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Psoriasis melanocyte

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https://www.readbyqxmd.com/read/29797312/a-prospective-observational-study-of-pigmented-naevi-changes-in-psoriasis-patients-on-biologic-therapy
#1
Seohee Deanne Choi, Mario I D'Souza, Scott W Menzies, Wolfgang Weninger
BACKGROUND/OBJECTIVES: Patients on biologic therapy are thought to be at increased risk of developing non-melanoma skin cancers and melanomas. It is unknown whether biologic therapy alters the natural history of melanocytic naevi. Therefore, a prospective observational study was conducted to determine whether psoriasis patients on biologic therapy develop changes in naevi. METHODS: Clinical and dermoscopic assessment of all melanocytic naevi was performed in 45 psoriasis patients on biologic therapy versus a control cohort of 43 subjects, using sequential digital dermoscopic imaging and total body photography...
May 23, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29760713/human-leukocyte-antigen-class-i-alleles-and-the-autoreactive-t-cell-response-in-psoriasis-pathogenesis
#2
REVIEW
Jörg Christoph Prinz
Psoriasis is a complex immune-mediated inflammatory skin disease characterized by T-cell-driven epidermal hyperplasia. It occurs on a strong genetic predisposition. The human leukocyte antigen (HLA)-class I allele HLA-C*06:02 on psoriasis susceptibility locus 1 (PSORS1 on 6p21.3) is the main psoriasis risk gene. Other HLA-class I alleles encoding HLA molecules presenting overlapping peptide repertoires show associations with psoriasis as well. Outside the major histocompatibility complex region, genome-wide association studies identified more than 60 psoriasis-associated common gene variants exerting only modest individual effects...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29697852/a-standardized-method-based-on-pigmented-epidermal-models-evaluates-sensitivity-against-uv-irradiation
#3
Freia F Schmid, Florian Groeber-Becker, Stefanie Schwab, Sibylle Thude, Heike Walles, Jan Hansmann
To protect the human skin from extensive solar radiation, melanocytes produce melanin and disperse it via melanosomes to keratinocytes in the basal and suprabasal layers of the human epidermis. Moreover, melanocytes are associated with pathological skin conditions such as vitiligo and psoriasis. Thus, an in vitro skin model that comprises a defined cutaneous pigmentation system is highly relevant in cosmetic, pharmaceutical and medical research. Here, we describe how the epidermal-melanin-unit can be established in vitro...
2018: ALTEX
https://www.readbyqxmd.com/read/29427464/the-expression-and-function-of-galectins-in-skin-physiology-and-pathology
#4
Nan-Lin Wu, Fu-Tong Liu
The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages and endothelial cells...
March 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29318585/dermoscopic-characterization-of-cutaneous-lymphomas-a-pilot-survey
#5
Grant K Ghahramani, Kirsten E Goetz, Vincent Liu
BACKGROUND: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures...
March 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29249120/the-variegated-histopathological-features-of-atypical-lentiginous-melanocytic-nevi-almns-a-single-institution-experience
#6
Alessia Barisani, Salvatore D Infusino, Cosimo Misciali, Beatrice Passarini, Nunzio C Salfi, Elisa Varotti, Annalisa Patrizi
BACKGROUND: Atypical lentiginous melanocytic nevi (ALMNs) are atypical pigmented lesions with histopathological features similar to those of dysplastic nevi, with a lentiginous pattern. Variable histopathological features of ALMNs were observed in our practice. METHODS: We described the histopathological features of ALMNs diagnosed in the period 2009- 2015. Our cases were divided into 2 groups: Group 1: ALMNs showing the same histopathological features as previously described in the literature; Group 2: ALMNs with different features...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29234546/repigmentation-of-tenacious-vitiligo-on-apremilast
#7
Sara B Huff, Lorie D Gottwald
Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28941475/melanocytes-target-cells-of-an-hla-c-06-02-restricted-autoimmune-response-in-psoriasis
#8
REVIEW
Jörg Christoph Prinz
HLA-C*06:02 is the main psoriasis risk allele. By the unbiased analysis of a Vα3S1/Vβ13S1 T-cell receptor from pathogenic psoriatic CD8+ T cells, we had recently proven that HLA-C*06:02 directs an autoimmune response against melanocytes through autoantigen presentation in psoriasis and identified ADAMTSL5 as a melanocyte autoantigen. We concluded that psoriasis is based on a melanocyte-specific immune response and that HLA-C*06:02 may predispose to psoriasis via this newly identified autoimmune pathway. Understanding this pathway, however, requires more detailed explanation...
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927891/vitiligo-skin-is-imprinted-with-resident-memory-cd8-t-cells-expressing-cxcr3
#9
Katia Boniface, Clément Jacquemin, Anne-Sophie Darrigade, Benoît Dessarthe, Christina Martins, Nesrine Boukhedouni, Charlotte Vernisse, Alexis Grasseau, Denis Thiolat, Jérôme Rambert, Fabienne Lucchese, Antoine Bertolotti, Khaled Ezzedine, Alain Taieb, Julien Seneschal
Vitiligo is a chronic autoimmune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM ). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared with psoriasis and control unaffected skin...
February 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28855257/the-molecular-basis-for-peptide-repertoire-selection-in-the-human-leucocyte-antigen-hla-c-06-02-molecule
#10
Jesse I Mobbs, Patricia T Illing, Nadine L Dudek, Andrew G Brooks, Daniel G Baker, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian
Human leukocyte antigen (HLA)-C*06:02 is identified as the allele associated with the highest risk for the development of the autoimmune skin disease psoriasis. However, the diversity and mode of peptide presentation by the HLA-C*06:02 molecule remains unclear. Here, we describe the endogenous peptide repertoire of ∼3,000 sequences for HLA-C*06:02 that defines the peptide-binding motif for this HLA allomorph. We found that HLA-C*06:02 predominantly presents nonamer peptides with dominant arginine anchors at the P2 and P7 positions and a preference for small hydrophobic residues at the C terminus (PΩ)...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28736236/patients-with-hidradenitis-suppurativa-have-a-high-psychiatric-disease-burden-a-finnish-nationwide-registry-study
#11
Laura Huilaja, Hannu Tiri, Jari Jokelainen, Markku Timonen, Kaisa Tasanen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles that is associated with various comorbidities. To further clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4,381 patients with HS, and 39,554 with psoriasis and 43,248 with melanocytic nevi as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. The incidence of HS was 3.0/100,000 persons/year. At least one psychiatric diagnosis was found in 24...
January 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28408849/a-retrospective-epidemiological-study-of-skin-diseases-among-pediatric-population-attending-a-tertiary-dermatology-referral-center-in-northern-greece
#12
Efstratios Vakirlis, Grigorios Theodosiou, Zoe Apalla, Michael Arabatzis, Elizabeth Lazaridou, Elena Sotiriou, Aimilios Lallas, Demetrios Ioannides
BACKGROUND: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece. PATIENTS AND METHODS: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Demographic data and the frequency of the various diagnoses in various age groups were studied...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28258573/aquaporins-in-the-skin
#13
REVIEW
Ravi Patel, L Kevin Heard, Xunsheng Chen, Wendy B Bollag
The skin is the largest organ of the body, serving as an important barrier between the internal milieu and the external environment. The skin is also one of the first lines of defense against microbial infection and other hazards, and thus, the skin has important immune functions . This organ is composed of many cell types, including immune-active dendritic cells (epidermal Langerhans cells and dermal dendritic cells), connective tissue-generating dermal fibroblasts and pigment-producing melanocytes. Comprising the outer skin layer are the epidermal keratinocytes, the predominant cell of this layer, the epidermis , which provides both a mechanical barrier and a water -permeability barrier...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28214226/cd49a-expression-defines-tissue-resident-cd8-t-cells-poised-for-cytotoxic-function-in-human-skin
#14
Stanley Cheuk, Heinrich Schlums, Irène Gallais Sérézal, Elisa Martini, Samuel C Chiang, Nicole Marquardt, Anna Gibbs, Ebba Detlofsson, Andrea Introini, Marianne Forkel, Charlotte Höög, Annelie Tjernlund, Jakob Michaëlsson, Lasse Folkersen, Jenny Mjösberg, Lennart Blomqvist, Marcus Ehrström, Mona Ståhle, Yenan T Bryceson, Liv Eidsmo
Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ Trm cells on a compartmental and functional basis. In human skin epithelia, CD8+ CD49a+ Trm cells produced interferon-γ, whereas CD8+ CD49a- Trm cells produced interleukin-17 (IL-17). In addition, CD8+ CD49a+ Trm cells from healthy skin rapidly induced the expression of the effector molecules perforin and granzyme B when stimulated with IL-15, thereby promoting a strong cytotoxic response...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28166613/melanocytic-nevus-count-and-dermoscopic-features-do-not-differ-in-psoriatic-patients-undergoing-biological-agent-versus-conventional-drug-therapy
#15
COMPARATIVE STUDY
Serpil Pirmit, Nahide Onsun, Ozlem Su, Dilek B Ozkaya
BACKGROUND: Psoriasis is a chronic immune-mediated disease and treatment of psoriasis includes conventional immunosuppressive agents and biological agents. There are a few data on the relationship between psoriasis and melanocytic lesions. Either benign or malignant proliferations may be seen with immunosuppressive treatment. Eruptive nevi and malignant melanoma (MM) have been reported also associated with biological agents There is raising link biological treatment and malignancies. The objective of this paper is to examine the effects of biological agents versus conventional drugs on melanocytic nevi count and dermoscopical features...
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28008606/derivation-of-marker-gene-signatures-from-human-skin-and-their-use-in-the-interpretation-of-the-transcriptional-changes-associated-with-dermatological-disorders
#16
Barbara B Shih, Ajit J Nirmal, Denis J Headon, Arne N Akbar, Neil A Mabbott, Tom C Freeman
Numerous studies have explored the altered transcriptional landscape associated with skin diseases to understand the nature of these disorders. However, data interpretation represents a significant challenge due to a lack of good maker sets for many of the specialized cell types that make up this tissue, whose composition may fundamentally alter during disease. Here we have sought to derive expression signatures that define the various cell types and structures that make up human skin, and demonstrate how they can be used to aid the interpretation of transcriptomic data derived from this organ...
April 2017: Journal of Pathology
https://www.readbyqxmd.com/read/27904187/the-relationship-of-psoriasis-and-melanocytic-nevi
#17
Fatma Pelin Cengiz, Nazan Emiroglu, Anil Gulsel Bahali, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
BACKGROUND: There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi. AIMS AND OBJECTIVES: To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. METHODS: We performed a prospective study in 100 psoriatic patients and 100 controls...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27857980/cutaneous-expression-of-a-disintegrin-like-and-metalloprotease-domain-containing-thrombospondin-type-1-motif-like-5-adamtsl5-in-psoriasis-goes-beyond-melanocytes
#18
Kathleen M Bonifacio, Norma Kunjravia, James G Krueger, Judilyn Fuentes-Duculan
A Disintegrin-like and Metalloprotease domain containing Thrombospondin type 1 motif-like 5 (ADAMTSL5) is a melanocyte-derived protein that has recently been implicated as an activating antigen for IL-17-producing T cells in psoriasis. There is a potential disconnect between the basal location of the melanocytes in the epidermis and the fact that T-cell infiltrates are seen mostly scattered in the epidermis with very large infiltrates in the dermis. Thus, we hypothesized that ADAMTSL5 may be expressed in other cells aside from melanocytes in skin...
October 2016: Journal of Pigmentary Disorders
https://www.readbyqxmd.com/read/27512186/heat-shock-protein-70-expression-in-vitiligo-and-its-relation-to-the-disease-activity
#19
Reham William Doss, Abdel-Aziz A El-Rifaie, Amr M Abdel-Wahab, Yasser M Gohary, Laila A Rashed
BACKGROUND: Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Heat shock proteins (HSPs) are prime candidates to connect stress to the skin. HSPs were found to be implicated in autoimmune diseases such as rheumatoid arthritis and other skin disorders as psoriasis. AIM AND OBJECTIVES: The aim of this study was to map the level of HSP-70 in vitiligo lesions to declare its role in the pathogenesis and activity of vitiligo...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27447175/targeting-the-vitamin-d-endocrine-system-vdes-for-the-management-of-inflammatory-and-malignant-skin-diseases-an-historical-view-and-outlook
#20
REVIEW
Jörg Reichrath, Christos C Zouboulis, Thomas Vogt, Michael F Holick
Vitamin D represents one of the major driving factors for the development of life on earth and for human evolution. While up to 10-20 % of the human organism's requirements in vitamin D can be obtained by the diet (under most living conditions in the USA and Europe), approximately 90 % of all needed vitamin D has to be photosynthesized in the skin through the action of the sun (ultraviolet-B (UV-B)). The skin represents a key organ of the human body's vitamin D endocrine system (VDES), being both the site of vitamin D synthesis and a target tissue for biologically active vitamin D metabolites...
September 2016: Reviews in Endocrine & Metabolic Disorders
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