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https://www.readbyqxmd.com/read/29681623/lack-of-improvement-of-impaired-chemical-clearance-characterizes-ppi-refractory-reflux-related-heartburn
#1
Marzio Frazzoni, Leonardo Frazzoni, Salvatore Tolone, Nicola De Bortoli, Vincenzo Savarino, Edoardo Savarino
OBJECTIVE: Heartburn is the most specific symptom of reflux disease and is highly responsive to proton pump inhibitor (PPI) therapy. Some patients do not respond to PPIs, but mechanisms of refractoriness have not yet been fully elucidated. Impedance-pH monitoring, allowing comprehensive on-therapy assessment of reflux, represents a valuable test to investigate PPI refractoriness. METHODS: Prospective multicenter study comparing endoscopy-negative patients with PPI-refractory and PPI-responsive heartburn...
April 23, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29670599/volatiles-mediated-interactions-between-aspergillus-oryzae-strains-modulate-morphological-transition-and-exometabolomes
#2
Digar Singh, Choong H Lee
Notwithstanding its mitosporic nature, an improbable morpho-transformation state i. e., sclerotial development (SD), is vaguely known in Aspergillus oryzae . Nevertheless an intriguing phenomenon governing mold's development and stress response, the effects of exogenous factors engendering SD, especially the volatile organic compounds (VOCs) mediated interactions (VMI) pervasive in microbial niches have largely remained unexplored. Herein, we examined the effects of intra-species VMI on SD in A. oryzae RIB 40, followed by comprehensive analyses of associated growth rates, pH alterations, biochemical phenotypes, and exometabolomes...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29669838/effects-of-adjuvants-on-hiv-1-envelope-glycoprotein-sosip-trimers-in-vitro
#3
Gabriel Ozorowski, Albert Cupo, Michael Golabek, Michelle LoPiccolo, Thomas A Ketas, Matt Cavallary, Christopher A Cottrell, P J Klasse, Andrew B Ward, John P Moore
Native-like, soluble, recombinant SOSIP trimers of various designs and based on several env genes of human immunodeficiency virus type 1 (HIV-1) are being tested as immunogens in different animal models. These experiments almost always involve co-formulating the trimers with an adjuvant to boost the magnitude of the immune responses. One factor relevant to the choice of an adjuvant is that it should not physically damage the immunogen or impede its ability to present relevant epitopes. As examples, an adjuvant formulation that includes harsh detergents could disrupt the structural integrity of a trimer, and any charged compounds in the formulation could bind to counter-charged regions of the trimer and physically occlude nearby epitopes...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29643293/-a-case-of-non-cardiac-chest-pain-caused-by-esophageal-motility-disorder-observed-on-esophageal-high-resolution-manometry
#4
Kazumasa Muta, Eikichi Ihara, Yusuke Kitagawa, Shohei Hamada, Keita Fukaura, Tsutomu Iwasa, Akira Aso, Haruei Ogino, Kazuhiko Nakamura, Yoshihiro Ogawa
A 20-year-old man was referred to our hospital with dysphagia and chest pain. Heart disease was denied. No abnormality was observed in upper esophagogastroduodenoscopy and fluoroscopy;furthermore, no gastric acid-related symptoms were observed on combined esophageal multichannel intraluminal impedance and pH monitoring. Esophageal high-resolution manometry (HRM) performed by liquid swallow revealed normal peristalsis;however, HRM performed while the patient was taking solid meals showed abnormal contraction, and the patient simultaneously complained of chest pain...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29642692/noncardiac-chest-pain-a-2018-update
#5
Marilena Durazzo, Giuseppe Gargiulo, Rinaldo Pellicano
Noncardiac chest pain (NCCP) is defined as recurring, angina-like, chest pain of noncardiac origin. Studies have estimated that gastroesophageal reflux disease (GERD) is the most common contributing factor for NCCP. In patients with non-GERD related NCCP, esophageal motility disorders, and functional chest pain (FCP) of presumed esophageal origin are the main underlying mechanisms for symptoms. Epidemiologic studies show a high prevalence of panic disorder, anxiety and major depression in NCCP patients. The diagnostic esophageal workup starts only after that cardiac and pulmonary diseases have been ruled out...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29623326/graphene-amplified-femtosensitive-aptasensing-of-estradiol-an-endocrine-disruptor
#6
Jahangir Ahmad Rather, Emad A Khudaish, Palanisamy Kannan
We report the construction of a novel electrochemical femtomolar aptasensing APT-ERGO/GCE interface based on the covalent immobilization of 38-mer amine-functionalized (NH2-APT) 17β-estradiol (E2) DNA aptamers on a graphene amplifying platform. Graphene oxide (GO) was synthesized and characterized by using FTIR, UV-vis spectroscopy, XRD spectroscopy, and SEM technique. The strategy for the construction of the E2-aptasensing interface involves in a three-step modification process. (i) First, we carried out the electrochemical reduction of GO on the GCE electrode to form ERGO/GCE...
April 6, 2018: Analyst
https://www.readbyqxmd.com/read/29609160/isolation-of-hl-60-cancer-cells-from-the-human-serum-sample-using-mno-2-pei-ni-au-aptamer-as-a-novel-nanomotor-and-electrochemical-determination-of-thereof-by-aptamer-gold-nanoparticles-poly-3-4-ethylene-dioxythiophene-modified-gc-electrode
#7
Mahmoud Amouzadeh Tabrizi, Mojtaba Shamsipur, Reza Saber, Saeed Sarkar
Herein, aptamer-modified self-propelled nanomotors were used for transportation of human promyelocytic leukemia cells (HL-60) from a human serum sample. For this purpose, the fabricated manganese oxide nanosheets-polyethyleneimine decorated with nickel/gold nanoparticles (MnO2 -PEI/Ni/Au) as nanomotors were added to a vial containing thiolated aptamer KH1C12 solution as a capture aptamer to attach to the gold nanoparticles on the surface of nanomotors covalently. The aptamer-modified self-propelled nanomotors (aptamerKH1C12 /nanomotors) were then separated by placing the vial in a magnetic stand...
March 17, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29608166/on-the-preparation-and-testing-of-fuel-cell-catalysts-using-the-thin-film-rotating-disk-electrode-method
#8
Masanori Inaba, Jonathan Quinson, Jan Rudolf Bucher, Matthias Arenz
We present a step-by-step tutorial to prepare proton exchange membrane fuel cell (PEMFC) catalysts, consisting of Pt nanoparticles (NPs) supported on a high surface area carbon, and to test their performance in thin film rotating disk electrode (TF-RDE) measurements. The TF-RDE methodology is widely used for catalyst screening; nevertheless, the measured performance sometimes considerably differs among research groups. These uncertainties impede the advancement of new catalyst materials and, consequently, several authors discussed possible best practice methods and the importance of benchmarking...
March 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29606884/proton-pump-inhibitor-refractory-gastroesophageal-reflux-disease-challenges-and-solutions
#9
REVIEW
Joseph Mermelstein, Alanna Chait Mermelstein, Maxwell M Chait
A significant percentage of patients with gastroesophageal reflux disease (GERD) will not respond to proton pump inhibitor (PPI) therapy. The causes of PPI-refractory GERD are numerous and diverse, and include adherence, persistent acid, functional disorders, nonacid reflux, and PPI bioavailability. The evaluation should start with a symptom assessment and may progress to imaging, endoscopy, and monitoring of esophageal pH, impedance, and bilirubin. There are a variety of pharmacologic and procedural interventions that should be selected based on the underlying mechanism of PPI failure...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29603354/combined-multichannel-intraluminal-impedance-ph-monitoring-should-be-used-to-diagnose-reflux-related-otitis-media-with-effusion-in-children
#10
Ivan Pavić, Irena Babić, Nuša Matijašić, Iva Hojsak
AIMS: This study investigated the diagnostic usefulness of combined multichannel intraluminal impedance-pH monitoring (MII-pH) in children with suspected reflux-related otitis media with effusion (OME) as existing data were scarce. METHODS: This was a prospective study that included children up to seven years of age who underwent MII-pH due to OME lasting more than three months. The study was conducted in the Children's Hospital Zagreb, Croatia, from January 2014 to August 2016...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29602998/clinical-feasibility-of-a-new-full-thickness-endoscopic-plication-device-gerdx%C3%A2-for-patients-with-gerd-results-of-a-prospective-trial
#11
Michael Weitzendorfer, Georg O Spaun, Stavros A Antoniou, Kai Witzel, Klaus Emmanuel, Oliver O Koch
BACKGROUND: Previous studies suggest clinical effectiveness of endoscopic full-thickness plication in selected patients with gastroesophageal reflux disease (GERD). The aim of this study was to assess the clinical safety and efficiency of the GERDx™ device by evaluating clinical parameters, reflux symptom scores, and quality of life (QoL). METHODS: Prospective one-arm trial evaluating the outcome of forty patients with GERD subjected to endoscopic plication with the GERDx™ device...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29602386/fabrication-of-an-amperometric-sarcosine-biosensor-based-on-sarcosine-oxidase-chitosan-cunps-c-mwcnt-au-electrode-for-detection-of-prostate-cancer
#12
Vinay Narwal, Parveen Kumar, Pooja Joon, C S Pundir
An amperometric sarcosine biosensor was fabricated based on covalent immobilization of sarcosine oxidase (SarOx) onto the nanocomposite of carboxylated multi-walled carbon nanotubes (cMWCNT)/chitosan (CHIT) and copper nanoparticles (CuNPs), electrodeposited on gold (Au) electrode. The SarOx/CHIT/CuNPs/c-MWCNT/Au electrode was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The enzyme electrode exhibited optimum current within 2 s at a potential of 0...
June 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29582172/gender-differences-in-the-presentation-of-dysphonia-related-to-laryngopharyngeal-reflux-disease-a-case-control-study
#13
Jérôme R Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Camille Finck, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies, Sven Saussez
OBJECTIVE: To investigate the voice quality impairments in patients with laryngopharyngeal reflux (LPR) according to the gender. DESIGN: Controlled multi-center study. MATERIALS AND METHODS: 80 LPR patients (40 males and 40 females) with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were included and clinically compared according to gender. To be considered as LPR patients, subjects responded to an empiric therapeutic trial based on pantoprazole intake and diet recommendations for 3 months or had positive pH/Impedance metry...
March 26, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29578344/effects-of-high-acidity-on-phase-transitions-of-organic-aerosol
#14
Delanie J Losey, Emily-Jean E Ott, Miriam Arak Freedman
Aerosol particle morphology influences the effect of particles on climate. Recent studies have documented the high acidity found in many ambient aerosol particles. The effect of this acidity on phase transitions of mixed organic/inorganic aerosol particles has not been addressed. To investigate this effect, six organic compounds and ammonium sulfate are investigated individually with varying amounts of sulfuric acid to determine the role of low pH on the separation, efflorescence, and deliquescence transitions...
March 26, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29569874/comparison-of-different-histological-protocols-for-the-preservation-and-quantification-of-the-intestinal-mucus-layer-in-pigs
#15
Ilen Röhe, Friedrich Joseph Hüttner, Johanna Plendl, Barbara Drewes, Jürgen Zentek
The histological characterization of the intestinal mucus layer is important for many scientific experiments investigating the interaction between intestinal microbiota, mucosal immune response and intestinal mucus production. The aim of this study was to examine and compare different fixation protocols for displaying and quantifying the intestinal mucus layer in piglets and to test which histomorphological parameters may correlate with the determined mucus layer thickness. Jejunal and colonal tissue samples of weaned piglets (n=10) were either frozen in liquid nitrogen or chemically fixed using methacarn solution...
February 5, 2018: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29562095/the-effect-of-adenine-adsorption-on-zn-ii-electroreduction-in-acetate-buffer
#16
Dorota Gugała-Fekner
The paper presents the thermodynamic analysis of adenine adsorption on a mercury electrode in an acetate buffer at pH 3 and pH 4. Adsorption energy and constants were determined using the Frumkin isotherm and the virial isotherm. Stronger adsorption in the buffer at pH 3 was observed in comparison to the buffer at pH 4. Using cyclic voltammetry and Faraday impedance measurement, an inhibitory effect of adenine on the kinetics of Zn (II) ion electro-reduction was observed.
March 2018: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29560662/diet-affects-reflux-in-a-rural-african-community
#17
E J Ndebia, A M Sammon, E Umapathy, J E Iputo
Reflux in this region of South Africa is known to be more frequent and less acidic than in other countries. We investigated the relationship between reflux and diet. We recruited 57 healthy participants. We carried out ambulant oesophageal pH-impedance monitoring for 24 hours. We used software and visual review to analyse data and to identify episodes of reflux and rapid alkaline rises in the stomach. A usual pattern diet questionnaire provided data on frequency of consumption of common foods. Associations between reflux, gastric pH and dietary components were sought using analysis of variance, and regression analyses...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29551382/electrochemical-behavior-of-titanium-exposed-to-a-biofilm-supplemented-with-different-sucrose-concentrations
#18
João Gabriel Silva Souza, Thamara Beline, Adaias Oliveira Matos, Bárbara Emanoele Costa Oliveira, Antônio Pedro Ricomini-Filho, Valentim Adelino Ricardo Barão
STATEMENT OF PROBLEM: Biofilms can reduce the corrosion resistance of titanium because of the bacterial metabolism of fermentable carbohydrates, including sucrose. However, studies evaluating whether biofilms exposed to higher sucrose concentrations can affect the electrochemical behavior of titanium are lacking. PURPOSE: The purpose of this in vitro study was to test the electrochemical behavior of titanium previously exposed to biofilm supplemented with different sucrose concentrations...
March 15, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29550433/structural-and-biochemical-insights-into-the-substrate-binding-mechanism-of-a-novel-glycoside-hydrolase-family-134-%C3%AE-mannanase
#19
Xin You, Zhen Qin, Yan-Xiao Li, Qiao-Juan Yan, Bin Li, Zheng-Qiang Jiang
Mannan is one of the major constituent groups of hemicellulose, which is a renewable resource from higher plants. β-Mannanases are enzymes capable of degrading lignocellulosic biomass. Here, an endo-β-mannanase from Rhizopus microsporus (RmMan134A) was cloned and expressed. The recombinant RmMan134A showed maximal activity at pH 5.0 and 50 °C, and exhibited high specific activity towards locust bean gum (2337 U/mg). To gain insight into the substrate-binding mechanism of RmMan134A, four complex structures (RmMan134A-M3, RmMan134A-M4, RmMan134A-M5 and RmMan134A-M6) were further solved...
March 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29549854/tracing-the-ph-dependent-activation-of-autophagy-in-cancer-cells-by-silicon-nanowire-based-impedance-biosensor
#20
Alireza Alikhani, Milad Gharooni, Hamed Abiri, Fatemeh Farokhmanesh, Mohammad Abdolahad
Monitoring the pH dependent behavior of normal and cancer cells by impedimetric biosensor based on Silicon Nanowires (SiNWs) was introduced to diagnose the invasive cancer cells. Autophagy as a biologically activated process in invasive cancer cells during acidosis, protect them from apoptosis in lower pH which presented in our work. As the autophagy is the only activated pathways which can maintain cellular proliferation in acidic media, responses of SiNW-ECIS in acidified cells could be correlated to the probability of autophagy activation in normal or cancer cells...
February 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
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