Cristina Leal Rodríguez, Shiraz A Shah, Morten Arendt Rasmussen, Jonathan Thorsen, Ulrika Boulund, Casper-Emil Tingskov Pedersen, Josué L Castro-Mejía, Christina Egeø Poulsen, Casper Sahl Poulsen, Ling Deng, Frej Andreas Nøhr Larsen, Michael Widdowson, Yichang Zhang, Søren J Sørensen, Sylvain Moineau, Marie-Agnès Petit, Bo Chawes, Klaus Bønnelykke, Dennis S Nielsen, Jakob Stokholm
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in early life remain unknown. Here, we analyze the gut virome of 647 children aged 1 year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010 ) mother-child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma...
January 2024: Nature Medicine