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Cerebroplacental ratio

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https://www.readbyqxmd.com/read/30104317/predicting-intrapartum-fetal-compromise-at-term-using-the-cerebroplacental-ratio-and-placental-growth-factor-levels-promise-study-randomised-controlled-trial-protocol
#1
Helen Sherrell, Vicky Clifton, Sailesh Kumar
INTRODUCTION: Intrapartum complications are a major contributor to adverse perinatal outcomes, including stillbirth, hypoxic-ischaemic brain injury and subsequent longer term disability. In many cases, hypoxia develops as a gradual process due to the inability of the fetus to tolerate the stress of parturition suggesting reduced fetoplacental reserve before labour commences. The fetal cerebroplacental ratio (CPR) is an independent predictor of intrapartum fetal compromise, poor acid base status at birth and of neonatal unit admission at term...
August 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/30089456/placental-erythropoietin-expression-is-upregulated-in-growth-restricted-fetuses-with-abnormal-umbilical-artery-doppler-findings-a-case-control-study-of-monochorionic-twins
#2
Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Kuan-Ju Chen, Po-Jen Cheng, Tzu-Hao Wang
BACKGROUND: We previously reported that fetal plasma erythropoietin (EPO) concentrations are significantly increased in growth-restricted fetuses with abnormal umbilical artery (UA) Doppler. During hypoxia in an ovine model, the primary site of fetal EPO synthesis was switched from the kidneys to the placenta. Therefore, we designed this study to evaluate human placental EPO gene expression and the correlation to fetal serum EPO concentration in growth-restricted fetuses in a monochorionic (MC) twin model...
August 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30084174/using-cerebroplacental-ratio-in-non-sga-infants-to-predict-adverse-perinatal-outcome-caution-is-required
#3
Sailesh Kumar, Francesc Figueras, Wessels Ganzevoort, Jessica Turner, Lesley McCowan
The CPR is the ratio of the fetal Middle Cerebral Artery Pulsatility index (MCA PI) to the Umbilical Artery Pulsatility index (UA PI) with gestation specific reference centiles available.1 2 A low CPR is now generally accepted as a proxy for late fetal growth restriction (FGR).3 4 This article is protected by copyright. All rights reserved.
August 6, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30033784/modified-myocardial-performance-index-and-its-prognostic-significance-for-adverse-perinatal-outcome-in-early-and-late-onset-fetal-growth-restriction
#4
Ebru Alici Davutoglu, Aysegul Ozel, Funda Oztunc, Riza Madazli
OBJECTIVE: To compare the fetal modified myocardial performance index (Mod-MPI) in appropriately grown, early (EO) and late onset (LO) fetal growth restricted (FGR) fetuses and to assess its prognostic significance for adverse perinatal outcome. STUDY DESIGN: In a prospective case-control study, Mod-MPI was performed in 22 and 51 fetuses with EO and LO-FGR fetuses, respectively. Mod-MPI values of FGR fetuses were compared against gestation-matched controls (34 for EO-, and 32 for LO-FGR, respectively)...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29980154/normogram-of-middle-cerebral-artery-doppler-indexes-and-cerebroplacental-ratio-at-12-to-14-weeks-in-an-unselected-pregnancy-population
#5
Reem S Abu-Rustum, M Fouad Ziade, Ibrahim Ghosn, Nabil Helou
OBJECTIVE:  The aim of this study is to assess the feasibility of visualizing the middle cerebral artery (MCA), establishing the normogram for MCA pulsatility index (PI) and peak systolic velocity (PSV), and calculating cerebroplacental ratio (CPR) at 12 to 14 weeks. STUDY DESIGN:  Prospective cross-sectional study on 186 gravidas presenting for nuchal translucency (NT) assessment. Maternal body mass index (BMI), fetal crown-rump length (CRL), biparietal diameter (BPD), and NT were obtained...
July 6, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29920817/predictive-accuracy-of-cerebroplacental-ratio-for-adverse-perinatal-and-neurodevelopmental-outcomes-in-suspected-fetal-growth-restriction-systematic-review-and-meta-analysis
#6
REVIEW
Agustin Conde-Agudelo, José Villar, Stephen H Kennedy, Aris T Papageorghiou
OBJECTIVE: The cerebroplacental ratio (CPR) has been proposed for the routine surveillance of pregnancies with suspected fetal growth restriction (FGR), but the predictive performance of this test is unclear. The aim of this study was to determine the accuracy of the CPR for predicting adverse perinatal and neurodevelopmental outcomes in suspected FGR. METHODS: PubMed, EMBASE, CINAHL, and Lilacs (all from inception to July 31, 2017) were searched for cohort or cross-sectional studies that reported on the accuracy of the CPR for predicting adverse perinatal and/or neurodevelopmental outcomes in singleton pregnancies with antenatally suspected FGR based on sonographic parameters...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29909268/the-relationship-between-intrapartum-cerebroplacental-ratio-and-adverse-perinatal-outcomes-in-term-fetuses
#7
Natthicha Chainarong, Chusana Petpichetchian
OBJECTIVES: The cerebroplacental ratio (CPR) Doppler has been proposed as an instrument for predicting adverse perinatal outcomes particularly during antepartum period. Abnormal CPR is associated with non-reassuring fetal status requiring operative delivery, low Apgar score and neonatal complications. The aim of this study was to assess the role of CPR Doppler in the labor triage suite, so as to identify fetuses at risk for non-reassuring status as well as other adverse perinatal outcomes...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29900608/early-labor-cerebroplacental-ratio-assessment-in-uncomplicated-term-pregnancies-and-prediction-of-adverse-perinatal-outcomes-a-prospective-multicentre-study
#8
Andrea Dall'Asta, Tullio Ghi, Giuseppe Rizzo, Annalisa Cancemi, Filomena Aloisio, Domenico Arduini, Giuseppe Pedrazzi, Francesc Figueras, Tiziana Frusca
INTRODUCTION: Doppler ultrasound has recently been suggested to identify subclinical placental functional impairment among normal sized term fetuses. The objective of this study was to evaluate the relationship between cerebroplacental ratio (CPR) measured in early labor and perinatal and delivery outcomes in a cohort of uncomplicated singleton term pregnancies. METHODS: This was a multicentre, prospective, observational study involving three Tertiary Centres. Low risk term pregnancies, as defined by the absence of any maternal morbidity and pregnancy complication and normal ultrasound and clinical screening of the fetal growth in the third trimester, with spontaneous onset of labor were included...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29888988/is-umbilical-vein-varix-associated-with-changes-in-cerebroplacental-ratio
#9
Leonti Grin, Simon Shenhav, Ahmed Elasbah, Mark Rabinovich, Hadar Sofer, Eyal Y Anteby, Efraim Zohav
OBJECTIVE: We aimed to review a single-center experience in follow-up and management of fetuses with umbilical vein varix (UVV) and to assess the effect of UVV on fetal Doppler parameters. METHODS: We reviewed retrospectively maternal antenatal records, delivery records, and newborn records to identify cases of UVV. Further, we retrospectively compared 25 fetuses with isolated UVV and available cerebroplacental ratio (CPR) analysis with 75 matched controls. RESULTS: We identified 67 cases of UVV...
July 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29844937/utility-of-doppler-parameters-at-36-42-weeks-gestation-in-the-prediction-of-adverse-perinatal-outcomes-in-appropriate-for-gestational-age-fetuses
#10
Michał Migda, Katarzyna Gieryn, Bartosz Migda, Marian Stanisław Migda, Marek Maleńczyk
Aim: To investigate the potential value of Doppler ultrasound and to assess cerebroplacental ratio (CPR) in the prediction of adverse perinatal outcome defined as Apgar score < 7 at 1 minute. Material and methods: This was a retrospective cross-sectional study in selected pregnant women undergoing an ultrasound examination between 36 and 42 weeks of gestation. We measured estimated fetal weight (EFW), mean umbilical artery pulsatility index (UA PI), mean middle cerebral artery pulsatility index (MCA PI), CPR, and Apgar score in 1 minute...
March 2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29742984/maternal-serum-endocan-concentration-in-pregnancies-complicated-by-intrauterine-growth-restriction
#11
Agata Szpera-Gozdziewicz, Katarzyna Kosicka, Tomasz Gozdziewicz, Mariola Krzyscin, Przemyslaw Wirstlein, Anna Siemiatkowska, Franciszek Glowka, Ewa Wender-Ozegowska, Grzegorz H Breborowicz
OBJECTIVES: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis. Therefore, this study aimed to investigate the relationship between maternal endocan serum level and intrauterine growth restriction (IUGR) as well as ultrasound Doppler flow measurements indicating placental insufficiency. METHODS: This study included a group of women with IUGR (n = 37) and a group of healthy pregnant women (controls, n = 37)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29730664/fetal-biometry-and-doppler-study-for-the-assessment-of-perinatal-outcome-in-stage-i-late-onset-fetal-growth-restriction
#12
Cecilia Villalaín, Ignacio Herraiz, María Soledad Quezada, Paula Isabel Gómez-Arriaga, Enery Gómez-Montes, Alberto Galindo
OBJECTIVE: To compare perinatal outcomes on fetuses classified as stage I late-onset fetal growth restriction (FGR) depending on the estimated fetal weight (EFW) centile category and the fetal and maternal Doppler study. MATERIAL AND METHODS: Retrospective cohort study on 131 cases of stage I late-onset FGR (diagnosis ≥32+0 weeks), defined as: EFW < 3rd centile and normal Doppler (G1) or EFW < 10th centile and mean uterine artery pulsatility index (PI) > 95th centile (G2) or EFW < 10th centile and mild fetal Doppler alteration: umbilical artery PI > 95th centile, middle cerebral artery PI < 5th centile, or cerebroplacental ratio < 5th centile (G3)...
May 4, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29699435/fetal-cerebral-and-cardiac-hemodynamics-in-postdate-pregnancy
#13
Aysegul Ozel, Ebru Alici Davutoglu, Sule Yildirim, Riza Madazli
OBJECTIVE: We aimed to determine the fetal cerebro-placental Doppler indices and modified myocardial performance index (Mod-myocardial performance index (MPI)) in this homogenous group of postdated pregnancies. METHODS: A total of 92 singleton pregnant women were included in this prospective study. The study involved three groups; full term control (Group 1, n = 42, 39 0/7 to 40 6/7 week' gestation), late term (Group 2, n = 34, 41 0/7 to 41 6/7 week' gestation) and post term (Group 3, n = 16, ≥ 42 0/7 weeks' gestation)...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29607579/ultrasonographic-prediction-of-antepartum-deterioration-of-growth-restricted-fetuses-after-late-preterm
#14
Ryo Yamamoto, Keisuke Ishii, Erika Nakajima, Jun Sasahara, Nobuaki Mitsuda
AIM: To examine the predictive value of ultrasound parameters for antepartum non-reassuring fetal status (NRFS) in fetal growth restriction (FGR) cases after late preterm. METHODS: Retrospective review of singleton FGR cases before 37 weeks gestation who delivered after 34 weeks gestation was performed. The association between ultrasound parameters that was assessed from 34 to 36 weeks gestation and the development of antepartum NRFS that was diagnosed by nonstress test and biophysical profile was analyzed by using multivariate Cox proportional hazards analyses...
June 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29606482/planning-management-and-delivery-of-the-growth-restricted-fetus
#15
REVIEW
Ahmet A Baschat
A uniform approach to management of fetal growth restriction (FGR) improves outcome, prevents stillbirth, and allows appropriately timed delivery. An estimated fetal weight below the tenth percentile with coexisting abnormal umbilical artery (UA), middle cerebral artery (MCA), or cerebroplacental ratio Doppler index best identifies the small fetus requiring surveillance. Placental perfusion defects are more common earlier in gestation; accordingly, early-onset (≤32 weeks of gestation) and late-onset (>32 weeks) FGR differ in clinical phenotype...
May 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29573501/first-trimester-and-combined-first-and-second-trimester-prediction-of-small-for-gestational-age-and-fetuses-with-late-growth-restriction
#16
Alexandros Sotiriadis, Francesc Figueras, Makarios Eleftheriades, George K Papaioannou, Georgios Chorozoglou, Konstantinos Dinas, Nikolaos Papantoniou
AIM: To develop a first-trimester or combined first- and second-trimester screening algorithm for the prediction of small-for-gestational age (SGA) and late growth-restriction (FGR). METHODS: This was a retrospective study of pregnant women with singleton pregnancy, who attended routine first- second- and third-trimester ultrasound scan. Late FGR was defined, at ≥32 weeks in the absence of congenital anomalies as, either (a) estimated fetal weight (EFW) or birthweight (BW) <3rd centile , OR (b) EFW<10th centile and either uterine artery mean PI >95th centile or cerebroplacental ratio (CPR) <5th centile...
March 24, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29564310/fetal-doppler-to-predict-cesarean-delivery-for-non-reassuring-fetal-status-in-the-severe-small-for-gestational-age-fetuses-of-late-preterm-and-term
#17
Ji Hye Jo, Yong Hee Choi, Jeong Ha Wie, Hyun Sun Ko, In Yang Park, Jong Chul Shin
Objective: To evaluate the significance of fetal Doppler parameters in predicting adverse neonatal outcomes and the risk of cesarean delivery due to non-reassuring fetal status, in severe small for gestational age (SGA) fetuses of late preterm and term gestation. Methods: Fetal brain and umbilical artery (UmA) Doppler parameters of cerebroplacental ratio (CPR) and UmA pulsatility index (PI) were evaluated in a cohort of 184 SGA fetuses between 34 and 41 weeks gestational age, who were less than the 5th percentile...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29514530/accuracy-of-the-fetal-cerebroplacental-ratio-for-the-detection-of-intrapartum-compromise-in-nonsmall-fetuses
#18
José Morales-Roselló, Asma Khalil, Victoria Fornés-Ferrer, Alfredo Perales-Marín
OBJECTIVE: To study the accuracy of the cerebroplacental ratio (CPR) for the detection of intrapartum fetal compromise (IFC) in fetuses growing over the 10th centile. METHODS: This was a prospective study of 569 nonsmall fetuses attending the day hospital unit of a tertiary hospital that underwent an ultrasound examination at 36-40 weeks, and were delivered within 4 weeks of examination. IFC was defined as a composite of abnormal intrapartum fetal heart rate or intrapartum fetal scalp pH <7...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29493778/effects-of-betamethasone-on-fetoplacental-and-maternal-hemodynamics-in-preterm-pregnancies
#19
Cihan Inan, N Cenk Sayin, Zehra N Dolgun, Selen G Erzincan, Isil Uzun, Havva Sutcu, Necdet Sut, Fusun G Varol
OBJECTIVE: To evaluate the possible effects of prenatal steroid administration on Doppler parameters of the umbilical artery, uterine artery, middle cerebral artery, and ductus venosus, the cerebroplacental ratio, and the amniotic fluid index in preterm fetuses. METHODS: The present prospective observational study was performed at the Perinatology Department of Trakya University, Edirne, Turkey, between June 1, 2015, and September 1, 2016. It included patients with healthy singleton pregnancies who had received betamethasone at 24-34 weeks of pregnancy...
June 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29455616/is-the-fetal-cerebroplacental-ratio-better-that-the-estimated-fetal-weight-in-predicting-adverse-perinatal-outcomes-in-a-low-risk-cohort
#20
Christopher Flatley, Sailesh Kumar
OBJECTIVE: In high-risk pregnancies combining the cerebro-placental ratio (CPR) with the estimated fetal weight (EFW) improves the identification of vulnerable fetuses. The purpose of this study was to assess the CPR and EFW's ability to predict adverse obstetric and perinatal outcomes in a low-risk pregnancy, when measured late in gestation. METHODS: This was a retrospective study of women who birthed at Mater Mothers Hospitals, Brisbane, Australia between 2010 and 2015...
February 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
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