keyword
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#1
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38533492/early-host-immune-responses-in-a-human-organoid-derived-gallbladder-monolayer-to-salmonella-typhi-strains-from-patients-with-acute-and-chronic-infections-a-comparative-analysis
#2
JOURNAL ARTICLE
Rosângela Salerno-Goncalves, Haiyan Chen, Andrea C Bafford, Mariana Izquierdo, Juan Carlos Hormazábal, Rosanna Lagos, Hervé Tettelin, Adonis D'Mello, Jayaum S Booth, Alessio Fasano, Myron M Levine, Marcelo B Sztein
Salmonella enterica serovar Typhi ( S . Typhi), a human-restricted pathogen, invades the host through the gut to cause typhoid fever. Recent calculations of the typhoid fever burden estimated that more than 10 million new typhoid fever cases occur in low and middle-income countries, resulting in 65,400-187,700 deaths yearly. Interestingly, if not antibiotic-treated, upon the resolution of acute disease, 1%-5% of patients become asymptomatic chronic carriers. Chronically infected hosts are not only critical reservoirs of infection that transmit the disease to naive individuals but are also predisposed to developing gallbladder carcinoma...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532634/ampk-activation-modulates-il-36-induced-inflammatory-responses-by-regulating-i%C3%AE%C2%BAb%C3%AE-expression-in-the-skin
#3
JOURNAL ARTICLE
Yi-Ting Huang, Ling-Ya Chiu, Po-Hsuan Lu, Pa-Fan Hsiao, Jen-Yu Wang, Ping-Hsun Lu, Nan-Lin Wu
BACKGROUND AND PURPOSE: The interleukin (IL)-36 pathway is a critical player in the pathogenesis of pustular psoriasis. However, therapies targeting this pathway are limited or unaffordable (e.g. the anti-IL-36 receptor antibody). AMP-activated protein kinase (AMPK), a regulator of cellular energy and metabolism, is known to participate in inflammatory diseases. However, its role in IL-36-induced skin inflammation remains unclear. Therefore, we sought to investigate the role of AMPK signals in regulating IL-36-induced responses in the skin...
March 26, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38532424/efficacy-of-different-doses-of-corticosteroids-in-treating-severe-covid-19-pneumonia
#4
JOURNAL ARTICLE
Ge Zhang, Lin Su, Wenwen Wu, Qing Qiao, Shuncui Gao, Yan Zhang, Yanmei Zhang
BACKGROUND: To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. METHODS: Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received standard care and high-dose corticosteroids, (high-dose group). The control group (27 patients) received standard care and low-dose corticosteroids (low-dose group)...
March 26, 2024: Virology Journal
https://read.qxmd.com/read/38529692/prenatal-and-postnatal-exposure-to-antibiotics-and-risk-of-food-allergy-in-the-offspring-a-nationwide-birth-cohort-study-in-south-korea
#5
JOURNAL ARTICLE
Jiyeon Oh, Myeongcheol Lee, Jaeyu Park, Hyeon Jin Kim, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F López Sánchez, Elena Dragioti, Chanyang Min, Nikolaos G Papadopoulos, Youn Ho Shin, Jae Il Shin, Dong Keon Yon
BACKGROUND: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. METHODS: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38529301/combined-detection-of-serum-il-6-and-cea-contributes-to-the-diagnosis-of-lung-adenocarcinoma-in-situ
#6
JOURNAL ARTICLE
Jing Pan, Wanzhen Zhuang, Yu Xia, Zhixin Huang, Yue Zheng, Xin Wang, Yi Huang
BACKGROUND: Effective discrimination of lung adenocarcinoma (LUAD) in situ (AIS) from benign pulmonary nodules (BPN) is critical for the early diagnosis of AIS. Our pilot study in a small cohort of 90 serum samples has shown that serum interleukin 6 (IL-6) detection can distinguish AIS from BPN and health controls (HC). In this study, we intend to comprehensively define the diagnostic value of individual and combined detection of serum IL-6 related to the traditional tumor markers carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1) for AIS...
2024: PeerJ
https://read.qxmd.com/read/38529014/invigorating-human-mscs-for-transplantation-therapy-via-nrf2-dkk1-co-stimulation-in-an-acute-on-chronic-liver-failure-mouse-model
#7
JOURNAL ARTICLE
Feng Chen, Zhaodi Che, Yingxia Liu, Pingping Luo, Lu Xiao, Yali Song, Cunchuan Wang, Zhiyong Dong, Mianhuan Li, George L Tipoe, Min Yang, Yi Lv, Hong Zhang, Fei Wang, Jia Xiao
BACKGROUND: Since boosting stem cell resilience in stressful environments is critical for the therapeutic efficacy of stem cell-based transplantations in liver disease, this study aimed to establish the efficacy of a transient plasmid-based preconditioning strategy for boosting the capability of mesenchymal stromal cells (MSCs) for anti-inflammation/antioxidant defenses and paracrine actions in recipient hepatocytes. METHODS: Human adipose mesenchymal stem cells (hADMSCs) were subjected to transfer, either with or without the nuclear factor erythroid 2-related factor 2 (Nrf2)/Dickkopf1 (DKK1) genes, followed by exposure to TNF-α/H2 O2 ...
2024: Gastroenterology Report
https://read.qxmd.com/read/38527692/hexavalent-chromium-exposure-activates-the-non-canonical-nuclear-factor-kappa-b-pathway-to-promote-immune-checkpoint-protein-programmed-death-ligand-1-expression-and-lung-carcinogenesis
#8
JOURNAL ARTICLE
Po-Shun Wang, Zulong Liu, Osama Sweef, Abdullah Farhan Saeed, Thomas Kluz, Max Costa, Kenneth R Shroyer, Kazuya Kondo, Zhishan Wang, Chengfeng Yang
Lung cancer is the leading cause of cancer-related death worldwide; however, the mechanism of lung carcinogenesis has not been clearly defined. Chronic exposure to hexavalent chromium [Cr(VI)], a common environmental and occupational pollutant, causes lung cancer, representing an important lung cancer etiology factor. The mechanism of how chronic Cr(VI) exposure causes lung cancer remains largely unknown. By using cell culture and mouse models and bioinformatics analyses of human lung cancer gene expression profiles, this study investigated the mechanism of Cr(VI)-induced lung carcinogenesis...
March 23, 2024: Cancer Letters
https://read.qxmd.com/read/38525928/phytotherapeutic-potential-of-compounds-identified-from-fractionated-extracts-of-morus-alba-l-as-an-inhibitor-of-interleukin-6-in-the-treatment-of-rheumatoid-arthritis-computational-approach
#9
JOURNAL ARTICLE
Tran Nhat Phong Dao, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Minh Hoang Le, Hen-Hong Chang
The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a multifunctional cytokine that controls both local and systemic acute inflammatory responses through its ability to induce a phase response, plays a serious role. Its overexpression leads to pathological challenges such as rheumatoid arthritis and menopausal osteoporosis...
March 25, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38525773/advancing-care-in-severe-asthma-the-art-of-switching-biologics
#10
REVIEW
Silvano Dragonieri, Andrea Portacci, Vitaliano Nicola Quaranta, Giovanna Elisiana Carpagnano
Biologics targeting IgE, IL-5, IL-4/IL-13, and TSLP are crucial in severe asthma treatment. Research, including randomized controlled trials and real-world studies, has been conducted to assess their efficacy and identify patient characteristics that may predict positive responses. The effectiveness of switching biologics, especially given overlaps in treatment eligibility, and the clinical outcomes post-cessation are critical areas of investigation. This work reviews the effects of switching between these biologics and the indicators of treatment success or failure...
February 21, 2024: Advances in Respiratory Medicine
https://read.qxmd.com/read/38524255/characterizing-cardiac-function-in-icu-survivors-of-sepsis-a-pilot-study-protocol
#11
JOURNAL ARTICLE
Kevin Garrity, Christie Docherty, Kenneth Mangion, Rosie Woodward, Martin Shaw, Giles Roditi, Benjamin Shelley, Tara Quasim, Philip McCall, Joanne McPeake
BACKGROUND: Sepsis is one of the most common reasons for ICU admission and a leading cause of mortality worldwide. More than one-half of survivors experience significant physical, psychological, or cognitive impairments, often termed post-intensive care syndrome (PICS). Sepsis is recognized increasingly as being associated with a risk of adverse cardiovascular events that is comparable with other major cardiovascular risk factors. It is plausible that sepsis survivors may be at risk of unidentified cardiovascular disease, and this may play a role in functional impairments seen after ICU discharge...
March 2024: CHEST Crit Care
https://read.qxmd.com/read/38524125/distinct-functional-neutrophil-phenotypes-in-sepsis-patients-correlate-with-disease-severity
#12
JOURNAL ARTICLE
Qingliang Yang, Jordan C Langston, Roman Prosniak, Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F Kiani, Laurie E Kilpatrick
PURPOSE: Sepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to infection. To develop targeted therapeutics, immunophenotyping is needed to identify distinct functional phenotypes of immune cells. In this study, we utilized our Organ-on-Chip assay to categorize sepsis patients into distinct phenotypes using patient data, neutrophil functional analysis, and proteomics...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38522555/neutrophil-derived-oxidative-stress-contributes-to-skin-inflammation-and-scratching-in-a-mouse-model-of-allergic-contact-dermatitis-via-triggering-pro-inflammatory-cytokine-and-pruritogen-production-in-skin
#13
JOURNAL ARTICLE
Yunqin Yang, Yushuang Pan, Boyu Liu, Yunwen Zhang, Chengyu Yin, Jie Wang, Huimin Nie, Ruoyao Xu, Yan Tai, Xiaofen He, Xiaomei Shao, Yi Liang, Jianqiao Fang, Boyi Liu
Allergic contact dermatitis (ACD) is a common skin disease featured with skin inflammation and a mixed itch/pain sensation. The itch/pain causes the desire to scratch, affecting both physical and psychological aspects of patients. Nevertheless, the mechanisms underlying itch/pain sensation of ACD still remain elusive. Here, we found that oxidative stress and oxidation-related injury were remarkably increased in the inflamed skin of a mouse model of ACD. Reducing oxidative stress significantly attenuated itch/pain-related scratching, allokonesis and skin inflammation...
March 22, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38520887/higher-interleukin-6-is-associated-with-greater-momentary-social-connection-in-close-relationships-in-daily-life
#14
JOURNAL ARTICLE
Tatum A Jolink, Taylor N West, Gabriella M Alvarez, Megan N Cardenas, Mallory J Feldman, Sara B Algoe, Keely A Muscatell
Recent evidence has documented associations between higher levels of inflammation and social approach behaviors toward close others in laboratory-based tasks. Yet it is unknown if this translates to interactions with close others in daily life. Given that momentary experiences of social connection have both relational and health consequences, this is a critical gap in our knowledge. To address the association between inflammation and momentary social connection experiences in close relationships, 55 participants provided blood samples on two consecutive days, which were assayed for circulating levels of the inflammatory marker interleukin-6 (IL-6)...
March 8, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38520688/a-stress-sensor-ire1%C3%AE-is-required-for-bacterial-exotoxin-induced-interleukin-1%C3%AE-production-in-tissue-resident-macrophages
#15
JOURNAL ARTICLE
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopolysaccharide (LPS), from resident peritoneal macrophages (RPMs) through the pyrin and NLRP3 inflammasomes. However, how CTB or CT activates these inflammasomes in the macrophages has been unclear. Here, we clarify the roles of inositol-requiring enzyme 1 alpha (IRE1α), an endoplasmic reticulum (ER) stress sensor, in CT-induced IL-1β production in RPMs...
March 22, 2024: Cell Reports
https://read.qxmd.com/read/38519142/novel-chemotype-nlrp3-inhibitors-that-target-the-crid3-binding-pocket-with-high-potency
#16
JOURNAL ARTICLE
Lieselotte Vande Walle, Madhukar Said, Oonagh Paerewijck, Arinna Bertoni, Marco Gattorno, Bruno Linclau, Mohamed Lamkanfi
The NLRP3 inflammasome plays a central role in various human diseases. Despite significant interest, most clinical-grade NLRP3 inhibitors are derived from sulfonylurea inhibitor CRID3 (also called MCC950). Here, we describe a novel chemical class of NLRP3-inhibiting compounds (NIC) that exhibit potent and selective NLRP3 inflammasome inhibition in human monocytes and mouse macrophages. BRET assays demonstrate that they physically interact with NLRP3. Structural modeling further reveals they occupy the same binding site of CRID3 but in a critically different conformation...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38517295/the-role-of-coinhibitory-receptors-in-b-cell-dysregulation-in-sars-cov-2-infected-individuals-with-severe-disease
#17
JOURNAL ARTICLE
Suguru Saito, Najmeh Bozorgmehr, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38515687/regulation-of-dihydroartemisinin-on-the-pathological-progression-of-laryngeal-carcinoma-through-the-periostin-yap-il-6-pathway
#18
JOURNAL ARTICLE
Xin-Yu Zhang, Rui-Cong Li, Cong Xu, Xiao-Ming Li
OBJECTIVE: Laryngeal cancer (LC) is one of the most common squamous cell carcinomas of the head and neck in clinical practice, and its incidence has been increasing in recent years, but the prognosis of the patients is not favorable. Hence, it is critical to re-understand and deeply study the causes and mechanisms of LC and explore new effective treatment methods and strategies. In this study, we analyzed the effect of Dihydroartemisinin (DHA) on the pathological progression of LC through the periostin (POSTN)/Yes-associated protein (YAP)/interleukin (IL)-6 pathway, which can provide new clinical references and guidelines...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515672/diagnostic-accuracy-of-interleukin-6-in-multiple-diseases-an-umbrella-review-of-meta-analyses
#19
REVIEW
Zeyu Han, Jin Li, Xianyanling Yi, Tianyi Zhang, Dazhou Liao, Jia You, Jianzhong Ai
OBJECTIVE: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses. METHODS: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of Systematic Reviews up to April 2023 to gather meta-analyses that investigate the diagnostic accuracy of IL-6. To assess the methodological quality of the studies, we employed the Assessing the Methodological Quality of Systematic Reviews-2 and Grading of Recommendations, Assessment, Development and Evaluation criteria...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38513666/interleukin-4-downregulates-transcription-factor-bcl6-to-promote-memory-b-cell-selection-in-germinal-centers
#20
JOURNAL ARTICLE
Laila Shehata, Christopher D Thouvenel, Brian D Hondowicz, Lucia A Pew, Gretchen Harms Pritchard, David J Rawlings, Jinyong Choi, Marion Pepper
Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as they differentiate into protective antibody-secreting cells during re-infection. GC formation and cellular interactions within the GC have been studied in detail, yet the exact signals that allow for the selection and exit of MBCs are not understood. Here, we showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation...
March 12, 2024: Immunity
keyword
keyword
162523
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.