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sustainable development

Viviane Silva de Jesus, Samylla Maira Costa Siqueira, Climene Laura de Camargo, Ridalva Dias Martins Felzemburgh, Maria Carolina Ortiz Whitaker, Márcia Lúcia Dos Santos, Carolina Larrosa de Almeida
OBJECTIVE: to report the experience of research phases on promoting sustainable development based on social technologies with palm fiber artifacts in a vulnerable community. METHOD: this is an experience report that describes the phases of a multiprofessional project that sought sustainable development, and was conducted with inhabitants from a vulnerable community. RESULTS: the actions were developed in four phases: exploratory, planning, implementation and evaluation...
November 2018: Revista Brasileira de Enfermagem
Thaís Jeronimo Vidal, Tatiana Aragão Figueiredo, Vera Lúcia Edais Pepe
Monoclonal antibodies (mABs) have been indicated as an innovative technology for the treatment of some types of cancer, since they are capable of targeting and selectively killing tumor cells. However, the high costs of these therapies raise questions as to the sustainability of access. This study aimed to identify the principal characteristics of monoclonal antibodies used in cancer treatment with active marketing authorization in Brazil as of 2016. This was a descriptive retrospective analysis based on consultation of the Brazilian Health Regulatory Agency (Anvisa) website, in which these mABs were characterized according to the target antigen, type of antibody, year of registration, therapeutic indications, and applicant...
November 29, 2018: Cadernos de Saúde Pública
Naglezi M Lovatto, Bruno B Loureiro, Dirleise Pianesso, Taida J Adorian, Fernanda R Goulart, Caroline S Speroni, Ana Betine B Bender, Jucieli Müller, Leila P DA Silva
The objective of this study was to evaluate growth and metabolic parameters of silver catfish fed with protein concentrates of sunflower meal (SMPC) and crambe meal (CrMPC). The study evaluated two levels of substitution, where 25 or 50% of animal protein was replaced with plant-based protein. A total of 300 silver catfish (14 ± 0.26 g) were used in five treatments and three replications, in fifteen 280-liter experimental units. The results were submitted to analysis of variance and the means of the control diet was compared to the remaining treatments by Dunnett's test at 5% significance level...
October 2018: Anais da Academia Brasileira de Ciências
Grishma N Pawar, Neha N Parayath, Angela L Nocera, Benjamin S Bleier, Mansoor M Amiji
Delivering therapeutics across the blood-brain barrier (BBB) for treating central nervous system (CNS) diseases is one of the biggest challenges today as the BBB limits the uptake of molecules greater than 500 Da into the CNS. Here we describe a novel trans-nasal mucosal drug delivery as an alternative to the intranasal drug delivery to overcome its limitations and deliver high molecular weight (HMW) therapeutics efficiently to the brain. This approach is based on human endoscopic skull base surgical techniques in which a surgical defect is repaired by engrafting semipermeable nasal mucosa over a skull base defect...
2018: PloS One
Mao Dai, Rui Xiao, Luyao Cai, Tong Ge, Liping Zhu, Qinghua Hu
Pulmonary hypertension (PH) is a mortal disease featured with pulmonary vascular constriction and remodeling, right heart failure and eventual death. Several reports showed that high mobility group box 1 (HMGB1) appears to be critical for the development of PH, the underlying mechanism, however has not been revealed. Experiments from the current study demonstrated that the HMGB1 level was elevated in the lung tissue and blood plasma of rats after chronic hypoxia exposure and monocrotaline treatment. The HMGB1 was originally located within nucleus and translocated to cytoplasm of pulmonary artery smooth muscle cells (PASMCs) upon hypoxia exposure, a process that appeared mediated by endogenous H2 O2 ...
December 5, 2018: American Journal of Physiology. Cell Physiology
Franklin Shaffer, Mukul Bakhshi, Niamh Farrell, Thomas Álvarez
Nurses and other health care professionals are in a unique position to shift the paradigm around migration debates. As caregivers and advocates for patients and other providers, nurses are crucial to the health and well-being of individuals, families, and communities. This is especially true for migrants, including increasingly vulnerable refugee populations around the world. As negotiations surrounding the Global Compact for Migration and Global Compact on Refugees come to a close, nurses' roles are becoming more apparent...
January 2019: Nursing Administration Quarterly
Diane K Brown, Sue Fosnight, Maureen Whitford, Susan Hazelett, Colleen Mcquown, Jenifer C Drost, Denise J Kropp, Cynthia A Hovland, Joan E Niederriter, Rikki Patton, Abigail Morgan, Eileen Fleming, Richard P Steiner, Edward Demond Scott, Fabiana Ortiz-Figueroa
Background: One in three people over the age of 65 fall every year, with 1/3 sustaining at least moderate injury. Falls risk reduction requires an interprofessional health team approach. The literature is lacking in effective models to teach students how to work collaboratively in interprofessional teams for geriatric falls prevention. The purpose of this paper is to describe the development, administration and outcome measures of an education programme to teach principles of interprofessional care for older adults in the context of falls prevention...
2018: BMJ Open Quality
Reneé de Waal, Richard Lessells, Anthony Hauser, Roger Kouyos, Mary-Ann Davies, Matthias Egger, Gilles Wandeler
The prevalence of pretreatment resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is >10% in many low-income countries. As a consequence, several sub-Saharan African countries have implemented, or are considering the introduction of, non-NNRTI-based first-line antiretroviral therapy (ART) for treatment-naïve and treatment-experienced patients. This is occurring at a time when ART programmes are expanding, in response to the World Health Organization guidelines, which recommend ART initiation regardless of CD4 cell count...
November 15, 2018: Journal of Virus Eradication
Carlos Sotomayor-Beltran
Introduction: The Sustainable Development Goal (SDG) number 2 aims to end malnutrition in all its forms. To reach this goal one of the several health problems to tackle is childhood obesity. Aim: In this study, spatial data for the prevalence of obesity among Peruvian children under five years of age in 2017 is presented and analyzed in order to observe in which regions this disease is a high risk. Material and Methods: By geo-referencing public data provided by the National Institute of Health from Peru and using a Geographic Information System (GIS) tool, it was possible to generate maps of prevalences and also of clusters and outliers at a regional and district level, respectively...
October 2018: Acta Informatica Medica: AIM
Jaemin Lee, Tae Heung Kang, Wonbeak Yoo, Hyunji Choi, Seongyea Jo, Kyungsu Kong, Sang-Rae Lee, Sun-Uk Kim, Ji-Su Kim, Duck Cho, Janghwan Kim, Jeong-Yoon Kim, Eun-Soo Kwon, Seokho Kim
Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer (PC). Despite their usefulness, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK cell-homing protein, named NK cell-recruiting protein-conjugated antibody (NRP-body)...
December 4, 2018: Cancer Immunology Research
Martina Petranikova, Burcak Ebin, Cristian Tunsu
Cobalt is considered to be a critical raw material for the European Union. Since it has limited supply, substantial efforts should be made to develop sustainable methods to recover cobalt from alternative sources. Hydrometallurgical processing of spent NiMH batteries generates a concentrated stream containing, preferably, Co (11.8 g/L) and impurities (2.3 g/L Ni, 0.2 g/L Al, 9.3 g/L Mn and 4.6 g/L rare earth elements) in the nitric acid media. In this study, the selective separation of Co from the other ions present was investigated...
January 2019: Waste Management
Huabo Duan, Travis R Miller, Gang Liu, Vivian W Y Tam
How can growing cities be expanded in a sustainable way? Huge waste generation has become a major challenge in many growing cities, particularly in developing countries. China's annual C&D waste generation was and estimated 2.4 billion tonnes in the past decade, which is 15 times more than municipal solid waste generation. India has less C&D waste generation than China, yet still is as high as 530 million tons in 2013. However, only around 5% of C&D waste was reused in these countries and the rest largely ends up in dumping sites for disposal...
January 2019: Waste Management
Corrine W Ruktanonchai, Kristine Nilsen, Victor A Alegana, Claudio Bosco, Rogers Ayiko, Andrew C Seven Kajeguka, Zöe Matthews, Andrew J Tatem
BACKGROUND: Sub-Saharan Africa continues to account for the highest regional maternal mortality ratio (MMR) in the world, at just under 550 maternal deaths per 100,000 live births in 2015, compared to a global rate of 216 deaths. Spatial inequalities in access to life-saving maternal and newborn health (MNH) services persist within sub-Saharan Africa, however, with varied improvement over the past two decades. While previous research within the East African Community (EAC) region has examined utilisation of MNH care as an emergent property of geographic accessibility, no research has examined how these spatial inequalities have evolved over time at similar spatial scales...
December 4, 2018: BMC Public Health
Michele R Decker, Shannon N Wood, Esther Ndinda, Gayane Yenokyan, Jacob Sinclair, Nankali Maksud, Brendan Ross, Benjamin Omondi, Martin Ndirangu
BACKGROUND: Globally, sexual violence is prevalent, particularly for adolescent women. This cluster-randomized controlled implementation trial examines empowerment self-defense (ESD) for sexual assault risk reduction among school-age women in Malawi. METHODS: The unit of randomization and analysis was the school (n = 141). Intervention participants received a 12-h intervention over 6 weeks, with refreshers. Primary outcomes were past-year prevalence and incident rate of sexual violence...
December 4, 2018: BMC Public Health
Teiji Watanabe, Shigeru Shirasaka
This study describes pastoralism practiced in the Karakul village, Northeast of Tajikistan, and discusses its sustainability. Tajikistan introduced a market economy at independence in 1991, and pastoralism is now practiced on a family-unit basis. The families in Karakul graze livestock in their summer pastureland ( jailoo ) and move their livestock to winter pastureland around the village ( kyshtoo ). They make groups for pasturage with several families in jailoo and also in kyshtoo . Each group pastures their livestock every day, using a system called novad ...
December 3, 2018: International Journal of Environmental Research and Public Health
Azhwar Raghunath, Kiruthika Sundarraj, Frank Arfuso, Gautam Sethi, Ekambaram Perumal
The liver executes versatile functions and is the chief organ for metabolism of toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the third foremost cause of cancer death worldwide. Oxidative stress is a key factor related with the development and progression of HCC. Nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2) is a cytosolic transcription factor, which regulates redox homeostasis by activating the expression of an array of antioxidant response element-dependent genes...
December 3, 2018: Cancers
Roy Chris Skinner, Derek C Warren, Soofia N Lateef, Vagner A Benedito, Janet C Tou
Apple pomace, which is a waste byproduct of processing, is rich in several nutrients, particularly dietary fiber, indicating potential benefits for diseases that are attributed to poor diets, such as non-alcoholic fatty liver disease (NAFLD). NAFLD affects over 25% of United States population and is increasing in children. Increasing fruit consumption can influence NAFLD. The study objective was to replace calories in standard or Western diets with apple pomace to determine the effects on genes regulating hepatic lipid metabolism and on risk of NAFLD...
December 3, 2018: Nutrients
Heidi Lynch, Carol Johnston, Christopher Wharton
Plant-based diets provide well-established physical and environmental health benefits. These benefits stem in part from the degree of restriction of animal-derived foods. Historically, meat and other animal-derived proteins have been viewed as an integral component of athletes' diets, leading some to question the adequacy of vegetarian or vegan diets for supporting athletic performance. The purpose of this review is to examine the impact of plant-based diets on human physical health, environmental sustainability, and exercise performance capacity...
December 1, 2018: Nutrients
Alice Cartoni Mancinelli, Alessandro Dal Bosco, Simona Mattioli, David Ranucci, Cesare Castellini
: Nowadays there is an increasing demand for poultry products from alternative rearing systems. These systems, commonly named pastured poultry production (PPP), are more expensive than intensive rearing system but sustain biodiversity, local economies and farm multi-functionality besides providing meat to which consumers attribute high ethical value and quality. PPP generally uses large outdoor runs, small number of animals and requires chickens adapted to natural environment. One of the most relevant obstacles to further development of PPP systems is related to the slaughtering of animals economically and at the same time complying with the sanitary regulations to maintain food safety standards...
November 30, 2018: Animals: An Open Access Journal From MDPI
Duncan C Meyers, Celene E Domitrovich, Rawan Dissi, Jordan Trejo, Mark T Greenberg
A strong body of research indicates that evidence-based programs designed to promote social and emotional learning (SEL) can lead to positive developmental outcomes for children and youth. Although these evidence-based programs have demonstrated benefits for students, it is also well-established that programs must be implemented with quality and sustained to maximize positive outcomes. To support schools in implementing SEL that is integrated into all aspects of a school community, the CASEL School Guide implementation model was developed to guide school leadership teams in establishing a vision; selecting, implementing, and sustaining evidence-based programs; and integrating SEL schoolwide...
November 10, 2018: Evaluation and Program Planning
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