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liver metastasis colorectal cancer

Mingyue Li, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Clara Bik-San Lau
BACKGROUND: Curcumin, a well-studied component in turmeric, exhibits potent antitumor effects in colorectal cancer. Previous studies showed that turmerones raised the accumulation of curcumin inside colonic cells, and curcumin present in turmeric ethanolic extract had enhanced anti-tumor activities in mice. Metastasis accounts for more than 90% colorectal cancer deaths. However, the anti-metastatic effect of turmeric extract on colorectal cancer is still unknown. METHODS: In the present study, colony formation, scratch, transwell and Western blot were used to assess colony formation, motility, migration and underlying mechanisms in vitro, respectively...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Yinghao Cao, Shenghe Deng, Ke Wu, Hai Zheng, Ping Cheng, Jingxiang Zhang, Libo Chen, Shouyuan Tang, Pingfa Wang, Xiaofeng Liao, Yongkang Zhang, Gaobo Zhu, Qiaoyun Tong, Jiliang Wang, Jinbo Gao, Xiaoming Shuai, KaiXiong Tao, Guobin Wang, Jiang Li, Kailin Cai
PURPOSE: Colonic perforation is a life-threatening complication after colonic stent insertion as a bridge to surgery for acute obstruction caused by colorectal cancer. The oncological consequence of colonic perforation after emergent surgical intervention was unknown. The aim of this short communication was to investigate whether or not the perforation and emergent surgery had obviously impact on the peritoneal recurrence and long-term survival of patients. METHODS: Data of the patients who underwent colorectal stenting as a bridge to surgery in 5 years from 2012 to 2017 was collected by the Endoscopical Surgery Group of Hubei...
August 8, 2018: International Journal of Colorectal Disease
Bruno Roque Lima, Caroline Correa de Tulio Augusto Roque, Maria Dirlei Begnami, Patricia Peresi, Eduardo Nobrega Pereira Lima, Celso Abdon Lopes de Mello, Felipe José Fernandez Coimbra, Rubens Chojniak, Tiago Goss Santos
Liver metastasis is the major cause of death for patients with colorectal cancer. Despite treatment with surgery and chemotherapy, patient outcomes are quite unfavorable. Thus, there is an urgent need to develop new treatment strategies with the associated establishment of good animal models. Metastatic disease can be modeled using patient-derived orthotopic xenografts, which accurately replicate intra-tumoral heterogeneity, so that various chemotherapeutic agents can be tested on individual tumors to aid in clinical decision-making...
August 8, 2018: Journal of Drug Targeting
Jagdeep Singh Bhangu, Andrea Beer, Martina Mittlböck, Dietmar Tamandl, Walter Pulverer, Hossein Taghizadeh, Stefan Stremitzer, Klaus Kaczirek, Thomas Gruenberger, Michael Gnant, Michael Bergmann, Christine Mannhalter, Andreas Weinhäusel, Rudolf Oehler, Thomas Bachleitner-Hofmann
BACKGROUND: Neoadjuvant chemotherapy (neoCTx) followed by hepatic resection is the treatment of choice for patients with colorectal cancer liver metastasis (CLM). Treatment response is generally assessed using radiologic imaging after several cycles of chemotherapy. However, earlier assessment of response would be desirable since nonresponders could be switched early to an alternative chemotherapy regimen. Recent evidence suggests that circulating free methylated tumor DNA is a highly sensitive biomarker and may more accurately reflect tumor burden and treatment response than conventional markers for CRC...
August 3, 2018: Annals of Surgery
Gustavo Nari, Daniela Mariot, Javier Góngora-Ortega, Santiago López-Ben, Maite Albiol, Joan Figueras
Introducción: Un alto porcentaje de pacientes que reciben una hepatectomía por metástasis de cáncer colorrectal presentarán recidiva hepática, y en algunas será posible una nueva resección. La utilidad de las hepatectomías repetidas continúa siendo discutida. Objetivo: Evaluar los resultados obtenidos a corto y largo plazo. Método: Fueron analizadas 68 rehepatectomías de dos instituciones. Se analizaron datos demográficos y características de la enfermedad metastásica y de las resecciones hepáticas...
2018: Cirugia y Cirujanos
Keith W H Chiu, Ka-On Lam, H An, Gavin T C Cheung, Johnny K S Lau, Tim-Shing Choy, Victor H F Lee
BACKGROUND: 18F-FDG PET-CT is commonly used to monitor treatment response in patients with metastatic colorectal cancer (mCRC). With improvement in systemic therapy, complete metabolic response (CMR) is increasingly encountered but its clinical significance is undefined. The study examined the long-term outcomes and recurrence patterns in these patients. METHODS: Consecutive patients with mCRC who achieved CMR on PET-CT during first-line systemic therapy were retrospectively analysed...
July 31, 2018: BMC Cancer
Mariana Campos-da-Paz, Jose GarrofeDorea, Alexsandro Sobreira Galdino, Zulmira Guerrero Marques Lacava, Maria de Fatima Menezes Almeida Santos
Carcinoembryonic antigen (CEA) is a prognostic marker in colorectal cancer (CRC) for tumor diagnosis and monitoring response to therapy. High CEA levels are specifically associated with CRC progression and liver metastasis. Due to its differential expression between cancer and healthy tissues, and between positive and negative lymph nodes CEA has been explored for new cancer therapy and diagnosis approaches. We revised the literature on CEA role in CRC as well as the patents relating to CEA targeting for cancer management...
July 30, 2018: Recent Patents on Biotechnology
Yu Yoshida, Takanori Goi, Hidetaka Kurebayashi, Mitsuhiro Morikawa, Yasuo Hirono, Kanji Katayama
Molecular tumor biomarkers hold considerable promise for accurately predicting colorectal cancer (CRC) recurrence and progression. Prokineticin 2 (PROK2) may be associated with angiogenesis and tumor formation in some malignant tumors. However, its prognostic value remains unknown. We focused on the association between PROK2 expression and clinical characteristics of CRC to assess value of PROK2 as a potential biomarker for stage I-III CRC patients prognosis. Between 1992 and 2006, 436 consecutive patients with stage I-III CRC treated with curative resection were included...
July 10, 2018: Oncotarget
Bharatsinh Gharia, Karan Seegobin, Hetavi Mahida, Marwan Shaikh, Trevanne Matthews Hew, Dat Pham
Type B lactic acidosis associated with malignancy is a life-threatening complication and mostly seen in hematological malignancies but can also be seen in solid tumors. We report a rare case of a 64-year-old female diagnosed with metastatic adenocarcinoma of the colon with liver metastasis associated with severe type B lactic acidosis. We discuss pathophysiology, previously reported cases, and their outcomes. The most widely used therapies are bicarbonate infusion, thiamine supplementation, chemotherapy, and supportive care but is associated with poor outcomes, and no standard treatment recommendations are available...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Thiru Prasanna, Christos S Karapetis, David Roder, Jeanne Tie, Robert Padbury, Timothy Price, Rachel Wong, Jeremy Shapiro, Louise Nott, Margaret Lee, Yu Jo Chua, Paul Craft, Cynthia Piantadosi, Michael Sorich, Peter Gibbs, Desmond Yip
BACKGROUND: Pattern of spread in patients with metastatic colorectal cancer (mCRC) is variable and may reflect different biology in subsets of patients. This is a retrospective study to explore the outcome of patients with mCRC based on their site of metastasis at diagnosis and to explore the association between tumor characteristics [KRAS/RAS, BRAF, mismatch repair (MMR) status, site of primary] and the site of metastasis. METHODS: Patients from two Australian databases were divided into six groups based on site of metastasis at time of diagnosis of metastatic disease; lung-only, liver-only, lymph node-only or any patients with brain, bone or peritoneal metastases...
July 23, 2018: Acta Oncologica
Simon A Joosse, François-Régis Souche, Anna Babayan, Christin Gasch, Ron M Kerkhoven, Jeanne Ramos, Jean-Michel Fabre, Sabine Riethdorf, Alexandra König, Harriet Wikman, Catherine Alix-Panabières, Klaus Pantel
BACKGROUND: Genomic information can help to identify colorectal tumors with high and low metastatic potential, thereby improving prediction of benefit of local and/or systemic treatment. Here we investigated chromosomal aberrations in relation to the different stages of the metastatic cascade: dissemination of tumor cells into the mesenteric vein, metastatic outgrowth in the liver, intravasation of the peripheral blood circulation, and development of further distant metastasis. METHODS: Peripheral and mesenteric blood from colorectal cancer patients (n = 72) were investigated for circulating tumor cells, and DNA extracted from their primary tumors was subjected to array comparative genomic hybridization profiling...
July 20, 2018: Clinical Chemistry
Qinrui Han, Ye Ma, Hao Wang, Yu Dai, Chunhui Chen, Yawei Liu, Linlin Jing, Xuegang Sun
BACKGROUND: Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) through induction of necroptosis in vivo. METHODS: SW480 cells with stably expressing enhanced green fluorescence protein were xenografted to BALB/c-nu mice to observe the growth of tumors. Liver metastasis was observed by injection of MC38 cells beneath the splenic capsule of mice...
July 20, 2018: Journal of Translational Medicine
Zhixun Zhao, Yibo Gao, Xu Guan, Zheng Liu, Zheng Jiang, Xiuyun Liu, Huixin Lin, Ming Yang, Chunxiang Li, Runkun Yang, Shuangmei Zou, Xishan Wang
GADD45B acts as a member of the growth arrest DNA damage-inducible gene family, which has demonstrated to play critical roles in DNA damage repair, cell growth, and apoptosis. This study aimed to explore the potential relationship between GADD45B expression and tumor progression and evaluate the clinical value of GADD45B in stage II colorectal cancer (CRC). The expression patterns and prognostic value of GADD45B in CRC were analyzed based on The Cancer Genomic Atlas (TCGA). GADD45B expression features of 306 patients with stage II CRC and 201 patients with liver metastasis of CRC were investigated using immunochemical staining on tissue microarrays...
July 19, 2018: Genes
Kenta Tominaga, Yasuhiro Kurumiya, Ei Sekoguchi, Satoshi Kobayashi, Kiyotaka Kawai, Muneyasu Kiriyama
A 62-year-old man was diagnosed with liver metastasis of sigmoid colon cancer, which resulted in bowel obstruction. SOX plus bevacizumab therapy was administered to perform hepatectomy, after the artificial anus construction; however, substantial liver dysfunction occurred. Therefore, we only performed primary tumor resection and waited for improvement in liver function. After 2 months, liver function improved and liver metastasis increased. However, another metastasis was not recognized, so hepatectomy was carried out, and R0 resection was performed...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Michihisa Iida, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Koji Fujita, Masahiko Kuroda, Hiroaki Nagano
The cancer stroma is important in cancer development, however, whether the aberrant expression of microRNAs (miRNAs) in the cancer stroma is associated with cancer progression remains to be fully elucidated. The aim of the present study was to identify the miRNAs associated with liver metastasis in the cancer stroma of human colorectal cancer (CRC). Using laser capture microdissection, cancer stroma was obtained from the primary lesion of six patients with CRC with liver metastasis (CRCwLM) and six patients with CRC without liver metastasis (CRCwoLM), and miRNA microarray analysis was performed...
September 2018: Oncology Reports
Haifeng Zhang, Zhiqin Deng, Dongxia Zhang, Huarong Li, Lei Zhang, Jin Niu, Wanhong Zuo, Rao Fu, Lihong Fan, Jiang-Hong Ye, Junjun She
To survive, cells need to avoid excessive volume change that jeopardizes structural integrity and stability of the intracellular milieu. Searching for the molecular identity of volume‑regulated anion channel (VRAC) has yielded multiple potential candidates, but none has been confirmed. Recently, it is reported that leucine‑rich repeat‑containing 8A (LRRC8A) is a main molecular determinant of VRAC current. The biological functions of LRRC8 family proteins are poorly understood, particularly in cancer...
September 2018: Oncology Reports
Xuehua Liu, Junhua Zuo, Yuan Fang, Jing Wen, Feihong Deng, Hui Zhong, Bo Jiang, Jide Wang, Biao Nie
The drug resistance of cancer remains a major obstacle to successful chemotherapy. New strategies for improving chemotherapeutic efficacy are urgently required. Recent studies have indicated that LIPC plays a role in promoting the liver metastasis of colorectal cancer. In the present study, we aimed to investigate the effects of LIPC on theproliferation and clone formation of colorectal cancer-derived cells, and chemoresistance in hepatoblastoma-derived HepG2 cells. The activity and expression of LIPC were determined in the cell lines by RT-qPCR and western blot analysis...
October 2018: International Journal of Molecular Medicine
Simon J McCluney, Alexandros A Giakoustidis, Angela Segler, Juliane Bissel, Robert L Miller, Roberto Valente, Robert R Hutchins, Ajit Abraham, Satyajit Bhattacharya, Hemant M Kocher
BACKGROUND: Colorectal cancer is one of the most common malignancies worldwide; whilst approximately 20% of patients have hepatic disease at presentation. Hepatic resection remains the gold standard of care; however, it is associated with significant morbidity. We sought to establish whether the lymphocyte-to-monocyte ratio (LMR) could help predict post-operative complications, thus improving patient outcomes. METHODS: We performed a retrospective cohort study of patients undergoing hepatic resection at a single centre...
July 16, 2018: ANZ Journal of Surgery
E Van Cutsem, T Yoshino, H J Lenz, S Lonardi, A Falcone, M L Limón, M Saunders, A Sobrero, Y S Park, R Ferreiro, Y S Hong, J Tomasek, H Taniguchi, F Ciardiello, J Stoehr, Z Oum'Hamed, S Vlassak, M Studeny, G Argiles
Background: Angiogenesis is critical to colorectal cancer (CRC) growth and metastasis. Phase I/II studies have demonstrated the efficacy of nintedanib, a triple angiokinase inhibitor, in patients with metastatic CRC. This global, randomized, phase III study investigated the efficacy and safety of nintedanib in patients with refractory CRC after failure of standard therapies. Patients and methods: Eligible patients (Eastern Cooperative Oncology Group performance status 0-1, with histologically/cytologically confirmed metastatic/locally advanced CRC adenocarcinoma unamenable to surgery and/or radiotherapy) were randomized 1:1 to receive nintedanib (200 mg twice daily) or placebo (twice daily), until disease progression or undue toxicity...
July 13, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
He Liu, Yongmin Li, Jingwen Li, Yanlong Liu, Binbin Cui
Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated factor, is a component of the H3K4me3 methyltransferase complex. An aim of the present study was to determine H3K4me3 and Wdr82 expression and their clinical significances in colorectal cancer (CRC)...
August 2018: Oncology Letters
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