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https://www.readbyqxmd.com/read/29626357/aberrant-expression-of-lncrna-mir31hg-regulates-cell-migration-and-proliferation-by-affecting-mir-31-and-mir-31-in-hirschsprung-s-disease
#1
Peng Cai, Hongxing Li, Weiwei Huo, Hairong Zhu, Chao Xu, Rujin Zang, Wei Lv, Yankai Xia, Weibing Tang
Hirschsprung's disease (HSCR) is a birth defect that causes a failure of the enteric nervous system to cover the distal gut during early embryonic development. Evidence shows that long non-coding RNAs (lncRNA) play important roles in HSCR. The MIR31 host gene (MIR31HG), also known as Loc554202, is a long non-coding RNA (lncRNA), which acts as the host gene of (microRNA) miR-31 and miR-31*. There have been no studies regarding its function in early developmental defects during pregnancy, and its downstream genetic receptors...
April 6, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29555200/computational-systems-biology-analysis-of-biomarkers-in-lung-cancer-unravelling-genomic-regions-which-frequently-encode-biomarkers-enriched-pathways-and-new-candidates
#2
Ibrahim O Alanazi, Sami A AlYahya, Esmaeil Ebrahimie, Manijeh Mohammadi-Dehcheshmeh
Exponentially growing scientific knowledge in scientific publications has resulted in the emergence of a new interdisciplinary science of literature mining. In text mining, the machine reads the published literature and transfers the discovered knowledge to mathematical-like formulas. In an integrative approach in this study, we used text mining in combination with network discovery, pathway analysis, and enrichment analysis of genomic regions for better understanding of biomarkers in lung cancer. Particular attention was paid to non-coding biomarkers...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29137387/infrequently-expressed-mirnas-influence-survival-after-diagnosis-with-colorectal-cancer
#3
Martha L Slattery, Andrew J Pellatt, Frances Y Lee, Jennifer S Herrick, Wade S Samowitz, John R Stevens, Roger K Wolff, Lila E Mullany
Half of miRNAs expressed in colorectal tissue are expressed < 50% of the population. Many infrequently expressed miRNAs have low levels of expression. We hypothesize that less frequently expressed miRNAs, when expressed at higher levels, influence both disease stage and survival after diagnosis with colorectal cancer (CRC); low levels of expression may be background noise. We examine 304 infrequently expressed miRNAs in 1893 population-based cases of CRC with paired carcinoma and normal mucosa miRNA profiles...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29056521/study-on-the-role-of-hsa-mir-31-5p-in-hypertrophic-scar-formation-and-the-mechanism
#4
X Wang, Y Zhang, B H Jiang, Q Zhang, R P Zhou, L Zhang, Chen Wang
Hypertrophic scar (HS) formation is associated with the fibrosis of fibrocytes caused by excessive extracellular matrix (ECM) synthesis and deposition, the initial event of HS formation. Our high throughput screen of miRNA expression profiles identified hsa-miR31-5p, whose transcription level was most differentially in normal skin fibroblasts (NS) and HS among other miRNAs. The level of hsa-miR31-5p in HS was significantly higher than in NS. In-vitro functional experiments showed hsa-miR31-5p knockdown remarkably suppressed the proliferation of hypertrophic scar fibroblasts (HSFBs) under hypoxia, promoted cell invasion, and inhibited the expression of Collagen I and III and Fibronectin (FN), suggesting that hsa-miR31-5p knockdown effectively reduces HS formation caused by excessive ECM synthesis and deposition in HSFBs under hypoxia...
December 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29051494/mir-31-promotes-mammary-stem-cell-expansion-and-breast-tumorigenesis-by-suppressing-wnt-signaling-antagonists
#5
Cong Lv, Fengyin Li, Xiang Li, Yuhua Tian, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, Xu Feng, Baowei Jiao, Mingang Xu, Maksim V Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E Millar, Zhengquan Yu
MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed in MaSC-enriched mammary basal cell population and in mammary tumors, and is regulated by NF-κB signaling. We demonstrate that miR-31 promotes mammary epithelial proliferation and MaSC expansion at the expense of differentiation in vivo...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28839466/the-grna-mirna-grna-ternary-cassette-combining-crispr-cas9-with-rnai-approach-strongly-inhibits-hepatitis-b-virus-replication
#6
Jie Wang, Ran Chen, Ruiyang Zhang, Shanlong Ding, Tianying Zhang, Quan Yuan, Guiwen Guan, Xiangmei Chen, Ting Zhang, Hui Zhuang, Frederick Nunes, Timothy Block, Shuang Liu, Zhongping Duan, Ningshao Xia, Zhongwei Xu, Fengmin Lu
The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication. Here, we described a novel gRNA-microRNA (miRNA)-gRNA ternary cassette driven by a single U6 promoter. With an anti-HBV pri-miR31 mimic integrated between two HBV-specific gRNAs, both gRNAs could be separated from the long transcript of gRNA-miR-HBV-gRNA ternary cassette through Drosha/DGCR8 processing. The results showed that the gRNA-miR-HBV-gRNA ternary cassette could efficiently express two gRNAs and miR-HBV...
2017: Theranostics
https://www.readbyqxmd.com/read/28475823/down-regulated-mirs-specifically-correlate-with-non-cardial-gastric-cancers-and-lauren-s-classification-system
#7
Laura Lorenzon, Claudia Cippitelli, Riccardo Avantifiori, Stefania Uccini, Deborah French, Maria Rosaria Torrisi, Danilo Ranieri, Paolo Mercantini, Valeria Canu, Giovanni Blandino, Marco Cavallini
BACKGROUND AND OBJECTIVES: Gastric cancers are usually characterized using Lauren's classification into intestinal and diffuse types. We previously documented the down-modulation of miR31, miR148a, miR204, and miR375 in gastric cancers. We aimed this manuscript to investigate these miRs with the end-points of diagnosis, Lauren's classification and prognosis. METHODS: A total of 117 resected non-cardial adenocarcinomas were evaluated for miRs' expressions. The performance of miRs' expressions for cancer diagnosis was tested using ROC curves...
August 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28322348/several-micrornas-could-predict-survival-in-patients-with-hepatitis-b-related-liver-cancer
#8
Ye Zhen, Zhao Xinghui, Wu Chao, Zhao Yi, Chen Jinwen, Gao Ruifang, Zhang Chao, Zhao Min, Guo Chunlei, Fang Yan, Du Lingfang, Shen Long, Shen Wenzhi, Luo Xiaohe, Xiang Rong
MicroRNAs as biomarkers play an important role in the tumorigenesis process, including hepatocellular carcinomas (HCCs). In this paper, we used The Cancer Genome Atlas (TCGA) database to mine hepatitis B-related liver cancer microRNAs that could predict survival in patients with hepatitis B-related liver cancer. There were 93 cases of HBV-HCC and 49 cases of adjacent normal controls included in the study. Kaplan-Meier survival analysis of a liver cancer group versus a normal control group of differentially expressed genes identified eight genes with statistical significance...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28006867/differential-profile-of-activated-regulatory-t-cell-subsets-and-micrornas-in-tolerant-liver-transplant-recipients
#9
Beatriz Revilla-Nuin, África de Bejar, Laura Martínez-Alarcón, José Ignacio Herrero, Carlos Manuel Martínez-Cáceres, Pablo Ramírez, Alberto Baroja-Mazo, José Antonio Pons
Regulatory T cells (Tregs) play a potential role in operational tolerance in liver transplantation (LT) patients, and microRNAs (miRNAs) are known to be involved in immunological responses and tolerance. Thus, we analyzed the implication of different peripheral blood Treg subsets and miRNAs on LT tolerance in 24 tolerant (Tol) and 23 non-tolerant (non-Tol) LT recipients by cellular, genetic, and epigenetic approximation. Non-Tol patients had a lower demethylation rate of the forkhead box P3 (FOXP3) regulatory T cell-specific demethylated region (TSDR) than Tol patients that correlated with the frequency of circulating Tregs...
July 2017: Liver Transplantation
https://www.readbyqxmd.com/read/27730344/expression-of-circulating-mirnas-associated-with-lymphocyte-differentiation-and-activation-in-cll-another-piece-in-the-puzzle
#10
Agata A Filip, Anna Grenda, Sylwia Popek, Dorota Koczkodaj, Małgorzata Michalak-Wojnowska, Michał Budzyński, Ewa Wąsik-Szczepanek, Szymon Zmorzyński, Agnieszka Karczmarczyk, Krzysztof Giannopoulos
Expression of microRNAs is altered in cancer. Circulating miRNA level assessed in body fluids commonly reflects their expression in tumor cells. In leukemias, however, both leukemic and nonleukemic cells compose circulating miRNA expression profile of peripheral blood. The latter contribution to extracellular miRNA pool may result in specific microenvironmental signaling, which promotes proliferation and survival. In our study, we used qT-PCR to assay peripheral blood serum of 22 chronic lymphocytic leukemia (CLL) patients for the expression of 84 miRNAs associated with activation and differentiation of B and T lymphocytes...
January 2017: Annals of Hematology
https://www.readbyqxmd.com/read/27729476/analysis-of-high-iron-rice-lines-reveals-new-mirnas-that-target-iron-transporters-in-roots
#11
Soumitra Paul, Dipak Gayen, Swapan K Datta, Karabi Datta
The present study highlights the molecular regulation of iron transport in soyFER1-overexpressing transgenic rice. Accumulation of iron in three different seed developmental stages, milk, dough, and mature, has been examined. The transgenic seeds of the milk stage showed significant augmentation of iron and zinc levels compared with wild-type seeds, and similar results were observed throughout the dough and mature stages. To investigate the regulation of iron transport, the role of miRNAs was studied in roots of transgenic rice...
October 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27597234/expression-deregulation-of-mir31-and-cxcl12-in-two-types-of-oral-precancers-and-cancer-importance-in-progression-of-precancer-and-cancer
#12
Esita Chattopadhyay, Richa Singh, Anindita Ray, Roshni Roy, Navonil De Sarkar, Ranjan Rashmi Paul, Mousumi Pal, Ritesh Aich, Bidyut Roy
Oral cancer generally progresses from precancerous lesions such as leukoplakia (LK), lichen planus (LP) and oral submucous fibrosis (OSMF). Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method...
September 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27525173/investigating-synthetic-oligonucleotide-targeting-of-mir31-in-duchenne-muscular-dystrophy
#13
John Cw Hildyard, Dominic J Wells
Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a subset of patients. The discovery that dystrophin mRNA is subject to translational suppression by the microRNA miR31, and that miR31 is elevated in the muscle of DMD patients, raises the possibility that the same oligonucleotide chemistries employed for exon skipping could be directed toward relieving this translational block...
2016: PLoS Currents
https://www.readbyqxmd.com/read/26877224/a-single-crispr-cas9-deletion-strategy-that-targets-the-majority-of-dmd-patients-restores-dystrophin-function-in-hipsc-derived-muscle-cells
#14
Courtney S Young, Michael R Hicks, Natalia V Ermolova, Haruko Nakano, Majib Jan, Shahab Younesi, Saravanan Karumbayaram, Chino Kumagai-Cresse, Derek Wang, Jerome A Zack, Donald B Kohn, Atsushi Nakano, Stanley F Nelson, M Carrie Miceli, Melissa J Spencer, April D Pyle
Mutations in DMD disrupt the reading frame, prevent dystrophin translation, and cause Duchenne muscular dystrophy (DMD). Here we describe a CRISPR/Cas9 platform applicable to 60% of DMD patient mutations. We applied the platform to DMD-derived hiPSCs where successful deletion and non-homologous end joining of up to 725 kb reframed the DMD gene. This is the largest CRISPR/Cas9-mediated deletion shown to date in DMD. Use of hiPSCs allowed evaluation of dystrophin in disease-relevant cell types. Cardiomyocytes and skeletal muscle myotubes derived from reframed hiPSC clonal lines had restored dystrophin protein...
April 7, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/26428916/gene-expression-profiling-of-dmu-212-induced-apoptosis-and-anti-angiogenesis-in-vascular-endothelial-cells
#15
YiMing Miao, LiuQing Cui, ZhiQiang Chen, Lu Zhang
CONTEXT: trans-3,4,5,4'-Tetramethoxystilbene (DMU-212), an derivative of resveratrol, shows strong antiproliferative activities against many cancer cells. In our previous study, we demonstrated that DMU-212 possesses potent proapoptosis and antiangiogenesis effects on vascular endothelial cells (VECs), which made it a promising agent for the treatment of angiogenesis-related diseases. OBJECTIVE: We studied the gene expression profile of DMU-212-treated VECs to gain further insight into the mechanisms by which DMU-212 exerts its potent pro-apoptosis and antiangiogenesis effects...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/24779718/microrna-31-functions-as-an-endometrial-cancer-oncogene-by-suppressing-hippo-tumor-suppressor-pathway
#16
Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, Mohamed Kamel Hassan, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka, Noriaki Sakuragi
BACKGROUND: We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with the malignant phenotype. METHODS: We investigated the growth potentials of MIR31-overexpressing HEC-50B cells in vitro and in vivo. In order to identify the target molecule of MIR31, a luciferase reporter assay was performed, and the corresponding downstream signaling pathway was examined using immunohistochemistry of human endometrial cancer tissues...
2014: Molecular Cancer
https://www.readbyqxmd.com/read/24343269/selective-inhibition-of-ifng-induced-autophagy-by-mir155-and-mir31-responsive-wnt5a-and-shh-signaling
#17
Sahana Holla, Mariola Kurowska-Stolarska, Jagadeesh Bayry, Kithiganahalli Narayanaswamy Balaji
Autophagy is one of the major immune mechanisms engaged to clear intracellular infectious agents. However, several pathogens have evolved strategies to evade autophagy. Here, we demonstrated that Mycobacteria, Shigella, and Listeria but not Klebsiella, Staphylococcus, and Escherichia inhibit IFNG-induced autophagy in macrophages by evoking selective and robust activation of WNT and SHH pathways via MTOR. Utilization of gain- or loss-of-function analyses as well as mir155-null macrophages emphasized the role of MTOR-responsive epigenetic modifications in the induction of Mir155 and Mir31...
February 2014: Autophagy
https://www.readbyqxmd.com/read/23552883/downregulation-of-mirna-31-induces-taxane-resistance-in-ovarian-cancer-cells-through-increase-of-receptor-tyrosine-kinase-met
#18
T Mitamura, H Watari, L Wang, H Kanno, M K Hassan, M Miyazaki, Y Katoh, T Kimura, M Tanino, H Nishihara, S Tanaka, N Sakuragi
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. However, ovarian cancers often acquire chemotherapeutic resistance to this agent. We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). We found that miR-31 was downregulated in KFr13Tx cells, and that re-introduction of miR31 re-sensitized them to PTX both in vitro and in vivo...
2013: Oncogenesis
https://www.readbyqxmd.com/read/20179198/molecular-profiling-uncovers-a-p53-associated-role-for-microrna-31-in-inhibiting-the-proliferation-of-serous-ovarian-carcinomas-and-other-cancers
#19
Chad J Creighton, Michael D Fountain, Zhifeng Yu, Ankur K Nagaraja, Huifeng Zhu, Mahjabeen Khan, Emuejevoke Olokpa, Azam Zariff, Preethi H Gunaratne, Martin M Matzuk, Matthew L Anderson
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively profiling expression of miRNAs and mRNAs in serous ovarian tumors and cell lines and normal ovarian surface epithelium, we identified hundreds of potential miRNA-mRNA targeting associations underlying cancer. Functional overexpression of miR-31, the most underexpressed miRNA in serous ovarian cancer, repressed predicted miR-31 gene targets including the cell cycle regulator E2F2...
March 1, 2010: Cancer Research
https://www.readbyqxmd.com/read/19864316/genomic-profiling-of-micrornas-and-messenger-rnas-reveals-hormonal-regulation-in-microrna-expression-in-human-endometrium
#20
Satu Kuokkanen, Bo Chen, Laureen Ojalvo, Lumie Benard, Nanette Santoro, Jeffrey W Pollard
MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate gene expression, have fundamental roles in biological processes, including cell differentiation and proliferation. These small molecules mainly direct either target messenger RNA (mRNA) degradation or translational repression, thereby functioning as gene silencers. Epithelial cells of the uterine lumen and glands undergo cyclic changes under the influence of the sex steroid hormones estradiol-17beta and progesterone. Because the expression of miRNAs in human endometrium has been established, it is important to understand whether miRNAs have a physiological role in modulating the expression of hormonally induced genes...
April 2010: Biology of Reproduction
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