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Canine lymphoma

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https://www.readbyqxmd.com/read/30117260/response-rate-to-a-single-dose-of-vinblastine-administered-to-dogs-with-treatment-naive-multicentric-lymphoma
#1
K Harding, N Bergman, A Smith, S Lindley, A Szivek, R Milner, W Brawner, A Lejeune
Vincristine is included in vincristine, cyclophosphamide, doxorubicin and prednisone (CHOP) chemotherapy protocols, which are the gold-standard treatment for high-grade canine lymphoma. Vincristine can result in relatively high rates of gastrointestinal toxicity, whereas vinblastine is generally well tolerated and thus may represent an under-utilized and minimally toxic alternative to vincristine. Our objective was to determine the response rate and toxicity associated with a single dose of vinblastine administered to dogs with treatment-naïve, intermediate to large-cell, multicentric lymphoma...
August 16, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/30117253/canine-t-cell-lymphoma-treated-with-lomustine-vincristine-procarbazine-and-prednisolone-chemotherapy-in-35-dogs
#2
E Morgan, K O'Connell, M Thomson, A Griffin
Canine T cell lymphoma has previously been found to be a poor prognostic indicator compared with its B cell counterpart. The cyclophosphamide, doxorubicin, vincristine, and prednisolone protocol is widely accepted as a first line treatment for canine lymphoma. There have been several studies investigating alternative protocols for T cell lymphoma. This study investigated the use of a modified lomustine, vincristine, procarbazine and prednisolone protocol as a first line treatment in 35 dogs with T Cell lymphoma...
August 16, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/30101447/targeting-nedd8-activating-enzyme-is-a-new-approach-to-treat-canine-diffuse-large-b-cell-lymphoma
#3
A L F V Assumpção, Z Lu, K W Marlowe, K S Shaffer, X Pan
Canine diffuse large B-cell lymphoma (DLBCL), the most common hematologic malignancy of dogs, is associated with poor overall survival. The lack of conventional chemotherapies with sustainable efficacy warrants investigation of novel therapies. Pevonedistat (MLN4924) is a potent and selective small molecule NEDD8-activating enzyme inhibitor. In human activated B-cell-like (ABC) diffuse large B-cell lymphoma, pevonedistat induces lymphoma cell apoptosis, DNA damage and G1 cell cycle arrest by inhibiting the nuclear factor-κB (NF-κB) pathway...
August 13, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/30085860/quantification-and-prognostic-value-of-programmed-cell-death-ligand-1-expression-in-dogs-with-diffuse-large-b-cell-lymphoma
#4
Lisbeth A Ambrosius, Deepika Dhawan, José A Ramos-Vara, Audrey Ruple, Deborah W Knapp, Michael O Childress
OBJECTIVE To measure programmed cell death ligand-1 (PD-L1) mRNA expression in archived primary nodal diffuse large B-cell lymphoma (DLBCL) specimens of dogs and determine whether that expression was associated with progression-free survival time (PFST). SAMPLE Archived tumoral lymph node specimens from 42 dogs with DLBCL and lymph node specimens from 10 healthy dogs (controls). PROCEDURES Archived tumoral and control lymph node specimens underwent multiplex qPCR analysis with probes and primers against canine PD-L1 and glyceraldehyde 3-phosphate dehydrogenase (housekeeping gene) to determine PD-L1 mRNA expression...
June 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/30081964/breed-associated-risks-for-developing-canine-lymphoma-differ-among-countries-an-european-canine-lymphoma-network-study
#5
Stefano Comazzi, Stefano Marelli, Marzia Cozzi, Rita Rizzi, Riccardo Finotello, Joaquim Henriques, Josep Pastor, Frederique Ponce, Carla Rohrer-Bley, Barbara C Rütgen, Erik Teske
BACKGROUND: Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with the aim of investigating the breed prevalence of canine lymphoma in different European countries and of investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes...
August 6, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30071780/subcutaneous-panniculitis-like-t-cell-lymphoma-in-dogs-morphologic-and-immunohistochemical-classification
#6
Erica L Noland, Stefan M Keller, Matti Kiupel
Canine nonepitheliotropic cutaneous T-cell lymphomas (NECTCL) are poorly characterized. In humans, a number of distinct subtypes of NECTCL have been recognized, including subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Five dogs with subcutaneous T-cell lymphomas histologically similar to SPTCL in humans are herein described. The mean age was 8.5 years (5.5 to 12 years). No breed or sex predilection was identified in this small cohort. Two dogs presented with an acute onset of multiple skin masses and 3 dogs had solitary masses with subsequent development of multiple smaller masses within 0...
August 2, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/30061364/nci-comparative-oncology-program-testing-of-non-camptothecin-indenoisoquinoline-topoisomerase-i-inhibitors-in-naturally-occurring-canine-lymphoma
#7
Jenna H Burton, Christina N Mazcko, Amy K LeBlanc, Joseph M Covey, Jiuping Jay Ji, Robert J Kinders, Ralph E Parchment, Chand Khanna, Melissa Paoloni, Susan E Lana, Kristen Weishaar, Cheryl A London, William C Kisseberth, Erika Krick, David M Vail, Michael O Childress, Jeffrey N Bryan, Lisa G Barber, E J Ehrhart, Michael S Kent, Timothy M Fan, Kelvin Y Kow, Nicole Northup, Heather Wilson-Robles, Joseph E Tomaszewski, Julianne L Holleran, Miguel Muzzio, Julie Eiseman, Jan H Beumer, James H Doroshow, Yves Pommier
PURPOSE: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance, and diarrhea), novel TOP1 inhibitors are warranted. Indenoisoquinoline non-camptothecin topoisomerase I (TOP1) inhibitors overcome chemical instability and drug resistance that limit camptothecin use. Three indenoisoquinolines, LMP400 (Indotecan), LMP776 (Indimitecan) and LMP744, were examined in a phase I study for lymphoma-bearing dogs to evaluate differential efficacy, pharmacodynamics, toxicology and pharmacokinetics...
July 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30040869/evaluation-of-costimulatory-molecules-in-dogs-with-b-cell-high-grade-lymphoma
#8
Michihito Tagawa, Chihiro Kurashima, Satoshi Takagi, Naoya Maekawa, Satoru Konnai, Genya Shimbo, Kotaro Matsumoto, Hisashi Inokuma, Keiko Kawamoto, Kazuro Miyahara
B cell high grade lymphoma is the most common hematopoietic malignancy in dogs. Although the immune checkpoint molecules, programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), and immune checkpoint inhibitors have been evaluated for the treatment of various human lymphoid malignancies, the expression of those molecules and their relationship with prognosis remain unknown in canine lymphoma. The objective of this study was to evaluate the expression of costimulatory molecules on peripheral blood lymphocytes and tumor infiltrating lymphocytes, in addition to associated ligand expression in the lymph nodes of patients with B cell multicentric high grade lymphoma...
2018: PloS One
https://www.readbyqxmd.com/read/30019325/t-cell-histiocyte-rich-large-b-cell-lymphoma-report-of-the-first-case-in-the-mandible
#9
Ricardo Natã Fonseca Silva, Elismauro Francisco Mendonça, Aline Carvalho Batista, Rita de Cássia Gonçalves Alencar, Ricardo Alves Mesquita, Nadia Lago Costa
T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region...
July 17, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29983882/the-histone-deacetylase-inhibitor-panobinostat-is-a-potent-antitumor-agent-in-canine-diffuse-large-b-cell-lymphoma
#10
Joana N R Dias, Sandra I Aguiar, Diane M Pereira, Ana S André, Lurdes Gano, João D G Correia, Belmira Carrapiço, Barbara Rütgen, Rui Malhó, Conceição Peleteiro, João Goncalves, Cecília M P Rodrigues, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Non-Hodgkin lymphoma (NHL) is one of the most common causes of cancer-related death in the United States and Europe. Although the outcome of NHL patients has improved over the last years with current therapies, the rate of mortality is still high. A plethora of new drugs is entering clinical development for NHL treatment; however, the approval of new treatments remains low due in part to the paucity of clinically relevant models for validation. Canine lymphoma shares remarkable similarities with its human counterpart, making the dog an excellent animal model to explore novel therapeutic molecules and approaches...
June 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29958524/evaluation-of-pgp-mdr1-immunohistochemistry-in-canine-lymphoma-prognostic-and-clinical-aspects
#11
Péter Vajdovich, Zsófia Koltai, Valéria Dékay, Krisztina Kungl, Andrea Harnos
Permeability glycoprotein (P-glycoprotein, Pgp) immunohistochemistry (IHC) was evaluated in dogs with multicentric lymphoma treated with cyclophosphamide- doxorubicin-vincristine-prednisolone with or without L-Asparaginase. Lymph nodes of 33 untreated dogs were immunophenotyped: Ki67% and Pgp analyses (with anti-Pgp, monoclonal mouse C494 clone) were performed. Pgp positivity rate and intensity were determined microscopically (by manual counting done by two blinded authors in two parallel specimens). The median overall survival time (OST) was 333 days and the relapse-free period (RFP) 134 days...
June 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29937462/lymphoma-associated-hemophagocytic-syndrome-in-six-dogs
#12
Akihisa Suwa, Tetsuya Shimoda
Hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by histiocytic proliferation, with marked hemophagocytosis in the reticuloendothelial organs. HPS caused by lymphoma is termed lymphoma-associated hemophagocytic syndrome (LAHS), and there are few reports on canine and feline LAHS. The objective of this study was to examine the clinical, diagnostic, and clinicopathologic features of LAHS in six dogs. The diagnostic criteria of LAHS consisted of lymphoma, bicytopenia or pancytopenia in the blood, and increased hemophagocytosis in the reticuloendothelial organs...
June 25, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29881551/spinal-extradural-t-cell-lymphoma-with-paraneoplastic-hypereosinophilia-in-a-dog-clinicopathological-features-treatment-and-outcome
#13
Katie A McNaught, Joanna Morris, Kali Lazzerini, Caroline Millins, Roberto José-López
Spinal lymphoma is a rare manifestation of a common canine hematopoietic neoplasia. Description of treatment, outcome, and MRI features are scarce. The latter can be heterogeneous, stressing the importance of lesion excision and analysis. Clinicians should also be aware of hypereosinophilia as accompanying paraneoplastic syndrome and its potential prognostic implications.
June 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29871757/cytomorphological-description-and-intra-observer-agreement-in-whole-slide-imaging-for-canine-lymphoma
#14
F Bonsembiante, V Martini, U Bonfanti, G Casarin, D Trez, M E Gelain
Whole slide imaging (WSI) uses robotic microscopes for computerising entire slides into digital images. The aim of this study was to assess the agreement between WSI and optical microscopy for evaluating canine lymphoma cytological samples. Forty-four slides were computerised using a WSI scanner and the digital and glass slides were examined by three observers with different levels of expertise. Morphology and grade of lymphoma were scored on the basis of the updated Kiel classification and intra-observer agreement was assessed...
June 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29807508/canine-splenic-nodular-lymphoid-lesions-immunophenotyping-proliferative-activity-and-clonality-assessment
#15
Silvia Sabattini, Rosa Maria Lopparelli, Antonella Rigillo, Mery Giantin, Andrea Renzi, Chiara Matteo, Ombretta Capitani, Mauro Dacasto, Marisa Mengoli, Giuliano Bettini
Canine splenic lymphoid nodules are currently classified as indolent lymphomas (marginal zone lymphoma [MZL], mantle cell lymphoma [MCL]) or nodular hyperplasia (lymphoid [LNH] or complex [CNH] type). Their differentiation can be difficult on morphology, because of similar histologic appearance and poorly defined diagnostic criteria. Thirty-five surgical samples of splenic lymphoid nodules were reviewed in order to assess the diagnostic contribution of immunophenotyping, proliferative activity and clonality (PARR) in differentiating between hyperplastic and neoplastic lesions...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29805960/clinical-response-to-a-lomustine-cytarabine-based-chemotherapy-protocol-in-a-case-of-canine-large-granular-lymphocyte-t-cell-lymphoma-with-spinal-involvement
#16
Elisabetta Treggiari, Lorna Provan Arrol
A 7-year-old, female neutered cross-breed dog was referred to our institution with a history of progressive hind limb weakness, which then progressed to paraplegia. An MRI of the spine revealed severe meningeal infiltrate consistent with lymphoma involvement, located at the level of L2-L7 with concurrent lymph node enlargement and abnormal bone marrow. Abdominal ultrasonography also identified changes in the spleen and confirmed enlargement of the lumbar aortic lymph node. Cytology of lymph nodes and spleen confirmed a high-grade lymphoma with features of a large granular lymphocyte (LGL) variant; PCR for antigen receptor re-arrangements (PARR) was positive for a clonal T-cell receptor rearrangement...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29781671/breed-prevalence-of-canine-lymphoma-in-south-africa
#17
Liesl J Van Rooyen, Emma Hooijberg, Fred Reyers
Lymphoma is a common haematopoietic neoplasm in dogs. Several breeds have been shown to have a predisposition to lymphoma; however, very little information exists regarding the South African dog population. This study assessed whether any breed had increased odds of developing lymphoma compared with others, and also investigated the effects of age, sex and neutering status on disease prevalence. Two study populations and their corresponding reference populations were studied retrospectively. Odds ratios (ORs) for lymphoma in 49 dog breeds, together with their 95% confidence intervals (CI), were calculated...
March 8, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29778492/tanovea%C3%A2-for-the-treatment-of-lymphoma-in-dogs
#18
REVIEW
Erik De Clercq
Tanovea® (first named GS-9219, then VDC-1101, generic name: rabacfosadine) is a pro-prodrug or "double" prodrug of PMEG [9-(2-phosphonylmethoxyethyl)guanine], which has been conditionally approved by the US FDA (Food and Drug Administration) for the treatment of lymphoma in dogs. Tanovea has been demonstrated to be effective against non-Hodgkin's lymphoma (NHL) in dogs, as well as canine cutaneous T-cell lymphoma, spontaneous canine multiple myeloma, naïve canine multicentric lymphoma and relapsed canine B-cell lymphoma...
August 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29760982/biodynamic-digital-holography-of-chemoresistance-in-a-pre-clinical-trial-of-canine-b-cell-lymphoma
#19
Honggu Choi, Zhe Li, Hao Sun, Dan Merrill, John Turek, Michael Childress, David Nolte
Biodynamic digital holography was used to obtain phenotypic profiles of canine non-Hodgkin B-cell lymphoma biopsies treated with standard-of-care chemotherapy. Biodynamic signatures from the living 3D tissues were extracted using fluctuation spectroscopy from intracellular Doppler light scattering in response to the molecular mechanisms of action of therapeutic drugs that modify a range of internal cellular motions. The standard-of-care to treat B-cell lymphoma in both humans and dogs is a combination CHOP therapy that consists of doxorubicin, prednisolone, cyclophosphamide and vincristine...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29724201/in-vitro-antineoplastic-effects-of-auranofin-in-canine-lymphoma-cells
#20
Hong Zhang, Barbara J Rose, Alex A Pyuen, Douglas H Thamm
BACKGROUND: The orally available gold complex auranofin (AF) has been used in humans, primarily as an antirheumatic/immunomodulatory agent. It has been safely administered to healthy dogs to establish pharmacokinetic parameters for oral administration, and has also been used as a treatment in some dogs with immune-mediated conditions. Multiple in vitro studies have recently suggested that AF may possess antineoplastic properties. Spontaneous canine lymphoma may be a very useful translational model for the study of human lymphoma, prompting the evaluation of AF in canine lymphoma cells...
May 3, 2018: BMC Cancer
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