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Mitral heart valve design

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https://www.readbyqxmd.com/read/28207320/cardiac-findings-in-quarter-horses-with-heritable-equine-regional-dermal-asthenia
#1
Erin L Brinkman, Benjamin C Weed, Sourav S Patnaik, Bryn L Brazile, Ryan M Centini, Robert W Wills, Bari Olivier, Dodd G Sledge, Jim Cooley, Jun Liao, Ann M Rashmir-Raven
OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28187474/new-mitral-annuloplasty-ring-enables-oversizing-of-transcatheter-heart-valve-and-prevents-central-or-paravalvular-leakage
#2
Georg Daniel Duerr, Jan-Malte Sinning, Armin Georg Welz, Fritz Mellert
Background Transcatheter valve-in-ring strategies have been developed to treat recurrent mitral regurgitation (MR) after failing surgical annuloplasty. However, suboptimal THV expansion with consecutive paravalvular leakage (PVL) is a procedure-immanent issue. Methods A rigid, saddle-shaped ring was cut at four locations. The segments were reconnected with pull-springs, rearranged to the original shape, and covered with a sewing cuff. The length of the annuloplasty ring construct, including extended pull-springs, was defined by the perimeter of an appropriate THV...
February 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28117617/patterns-and-determinants-of-functional-and-absolute-iron-deficiency-in-patients-undergoing-cardiac-rehabilitation-following-heart-surgery
#3
Roberto Tramarin, Valeria Pistuddi, Luigi Maresca, Marco Pavesi, Serenella Castelvecchio, Lorenzo Menicanti, Carlo de Vincentiis, Marco Ranucci
Background Anaemia and iron deficiency are frequent following major surgery. The present study aims to identify the iron deficiency patterns in cardiac surgery patients at their admission to a cardiac rehabilitation programme, and to determine which perioperative risk factor(s) may be associated with functional and absolute iron deficiency. Design This was a retrospective study on prospectively collected data. Methods The patient population included 339 patients. Functional iron deficiency was defined in the presence of transferrin saturation <20% and serum ferritin ≥100 µg/l...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28100277/stress-echo-2020-the-international-stress-echo-study-in-ischemic-and-non-ischemic-heart-disease
#4
Eugenio Picano, Quirino Ciampi, Rodolfo Citro, Antonello D'Andrea, Maria Chiara Scali, Lauro Cortigiani, Iacopo Olivotto, Fabio Mori, Maurizio Galderisi, Marco Fabio Costantino, Lorenza Pratali, Giovanni Di Salvo, Eduardo Bossone, Francesco Ferrara, Luna Gargani, Fausto Rigo, Nicola Gaibazzi, Giuseppe Limongelli, Giuseppe Pacileo, Maria Grazia Andreassi, Bruno Pinamonti, Laura Massa, Marco A R Torres, Marcelo H Miglioranza, Clarissa Borguezan Daros, José Luis de Castro E Silva Pretto, Branko Beleslin, Ana Djordjevic-Dikic, Albert Varga, Attila Palinkas, Gergely Agoston, Dario Gregori, Paolo Trambaiolo, Sergio Severino, Ayana Arystan, Marco Paterni, Clara Carpeggiani, Paolo Colonna
BACKGROUND: Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently its breadth and variety of applications have extended well beyond coronary artery disease (CAD). We lack a prospective research study of SE applications, in and beyond CAD, also considering a variety of signs in addition to regional wall motion abnormalities. METHODS: In a prospective, multicenter, international, observational study design, > 100 certified high-volume SE labs (initially from Italy, Brazil, Hungary, and Serbia) will be networked with an organized system of clinical, laboratory and imaging data collection at the time of physical or pharmacological SE, with structured follow-up information...
January 18, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28071960/community-based-prevalence-study-of-rheumatic-heart-disease-in-rural-ethiopia
#5
Tadesse Gemechu, Hani Mahmoud, Eldryd Ho Parry, David Iw Phillips, Magdi H Yacoub
Background Chronic Rheumatic Heart disease (RHD) continues to be a health problem in many low and middle income countries and especially in sub-Saharan Africa. Echocardiography has shown that the disease is far more widespread than may be detected by clinical assessment, but data are lacking on the prevalence and epidemiological features in rural Africa. Design Community-based prevalence survey Methods We used transthoracic echocardiography to carry out a population-based study of RHD in a rural area of Ethiopia...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28040318/transcatheter-mitral-valve-replacement-for-patients-with-symptomatic%C3%A2-mitral%C3%A2-regurgitation-a-global-feasibility-trial
#6
David W M Muller, Robert Saeid Farivar, Paul Jansz, Richard Bae, Darren Walters, Andrew Clarke, Paul A Grayburn, Robert C Stoler, Gry Dahle, Kjell A Rein, Marty Shaw, Gregory M Scalia, Mayra Guerrero, Paul Pearson, Samir Kapadia, Marc Gillinov, Augusto Pichard, Paul Corso, Jeffrey Popma, Michael Chuang, Philipp Blanke, Jonathon Leipsic, Paul Sorajja
BACKGROUND: Symptomatic mitral regurgitation (MR) is associated with high morbidity and mortality that can be ameliorated by surgical valve repair or replacement. Despite this, many patients with MR do not undergo surgery. Transcatheter mitral valve replacement (TMVR) may be an option for selected patients with severe MR. OBJECTIVES: This study aimed to examine the effectiveness and safety of TMVR in a cohort of patients with native valve MR who were at high risk for cardiac surgery...
January 31, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27861426/mastering-mitral-leaflets-coaptation-after-valve-repair-with-adjustable-mitral-annuloplasty-ring-prove-of-concept-in-mock-loop-study
#7
Piergiorgio Tozzi, Daniel Hayoz, Carlo Antona, Gianfranco B Fiore, Giuseppe Siniscalchi, Enrico Ferrari, Gérard Baeriswyl, Riccardo Vismara
This investigation sought to determine the feasibility of a novel mitral ring designed to reshape mitral annulus on beating heart, after surgery. The mitral ring is intended to improve mitral leaflets coaptation to correct residual and recurrent mitral regurgitations. It could also provide progressive correction of mitral regurgitation. The device was tested in ex vivo beating heart model.The novel mitral ring is selectively deformable in P1, P2 and P3 segments using a dedicated angioplasty-type balloon. The deformation should increase leaflets' coaptation reducing distance between the two leaflets...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27699507/ex-vivo-methods-for-informing-computational-models-of-the-mitral-valve
#8
Charles H Bloodworth, Eric L Pierce, Thomas F Easley, Andrew Drach, Amir H Khalighi, Milan Toma, Morten O Jensen, Michael S Sacks, Ajit P Yoganathan
Computational modeling of the mitral valve (MV) has potential applications for determining optimal MV repair techniques and risk of recurrent mitral regurgitation. Two key concerns for informing these models are (1) sensitivity of model performance to the accuracy of the input geometry, and, (2) acquisition of comprehensive data sets against which the simulation can be validated across clinically relevant geometries. Addressing the first concern, ex vivo micro-computed tomography (microCT) was used to image MVs at high resolution (~40 micron voxel size)...
February 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27639743/a-new-transcatheter-heart-valve-concept-the-triskele-feasibility-in-an-acute-preclinical-model
#9
Benyamin Rahmani, Spyros Tzamtzis, Rose Sheridan, Michael J Mullen, John Yap, Alexander M Seifalian, Gaetano Burriesci
AIMS: The aim of this study was to introduce and demonstrate the feasibility in an acute preclinical model of a new transcatheter heart valve concept with a self-expanding wire frame, polymeric leaflets and a sealing component. METHODS AND RESULTS: The TRISKELE valve was developed based on a previously validated polymeric leaflet design, an adaptive sealing cuff and a novel nitinol wire frame which reduces stress on the leaflets and radial pressure on the surrounding tissue...
September 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27610282/analysis-of-dose-distribution-in-the-heart-for-radiosurgical-ablation-of-atrial-fibrillation
#10
Edward A Gardner, Georg A Weidlich
In a treatment planning study, radiosurgical treatment plans designed to produce lesions on the left atrium were created using two different methodologies. In one, structures in the heart (mitral valve and coronary arteries) were designated as critical structures while this was not done in the second plan. The treatment plans that were created were compared with standards for heart dose used when treating spine tumors. Although the dosage for the whole heart greatly exceeded the dose standards, when only the dose to the ventricles was considered, the plan where the mitral valve was spared was very close to the dose standards...
July 18, 2016: Curēus
https://www.readbyqxmd.com/read/27544292/left-sided-surgical-ablation-for-patients-with-atrial-fibrillation-who-are-undergoing-concomitant-cardiac-surgical-procedures
#11
Niv Ad, Sari D Holmes, Deborah Lamont, Deborah J Shuman
BACKGROUND: Growing evidence indicates the effectiveness of surgical ablation confined to the left atrium, especially with short duration of atrial fibrillation (AF) and smaller left atrial (LA) size. This study examined rhythm status and predictors of failure in this group of patients. METHODS: Of 800 patients who underwent concomitant surgical ablation (2005 to 2015), 110 had LA-only ablation. Rhythm status was defined according to Heart Rhythm Society guidelines: sinus rhythm (SR) without class I/III antiarrhythmic drugs (AADs)...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27537190/transcatheter-mitral-valve-implantation-30-day-outcome-of-first-in-man-experience-with-an-apically-tethered-device
#12
Cesare Quarto, Simon Davies, Alison Duncan, Alistair Lindsay, Georg Lutter, Lucian Lozonschi, Neil Moat
OBJECTIVE: A small number of transcatheter mitral valve implants (TMVIs) have been reported using devices designed to treat secondary mitral regurgitation (MR). However, MR has many etiologies, and patients have a broad spectrum of annular size, geometry, and lesions. There are a number of technical challenges for TMVI including left ventricular outflow tract obstruction and paravalvular MR. Thirty days' outcome of first-in-man implants with a novel TMVI device is reported. METHODS: The Tendyne TMVI system consists of a porcine pericardial valve in a tethered nitinol frame...
May 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27503339/transapical-aortic-valve-implantation-in-patients-with-pre-existing-mitral-valve-prostheses-a-case-report
#13
Kristina Wachter, Samir Ahad, Christian J Rustenbach, Ulrich F W Franke, Hardy Baumbach
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has proven to be a valid option for patients with severe aortic stenosis who are at high perioperative risk, particularly in patients with previous cardiac surgery. Several patients with previous mitral valve surgery were reported to have been successfully treated with TAVI. CASE PRESENTATION: Two patients, one with mechanical and one with biological mitral valve prosthesis, presented with symptomatic severe aortic stenosis...
August 8, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27473220/off-pump-mitral-valved-stent-implantation-comparison-of-apical-and-subannular-fixation-techniques
#14
Saskia Pokorny, Katharina Huenges, Jan Hinerk Hansen, Yannik Schadow, Gunther Fischer, Michael M Morlock, Jochen Cremer, Georg Lutter
OBJECTIVES: A large cohort of patients suffering from severe mitral regurgitation does not meet the indications for conventional surgery and would greatly benefit from a transcatheter approach in the beating heart. Consequently, off-pump transcatheter mitral valve procedures have been the focus of recent research. The aim of this study was the in vivo evaluation and comparison of subannular versus apical fixation of mitral valved stents to show the feasibility of subannular anchorage...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27436878/transapical-beating-heart-mitral-valve-repair-with-an-expanded-polytetrafluoroethylene-cordal-implantation-device-initial-clinical-experience
#15
MULTICENTER STUDY
James S Gammie, Peter Wilson, Krzysztof Bartus, Andrzej Gackowski, Judy Hung, Michael N D'Ambra, Piotr Kolsut, Gregory J Bittle, Piotr Szymanski, Jerzy Sadowski, Boguslaw Kapelak, Agata Bilewska, Mariusz Kusmierczyk, Mehrdad Ghoreishi
BACKGROUND: Degenerative mitral valve (MV) disease is a common cause of severe mitral regurgitation (MR) and accounts for the majority of MV operations. Conventional MV surgery requires cardiopulmonary bypass, aortic cross-clamping, cardioplegia, and a thoracotomy or sternotomy and, therefore, is associated with significant disability, risks, and unpredictable rates of MV repair. Transesophageal echocardiography-guided beating-heart MV repair with expanded polytetrafluoroethylene cordal insertion has the potential to significantly reduce surgical morbidity...
July 19, 2016: Circulation
https://www.readbyqxmd.com/read/27434273/hemodynamic-assessment-of-a-murine-heterotopic-biventricularly-loaded-cardiac-transplant-in-vivo-model
#16
Agnieszka A Książek, Katharyn J Mitchell, Laurent Morax, Colin C Schwarzwald, Simon P Hoerstrup, Benedikt Weber
BACKGROUND: Heterotopic heart transplantation (HHT) in rodent animal models represents an important technique enabling studies on organ transplantation immunology and pharmaceutical development. Recent investigations used nonworking HHT designs, with the left ventricle (LV) bypassed in the anastomosis system. In spite of their principal success, the lack of orthogonal ventricular filling leads to myocardial atrophy. However, when focusing on the cellular and molecular mechanisms involved in the in vivo remodeling of the myocardium or cell-based cardiovascular implants, a nonworking model is suboptimal as it lacks the native-analogous hemodynamic and metabolic situation...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27308884/impact-of-collaborative-care-on-survival-time-for-dogs-with-congestive-heart-failure-and-revenue-for-attending-primary-care-veterinarians
#17
Bonnie K Lefbom, Neal K Peckens
OBJECTIVE To assess the effects of in-person collaborative care by primary care veterinarians (pcDVMs) and board-certified veterinary cardiologists (BCVCs) on survival time of dogs after onset of congestive heart failure (CHF) and on associated revenue for the attending pcDVMs. DESIGN Retrospective cohort study. ANIMALS 26 small-breed dogs treated for naturally occurring CHF secondary to myxomatous mitral valve disease at a multilocation primary care veterinary hospital between 2008 and 2013. PROCEDURES Electronic medical records were reviewed to identify dogs with confirmed CHF secondary to myxomatous mitral valve disease and collect information on patient care, survival time, and pcDVM revenue...
July 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27279872/transcatheter-closure-of-paravalvular-leaks-using-a-paravalvular-leak-device-a-prospective-polish-registry
#18
Grzegorz Smolka, Piotr Pysz, Michał Kozłowski, Marek Jasiński, Radosław Gocoł, Tomasz Roleder, Agnieszka Kargul, Andrzej Ochała, Wojciech Wojakowski
INTRODUCTION: Transcatheter paravalvular leak closure (TPVLC) has become an established treatment option but is mostly performed with off-label use of different non-dedicated occluders. The first one specifically designed for TPVLC is the paravalvular leak device (PLD - Occlutech). AIM: We present initial short-term results of a prospective registry intended to assess the safety and efficacy of TPVLC with PLD. MATERIAL AND METHODS: We screened patients with paravalvular leak (PVL) after surgical valve replacement (SVR)...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27258099/a-d-shaped-bileaflet-bioprosthesis-which-replicates-physiological-left-ventricular-flow-patterns
#19
Sean Guo-Dong Tan, Sangho Kim, Jimmy Kim Fatt Hon, Hwa Liang Leo
Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physiological flow pattern. In light of this, a novel D-shaped bileaflet porcine bioprosthesis (GD valve) has been designed based on the native geometry mitral valve, with the hypothesis that biomimicry in valve design can restore physiological left ventricle flow patterns after valve implantation...
2016: PloS One
https://www.readbyqxmd.com/read/27140294/in-vitro-2d-piv-measurements-and-related-aperture-areas-of-tricuspid-bioprosthetic-mitral-valves-at-the-beginning-of-diastole
#20
Ovandir Bazan, Jayme Pinto Ortiz, Newton Kiyoshi Fukumasu, Antonio Luiz Pacifico, Jurandir Itizo Yanagihara
PURPOSE: Besides ventricular parameters, the design and angular orientation of a prosthetic heart valve induce a specific flow field. The aim of this study was to know the inflow characteristics of a left ventricular model (LVM), investigating the behavior of tricuspid bioprosthetic mitral valves in terms of velocity profiles and related valve aperture areas at the beginning of diastole, under different conditions. METHODS: 3 heart rates (HRs) were established in the LVM and each mitral bioprosthesis (27 and 31 mm diameter) was installed in 2 orientations, rotated by 180° ...
July 4, 2016: International Journal of Artificial Organs
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