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https://www.readbyqxmd.com/read/28078818/objectively-diagnosing-rumination-syndrome-in-children-using-esophageal-ph-impedance-and-manometry
#1
M M J Singendonk, J M Oors, A J Bredenoord, T I Omari, R J van der Pol, M J Smits, M A Benninga, M P van Wijk
BACKGROUND: Rumination syndrome is characterized by recurrent regurgitation of recently ingested food into the mouth. Differentiation with other diagnoses and gastroesophageal reflux disease (GERD) in particular, is difficult. Recently, objective pH-impedance (pH-MII) and manometry criteria were proposed for adults. The aim of this study was to determine diagnostic ambulatory pH-MII and manometry criteria for rumination syndrome in children. METHODS: Clinical data and 24-hour pH-MII and manometry recordings of children with a clinical suspicion of rumination syndrome were reviewed...
January 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28068288/monitoring-of-breath-vocs-and-electrical-impedance-tomography-under-pulmonary-recruitment-in-mechanically-ventilated-patients
#2
Beate Brock, Svend Kamysek, Josephine Silz, Phillip Trefz, Jochen K Schubert, Wolfram Miekisch
Analysis of exhaled VOCs can provide information on physiology, metabolic processes, oxidative stress and lung diseases. In critically ill patients, VOC analysis may be used to gain complimentary information beyond global clinical parameters. This seems especially attractive in mechanically ventilated patients frequently suffering from impairment of gas exchange. This study was intended to assess (a) the effects of recruitment maneuvers onto VOC profiles, (b) the correlations between electrical impedance tomography (EIT) data and VOC profiles and (c) the effects of recruitment onto distribution of ventilation...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28067433/plasmonic-imaging-of-the-interfacial-potential-distribution-on-bipolar-electrodes
#3
Meisam Hasheminejad, Yimin Fang, Meng Li, Yingyan Jiang, Wei Wang, Hong-Yuan Chen
Bipolar electrochemistry is based on the gradient distribution of free-electron density along an electrically isolated electrode, which causes a positive electrode potential at one end and a negative potential at the other, allowing for wide applications in analytical chemistry and materials science. To take full advantage of its wireless and high-throughput features, various types of optical probes, such as pH indicators and fluorescence and electrochemiluminescence reagents, have often been used to indirectly monitor the interfacial electron transfer through chromogenic or fluorogenic reactions...
January 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28067281/spatial-competition-dynamics-between-reef-corals-under-ocean-acidification
#4
Rael Horwitz, Mia O Hoogenboom, Maoz Fine
Climate change, including ocean acidification (OA), represents a major threat to coral-reef ecosystems. Although previous experiments have shown that OA can negatively affect the fitness of reef corals, these have not included the long-term effects of competition for space on coral growth rates. Our multispecies year-long study subjected reef-building corals from the Gulf of Aqaba (Red Sea) to competitive interactions under present-day ocean pH (pH 8.1) and predicted end-of-century ocean pH (pH 7.6). Results showed coral growth is significantly impeded by OA under intraspecific competition for five out of six study species...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061013/esophagogastric-junction-contractile-integral-and-morphology-two-high-resolution-manometry-metrics-of-the-anti-reflux-barrier
#5
Hyoju Ham, Y U Kyung Cho, Han Hee Lee, Seung Bae Yoon, Chul-Hyun Lim, Jin Su Kim, Jae Myung Park, Myung-Gyu Choi
AIMS: We evaluated associations of esophagogastric junction (EGJ) metrics as an anti-reflux barrier with impedance-pH, endoscopic esophagitis, and lower esophageal sphincter (LES) metrics. METHODS: We reviewed high resolution manometry data from consecutive patients with GERD symptoms who underwent impedance-pH and endoscopy, and asymptomatic volunteers. The EGJ contractile integral (CI) was calculated as the mean contractile integral/second during three respiratory cycles...
January 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28049863/the-effect-of-acute-stress-on-esophageal-motility-and-gastroesophageal-reflux-in-healthy-humans
#6
Hong Sub Lee, Chung Kyun Noh, Kwang Jae Lee
Background/Aims: Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. Methods: A total of 10 (M:F = 8:2, median age 34 years-old) healthy volunteers without any recurrent gastrointestinal symptoms participated in this study. They underwent esophageal high-resolution manometry with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28045635/association-between-laryngeal-pepsin-levels-and-the-presence-of-vocal-fold-polyps
#7
Lu Wang, Jia-Jie Tan, Ting Wu, Rui Zhang, Jia-Nuan Wu, Fang-Fang Zeng, You-Li Liu, Xiao-Yan Han, Yan-Fei Li, Xiang-Ping Li
Objective To determine whether pepsin, the main component of refluxed gastric contents, is significantly associated with vocal fold polyps and to evaluate the diagnostic value of pepsin in vocal fold polyps' tissues. Study Design Cross-sectional study. Setting Nanfang Hospital of Southern Medical University. Subjects and Methods The study included 32 patients with vocal fold polyps and 16 healthy controls between 2011 and 2012. Reflux symptom index and reflux finding score assessments, 24-hour combined multichannel intraluminal impedance and pH monitoring, and biopsy of the vocal fold polyp tissues or posterior laryngeal mucosa (healthy controls) for immunohistochemical pepsin staining were performed...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28044052/the-relationship-of-the-post-reflux-swallow-induced-peristaltic-wave-index-and-esophageal-baseline-impedance-with-gastroesophageal-reflux-disease-symptoms
#8
Young Kyu Cho, Joon Seong Lee, Tae Hee Lee, Su Jin Hong, Sang Joon Park, Seong Ran Jeon, Hyun Gun Kim, Jin-Oh Kim
Background/Aims: The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with reflux symptoms is not known. We aimed to evaluate the correlations of the PSPW index and esophageal BI with gastroesophageal reflux disease (GERD) symptoms. Methods: We performed a retrospective review of multichannel intraluminal impedance and pH (MII-pH) tracings in patients with suspected GERD...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28040500/a-modification-of-nissen-fundoplication-improves-patients-outcome-and-may-reduce-procedure-related-failure-rate
#9
Romeo Bardini, Sabrina Rampado, Renato Salvador, Lisa Zanatta, Imerio Angriman, Silvia Degasperi, Angelica Ganss, Edoardo Savarino
BACKGROUND: Laparoscopic anti-reflux surgery has a failure rate of 10-20%. We aimed to investigate whether a modification of Nissen fundoplication (MNF) may improve patients' outcome and reduce failure rate. MATERIALS & METHODS: We prospectively compared 40 consecutive patients with gastroesophageal reflux disease who underwent anti-reflux surgery: 20 Nissen fundoplication (NF) and 20 the MNF approach. Eight cases in the MNF group needed redo surgery. The MNF consisted in suturing the esophagus to the diaphragmatic crura on each side by means of 4 non-absorbable stitches and in fixing the upper stitch of the valve to diaphragm...
December 28, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28028956/assessment-of-clinical-symptoms-and-multichannel-intraluminal-impedance-and-ph-monitoring-in-children-after-thoracoscopic-repair-of-esophageal-atresia-and-distal-tracheoesophageal-fistula
#10
Barbara M Iwańczak, Agnieszka Kosmowska-Miśków, Anna Kofla-Dłubacz, Mateusz Palczewski, Michał Grabiński, Katarzyna Pawłowska, Krzysztof Matusiewicz, Dariusz Patkowski
BACKGROUND: Motility disturbances of the esophagus and gastroesophageal reflux disease (GERD) are observed frequently in children after repair of congenital esophageal atresia with distal tracheoesophageal fistula (EA/TEF). Recently, in many pediatric surgical centers, thoracoscopic repair was introduced, which theoretically would change the postoperative course. OBJECTIVES: The goal of the study was to assess physical development, disease symptoms, and GERD symptom frequency in children who underwent thoracoscopic surgery of congenital EA/TEF...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28027887/adsorptive-anodic-stripping-differential-pulse-voltammetric-determination-of-cellcept-at-fe3o4-nanoparticles-decorated-multi-walled-carbon-nanotubes-modified-glassy-carbon-electrode
#11
Mohammad Bagher Gholivand, Mohammad Solgi
A simple and sensitive method based on adsorptive anodic stripping differential pulse voltammetry (AASDPV) for the determination of cellcept, using a magnetic Fe3O4 nanoparticles and functionalized (carboxylated) multi-walled carbon nanotubes modified glassy carbon electrode (f-MWCNs/Fe3O4/GCE) was developed. In phosphate buffer solution (pH = 5), the voltammogram of cellcept exhibited tow anodic peaks and the well-defined peak at about 0.611 V vs SCE was used for its monitoring. The modified electrode was characterized by different methods such as electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and cyclic voltammetry (CV)...
December 24, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/28027584/il6-dependent-genomic-instability-heralds-accelerated-carcinogenesis-following-liver-regeneration-on-a-background-of-chronic-hepatitis
#12
Tali Lanton, Anat Shriki, Yael Nechemia-Arbely, Rinat Abramovitch, Orr Levkovitch, Revital Adar, Nofar Rosenberg, Mor Paldor, Daniel Goldenberg, Amir Sonnenblick, Amnon Peled, Stefan Rose-John, Eithan Galun, Jonathan H Axelrod
: Liver cancer, which typically develops on a background of chronic liver inflammation, is now the second leading cause of cancer mortality worldwide. For these patients surgical resection is a principal treatment modality that offers a chance of prolonged survival. However, tumor recurrence after resection, the mechanisms of which remain obscure, markedly limits the long-term survival of these patients. We have previously shown that partial hepatectomy (PH) in Mdr2 knockout (Mdr2(-/-) ) mice, a model of chronic inflammation-associated liver cancer, significantly accelerates hepatocarcinogenesis...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28025772/laparoscopically-assisted-proximal-gastrectomy-with-esophagogastrostomy-using-a-novel-open-door-technique-lapg-with-novel-reconstruction
#13
Kei Hosoda, Keishi Yamashita, Hiromitsu Moriya, Hiroaki Mieno, Akira Ema, Marie Washio, Masahiko Watanabe
Laparoscopy-assisted proximal gastrectomy (LAPG) with esophagogastrostomy using a novel "open-door" technique was introduced recently, with the aim of preventing gastroesophageal reflux. However, quantitate assessment of gastroesophageal reflux after this surgery has not been performed till date. The aims of the current study were to investigate the safety and feasibility of this operation and to elucidate the postoperative reflux status. Twenty consecutive patients (18 men) with (y)cStage I gastric cancer in the upper third of the stomach who underwent LAPG at Kitasato University Hospital from May 2015 through September 2016 were retrospectively reviewed...
December 26, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28006679/a-disposable-amperometric-dual-sensor-for-the-detection-of-hemoglobin-and-glycated-hemoglobin-in-a-finger-prick-blood-sample
#14
Jong-Min Moon, Dong-Min Kim, Moo Hyun Kim, Jin-Yeong Han, Dong-Keun Jung, Yoon-Bo Shim
A disposable microfluidic amperometric dual-sensor was developed for the detection of glycated hemoglobin (HbA1C) and total hemoglobin (Hb), separately, in a finger prick blood sample. The accurate level of total Hb was determined through the measurements of the cathodic currents of total Hb catalyzed by a toluidine blue O (TBO)-modified working electrode. Subsequently, after washing unbound Hb in the fluidic channel of dual sensor with PBS, the cathodic current by only HbA1C captured on aptamer was monitored using another aptamer/TBO-modified working electrode in the channel...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28004504/association-between-24-hour-combined-multichannel-intraluminal-impedance-ph-monitoring-and-symptoms-or-quality-of-life-in-patients-with-laryngopharyngeal-reflux
#15
S I Kim, O E Kwon, S Y Na, Y C Lee, J M Park, Y G Eun
OBJECTIVE: To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients. DESIGN: Prospective cohort study without controls. SETTING: University teaching hospital. METHODS: Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015...
December 22, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27997805/physiologic-effects-of-high-flow-nasal-cannula-in-acute-hypoxemic-respiratory-failure
#16
Tommaso Mauri, Cecilia Turrini, Nilde Eronia, Giacomo Grasselli, Carlo Alberto Volta, Giacomo Bellani, Antonio Pesenti
RATIONALE: High-flow nasal cannula (HFNC) improves the clinical outcomes of non-intubated acute hypoxemic respiratory failure (AHRF) patients. OBJECTIVES: To assess the effects of HFNC on gas exchange, inspiratory effort, minute ventilation, end-expiratory lung volume, dynamic compliance and ventilation homogeneity in AHRF patients. METHODS: This was a prospective randomized cross-over study in non-intubated AHRF patients with PaO2/setFiO2 ≤300 mmHg admitted to the Intensive Care Unit...
December 20, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27988112/addition-of-sodium-caseinate-to-skim-milk-increases-nonsedimentable-casein-and-causes-significant-changes-in-rennet-induced-gelation-heat-stability-and-ethanol-stability
#17
Yingchen Lin, Alan L Kelly, James A O'Mahony, Timothy P Guinee
The protein content of skim milk was increased from 3.3 to 4.1% (wt/wt) by the addition of a blend of skim milk powder and sodium caseinate (NaCas), in which the weight ratio of skim milk powder to NaCas was varied from 0.8:0.0 to 0.0:0.8. Addition of NaCas increased the levels of nonsedimentable casein (from ∼6 to 18% of total casein) and calcium (from ∼36 to 43% of total calcium) and reduced the turbidity of the fortified milk, to a degree depending on level of NaCas added. Rennet gelation was adversely affected by the addition of NaCas at 0...
December 14, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27987714/microstructure-surface-characterization-and-long-term-stability-of-new-quaternary-ti-zr-ta-ag-alloy-for-implant-use
#18
C Vasilescu, P Osiceanu, J M Calderon Moreno, S I Drob, S Preda, M Popa, I Dan, M Marcu, M Prodana, I A Popovici, D Ionita, E Vasilescu
The novel Ti-20Zr-5Ta-2Ag alloy was characterised concerning its microstructure, morphology, mechanical properties, its passive film composition and thickness, its long-term electrochemical stability, corrosion resistance, ion release rate in Ringer solution of acid, neutral and alkaline pH values and antibacterial activity. The new alloy has a crystalline α microstructure (by XRD). Long-term XPS and SEM analyses show the thickening of the passive film and the deposition of hydroxyapatite in neutral and alkaline Ringer solution...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987699/effects-of-simulated-inflammation-on-the-corrosion-of-316l-stainless-steel
#19
Emily K Brooks, Richard P Brooks, Mark T Ehrensberger
Stainless steel alloys, including 316L, find use in orthopaedics, commonly as fracture fixation devices. Invasive procedures involved in the placement of these devices will provoke a local inflammatory response that produces hydrogen peroxide (H2O2) and an acidic environment surrounding the implant. This study assessed the influence of a simulated inflammatory response on the corrosion of 316L stainless steel. Samples were immersed in an electrolyte representing either normal or inflammatory physiological conditions...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987250/lung-disease-severity-in-idiopathic-pulmonary-fibrosis-is-more-strongly-associated-with-impedance-measures-of-bolus-reflux-than-ph-parameters-of-acid-reflux-alone
#20
S Gavini, L F Borges, R T Finn, W-K Lo, H J Goldberg, R Burakoff, N Feldman, W W Chan
BACKGROUND: Gastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF). Pathogenesis may be related to chronic micro-aspiration. We aimed to assess objective measures of GER on multichannel intraluminal impedance and pH study (MII-pH) and their relationship with pulmonary function testing (PFT) results, and to compare the performance of pH/acid reflux parameters vs corresponding MII/bolus parameters in predicting pulmonary dysfunction in IPF. METHODS: This was a retrospective cohort study of IPF patients undergoing prelung transplant evaluation with MII-pH off acid suppression, and having received PFT within 3 months...
December 16, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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