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https://www.readbyqxmd.com/read/30336174/sirt1-activation-by-butein-attenuates-sepsis-induced-brain-injury-in-mice-subjected-to-cecal-ligation-and-puncture-via-alleviating-inflammatory-and-oxidative-stress
#1
Yanrong Zhu, Ke Wang, Zhiqiang Ma, Dong Liu, Yang Yang, Meng Sun, Aidong Wen, Yuewen Hao, Shanbo Ma, Fang Ren, Zhenlong Xin, Yue Li, Shouyin Di, Juntian Liu
Sepsis-induced brain injury is frequently encountered in critically ill patients with severe systemic infection. Butein (3,4,2',4'-tetrahydroxychalcone) has been demonstrated as the neuro-protective agent via reducing inflammation and oxidative stress on neurons. Moreover, activation of silent information regulator 1 (SIRT1) inhibits apoptosis, oxidation and inflammation thus alleviating sepsis-induced multiorgan injuries. In present study, we show that butein administrated intraperitoneally (10 mg/kg) saved mice from sepsis-induced lethality by increasing 7-day survival rate after cecal ligation and puncture (CLP) surgery...
October 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30335564/interleukin-22-a-potent-target-for-treatment-of-non-autoimmune-diseases
#2
Yue Zheng, Tong Li
Interleukin -22 (IL-22) is a member of interleukin-10 (IL-10) family cytokines that is produced by different types of lymphocytes included in both innate and adaptive immune systems. These lymphocytes include activated T cells, most notably Th17 and Th22 cells, as well as NK cells, γδ T cells, etc. IL-22 mediate its effects via the IL-22-IL-22R complex and subsequent Janus Kinase-signal transduces and activators transcription (JAK-STAT) signaling pathway. According to recent evidence, IL-22 played a critical role in the pathogenesis of many non-autoimmune diseases...
October 18, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30335529/comparative-analysis-of-bone-marrow-derived-mast-cell-differentiation-in-c57bl-6-and-balb-c-mice
#3
Miki Nagashima, Madoka Koyanagi, Yutaka Arimura
Allergic diseases have increased in the last three decades. Mast cells play a critical role in allergic diseases along with allergen-specific immunoglobulin E (IgE). Following mast cell degranulation elicited by ligation of the IgE-FcεRI receptor complex with allergen, allergic reactions are followed by various symptoms such as vascular hyperpermeability, mucous secretion, itching, sneezing, wheezing, rashes, fever, and anaphylactic shock. Susceptibility or inclination to allergy varies depending on individual genetic traits and living environment, and it has long been believed that such an inclination is determined by an immunologic balance of T helper cell types...
October 18, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/30334399/il-33-mediates-allergy-through-mast-cell-activation-potential-inhibitory-effect-of-certain-cytokines
#4
EDITORIAL
L Tettamanti, S K Kritas, C E Gallenga, C D'Ovidio, F Mastrangelo, G Ronconi, Al Caraffa, E Toniato, P Conti
Mast cells (MCs) are hematopoietic immune cells commonly found in adjacent to blood vessels in the lamina propria of airway mucosa. They are important in allergic reactions since the cross-linking of their surface high affinity receptor FceRI induces activation of these cells, and provokes the synthesis, degranulation and release of inflammatory mediators including arachidonic acid-derived eicosanoids (de novo synthesized), stored enzyme mediators, and inflammatory TH1 and TH2 cytokines, and chemokines. Interleukin (IL)-33 participates in innate and adaptive immunity and inflammation and, acting on CD34+ cells, causes MC differentiation and maturation...
September 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/30333233/heme-oxygenase-1-protects-airway-epithelium-against-apoptosis-by-targeting-the-proinflammatory-nlrp3-rxr-axis-in-asthma
#5
Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xia
Asthma is thought to be caused by malfunction of type 2 T helper cell (Th2)-mediated immunity, causing excessive inflammation, mucus overproduction, and apoptosis of airway epithelial cells. Heme oxygenase-1 (HO-1) functions in heme catabolism and is both cytoprotective and anti-inflammatory. We hypothesized that this dual function may be related to asthma's etiology. Using primary airway epithelial cells (pAECs) and an asthma mouse model, we demonstrate that severe lung inflammation is associated with rapid pAEC apoptosis...
October 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30327532/mir-106a-deficiency-attenuates-inflammation-in-murine-ibd-models
#6
Megan R Sanctuary, Rick H Huang, Ashleigh A Jones, Marisa E Luck, Carol M Aherne, Paul Jedlicka, Edwin F de Zoeten, Colm B Collins
Pro-inflammatory cytokine TNFα antagonizes regulatory T cell (Treg) suppressive function with a measurable reduction of IL-10 protein secretion. Tregs are critical to suppress excessive immune activation, particularly within the intestine where high antigenic loads elicit chronic subclinical immune activation. Employing a TNFα-driven murine inflammatory bowel disease (IBD) model (TNFΔARE/+ ), which mirrors the Treg expansion and transmural ileitis seen in Crohn's disease, we demonstrate that the TNFα-mediated loss of Treg suppressive function coincides with induction of a specific miRNA, miR-106a in both humans and mice, via NFκB promoter binding to suppress post-transcriptional regulation of IL-10 release...
October 16, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/30323894/comparative-proteomic-analysis-of-cat-eye-syndrome-critical-region-protein-1-function-in-tumor-associated-macrophages-and-immune-response-regulation-of-glial-tumors
#7
Changbin Zhu, Dana A M Mustafa, Merle M Krebber, Ihsan Chrifi, Pieter J M Leenen, Dirk J Duncker, Lennard Dekker, Theo M Luider, Johan M Kros, Caroline Cheng
Introduction: Tumor associated macrophages (TAMs) promote tumor development, angiogenesis and distal metastasis. In previous studies, we showed that Cat Eye Syndrome Critical Region Protein 1 (CECR1) is expressed by M2-like TAMs in human glioma samples. CECR1 promoted M2 TAMs differentiation and affected glioma cell proliferation and migration. Here we investigated the proteomic profile of TAMs expressing CECR1 in absence or presence of glioma cells. Results: CECR1 siRNA transfection upregulated 67 proteins in THP-1-derived Macrophages (MQs)...
September 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/30323819/lack-of-fcrn-impairs-natural-killer-cell-development-and-functions-in-the-tumor-microenvironment
#8
Diana Cadena Castaneda, Christine Dhommée, Thomas Baranek, Emilie Dalloneau, Laurie Lajoie, Alexandre Valayer, Christophe Arnoult, Marie-Véronique Demattéi, Delphine Fouquenet, Christelle Parent, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth. However, the consequences of FcRn down-regulation in the anti-tumor immune response are not fully elucidated. By using the B16F10 experimental lung metastasis model in an FcRn-deficient microenvironment (FcRn-/- mice), we found lung metastasis associated with an abnormal natural killer (NK) cell phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30323812/phosphorylation-of-trim28-enhances-the-expression-of-ifn-%C3%AE-and-proinflammatory-cytokines-during-hpaiv-infection-of-human-lung-epithelial-cells
#9
Tim Krischuns, Franziska Günl, Lea Henschel, Marco Binder, Joschka Willemsen, Sebastian Schloer, Ursula Rescher, Vanessa Gerlt, Gert Zimmer, Carolin Nordhoff, Stephan Ludwig, Linda Brunotte
Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated with severe tissue damage due to hyperinduction of interferons and proinflammatory cytokines. The reasons for this excessive cytokine expression are still incompletely understood, which has hampered the development of efficient immunomodulatory treatment options. The host protein TRIM28 associates to the promoter regions of over 13,000 genes and is recognized as a genomic corepressor and negative immune regulator. TRIM28 corepressor activity is regulated by post-translational modifications, specifically phosphorylation of S473, which modulates binding of TRIM28 to the heterochromatin-binding protein HP1...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30323623/the-regulation-of-cytokine-signaling-by-retinal-determination-gene-network-pathway-in-cancer
#10
REVIEW
Xinhua Zheng, Qian Liu, Ming Yi, Shuang Qin, Kongming Wu
Tumor environment plays a pivotal role in determining cancer biology characteristics. Cytokine factors, as a critical component in tumor milieu, execute distinct functions in the process of tumorigenesis and progression via the autocrine or paracrine manner. The retinal determination gene network (RDGN), which mainly comprised DACH, SIX, and EYA family members, is required for the organ development in mammalian species. While the aberrant expression of RDGN is involved in the proliferation, apoptosis, angiogenesis, and metastasis of tumors via interacting with different cytokine-related signals, such as CXCL8, IL-6, TGF-β, FGF, and VEGF, in a cell- or tissue-dependent manner...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30322615/mln64-deletion-suppresses-rankl-induced-osteoclastic-differentiation-and-attenuates-diabetic-osteoporosis-in-streptozotocin-stz-induced-mice
#11
Chen Lei, Han Xueming, Duan Ruihang
Diabetes mellitus is known as a main cause to induce osteoporosis. However, the pathogenesis of osteoporosis induced by diabetes has not been fully understood. MLN64 is highly homologous to the steroidogenic acute regulatory (STAR) protein, sharing the highly conserved START domain and exhibiting various biological activities. In the study, we attempted to explore the role of MLN64 in osteoporosis progression through the in vitro and in vivo studies. At first, the in vitro study suggested that MLN64 was over-expressed during the osteoclast differentiation induced by receptor activator of NF-kB ligand (RANKL)...
October 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30322354/pathologic-fibroblasts-in-idiopathic-subglottic-stenosis-amplify-local-inflammatory-signals
#12
Robert J Morrison, Nicolas-George Katsantonis, Kevin M Motz, Alexander T Hillel, C Gaelyn Garrett, James L Netterville, Christopher T Wootten, Susan M Majka, Timothy S Blackwell, Wonder P Drake, Alexander Gelbard
Objective To characterize the phenotype and function of fibroblasts derived from airway scar in idiopathic subglottic stenosis (iSGS) and to explore scar fibroblast response to interleukin 17A (IL-17A). Study Design Basic science. Setting Laboratory. Subjects and Methods Primary fibroblast cell lines from iSGS subjects, idiopathic pulmonary fibrosis subjects, and normal control airways were utilized for analysis. Protein, molecular, and flow cytometric techniques were applied in vitro to assess the phenotype and functional response of disease fibroblasts to IL-17A...
October 16, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/30320600/thirty-eight-negative-kinase-1-mediates-trauma-induced-intestinal-injury-and-multi-organ-failure
#13
Milena Armacki, Anna Katharina Trugenberger, Ann K Ellwanger, Tim Eiseler, Christiane Schwerdt, Lucas Bettac, Dominik Langgartner, Ninel Azoitei, Rebecca Halbgebauer, Rüdiger Groß, Tabea Barth, André Lechel, Benjamin M Walter, Johann M Kraus, Christoph Wiegreffe, Johannes Grimm, Annika Scheffold, Marlon R Schneider, Kenneth Peuker, Sebastian Zeißig, Stefan Britsch, Stefan Rose-John, Sabine Vettorazzi, Eckhart Wolf, Andrea Tannapfel, Konrad Steinestel, Stefan O Reber, Paul Walther, Hans A Kestler, Peter Radermacher, Thomas Fe Barth, Markus Huber-Lang, Alexander Kleger, Thomas Seufferlein
Dysregulated intestinal epithelial apoptosis initiates gut injury, alters the intestinal barrier, and can facilitate bacterial translocation leading to a systemic inflammatory response syndrome (SIRS) and/or multi-organ dysfunction syndrome (MODS). A variety of gastrointestinal disorders, including inflammatory bowel disease, have been linked to intestinal apoptosis. Similarly, intestinal hyperpermeability and gut failure occur in critically ill patients, putting the gut at the center of SIRS pathology. Regulation of apoptosis and immune-modulatory functions have been ascribed to Thirty-eight-negative kinase 1 (TNK1), whose activity is regulated merely by expression...
October 15, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30319645/inflammasome-a-double-edged-sword-in-liver-diseases
#14
REVIEW
Jingyun Luan, Dianwen Ju
Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30316511/calcium-sensing-receptor-activates-the-nlrp3-inflammasome-via-a-chaperone-assisted-degradative-pathway-involving-hsp70-and-lc3-ii
#15
Tania Yareli Gutiérrez-López, Lennis Beatríz Orduña-Castillo, Magda Nohemí Hernández-Vásquez, José Vázquez-Prado, Guadalupe Reyes-Cruz
Calcium sensing receptor (CaSR) activates the NLRP3 inflammasome with consequences on homeostatic responses. However, little is known about how this process is orchestrated. Since proteolysis of critical regulators of NLRP3 inflammasome contribute to its activation, we aimed to understand how CaSR stimulates proteolytic pathways to activate the NLRP3 inflammasome. We found that proteasome and lysosome-dependent mechanisms are activated by CaSR to promote the degradation of important regulators of NLRP inflammasome...
October 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30315140/il-6-promotes-t-cell-proliferation-and-expansion-under-inflammatory-conditions-in-association-with-low-level-ror%C3%AE-t-expression
#16
Bofeng Li, Lindsay L Jones, Terrence L Geiger
IL-6 is a critical driver of acute and chronic inflammation and has been reported to act as a T cell survival factor. The influence of IL-6 on T cell homeostasis is not well resolved. We demonstrate that IL-6 signaling drives T cell expansion under inflammatory conditions but not during normal homeostasis. During inflammation, IL-6Rα-deficient T cells are unable to effectively compete with wild type T cells. IL-6 promotes T cell proliferation, and this is associated with low-level expression of the RORγt transcription factor...
October 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30315101/yes-associated-protein-yap-and-transcriptional-co-activator-with-pdz-binding-motif-taz-mediate-cell-density-dependent-proinflammatory-responses
#17
Qiong Zhang, Xu Han, Jinfeng Chen, Xiaomei Xie, Jiafeng Xu, Yang Zhao, Jie Shen, Lin Hu, Pinglong Xu, Hai Song, Long Zhang, Bin Zhao, Ying-Jie Wang, Zongping Xia
A proper inflammatory response is critical to the restoration of tissue homeostasis after injury or infection, but how such a response is modulated by the physical properties of the cellular and tissue microenvironment is not fully understood. Here, using H358, HeLa and HEK293T cells, we report that cell density can modulate inflammatory responses through the Hippo signaling pathway. We found that NF-κβ activation through the proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α) is not affected by cell density...
October 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30315078/amentoflavone-ameliorates-streptococcus-suis-induced-infection-in-vitro-and-in-vivo
#18
Xue Shen, Xiaodi Niu, Gen Li, Jianfeng Wang, Xuming Deng
Streptococcus suis (S.suis), an important zoonotic pathogen, has caused considerable economic losses in swine industry and severe public health issues worldwide. It is urgent to develop novel effective strategy for prevention and therapy of S.suis Here, amentoflavone, a natural biflavonoid compound isolated from Chinese herbs that has negligible anti- S.suis activity, was identified to be a potent antagonist of suilysin (SLY)-mediated hemolysis without interfering with expression of SLY. Amentoflavone effectively inhibited SLY oligomerization, which is critical for its pore-forming activity...
October 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/30314869/the-suppression-of-ox-ldl-induced-inflammatory-cytokine-release-and-apoptosis-of-hcaecs-by-long-non-coding-rna-malat1-via-regulating-microrna-155-socs1-pathway
#19
S Li, Y Sun, L Zhong, Z Xiao, M Yang, M Chen, C Wang, X Xie, X Chen
BACKGROUND: Atherosclerosis is a chronic inflammatory disease. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) and microRNAs have emerged as critical regulators of atherosclerosis; however, whether they have crosstalk on this issue remains elusive. Here, we investigated the potential associations between lncRNA-MALAT1 and miR-155 on the regulation of atherosclerosis. METHODS: Quantitative real-time PCR was employed to assess the expression of MALAT1, IL-6 and IL-8...
June 28, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/30314496/mir-218-produces-anti-tumor-effects-on-cervical-cancer-cells-in-vitro
#20
Li Zhu, Huaidong Tu, Yanmei Liang, Dihong Tang
BACKGROUND: As indoleamine-2,3-dioxygenase 1 (IDO1) is critical in tumor immune escape, we determined to study the regulatory mechanism of miR-218 on IDO1 in cervical cancer. METHODS: Real-time PCR (RT-qPCR) was carried out to measure the expression of miR-218. RT-qPCR and Western blot were performed to detect the expression of IDO1 in cervical cancer. Dual-luciferase reporter assay was used to determine the binding of miR-218 on the IDO1 3'UTR. Cell viability, apoptosis, and related factors were determined using cell counting kit-8 (CCK-8), Annexin-V/PI (propidium) assay, enzyme-linked immunosorbnent assay (ELISA), RT-qPCR, and Western blot assays after miR-218 mimics has been transfected to HeLa cervical cancer cells...
October 12, 2018: World Journal of Surgical Oncology
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