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https://www.readbyqxmd.com/read/28449422/the-effect-of-anti-reflux-therapy-on-patients-diagnosed-with-minor-disorders-of-peristalsis-in-high-resolution-manometry
#1
Joonho Jeong, Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Youn Jung Choi, Jun Yeob Lee, Young Dal Lee
Background/Aims: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. Methods: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28445106/tension-free-inlay-repair-of-large-hiatal-hernias-using-dual-sided-composite-ptfe-eptfe-meshes-in-laparoscopic-surgery-for-gastroesophageal-reflux-disease
#2
Alexander M Prusa, Ivan Kristo, Erwin Rieder, Claudia Ringhofer, Reza Asari, Johannes Miholic, Sebastian F Schoppmann
BACKGROUND: Patients with gastroesophageal reflux disease (GERD) also frequently suffer from concomitant hiatal hernia. It has been described that a preoperative hiatal hernia of ≥3 cm is associated with a more than threefold relative risk for reflux symptom recurrence after fundoplication without mesh reinforcement. In this report, we describe our experience with the implantation of dual-sided composite PTFE/ePTFE meshes in a tension-free fashion during laparoscopic antireflux surgery (LARS)...
April 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28437259/utility-of-esophageal-mucosal-impedance-as-a-diagnostic-test-for-esophageal-disease
#3
Dhyanesh A Patel, Michael F Vaezi
PURPOSE OF REVIEW: The aim of this review is to summarize the use of direct mucosal impedance (MI) for the evaluation and management of esophageal diseases. RECENT FINDINGS: Esophageal multichannel intraluminal impedance with pH (MII-pH) monitoring has been considered the most sensitive test for gastroesophageal reflux disease (GERD), but recent studies have failed to establish impedance parameters that reliably predict treatment response to medical and surgical GERD therapies...
April 21, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28425145/prevalence-of-gastroesophageal-reflux-in-cats-during-anesthesia-and-effect-of-omeprazole-on-gastric-ph
#4
R S Garcia, P C Belafsky, A Della Maggiore, J M Osborn, B H Pypendop, T Pierce, V J Walker, A Fulton, S L Marks
BACKGROUND: Gastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation. OBJECTIVE: To determine whether pre-anesthetic orally administered omeprazole increases gastric and esophageal pH and increases serum gastrin concentrations in anesthetized cats, and to determine the prevalence of GER using combined multichannel impedance and pH monitoring. ANIMALS: Twenty-seven healthy cats undergoing elective dental procedures...
April 19, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28417633/ph-responsive-graphene-oxide-dna-nanosystem-for-live-cell-imaging-and-detection
#5
Chen Shao, Jia Liang, Sihui He, Tianqi Luan, Jiantao Yu, Haoran Zhao, Jingyuan Xu, Leilei Tian
The interaction between graphene oxide (GO) and DNA is very sensitive to the environment. For example, under acidic conditions, the affinity of GO for DNA is enhanced, weakening the capability of GO to distinguish DNAs with different conformations. This effect has impeded the development of sensitive pH biosensors based on GO-DNA nanosystems. In this work, we systematically studied the affinity between GO and i-motif forming oligonucleotides (IFOs) at different pH values and developed a herring sperm DNA (HSD) treatment method...
April 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28405322/specific-dyspeptic-symptoms-are-associated-with-poor-response-to-therapy-in-patients-with-gastroesophageal-reflux-disease
#6
A D'Alessandro, F P Zito, M Pesce, P Andreozzi, E Efficie, M Cargiolli, F Maione, G D De Palma, R Cuomo, G Sarnelli
INTRODUCTION: In patients with gastroesophageal reflux disease (GORD), co-existence of functional dyspepsia (FD) is known to be associated with poor response to proton pump inhibitors (PPIs), but the contribution of specific dyspepsia symptoms has not yet been systematically investigated. OBJECTIVE: We aimed to characterize the impact of dyspepsia symptoms on response to PPIs in patients with GORD. METHODS: The enrolled subjects were consecutive patients with a diagnosis of GORD...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28393826/-possibilities-of-ph-impedance-and-high-resolution-manometry-in-managing-patients-with-refractory-gastroesophageal-reflux-disease
#7
I V Maev, E V Barkalova, M A Ovsepyan, Yu A Kucheryavyi, D N Andreev
Gastroesophageal reflux disease (GERD) is a common condition that has a substantial impact on quality of life in patients and is a leading risk factor for esophageal adenocarcinoma. Now therapy with proton pump inhibitors (PPIs) is a basic method in the treatment of patients with GERD; however, one third of the patients do not respond to the therapy used. The causes of refractory GERD are a fairly large group of heterogeneous factors contributing to the inefficacy of PPIs in adequate dosage. Among these factors, there is low compliance by patients to the prescribed treatment regimen; nocturnal acid breakthrough; СУР2С19 gene polymorphism; chiasm syndrome with functional diseases of the gastrointestinal tract; non-acidic refluxes in a patient; thoracic esophageal motility disorders; the increased number and duration of transient lower esophageal sphincter relaxation periods; hiatus hernia; and misdiagnosis...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28391829/electrochemical-behavior-and-voltammetric-detection-of-fenitrothion-based-on-a-pencil-graphite-electrode-modified-with-reduced-graphene-oxide-rgo-poly-e-1-4-4-phenylamino-phenyl-diazenyl-phenyl-ethanone-dpa-composite-film
#8
Ozge Surucu, Gulcin Bolat, Serdar Abaci
A combination of a novel synthesized azo dye (E)-1-(4-((4-(phenylamino)phenyl)diazenyl) phenyl)ethanone and reduced graphene oxide was used to electrochemically modify the surface of a pencil graphite electrode. The surfaces of the modified electrodes were characterized using electrochemical techniques (cyclic voltammetry and electrochemical impedance spectroscopy) and spectroscopic techniques (scanning electron microscopy and attenuated total reflectance). This azo dye/reduced graphene oxide modified electrode was applied first time for the electrochemical detection of an organophosphorus pesticide, fenitrothion...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28384225/ambulatory-24-hour-multichannel-intraluminal-impedance-ph-monitoring-and-high-resolution-endoscopy-distinguish-patients-with-non-erosive-reflux-disease-from-those-with-functional-heartburn
#9
Chuanlian Chu, Quanlin Du, Changqing Li, Linlu Zhang, Xiaoyan Zhou, Fang Zuo, Yanmin Zhang, Fang Li, Guofeng Xie, Yanqing Li
AIMS: To assess the contribution of 24-h esophageal multichannel intraluminal impedance and pH (MII-pH) monitoring and high resolution endoscopy (HRE) with i-scan imaging in differentiating non erosive reflux disease (NERD) from functional heartburn (FH). METHODS: This is a retrospective cohort study of patients with heartburn from the Endoscopy Unit. NERD patients and FH patients were defined by 24-h MII-pH monitoring and white light endoscopy. Minimal mucosal changes were assessed by HRE with i-scan imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28383316/interim-report-of-a-prospective-trial-on-the-clinical-efficiency-of-a-new-full-thickness-endoscopic-plication-device-for-patients-with-gerd-impact-of-changed-suture-material
#10
Michael Weitzendorfer, Georg O Spaun, Stavros A Antoniou, Andreas Tschoner, Philipp Schredl, Klaus Emmanuel, Oliver O Koch
BACKGROUND: The aim of the present trial is to investigate the clinical efficiency of the GERDx device for patients with gastroesophageal reflux disease (GERD). MATERIALS AND METHODS: Prospective study evaluating Gastrointestinal Quality of Life Index, symptoms scores, as well as esophageal manometry and impedance-pH-monitoring data at baseline and 3 months after endoscopic full-thickness plication with the GERDx device. RESULTS: In total, 28 patients underwent the procedure so far...
April 5, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28376225/assay-development-for-aminoglycosides-by-hplc-with-direct-uv-detection
#11
Bart Blanchaert, Shengyun Huang, Katarzyna Wach, Erwin Adams, Ann Van Schepdael
The absence of UV chromophores in the structure of most aminoglycosides impedes an easy and straightforward development of analytical methods. It was demonstrated that addition of borate to the mobile phase allowed direct detection of aminoglycosides at the lower end of the UV spectrum. Although the borate ion complexes preferably with compounds possessing vicinal diols, the aim of this study was to develop an assay for tobramycin that does not contain vicinal diols in its structure. Amikacin, an aminoglycoside with a broad spectrum, was added to the study for its high therapeutic importance...
March 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28374909/doxorubicin-loaded-chitosan-w18-o49-hybrid-nanoparticles-for-combined-photothermal-chemotherapy
#12
Shanmei Yuan, Jisong Hua, Yinyin Zhou, Yin Ding, Yong Hu
Combined treatment is more effective than single treatment against most forms of cancer. In this work, doxorubicin loaded chitosan-W18 O49 nanoparticles combined with the photothermal therapy and chemotherapy are fabricated through the electrostatic interaction between positively charged chitosan and negatively charged W18 O49 nanoparticles. The in vitro and in vivo behaviors of these nanoparticles are examined by dynamic light scattering, transmission electron microscopy, cytotoxicity, near-infrared fluorescence imaging, and tumor growth inhibition experiment...
April 4, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28370768/ambulatory-reflux-monitoring-for-diagnosis-of-gastro-esophageal-reflux-disease-update-of-the-porto-consensus-and-recommendations-from-an-international-consensus-group
#13
REVIEW
S Roman, C P Gyawali, E Savarino, R Yadlapati, F Zerbib, J Wu, M Vela, R Tutuian, R Tatum, D Sifrim, J Keller, M Fox, J E Pandolfino, A J Bredenoord
BACKGROUND: An international group of experts evaluated and revised recommendations for ambulatory reflux monitoring for the diagnosis of gastro-esophageal reflux disease (GERD). METHODS: Literature search was focused on indications and technical recommendations for GERD testing and phenotypes definitions. Statements were proposed and discussed during several structured meetings. KEY RESULTS: Reflux testing should be performed after cessation of acid suppressive medication in patients with a low likelihood of GERD...
March 31, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28365873/effects-of-esophageal-acidification-on-troublesome-symptoms-an-approach-to-characterize-true-acid-gerd-in-dysphagic-neonates
#14
Maneesha Sivalingam, Swetha Sitaram, Kathryn A Hasenstab, Lai Wei, Frederick W Woodley, Sudarshan R Jadcherla
To quantify and compare maximal extent (height) of acid reflux events (AREs) on symptom generation in dysphagic neonates. Dysphagic neonates (N = 53), born at 30 ± 5.3 weeks gestation, underwent 24-hour pH-impedance study for the evaluation of troublesome symptoms purported to be due to gastroesophageal reflux disease (GERD). AREs (pH < 4 for >4 s) detected by impedance (Z) were categorized by maximal extent as refluxate reaching distal (Z6, Z5), middle (Z4, Z3), or proximal (Z2, Z1) impedance channels...
April 1, 2017: Dysphagia
https://www.readbyqxmd.com/read/28344363/electrochemical-determination-of-closantel-in-the-commercial-formulation-by-square-wave-adsorptive-stripping-voltammetry
#15
Mariola Brycht, Agnieszka Nosal-Wiercińska, Karolina Sipa, Konrad Rudnicki, Sławomira Skrzypek
ABSTRACT: In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal conditions, the SWAdSV response of Hg(Ag)FE for determining closantel was linear over two concentration ranges of 5...
2017: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/28327750/dynamic-studies-of-the-interaction-of-a-ph-responsive-amphiphilic-polymer-with-a-dopc-lipid-membrane
#16
Sivaramakrishnan Ramadurai, Marco Werner, Nigel K H Slater, Aaron Martin, Vladimir A Baulin, Tia E Keyes
Deeper understanding of the molecular interactions between polymeric materials and the lipid membrane is important across a range of applications from permeation for drug delivery to encapsulation for immuno-evasion. Using highly fluidic microcavity supported lipid bilayers, we studied the interactions between amphiphilic polymer PP50 and a DOPC lipid bilayer. As the PP50 polymer is pH responsive the studies were carried out at pH 6.5, 7.05 and 7.5, corresponding to fully, partly protonated (pH = pKa = 7.05) and fully ionized states of the polymer, respectively...
March 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28320941/potent-neuroprotection-after-stroke-afforded-by-a-double-knot-spider-venom-peptide-that-inhibits-acid-sensing-ion-channel-1a
#17
Irène R Chassagnon, Claudia A McCarthy, Yanni K-Y Chin, Sandy S Pineda, Angelo Keramidas, Mehdi Mobli, Vi Pham, T Michael De Silva, Joseph W Lynch, Robert E Widdop, Lachlan D Rash, Glenn F King
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and a key mediator of acidosis-induced neuronal damage following cerebral ischemia. Genetic ablation and selective pharmacologic inhibition of ASIC1a reduces neuronal death following ischemic stroke in rodents. Here, we demonstrate that Hi1a, a disulfide-rich spider venom peptide, is highly neuroprotective in a focal model of ischemic stroke...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28317452/recent-advances-in-diagnostic-testing-for-gastroesophageal-reflux-disease
#18
Rishi D Naik, Michael F Vaezi
Gastroesophageal reflux disease (GERD) has a large economic burden with important complications that include esophagitis, Barrett's esophagus, and adenocarcinoma. Despite endoscopy, validated patient questionnaires, and traditional ambulatory pH monitoring, the diagnosis of GERD continues to be challenging. Areas covered: This review will explore the difficulties in diagnosing GERD with a focus on new developments, ranging from basic fundamental changes (histology and immunohistochemistry) to direct patient care (narrow-band imaging, impedance, and response to anti-reflux surgery)...
March 27, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28303290/relationship-between-functional%C3%A2-endoscopy%C3%A2-and-impedance-ph%C3%A2-measurement
#19
F Michel, T Stroh, R Fritsche, P Ahrens
Classic gastroenterological diagnostic tools have proven to be insufficient in identifying the causal relationship between extra-esophageal symptoms and presumed pathological reflux activity. Some new methodological approaches, such as functional endoscopy (video panendoscopy, VPE), are considered to be helpful. However, there are currently no data objectively verifying the success of this method. In a previous study, we found a good correlation between the reflux symptom index (RSI) according to Belafsky and endoscopic findings...
March 16, 2017: HNO
https://www.readbyqxmd.com/read/28302442/symptoms-endoscopic-findings-and-reflux-monitoring-results-in-candidates-for-bariatric-surgery
#20
Benjamin Heimgartner, Marcus Herzig, Yves Borbély, Dino Kröll, Philipp Nett, Radu Tutuian
BACKGROUND: Gastroesophageal reflux disease (GERD) is common in patients with obesity. Diagnosing GERD is important as bariatric operations have different influence on GERD. We assessed reflux symptoms and objective findings prior to surgery. METHODS: Work-up included esophageal symptoms quantification by VAS-scores, esophagogastroduodenoscopy (EGD) and 24-h impedance-pH (imp-pH) monitoring off PPI therapy. Imp-pH was classified as abnormal if either %time pH<4 was abnormal, total number of reflux episodes was elevated or symptom index (SI) was positive...
February 3, 2017: Digestive and Liver Disease
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