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Mitral heart valve design

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https://www.readbyqxmd.com/read/28876686/management-of-failed-mitral-valve-replacement-the-durban-experience
#1
D Kistan, M Booysen, G Alexander, T E Madiba
BACKGROUND: Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications. METHOD: Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January 2005 and December 2014...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28854273/high-resolution-imaging-of-the-mitral-valve-in-the-natural-state-with-7-tesla-mri
#2
Sam E Stephens, Serguei Liachenko, Neil B Ingels, Jonathan F Wenk, Morten O Jensen
Imaging techniques of the mitral valve have improved tremendously during the last decade, but challenges persist. The delicate changes in annulus shape and papillary muscle position throughout the cardiac cycle have significant impact on the stress distribution in the leaflets and chords, thus preservation of anatomically accurate positioning is critical. The aim of this study was to develop an in vitro method and apparatus for obtaining high-resolution 3D MRI images of porcine mitral valves in both the diastolic and systolic configurations with physiologically appropriate annular shape, papillary muscle positions and orientations, specific to the heart from which the valve was harvested...
2017: PloS One
https://www.readbyqxmd.com/read/28847146/on-x-versus-st-jude-medical-mechanical-prosthesis-in-mitral-position-are-we-moving-forward-in-design-technology
#3
Ezzeldin A Mostafa, Ashraf A El Midany, Ahmed S Taha, Saeed R El Aasy, Ayman A Doghish, Ahmed Helmy, Sherif A Mansour, Ramy Khorshid, Hosam E Ashor, Yaser Elnahas, Mohammed Saffan
BACKGROUND: Continuous effort is still provided in designing optimal artificial heart valves with better hemodynamic function and reduced thromboembolic potential. The question is do we have moved forward toward this goal or not. METHODS: A prospective, randomized comparative study was done on 360 patients scheduled for elective mitral valve replacement. Patients were grouped into On-X group (n=180) who received On-X mechanical valve and SJM (n=180) who received St Jude mechanical valve...
July 28, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28741245/the-last-frontier-transcatheter-devices-for-percutaneous-or-minimally-invasive-treatment-of-chronic-heart-failure
#4
REVIEW
V J Nijenhuis, L Sanchis, J A S van der Heyden, P Klein, B J W M Rensing, A Latib, F Maisano, J M Ten Berg, P Agostoni, M J Swaans
Heart failure has a high prevalence in the general population. Morbidity and mortality of heart failure patients remain high, despite improvements in drug therapy, implantable cardioverter-defibrillators and cardiac resynchronisation therapy. New transcatheter implantable devices have been developed to improve the treatment of heart failure. There has been a rapid development of minimally invasive or transcatheter devices used in the treatment of heart failure associated with aortic and mitral valve disease and these devices are being incorporated into routine clinical practice at a fast rate...
July 24, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28721493/modelling-of-lesions-associated-with-functional-mitral-regurgitation-in-an-ex-vivo-platform
#5
Michal Jaworek, Federico Lucherini, Claudia Romagnoni, Guido Gelpi, Monica Contino, Paolo Romitelli, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Functional mitral regurgitation (FMR) is a complex pathology involving valvular and subvalvular structures reconfiguration, and its treatment is considered challenging. There is a lack of experimental models allowing for reliable preclinical FMR treatments' evaluation in a realistic setting. A novel approach to simulate FMR was developed and incorporated into an ex vivo passive beating heart platform. FMR was obtained by dilating the mitral annulus (MA) mainly in the antero-posterior direction and displacing the papillary muscles (PMs) apically and laterally by ad hoc designed and 3D printed dilation and displacing devices...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28695443/3d-experimental-and-computational-analysis-of-eccentric-mitral-regurgitant-jets-in-a-mock-imaging-heart-chamber
#6
Yifan Wang, Annalisa Quaini, Sunčica Čanić, Marija Vukicevic, Stephen H Little
Mitral valve regurgitation (MR) is a disorder of the heart in which the mitral valve does not close properly. This causes an abnormal leaking of blood backwards from the left ventricle into the left atrium during the systolic contractions of the left ventricle. Noninvasive assessment of MR using echocardiography is an ongoing challenge. In particular, a major problem are eccentric or Coanda regurgitant jets which hug the walls of the left atrium and appear smaller in the color Doppler image of regurgitant flow...
July 10, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28634521/a-review-of-echocardiograms-in-hypertensive-patients-greater-than-60-years-in-a-community-based-family-medicine-program
#7
Shideh Doroudi, Michael D DeLisi, Vincent A DeBari
Background: Heart disease as a result of Hypertension is known to occur. Anatomical and functional changes of the heart can easily be detected by echocardiography, which is a safe and readily available study. Objectives: The aims of this study were to evaluate the prevalence of common echocardiographic changes in chronic hypertensive patients and to compare these changes in male and female populations. Design/methods: The study was a community-based cross-sectional study, on 227 hypertensive patients, 60 years and older, seen in St...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28576479/aldosterone-breakthrough-in-dogs-with-naturally-occurring-myxomatous-mitral-valve-disease
#8
M K Ames, C E Atkins, A Eriksson, A M Hess
INTRODUCTION: Aldosterone breakthrough (ABT) is the condition in which angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers fail to effectively suppress the activity of the renin angiotensin aldosterone system. The objective of this study was to determine if ABT occurs in dogs with naturally occurring myxomatous mitral valve disease receiving an ACEI, using the urine aldosterone to creatinine ratio (UAldo:C) as a measure of renin angiotensin aldosterone system activation...
June 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28566364/randomised-trial-of-mitral-valve-repair-with-leaflet-resection-versus-leaflet-preservation-on-functional-mitral-stenosis-the-camra-cardiolink-2-trial
#9
Vincent Chan, Michael W A Chu, Howard Leong-Poi, David A Latter, Judith Hall, Kevin E Thorpe, Benoit E de Varennes, Adrian Quan, Wendy Tsang, Natasha Dhingra, Kibar Yared, Hwee Teoh, F Victor Chu, Kwan-Leung Chan, Thierry G Mesana, Kim A Connelly, Marc Ruel, Peter Jüni, C David Mazer, Subodh Verma
BACKGROUND: The gold-standard treatment of severe mitral regurgitation (MR) due to degenerative disease is valve repair, which is surgically performed with either a leaflet resection or leaflet preservation approach. Recent data suggest that functional mitral stenosis (MS) may occur following valve repair using a leaflet resection strategy, which adversely affects patient prognosis. A randomised comparison of these two approaches to mitral repair on functional MS has not been conducted...
May 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28544833/how-heart-valves-evolve-to-adapt-to-an-extreme-pressure-system-morphologic-and-biomechanical-properties-of-giraffe-heart-valves
#10
Jonas Amstrup Funder, Carl Christian Danielsen, Ulrik Baandrup, Bo Martin Bibby, Ted Carl Andelius, Emil Toft Brøndum, Tobias Wang, J Michael Hasenkam
BACKGROUND: Heart valves which exist naturally in an extreme-pressure system must have evolved in a way to resist the stresses of high pressure. Giraffes are interesting as they naturally have a blood pressure twice that of humans. Thus, knowledge regarding giraffe heart valves may aid in developing techniques to design improved pressure-resistant biological heart valves. METHODS: Heart valves from 12 giraffes and 10 calves were explanted and subjected to either biomechanical or morphological examinations...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28453437/umbilical-cord-as-human-cell-source-for-mitral-valve-tissue-engineering-venous-vs-arterial-cells
#11
Axel Malischewski, Ricardo Moreira, Luis Hurtado, Valentine Gesché, Thomas Schmitz-Rode, Stefan Jockenhoevel, Petra Mela
Around 2% of the population in developed nations are affected by mitral valve disease and available valvular replacements are not designed for the atrioventricular position. Recently our group developed the first tissue-engineered heart valve (TEHV) specifically designed for the mitral position - the TexMi valve. The valve recapitulates the main components of the native valve, i.e. annulus, asymmetric leaflets and the crucial chordae tendineae. In the present study, we evaluated the human umbilical cord as a clinically applicable cell source for the TexMi valve...
April 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28444177/single-centre-experience-with-transapical-transcatheter-mitral-valve-implantation%C3%A2
#12
Gry Dahle, Kjell-Arne Rein, Arnt E Fiane
OBJECTIVES: A transcatheter heart valve technique can be used in failed mitral valve repairs with annuloplasty rings, deterioriated bioprostheses and in mitral annular calcification, all serving as 'docking stations' for balloon-expandable valves. Specially designed transcatheter mitral valve platforms are used in ongoing studies for native mitral valve regurgitation. We present our single centre experience with transcatheter mitral valve implantation-transapical approach procedures in eleven patients...
April 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28425027/10-year-results-of-on-x-bileaflet-mechanical-heart-valve-in-the-aortic-position-low-target-inr-regimen-in-japanese
#13
Hideki Teshima, Masahiko Ikebuchi, Yosuke Miyamoto, Ryuta Tai, Toshikazu Sano, Yusuke Kinugasa, Hiroyuki Irie
OBJECTIVES: This study was designed to establish clinical outcomes after aortic valve replacement (AVR) with On-X bileaflet mechanical heart valve. METHODS: Between 2006 and 2014, AVR was performed to 686 patients. Of them, 78 patients using On-X valve were enrolled. The mean age was 65 ± 11 years (ranged 33-85); 65% were men; and 81% were in sinus rhythm preoperatively. Calcific or degenerative tricuspid aortic valve was present in 73%. Concomitant procedures included coronary artery bypass grafting (22%), Bentall (8%), mitral valve procedure (3%) and other (9%)...
August 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28374279/design-analysis-and-testing-of-a-novel-mitral-valve-for-transcatheter-implantation
#14
Selim Bozkurt, Georgia L Preston-Maher, Ryo Torii, Gaetano Burriesci
Mitral regurgitation is a common mitral valve dysfunction which may lead to heart failure. Because of the rapid aging of the population, conventional surgical repair and replacement of the pathological valve are often unsuitable for about half of symptomatic patients, who are judged high-risk. Transcatheter valve implantation could represent an effective solution. However, currently available aortic valve devices are inapt for the mitral position. This paper presents the design, development and hydrodynamic assessment of a novel bi-leaflet mitral valve suitable for transcatheter implantation...
August 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28329042/longitudinal-cardiovascular-outcomes-of-sleep-disordered-breathing-in-children-a-meta-analysis-and-systematic-review
#15
REVIEW
Zarmina Ehsan, Stacey L Ishman, Thomas R Kimball, Nanhua Zhang, Yuanshu Zou, Raouf S Amin
Objectives: The presence of sleep disordered breathing (SDB) is known to impact long-term cardiovascular morbidity in adults; however, the long-term effects in children are poorly understood. We aimed to systematically review and synthesize studies published to date on the long-term effects of SDB in children. Study Design: Meta-analysis and systematic review using PubMed, CINAHL, Embase, and Scopus (all indexed years). Methods: We searched for English-language articles containing original human data from prospective studies, with ≥7 participants, in children ≤18 years of age...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28317490/speculative-considerations-about-some-cardiology-enigmas
#16
Paulo Roberto Barbosa Evora, Andre Schmidt, Livia Arcêncio, José Antonio Marin-Neto
Write a review text or point-of-view that takes into account the interests, if not of all, but of most readers of a scientific journal is an arduous task. The editorial can be grounded in published articles, even in a single article of undeniable importance and, it can also represent a trend of specialty. Therefore, especially for the sake of the reader's motivation, the present text was freely designed to discuss some cardiology enigmas in the context of the heart valve and coronary artery disease (CAD). Concerning the CAD five well-known enigmas will be considered: 1) The absence of arteriosclerosis in intramyocardial coronary arteries; 2) The unique and always confirmed superior evolution of the left internal thoracic artery as a coronary graft; 3) The prophylactic left internal thoracic artery graft in mildly-stenosed coronary lesions, and; 4) The high incidence of perioperative atrial fibrillation (AF) in patients with CAD, and; 5) The handling of disease-free saphenous vein graft at the time of reoperation...
March 17, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28295792/biventricular-impact-of-mild-to-moderate-pulmonary-valve-stenosis-in-fetal-life
#17
L Guirado, F Crispi, N Masoller, M Bennasar, E Marimon, J Carretero, E Gratacós, J M Martínez, M K Friedberg, O Gómez
OBJECTIVES: to define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate the echocardiographic findings with the neonatal outcome and the need of postnatal pulmonary valvuloplasty within the first 12 months of life. METHODS: a prospective cohort study was designed on 16 fetuses with isolated PS and 48 controls matched by gestational age at scan (+/- 2 weeks). Fetal standard ultrasound and comprehensive echocardiography, which included cardiovascular morphometric parameters, systolic and diastolic functional and timing-measurements, were performed in all cases...
March 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28281857/engineering-challenges-and-the-future-prospects-of-transcatheter-mitral-valve-replacement-technologies-a-comprehensive-review-of-case-studies
#18
Ranjitha Rebecca Jeevan, Bhaskar Mohan Murari
Catheter based Interventional procedures have become an indispensable treatment option for patients contraindicated for surgical heart valve replacement . The broad spectrum of disease that affect the mitral valve have increased the need for a transcatheter mitral valve replacement (TMVR) device. As complex as the mitral valve anatomy is, so are challenges in the development of a TMVR device. Areas covered: This review article analyses the challenges in the development of the TMVR device from an engineering perspective of material and device design...
April 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28276754/evaluation-of-valtech-s-transcatheter-mitral-valve-repair-device
#19
REVIEW
Shingo Kuwata, Maurizio Taramasso, Andrea Guidotti, Fabian Nietlispach, Francesco Maisano
Functional mitral regurgitation is a debilitating condition, related to worsening of functional capacity and heart failure symptomatology. Cardioband (Valtech Cardio, Or Yehuda, Israel) is a novel technology designed for transcatheter repair of the mitral valve in the treatment of functional MR. Areas covered: A brief summary to direct the reader to important further reading, relevant websites; www.valtechcardio.com . An article about this device, relevant websites; www.ncbi.nlm.nih.gov/pubmed using search word 'Cardioband'...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28207320/cardiac-findings-in-quarter-horses-with-heritable-equine-regional-dermal-asthenia
#20
Erin L Brinkman, Benjamin C Weed, Sourav S Patnaik, Bryn L Brazile, Ryan M Centini, Robert W Wills, Bari Olivier, Dodd G Sledge, Jim Cooley, Jun Liao, Ann M Rashmir-Raven
OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses...
March 1, 2017: Journal of the American Veterinary Medical Association
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