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liver metastasis colorectal cancer

Barbara Alicja Jereczek-Fossa, Barbara Bortolato, Marianna Alessandra Gerardi, Samantha Dicuonzo, Virginia Maria Arienti, Stefania Berlinghieri, Stefano Bracelli, Michela Buglione, Mariangela Caputo, Gianpiero Catalano, Luigi Franco Cazzaniga, Luigi De Cicco, Nadia Di Muzio, Francesco Romeo Filippone, Andrei Fodor, Davide Franceschini, Paolo Frata, Stefania Gottardo, Giovanni Battista Ivaldi, Antonio Laudati, Stefano Maria Magrini, Elisa Mantero, Ilaria Meaglia, Sara Morlino, Mauro Palazzi, Fabio Piccoli, Paola Romanelli, Marta Scorsetti, Flavia Serafini, Luciano Scandolaro, Riccardo Valdagni, Roberto Orecchia, Paolo Antognoni
AIMS: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy. METHODS AND STUDY DESIGN: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. RESULTS: Thirteen centers answered the survey (38%). All centers responded to general items and 12 centers submitted patient/disease/treatment data...
December 15, 2018: La Radiologia Medica
Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia
BACKGROUND: Long non-coding RNAs (LncRNAs) emerging as pivotal marker in the procession of cancer, including colorectal cancer (CRC). Abnormal O-glycosylation is a crucial modification during cancer malignancy. The aim of this work is to analyze the alteration of O-glycosylation involved in CRC progression. METHODS: qRT-PCR is utilized to screen the differential linc01296 expression in CRC tissues and cell lines. Functionally, CRC cell proliferation, aggressiveness and apoptosis are measured through relevant experiments, including CCK8 assay, colony formation assay, transwell assay, western blot and flow cytometry...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Mingyu Zhang, Huijie Jiang, Rongjun Zhang, Hailong Xu, Hao Jiang, Wenbin Pan, Xin Li, Yiqiao Wang, Song Wang
This study aimed to explore the application of two radiotracers (18 F-fluorodeoxyglucose (FDG) and 18 F-fluoromisonidazole (FMISO)) in monitoring hepatic metastases of human colorectal cancer (CRC). Mouse models of CRC hepatic metastases were established by implantation of the human CRC cell lines LoVo and HT29 by intrasplenic injection. Wound healing and Transwell assays were performed to examine cell migration and invasion abilities. Radiotracer-based cellular uptake in vitro and micro-positron emission tomography imaging of liver metastases in vivo were performed...
December 13, 2018: Scientific Reports
Tao Zhang, Jianrong Guo, Jian Gu, Zheng Wang, Guobin Wang, Huili Li, Jiliang Wang
Colorectal cancer (CRC) is one of the principal causes of cancer‑associated mortality worldwide. The high incidence of liver metastasis is the leading risk factor of mortality in patients with CRC, and the mechanisms of CRC liver metastasis are poorly understood. In the present study, 7 datasets, including 3 gene expression profile datasets and 4 microRNA (miRNA) expression profile datasets were downloaded from the NCBI Gene Expression Omnibus (GEO) database to identify potential key genes and miRNAs, which may be candidate biomarkers for CRC liver metastasis...
November 1, 2018: Oncology Reports
Claudemiro Quireze Junior, Andressa Machado Santana Brasil, Lúcio Kenny Morais, Edmond Raymond Le Campion, Eliseu José Fleury Taveira, Matheus Castrillon Rassi
BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis...
July 2018: Arquivos de Gastroenterologia
Shekhar Gogna, Priya Goyal
The liver is the most common site for metastasis from colorectal cancers (CRCs). There are so many new armamentarium, which have increased the life expectancy and progression-free survival. There are various available guidelines, such as NCCN, ESMO, and ASCO, which provide an insight into the latest modalities and new protocols. We have tried to elucidate into paradigm shift of the management.
December 2018: Indian Journal of Surgical Oncology
Garima Suman, Akshay D Baheti, Suman Kumar Ankathi, Nitin Shetty, Suyash Kulkarni, Vikas Ostwal, Avanish P Saklani
Close surveillance of colorectal cancer (CRC) patients is helpful as early detection of resectable metastasis has a survival benefit. Ultrasonography (USG) is a frequently used modality to detect liver recurrence, although international guidelines do not include it. To evaluate the potential added role of USG in early detection of CRC recurrence. We performed a retrospective analysis of 230 patients of colorectal cancer treated at our institute in 2013-2014 who underwent abdominal USG for surveillance. 77/230 (33%) developed recurrence, with liver being the second most common site (22/230)...
December 2018: Indian Journal of Surgical Oncology
Lingchuan Guo, Jianhong Fu, Shimei Sun, Minsheng Zhu, Lifeng Zhang, Hui Niu, Zhi Chen, Yongsheng Zhang, Lingling Guo, Shouli Wang
MicroRNAs, which regulate messenger RNAs, operate through a variety of signaling pathways to participate in the development of colorectal cancer (CRC). In this study, we found that miR-143-3p expression was significantly lower in both CRC and liver metastatic CRC tissues from liver compared with normal colonic tissues. Functional assays showed that miR-143-3p inhibited CRC cell invasion and migration in vitro. Using a bioinformatics approach, we identified miR-143-3p target mRNAs. Among the candidate targets, only the expression of integrin alpha 6 (ITGA6) and ArfGAP with the SH3 domain and ankyrin repeat and PH domain 3 (ASAP3) were significantly reduced by miR-143-3p mimics as examined by western blot, and the metastasis potential of CRC cells was attenuated by endogenous ITGA6 and ASAP3 knockdown, determined by migration and invasion assays...
December 11, 2018: Cancer Science
Mostafa Sarvizadeh, Faezeh Ghasemi, Fatemeh Tavakoli, Sara Sadat Khatami, Ebrahim Razi, Hossein Sharifi, Nousin Moussavi Biouki, Mohsen Taghizadeh
Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have introduced for detecting CRC in different stages particularly in early stages. The standard treatments for CRC are surgery, chemotherapy and radiotherapy, in alone or combination. Immunotherapy is a set of novel approaches with the aim of remodeling the immune system battle with metastatic cancer cells, such as immunomodulatory monoclonal antibodies (immune checkpoint inhibitors), adoptive cell transfer (ACT) and cancer vaccine...
December 9, 2018: Journal of Cellular Biochemistry
Kun Wang, Tengyan Li, Chang Xu, Yuhan Ding, Wenjing Li, Lei Ding
The dysregulation of the tight junctions (TJs) protein claudin-7 is closely related to the development and metastasis of colorectal cancer (CRC). The aim of this study was to investigate the expression of claudin-7 and characterize the relationship between claudin-7 expression and epithelial-mesenchymal transition (EMT) in CRC. In this study, the expression of claudin-7, E-cadherin, vimentin and snail-1 was detected by immunohistochemistry (IHC) in a set of 80 CRC specimens comprising 20 specimens each of well-differentiated, moderately differentiated, poorly differentiated and liver metastases tissues...
December 6, 2018: Biochemical and Biophysical Research Communications
Yang Feng, Yaqi Li, Weixing Dai, Shaobo Mo, Qingguo Li, Sanjun Cai
BACKGROUND/AIMS: Alpha-fetoprotein-producing colorectal cancer (AFPP-CRC) is quite rarely seen. This study aimed to elucidate the clinicopathologic characteristics and prognostic factors of AFPP-CRC. METHODS: Among 5,051 colorectal cancer patients receiving surgery in the Fudan University Shanghai Cancer Center from 2006 to 2016, we identified 78 patients with elevated serum level of AFP (> 10 µg/L) preoperatively. A propensity score matching (PSM) analysis was performed which matched 75 AFPP-CRC patients to the same number of AFP-negative colorectal cancer (AFPN-CRC) patients...
2018: Cellular Physiology and Biochemistry
Cecilie Okholm, Talie Khadem Mollerup, Nicolai Aagaard Schultz, Rune Broni Strandby, Michael Patrick Achiam
INTRODUCTION: Liver metastases are the most common complication to colorectal cancer, and the presence of metastatic disease severely impacts the overall prognosis of the disease. Since the diagnostic work-up of metastasised colorectal cancer has undergone tremendous changes in past decades, an impact on the incidence of metastatic disease is anticipated. The aim of this study was to evaluate the incidence and prognosis of liver metastasis in patients with colorectal cancer. METHODS: From 1 January 2005 to 31 December 2011, all patients with a primary diagnosis of colorectal cancer were identified...
December 2018: Danish Medical Journal
Feng Xu, Bin Tang, Tian-Qiang Jin, Chao-Liu Dai
Liver metastasis (LM) is one of the major causes of death in patients with colorectal cancer (CRC). Approximately 60% of CRC patients develop LM during the course of their illness. About 85% of these patients have unresectable disease at the time of presentation. Surgical resection is currently the only curative treatment for patients with colorectal LM (CRLM). In recent years, with the help of modern multimodality therapy including systemic chemotherapy, radiation therapy, and surgery, the outcomes of CRLM treatment have significantly improved...
November 26, 2018: World Journal of Clinical Cases
Hailan He, Wei Shen, Wei Chen, Huanhuan Liu, Wei Gong, Jihong Fu, Xuguang Hu, Long Cui
OBJECTIVE: To explore the prognostic factors of patients with unresectable liver metastasis colorectal cancer after failed conversion chemotherapy. METHODS: A retrospective, case-controlled study was performed. Study subjects were 105 patients who were diagnosed with synchronous liver metastasis colorectal cancer after failed chemotherapy (metastasis evaluated as unresectable after the conversion chemotherapy) at Xinhua Hospital, Shanghai Jiaotong University from January 2012 to December 2015...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Tyler J Mouw, Jennifer Lu, Meghan Woody-Fowler, John Ashcraft, Joseph Valentino, Peter DiPasco, Joshua Mammen, Mazin Al-Kasspooles
Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer. Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Cancers other than colorectal adenocarcinoma and high grade appendiceal carcinoma were excluded...
October 2018: Journal of Gastrointestinal Oncology
Heeji Shin, Chan Wook Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
BACKGROUND: The aim of this study was to identify the prognostic factors affecting recurrence and survival in patients who underwent curative intent surgery for colorectal cancer (CRC) with a single liver metastasis. METHODS: Between January 2006 and August 2012, we retrospectively evaluated 141 patients for CRC with single liver metastasis underwent curative intent surgery for colon and liver simultaneously. Some patients (11.3%) had radiofrequency ablation as an option...
November 28, 2018: ANZ Journal of Surgery
Masanori Oshi, Georgios Antonios Margonis, Yu Sawada, Nikolaos Andreatos, Jin He, Takafumi Kumamoto, Daisuke Morioka, Christopher Lee Wolfgang, Kuniya Tanaka, Matthew John Weiss, Itaru Endo
OBJECTIVE: The aim of this study was to examine if the prognostic significance of margin status in hepatectomy for colorectal cancer liver metastasis (CRLM) varies for different levels of tumor burden because hepatectomy indications for CRLM have been recently expanded to include patients with a higher tumor burden in whom achieving an R0 resection is difficult. METHODS: Clinicopathological variables in an exploration cohort of 290 patients receiving hepatectomy in Japan for CRLM were investigated...
November 27, 2018: Annals of Surgical Oncology
Yangyang Chen, Yifei Liu, Yanhong Zhou, Hongxia You
The occurrence of colorectal cancer (CRC) is associated with a variety of oncogenes and tumor‑suppressor genes. As a tumor‑suppressor gene, the liver kinase B1 gene (LKB1, also known as serine/threonine kinase 11, STK11) is closely related to tumor angiogenesis, invasion and metastasis, but its molecular mechanisms remain unclear. The aim of the present study was to investigate the effects of LKB1 on the invasion and metastasis of CRC, and to explore its molecular mechanisms. By detecting the expression of LKB1 in CRC, we can provide a reference index for diagnosing the depth of invasion and lymph node metastasis...
November 21, 2018: Oncology Reports
Dimitrios Moris, Diamantis I Tsilimigras, Nikolaos Machairas, Katiuscha Merath, Marcelo Cerullo, Natasha Hasemaki, Anastasia Prodromidou, Jordan M Cloyd, Timothy M Pawlik
While colorectal and hepatic resections are commonly performed through a laparoscopic approach, the safety and feasibility of total laparoscopic synchronous resections (LSR) of colorectal liver metastasis (CRLM) have not been established. In this systematic review, short- and long-term outcomes were comparable for patients undergoing LSR and open synchronous resection. LSR was safe and feasible for patients with synchronous CRLM and should be considered in well-selected patients.
November 27, 2018: Journal of Surgical Oncology
Corey T Jensen, Nicolaus A Wagner-Bartak, Lan N Vu, Xinming Liu, Bharat Raval, David Martinez, Wei Wei, Yuan Cheng, Ehsan Samei, Shiva Gupta
Purpose To evaluate colorectal cancer hepatic metastasis detection and characterization between reduced radiation dose (RD) and standard dose (SD) contrast material-enhanced CT of the abdomen and to qualitatively compare between filtered back projection (FBP) and iterative reconstruction algorithms. Materials and Methods In this prospective study (from May 2017 through November 2017), 52 adults with biopsy-proven colorectal cancer and suspected hepatic metastases at baseline CT underwent two portal venous phase CT scans: SD and RD in the same breath hold...
November 27, 2018: Radiology
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