nonsyndromic groups. The primary predictor variable was postnatal syndromic diagnosis (yes/no). Additional predictor variables included gestational age at birth, birthweight, sex, presence of cleft palate, and other congenital anomalies...
November 19, 2018: Cleft Palate-craniofacial Journal
Alexa A Freedman, Carol J Hogue, Carmen J Marsit, Augustine Rajakumar, Alicia K Smith, Katherine L Grantz, Robert L Goldenberg, Donald J Dudley, George R Saade, Robert M Silver, Karen J Gibbins, Radek Bukowski, Carolyn Drews-Botsch
Low birthweight is associated with both perinatal and long-term morbidity and mortality and may be a result of abnormal placental development and function. Studies in singletons have reported associations between features of placental morphology and birthweight. Evaluating similar associations within twin pairs offers a unique opportunity to control for key confounders shared within a twin pair, including gestational age, parental characteristics, and intrauterine environment, which may otherwise be unfeasible...
November 19, 2018: American Journal of Epidemiology
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