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Heart valve flow mediated dilation

Philipp E Bartko, Jacob P Dal-Bianco, J Luis Guerrero, Jonathan Beaudoin, Catherine Szymanski, Dae-Hee Kim, Margo M Seybolt, Mark D Handschumacher, Suzanne Sullivan, Michael L Garcia, James S Titus, Jill Wylie-Sears, Whitney S Irvin, Emmanuel Messas, Albert A Hagège, Alain Carpentier, Elena Aikawa, Joyce Bischoff, Robert A Levine
BACKGROUND: After myocardial infarction (MI), mitral valve (MV) tethering stimulates adaptive leaflet growth, but counterproductive leaflet thickening and fibrosis augment mitral regurgitation (MR), doubling heart failure and mortality. MV fibrosis post-MI is associated with excessive endothelial-to-mesenchymal transition (EMT), driven by transforming growth factor (TGF)-β overexpression. In vitro, losartan-mediated TGF-β inhibition reduces EMT of MV endothelial cells. OBJECTIVES: This study tested the hypothesis that profibrotic MV changes post-MI are therapeutically accessible, specifically by losartan-mediated TGF-β inhibition...
September 5, 2017: Journal of the American College of Cardiology
Munenori Takata, Eisuke Amiya, Masafumi Watanabe, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Yumiko Hosoya, Kansei Uno, Aya Saito, Takahide Murasawa, Minoru Ono, Ryozo Nagai, Issei Komuro
Aortic stenosis (AS) is the most common valvular disease and aortic valve replacement (AVR) is one of its most effective interventions. AS affects not only the left ventricle, but also vascular function beyond the stenotic valve, which can lead to various types of vascular dysfunction. However, research evaluating the effect of AS on aortic vascular function is limited. In this study, we investigated clinical meaning to evaluate endothelial function in subjects with AS. From April 2011 to April 2012, 20 consecutive adult patients with degenerative AS (mean age, 74...
March 2015: Heart and Vessels
Katarzyna Mizia-Stec, Joanna Wieczorek, Michał Orszulak, Magdalena Mizia, Klaudia Gieszczyk-Strózik, Agnieszka Sikora-Puz, Maciej Haberka, Bartosz Lasota, Artur Chmiel
BACKGROUND: Since flow-mediated dilatation (FMD) is influenced by different factors, its clinical usefulness and validation is widely discussed. AIM: To assess the major factors that determine FMD values in a wide range of subjects with and without cardiovascular (CV) risk factors/diseases (CVRF/CVD). METHODS AND RESULTS: 617 consecutive patients (mean age: 50.1 ± 14.9 years, males: 349/56.5%) hospitalised between 2005 and 2011 were enrolled into the study...
2014: Kardiologia Polska
Min Tang, Wuzhou Yuan, Rolf Bodmer, Xiushan Wu, Karen Ocorr
Cardiac valves serve an important function; they support unidirectional blood flow and prevent blood regurgitation. Wnt signaling plays an important role in the formation of mouse cardiac valves and cardiac valve proliferation in Zebrafish, but identification of the specific signaling components involved has not been addressed systematically. Of the components involved in Wnt signal transduction, pygopus (pygo), first identified as a core component of Wnt signaling in Drosophila, has not yet to be investigated with respect to valve development and differentiation...
January 2014: Genesis: the Journal of Genetics and Development
H Kaya, M Ozkan, M Yildiz
AIM: The etiopathogenesis of prosthetic heart valve thrombosis (PHVT) is multifactorial. Since the relationship between PHVT and endothelial function is never studied, we aimed to analyze the role of endothelial function in patients with PHVT. PATIENTS AND METHODS: Twenty-two patients with PHVT (14 female, 31.8% with atrial fibrillation, mean age 46.0±12.2) and 22 controls with prosthetic heart valves (17 female, 36.4% with atrial fibrillation, mean age 45.7±11...
June 2013: European Review for Medical and Pharmacological Sciences
Julia E Ostberg, Ann E Donald, Julian P J Halcox, Clare Storry, Carolyn McCarthy, Gerard S Conway
CONTEXT: Women with Turner syndrome (TS) have an increased cardiovascular mortality rate from both structural and ischemic heart disease, especially aortic dissection. OBJECTIVE: We hypothesized that TS women have a fundamental arterial wall defect that may be due to genetic factors or estrogen deficiency. DESIGN, SETTING, AND PATIENTS: TS women (n = 93) were compared with normal controls (n = 25) and women with 46,XX primary amenorrhea (PA) (n = 11) with a similar history of estrogen deficiency...
September 2005: Journal of Clinical Endocrinology and Metabolism
Elisa Poggianti, Lucia Venneri, Vlad Chubuchny, Zoltan Jambrik, Liz Andrea Baroncini, Eugenio Picano
OBJECTIVES: We sought to examine the association between aortic valve sclerosis (AVS) and systemic endothelial manifestations of the atherosclerotic process. BACKGROUND: Clinical and experimental studies suggest that AVS is a manifestation of the atherosclerotic process. Systemic endothelial dysfunction is an early sign of the atherosclerotic process and can be assessed by ultrasonography of the brachial artery. METHODS: A total of 102 in-hospital patients (76 men; mean age 63...
January 1, 2003: Journal of the American College of Cardiology
M Morelos, R Amyot, E Picano, O Rodriguez, A M Mazzone, M Glauber, A Biagini
Seventeen patients scheduled for a cardiac procedure necessitating cardiopulmonary bypass underwent serial perioperative assessment of brachial artery flow-mediated dilation. Patients who underwent coronary bypass surgery had a sustained systemic endothelial dysfunction in the perioperative period, whereas those undergoing cardiac valve surgery experienced transient postoperative systemic endothelial dysfunction.
February 1, 2001: American Journal of Cardiology
K McEntee, C Clercx, H Amory, C Michaux, J J Dardenne, D Soyeur, M Henroteaux
OBJECTIVE: To evaluate left and right ventricular filling and ejection performances by use of Doppler echocardiography in healthy, conscious dogs submitted to dobutamine stress testing. ANIMALS: 10 unsedated, healthy adult Beagles. PROCEDURE: Doppler echocardiography was performed during cardiac stress testing on each dog twice at 24-hour intervals. Dobutamine was infused in 10 micrograms/kg of body weight/min incremental dosages, from 12...
July 1999: American Journal of Veterinary Research
P D Drummond
Facial flushing was studied in 38 young women who scored high or low on trait anger. To induce anger in the subjects, their task was to solve a difficult puzzle, with or without harassment from a female research assistant. Facial blood flow increased in response to provocation, together with increases in cardiovascular and electrodermal activity. Flushing was associated with large increases in electrodermal activity and small increases in diastolic blood pressure. Subjects high in trait anger reported most anger and embarrassment, but physiological activity did not differ from subjects with low trait anger...
May 1999: Psychophysiology
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