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Onabotulinum toxin A

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https://www.readbyqxmd.com/read/30094699/injection-of-onabotulinum-toxin-a-into-the-bilateral-external-oblique-muscle-attenuated-camptocormia-a-prospective-open-label-study-in-six-patients-with-parkinson-s-disease
#1
Hiroyuki Todo, Hiroshi Yamasaki, Go Ogawa, Katsuya Nishida, Naonobu Futamura, Itaru Funakawa
INTRODUCTION: Camptocormia (severe bending of the spine) is a debilitating complication of Parkinson's disease (PD) without established treatment. Botulinum toxin (BT) may be beneficial, but data is scarce regarding the efficacy of administration of BT into the bilateral external oblique (EO) muscle for treatment of camptocormia in PD. METHODS: Six patients with PD and camptocormia, with flexion of the thoracic spine, were enrolled in the study. BT (75 or 90 units, onabotulinum toxin A) were injected into each EO bilaterally under sonographic guidance...
August 9, 2018: Neurology and Therapy
https://www.readbyqxmd.com/read/30091253/italian-consensus-report-on-the-aesthetic-use-of-onabotulinum-toxin-a
#2
Dario Bertossi, Maurizio Cavallini, Pierfrancesco Cirillo, Salvatore Piero Fundarò, Sandro Quartucci, Chantal Sciuto, Davide Tonini, Gloria Trocchi, Massimo Signorini
BACKGROUND: The aesthetic treatment of facial and neck wrinkles with botulinum toxin is constantly increasing, thus making it necessary to collect procedures guidelines for the use of botulinum toxin in the treatment of wrinkles and/or cosmetic defects. METHODS: A group of nine Italian doctors, plastic and maxillo-facial surgeons, dermatologists and aesthetic physicians, experts in face and neck aesthetic treatments with onabotulinum toxin A, discussed on procedures used in their clinical practice...
August 9, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/30074062/what-is-the-ideal-antibiotic-prophylaxis-for-intravesically-administered-botox-injection-a-comparison-of-two-different-regimens
#3
Justin Houman, Ariel Moradzadeh, Devin N Patel, Kian Asanad, Jennifer T Anger, Karyn S Eilber
INTRODUCTION: Onabotulinum toxin A (Botox®) administered intravescially is an effective treatment for idiopathic detrusor overactivity, of which urinary tract infections (UTIs) are a common complication. The purpose of this study was to compare two prophylactic antibiotic regimens with the goal of decreasing UTI rates following intravesically administered Botox® injection. MATERIALS AND METHODS: A retrospective review of two groups of patients undergoing intravesically administered Botox® injections was performed-one with idiopathic and one with neurogenic detrusor overactivity...
August 3, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29995725/female-sexual-dysfunction-and-the-placebo-effect-a-meta-analysis
#4
James M Weinberger, Justin Houman, Ashley T Caron, Devin N Patel, Avi S Baskin, A Lenore Ackerman, Karyn S Eilber, Jennifer T Anger
OBJECTIVE: To quantify the placebo effect of various pharmacologic modalities including neuromodulators, hormonal agents, and onabotulinum toxin A for female sexual dysfunction. DATA SOURCES: Using Meta-analyses Of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, ClinicalTrials.gov, and the Cochrane Review databases. METHODS OF STUDY SELECTION: Eleven search terms, "female sexual dysfunction" "treatment" in combination with "hypoactive sexual desire," "arousal disorder," "sexual pain disorder," "genitourinary syndrome of menopause," "orgasmic disorder," "vulvovaginal atrophy," "vaginismus," "vaginal atrophy," "vulvodynia," and "vestibulitis," were used...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29968144/non-invasive-evaluation-of-botulinum-a-toxin-treatment-efficacy-in-children-with-refractory-overactive-bladder
#5
Murat Uçar, Ahsen Karagözlü Akgül, Ayşe Parlak, Cem Yücel, Nizamettin Kılıç, Emin Balkan
OBJECTIVE: We aimed to evaluate the efficacy and safety of intravesical onabotulinum toxin A (onaBoNTA) injections for the treatment of children diagnosed with refractory overactive bladder (OAB) by using non-invasive methods. METHODS: A total of 31 pediatric patients with a mean age of 10.2 years received intravesical onaBoNTA injection at the dose of 10 U/kg (max: 200 U). Twenty-one patients who failed to respond to the first injection, received second injection 6 months after the first one...
July 2, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29932046/chronic-headache-due-to-overuse-of-analgesics-and-anti-migraine-agents
#6
Hans-Christoph Diener, Dagny Holle, Thomas Dresler, Charly Gaul
BACKGROUND: The frequent or regular use of analgesics and anti-migraine drugs can make headache more frequent and induce the transformation of episodic to chronic headache. Chronic headache due to medication overuse is defined as headache that is present on ≥ 15 days per month for at least three months in a patient who previously suffered from primary headaches, and who takes analgesics on ≥ 15 days per month or anti-migraine drugs (triptans or ergot alkaloids), opioid drugs, or combined analgesics on ≥ 10 days per month...
June 1, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29916853/onabotulinumtoxin-a-injections-into-the-salivary-glands-for-spinal-muscle-atrophy-type-i-a-prospective-case-series-of-four-patients
#7
Hannah Shoval, Esther Antelis, Andrew Hillman, Xiaofang Wei, Patricia Tan, Ruth Alejandro, Heakyung Kim
OBJECTIVE: To investigate the safety and efficacy of Onabotulinum Toxin-A (BTX-A) injection to the salivary glands under ultrasound guidance for the treatment of sialorrhea in patients with spinal muscular atrophy type I (SMA I). DESIGN: Prospective case series with four patients with SMA I who received BTX-A injection to parotid and submandibular glands for sialorrhea as part of clinical care. All four patients received validated surveys for measuring drooling, including objective measures of number of bib changes, and number of mouth wipes before injection and 4-6 weeks after injection...
June 18, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29910630/botulinum-neurotoxin-formulations-overcoming-the-confusion
#8
REVIEW
Souphiyeh Samizadeh, Koenraad De Boulle
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide. Despite an increased demand for botulinum toxin A injections, the clinical pharmacology and differences in formulation of commonly available products are poorly understood. The various products available in the market are unique and vary in terms of units, chemical properties, biological activities, and weight, and are therefore not interchangeable...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29904874/may-migraine-attack-response-to-triptans-be-a-predictor-of-the-efficacy-of-onabotulinum-toxin-a-prophylaxis
#9
Carlo Lovati, Luca Giani, Caterina Mariotti D Alessandro, Payam Tabaee Damavandi, Claudio Mariani, Leonardo Pantoni
No abstract text is available yet for this article.
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29902447/randomized-controlled-trial-of-belladonna-and-opiate-suppository-during-intravesical-onabotulinum-toxin-a-injection
#10
Edgar L Leclaire, Jennifer Duong, Rachel M Wykes, Kevin E Miller, Tessa L Winterton, Milan Bimali
BACKGROUND: Intravesical injection with onabotulinum toxin A (BTX-A) injection can be performed in-office under local anesthesia. Rectally administered pain medication presents a potentially feasible and previously uninvestigated adjunct to office-based anesthesia protocols. OBJECTIVES: The primary aim of this study was to determine whether adding a belladonna and opiate (BO) suppository to standard lidocaine instillation resulted in reduction of bladder injection pain during BTX-A injection procedure...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29767449/outcomes-of-intradetrusor-onabotulinum-toxin-a-injection-in-patients-with-parkinson-s-disease
#11
Gregory Vurture, Benoit Peyronnet, Andrew Feigin, Milton C Biagioni, Rebecca Gilbert, Nirit Rosenblum, Steven Frucht, Alessandro Di Rocco, Victor W Nitti, Benjamin M Brucker
OBJECTIVE: To assess the safety and efficacy of intradetrusor onabotulinum toxin A injections for the treatment of overactive bladder (OAB) in patients with Parkinson's disease (PD). METHODS: All PD patients who underwent intradetrusor injections of onabotulinum toxin A (BoNT-A) for storage symptoms between 2010 and 2017 were included in a retrospective study. A 100 U dose of BoNT-A (Botox®, Allergan Irvine, CA) was used for the first injection in all patients...
May 16, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29665997/lower-urinary-tract-symptoms-what-s-new-in-medical-treatment
#12
REVIEW
Benoit Peyronnet, Benjamin M Brucker, Martin C Michel
CONTEXT: Pharmacological treatment is a cornerstone in the management of patients with lower urinary tract symptoms (LUTS). OBJECTIVE: To review emerging evidence in the medical treatment of LUTS. EVIDENCE ACQUISITION: An Embase/Pubmed-based literature search was conducted in December 2017, screening for randomized controlled trials (RCTs), prospective and retrospective series, animal model studies, and reviews on medical treatment of LUTS...
January 2018: European Urology Focus
https://www.readbyqxmd.com/read/29664124/a-comparison-of-the-treatment-recommendations-for-neurogenic-lower-urinary-tract-dysfunction-in-the-national-institute-for-health-and-care-excellence-european-association-of-urology-and-international-consultations-on-incontinence-guidelines
#13
Ashley Jaggi, Marcus Drake, Emad Siddiqui, Francis Fatoye
AIMS: Healthcare guidelines are an important vehicle in establishing up-to-date evidence based medicine (EBM) in clinical practice. Due to varying development processes, clinical guidelines created by different institutions can often contain contrasting recommendations. This can have implications for optimal and standardized patient care across management settings. METHODS: The similarities and differences of treatment recommendations made in the National Institute for Health and Care Excellence (NICE), The European Association of Urology (EAU), and the International Consultation on Continence (ICI) guidelines for neurogenic lower urinary tract dysfunction (NLUTD) were assessed...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29578428/unilateral-frontalis-muscle-paralysis-management-with-botulinum-toxin-a-case-reports
#14
A Goldman, U Wollina
Unilateral frontalis muscle palsy is a debilitating disease with a heterogeneous etiology. Congenital or acquired unilateral paralysis of the frontalis muscle causes ipsilateral brow ptosis and contralateral hypermobility of the non-paralytic frontalis muscle, resulting in a bizarre asymmetry and emotional embarrassment. We present five patients with unilateral frontal muscle paralysis, two males and three females, aged between 32 and 68, treated with botulinum toxin A injection to the contralateral (non-affected) side...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29462596/onabotulinumtoxin-type-a-improves-lower-urinary-tract-symptoms-and-quality-of-life-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-overactive-bladder
#15
Jose Abraão Carneiro Neto, Silvane Braga Santos, Gloria Orge Orge, Davi Tanajura, Lucia Passos, Cassius José Oliveira, Rosana Andrade, Cláudio Galeno de Melo, Ubirajara Barroso, Edgar M Carvalho
AIM: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL). METHODS: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire. RESULTS: The mean (SD) of the age was 52+14...
March 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29423509/outcomes-of-onabotulinum-toxin-a-treatment-for-adductor-spasmodic-dysphonia-and-laryngeal-tremor
#16
Priyesh N Patel, Edmond K Kabagambe, Jennifer C Starkweather, Matthew Keller, Vahram Gamsarian, Jane Lee, Vishnutheert Kulkarni, C Gaelyn Garrett, David O Francis
Importance: The relative outcomes of onabotulinum toxin A injections for treatment of adductor spasmodic dysphonia (ADSD), ADSD with lateral laryngeal tremor (ADSD+LT), and lateral LT without ADSD are unclear. Objective: To compare the outcomes of onabotulinum toxin A treatment on ADSD, ADSD+LT, and lateral LT without ADSD. Design, Setting, and Participants: A retrospective cohort study was conducted from January 1, 1990, to September 30, 2016, at a tertiary referral voice center...
April 1, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29406405/quantifying-effect-of-onabotulinum-toxin-a-on-passive-muscle-stiffness-in-children-with-cerebral-palsy-using-ultrasound-shear-wave-elastography
#17
Joline E Brandenburg, Sarah F Eby, Pengfei Song, William R Bamlet, Gary C Sieck, Kai-Nan An
OBJECTIVE: A pilot study was conducted to longitudinally quantify effect of onabotulinum toxin A (BoNT-A) on passive muscle properties in children with cerebral palsy using ultrasound shear wave elastography. DESIGN: This was a prospective longitudinal cohort study. RESULTS: Between 1 and 3 mos post-BoNT-A, a significant improvement in the shear modulus of the lateral gastrocnemius was found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5...
July 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29379998/road-to-recovery-after-transvaginal-surgery-for-urethral-mesh-perforation-evaluation-of-outcomes-and-subsequent-procedures
#18
Casey G Kowalik, Joshua A Cohn, Andrea Kakos, Patrick Lang, W Stuart Reynolds, Melissa R Kaufman, Mickey M Karram, Roger R Dmochowski
INTRODUCTION AND HYPOTHESIS: Urethral injury resulting from transvaginal mesh slings is a rare complication with an estimated incidence of <1%. Our objective was to review the surgical management and functional outcomes of women presenting with urethral mesh perforation following midurethral sling (MUS) placement. METHODS: This was a retrospective multicenter review of women who from January 2011 to March 2016 at two institutions underwent mesh sling excision for urethral perforation with Female Pelvic Medicine and Reconstructive Surgery fellowship-trained surgeons...
June 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29343468/onabotulinum-toxin-a-injections-for-sleep-bruxism-a-double-blind-placebo-controlled-study
#19
William G Ondo, Jerald H Simmons, Muhammad H Shahid, Vera Hashem, Christine Hunter, Joseph Jankovic
OBJECTIVES: To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. METHODS: Participants 18 to 85 years old with clinically diagnosed sleep bruxism confirmed by polysomnography were enrolled in this randomized, placebo-controlled, 1:1, parallel-design trial with open-label extension. Participants were injected with BoNT-A 200 units (60 into each masseter and 40 into each temporalis) or placebo and were evaluated at 4 to 8 weeks after the initial treatment visit...
February 13, 2018: Neurology
https://www.readbyqxmd.com/read/29323625/catheter-associated-urinary-tract-infections-in-persons-with-neurogenic-bladders
#20
Todd A Linsenmeyer
This review is based on the author's Donald Munro Lecture given at the annual conference of the Academy of Spinal Cord Injury Professionals in New Orleans, LA. Indwelling catheters play an important role in bladder management following SCI for many individuals with neurogenic bladders. There is an increased risk of UTI compared to other types of bladder management with indwelling urethral catheters but not SP catheters. To minimize the risk of symptomatic UTI, the following steps are essential: prevent bladder wall distention and resulting ischemia, maintain colonization with "good" bacteria, and prevent bladder stones...
March 2018: Journal of Spinal Cord Medicine
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