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Human milk fortified

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https://www.readbyqxmd.com/read/30544244/routine-versus-selective-fortification-of-human-milk-with-powdered-human-milk-fortifiers-in-very-low-birth-weight-vlbw-preterm-infants-a-retrospective-pre-post-cohort-study
#1
Gopal Agrawal, Sanjay Wazir, Surender Kumar, Bir Singh Yadav, Manish Balde
Objectives: The objective of this study was to show the effects of routine vs. selective fortification of human milk (HM) on short-term growth and metabolic parameters. Methods: Single-centre retrospective pre-post cohort study in India. Preterm infants ≤32 weeks' gestation and weighing ≤1500 g were included. Routine fortification: pre-fixed feed volume (100 ml/kg/day in our unit) at which fortification was done. Selective fortification: feed volume was gradually optimized till 180-200 ml/kg/day...
December 12, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/30496293/release-of-functional-peptides-from-mother-s-milk-and-fortifier-proteins-in-the-premature-infant-stomach
#2
Søren D Nielsen, Robert L Beverly, Mark A Underwood, David C Dallas
Digestion of milk proteins in the premature infant stomach releases functional peptides; however, which peptides are present has not been reported. Premature infants are often fed a combination of human milk and bovine milk fortifiers, but the variety of functional peptides released from both human and bovine milk proteins remains uncharacterized. This study applied peptidomics to investigate the peptides released in gastric digestion of mother's milk proteins and supplemental bovine milk proteins in premature infants...
2018: PloS One
https://www.readbyqxmd.com/read/30486700/a-randomized-controlled-trial-comparing-the-effect-of-fortification-of-human-milk-with-an-infant-formula-powder-versus-unfortified-human-milk-on-the-growth-of-preterm-very-low-birth-weight-infants
#3
Vijay Gupta, Grace Rebekah, Yesudas Sudhakar, Sridhar Santhanam, Manish Kumar, Niranjan Thomas
OBJECTIVE: To optimize growth in very low birth weight (VLBW) infants, human milk fortification is standard of care in neonatal units of high income countries. However, commercial fortifiers may not be available or it may be too expensive in resource limited settings. As an alternative to using human milk fortifiers, we studied the effects of milk fortification with an infant formula on growth and biochemical parameters of very low birth weight (VLBW) infants Methods: We undertook a prospective, randomized controlled trial in the neonatal unit of a tertiary care hospital in south India...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30452092/effects-of-nutrition-supplementation-on-osmolality-of-expressed-human-milk
#4
Lyssa Lamport, Chelsea Hartman, Champa Codipilly, Barry Weinberger, Richard Schanler
BACKGROUND: Provision of human milk to premature infants optimizes outcomes, but it must be supplemented to meet their nutrient and caloric requirements for growth. Our objective was to quantify the osmolality of human milk mixed with commercially available human milk fortifiers (HMF) and powdered infant formula, as currently fed to premature infants, simulating standard neonatal intensive care unit feeding practices for mixing and refrigerator storage. METHODS: Expressed human milk (EHM) samples obtained from mothers of premature infants (≤32 weeks gestation) were mixed with standard commercial products, and osmolalities were quantified...
November 19, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30430102/individualized-fortification-influences-the-osmolality-of-human-milk
#5
Nathalie Kreins, Rachel Buffin, Diane Michel-Molnar, Veronique Chambon, Pierre Pradat, Jean-Charles Picaud
Background: Fortification of human milk (HM) increases its osmolality, which is associated with an increased risk of necrotizing enterocolitis. The impact of new fortifiers on osmolality is not well-known, nor are the kinetics regarding the increase in osmolality. Aim: To determine the optimum fortifier composition for HM fortification by measuring the osmolality of fortified HM made with three powder multicomponent fortifiers (MCFs) and a protein fortifier (PF). Methods: The osmolality of HM was assessed at 2 (H2) and 24 (H24) h after fortification to compare the effects of MCF (MCF1-3) and PF used in quantities that ensured that infants' nutrient needs would be met (MCF: 4 g/100 ml HM; PF: 0...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30407223/human-milk-protein-vs-formula-protein-and-their-use-in-preterm-infants
#6
Maria L Gianni, Paola Roggero, Fabio Mosca
PURPOSE OF REVIEW: We review the current available evidence on the metabolic fate of human milk proteins and their potential clinical implications for growth and body composition development vs. those of formula proteins in preterm infants. RECENT FINDINGS: The decreased content of human milk protein in preterm mothers throughout lactation might contribute to the reduced growth reported in exclusively human milk-fed infants compared with that of formula-fed infants...
January 2019: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/30356677/the-effect-of-human-milk-on-modulating-the-quality-of-growth-in-preterm-infants
#7
Pasqua Piemontese, Nadia Liotto, Domenica Mallardi, Paola Roggero, Valeria Puricelli, Maria Lorella Giannì, Daniela Morniroli, Chiara Tabasso, Michela Perrone, Camilla Menis, Anna Orsi, Orsola Amato, Fabio Mosca
Introduction: Human milk is the optimal nutrition for preterm infants. When the mother's own milk is unavailable, donor human milk is recommended as an alternative for preterm infants. The association among early nutrition, body composition and the future risk of disease has recently attracted much interest. The aim of this study was to investigate the effect of human milk on the body composition of preterm infants. Materials and Methods: Very low birth weight infants (VLBW: birth weight <1,500 g) with a gestational age (GA) between 26 and 34 weeks were included...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30339378/highly-sensitive-detection-of-bovine-%C3%AE-lactoglobulin-with-wide-linear-dynamic-range-based-on-platinum-nanoparticles-probe
#8
Shengfa He, Xin Li, Yong Wu, Shandong Wu, Zhihua Wu, Anshu Yang, Ping Tong, Juanli Yuan, Jinyan Gao, Hongbing Chen
Cow's milk allergy is one of the most frequent and severe IgE-induced food allergies for children, demanding sensitive analytical methods, and β-lactoglobulin (BLG) can be as an important biomarker for detection of milk protein. In this study, a highly sensitive sandwich enzyme-linked immunosorbent assay (sELISA) based on a specific polyclonal antibody against human IgE linear epitopes of BLG and an anti-BLG polyclonal antibody-platinum nanoparticles probe was described for detection of BLG. This sELISA exhibited an ultrawide linear range of 0...
November 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30325750/nicu-discharge-feeding-bundle-improves-accuracy-of-postdischarge-feeding-preparation-and-potentially-prevents-readmission
#9
Kimberly Vollrath, Adam Rosenberg, Lisbeth Gabrielski, Jane Deacon, Susan Marshall, Andrew Rihn, Theresa Grover
BACKGROUND: Hospitalized infants often need fortified human milk and formulas for growth in the neonatal intensive care unit and postdischarge. Parents must learn how to properly mix infant feedings.At the initial Children's Hospital Colorado follow-up visit, baseline data revealed a 50% rate of mixing inaccuracy of discharge feeding recipes and identified the readmission of 2 infants with life-threatening hypernatremia. A gap in discharge teaching was identified. A quality improvement project was implemented at 2 affiliated neonatal intensive care units...
October 15, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/30320665/a-novel-donkey-milk-derived-human-milk-fortifier-in-feeding-preterm-infants-a-randomized-controlled-trial
#10
Enrico Bertino, Laura Cavallarin, Francesco Cresi, Paola Tonetto, Chiara Peila, Giulia Ansaldi, Melissa Raia, Alessia Varalda, Marzia Giribaldi, Amedeo Conti, Sara Antoniazzi, Guido E Moro, Elena Spada, Silvano Milani, Alessandra Coscia
OBJECTIVES: The purpose of the present randomized controlled clinical trial was to compare the use of donkey milk-derived fortifier with commercial bovine milk-derived fortifier in very preterm or very low-birthweight newborns, in terms of feeding tolerance. METHODS: This trial included 156 newborns born at <32 weeks of gestational age and/or with a birthweight ≤1500 g. Newborns were randomized 1:1 to receive enteral feeding with either a bovine milk-based fortifier (BF-arm), or a new, donkey milk-derived fortifier (DF-arm) for 21 days...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320413/tolerance-of-hydrolyzed-liquid-protein-fortified-human-milk-and-effect-on-growth-in-premature-infants
#11
Fauzia Shakeel, Melanie Newkirk, Taymeyah Altoubah, Denise Martinez, Ernest K Amankwah
BACKGROUND: We evaluated tolerance of hydrolyzed liquid protein (LP) supplement added to fortified human milk (HM) to optimize protein intake in preterm infants. METHODS: A prospective observational study of 31 subjects compared with 31 historic controls, receiving mothers own milk (MOM) and/or donor milk (DM) to assess LP tolerance, growth, and risk for morbidities was conducted. Milk was analyzed for nutrient content. Feeding intolerance, defined as cessation of feedings for ≥48 hours, abdominal distension and/or residuals, necrotizing enterocolitis (NEC), and metabolic acidosis were used to assess safety, while weight and head circumference (HC) were used to evaluate growth...
October 15, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30287775/evaluation-of-a-concentrated-preterm-formula-as-a-liquid-human-milk-fortifier-in-preterm-babies-at-increased-risk-of-feed-intolerance
#12
Anish Pillai, Susan Albersheim, Julie Matheson, Vikki Lalari, Sylvia Wei, Sheila M Innis, Rajavel Elango
There are concerns around safety and tolerance of powder human milk fortifiers to optimize nutrition in preterm infants. The purpose of this study was to evaluate the tolerance and safety of a concentrated preterm formula (CPF) as a liquid human milk fortifier (HMF) for premature infants at increased risk of feeding intolerance. We prospectively enrolled preterm infants over an 18-month period, for whom a clinical decision had been made to add CPF to human milk due to concerns regarding tolerance of powder HMF...
October 4, 2018: Nutrients
https://www.readbyqxmd.com/read/30252854/human-milk-enriched-with-human-milk-lyophilisate-for-feeding-very-low-birth-weight-preterm-infants-a-preclinical-experimental-study-focusing-on-fatty-acid-profile
#13
Vanessa S Bomfim, Alceu A Jordão, Larissa G Alves, Francisco E Martinez, José Simon Camelo
BACKGROUND: Human milk, with essential nutrients and long chain polyunsaturated fatty acids (LC-PUFAs) such as the omega 3 and 6 fatty acids is important for development of the central nervous system and the retina in very low birth weight infants (<1,500 g). However, breast milk may not be sufficient to meet these needs. The possibility of supplementing breast milk with a lyophilisate of human milk was explored in this study. The objectives of this study were to determine the total lipid content and the lipid profile of the Human Milk on Baseline (HMB) and that of the Concentrates with the Human Milk + lyophilisate (with lyophilisate of milk in the immediate period (HMCI), at 3 months (HMC3m), and at 6 months (HMC6m) of storage)...
2018: PloS One
https://www.readbyqxmd.com/read/30241780/osmolality-of-a-fortified-human-preterm-milk-the-effect-of-fortifier-dosage-gestational-age-lactation-stage-and-hospital-practices
#14
A Sauret, M-C Andro-Garçon, J Chauvel, A Ligneul, P Dupas, C Fressange-Mazda, P Le Ruyet, A Dabadie
OBJECTIVE: The purpose of this study was to evaluate the dose-dependent effect of human milk fortifier (HMF) on the osmolality of various preterm human milks (PHMs) at different gestational and lactation stages, and with different storage and treatment conditions that are routinely used in neonatal intensive care units (NICUs). STUDY DESIGN: Twenty-four mothers who had given birth to their baby before 28 or between 29 and 31 weeks of pregnancy participated in the study after 1-2 weeks or 3-4 weeks breastfeeding after delivery...
October 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/30237896/the-fortification-method-relying-on-assumed-human-milk-composition-overestimates-the-actual-energy-and-macronutrient-intakes-in-very-preterm-infants
#15
Israel Macedo, Luis Pereira-da-Silva, Manuela Cardoso
Background: To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM), in a cohort of HM-fed very preterm infants. Methods: This study is a secondary retrospective analysis, in which assumed energy and macronutrient contents of daily pools of own mother's milk (OMM) from 33 mothers and donated HM (DHM) delivered to infants were compared with the measured values using a mid-infrared HM analyzer...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/30234121/best-practices-for-handling-and-administration-of-expressed-human-milk-and-donor-human-milk-for-hospitalized-preterm-infants
#16
REVIEW
Caroline Steele
The importance of human milk for the preterm infant is well established (1-3). However, the feeding of human milk to preterm infants is typically much more complicated than the mere act of breastfeeding (3, 4). The limited oral feeding skills of many preterm infants often results in human milk being administered via an enteral feeding tube (4). In addition, fortification is commonly required to promote optimal growth and development-particularly in the smallest of preterm infants (2, 4, 5). Consequently, a mother's own milk must be pumped, labeled, transported to the hospital, stored, tracked for appropriate expiration dates and times, thawed (if previously frozen), fortified, and administered to the infant with care taken at each step of the process to avoid microbial contamination, misadministration (the wrong milk for the wrong patient), fortification errors, and waste (1-5)...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/30215639/efficient-synthesis-of-riboflavin-imprinted-magnetic-nanoparticles-by-boronate-affinity-based-surface-imprinting-for-the-selective-recognition-of-riboflavin
#17
Daojin Li, Zijun Bie, Fangfang Wang, Enhui Guo
Riboflavin (vitamin B2), a cis-diol-containing compound, is an essential vitamin for maintaining human health mainly in energy metabolism and is a critical component of enzyme cofactors and flavoproteins. Thus, the determination of riboflavin in food products is essential in riboflavin-fortified foods. However, analysis of riboflavin at natural levels in foods or biological samples is difficult because of its very low concentration level and the presence of undesirable matrix effects which could interfere with the measuring system...
September 14, 2018: Analyst
https://www.readbyqxmd.com/read/30195561/improved-outcomes-in-preterm-infants-fed-a-nonacidified-liquid-human-milk-fortifier-a-prospective-randomized-clinical-trial
#18
Richard J Schanler, Sharon L Groh-Wargo, Bridget Barrett-Reis, Robert D White, Kaashif A Ahmad, Jeffery Oliver, Geraldine Baggs, Larry Williams, David Adamkin
OBJECTIVE: To compare growth, feeding tolerance, and clinical and biochemical evaluations in human milk-fed preterm infants randomized to receive either an acidified or a nonacidified liquid human milk fortifier. STUDY DESIGN: This prospective, controlled, parallel, multicenter growth and tolerance study included 164 preterm infants (≤32 weeks of gestation, birth weight 700-1500 g) who were randomized to acidified or nonacidified liquid human milk fortifier from study day 1, the first day of fortification, through study day 29 or until hospital discharge...
November 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30194887/improved-lung-function-at-age-6-in-children-born-very-preterm-and-fed-extra-protein-post-discharge
#19
Line Hedegaard Toftlund, Lone Agertoft, Susanne Halken, Gitte Zachariassen
BACKGROUND: In very preterm-born children alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm. METHODS: This study is a six years follow-up of 281 very preterm-born infants (VPI) with a gestational age (GA) < 32+0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF)...
September 8, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30149743/late-onset-hyponatremia-in-preterm-newborns-is-the-sodium-content-of-human-milk-fortifier-insufficient
#20
İsmail Kursad Gokçe, Serife Suna Oguz
INTRODUCTION: In this study, we aimed to define the incidence and time to detection of late onset hyponatremia (LOH) as well as factors affecting its development in preterm newborns. We also aimed to determine the daily sodium requirement of these patients. METHODS: We studied a total of 145 very low birth weight infants with a full or nearly full enteral diet and followed them up until discharge. We recorded demographic and clinic characteristics. We measured serum sodium (SNa) levels at least once a week after the second week...
September 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
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