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https://www.readbyqxmd.com/read/30290157/long-non-coding-rna-hoxd-as1-in-cancer
#1
REVIEW
Lianlian Li, Yong Wang, Xiaoyu Zhang, Qiwei Huang, Yutao Diao, Haipeng Yin, Hongyan Liu
Cancer is one of the leading causes of death worldwide with a high risk of incidence and mortality. Long non-coding RNAs (lncRNAs) have been shown to participate in various biological processes, including tumorigenesis and progression. The HOXD-AS1 (also known as HAGLR and Mdgt) gene is located between the HOXD1 and HOXD3 genes in the HOXD cluster and has been reported to play a critical role in the development and progression of cancers. This review summarizes the current knowledge on the biological functions and mechanisms of HOXD-AS1 in different human cancers, including bladder, cervical, colorectal, gastric, ovarian, and prostate cancers, glioma, hepatocellular carcinoma, melanoma, osteosarcoma, and non-small cell lung cancer...
October 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30212475/trend-analysis-of-major-cancer-statistics-according-to-sex-and-severity-levels-in-korea
#2
Minsu Ock, Woong Jae Choi, Min-Woo Jo
Existing epidemiologic reports or studies of cancer statistics in Korea lack sufficient data on cancer severity distributions and observed survival rates. This study analyzed trends in major cancer statistics according to sex and severity levels in Korea from 2006 to 2013. We included eight cancers (hepatocellular carcinoma, and thyroid, colorectal, gastric, lung, prostate, breast, and cervical cancer), using Korea Central Cancer Registry data. Severity level was classified by Surveillance, Epidemiology, and End Results (SEER) stage as follows: localized, regional, distant, or unknown...
2018: PloS One
https://www.readbyqxmd.com/read/30107989/small-nucleolar-rna-host-gene-1-a-new-biomarker-and-therapeutic-target-for-cancers
#3
REVIEW
Lining Huang, Xingming Jiang, Zhidong Wang, Xiangyu Zhong, Sheng Tai, Yunfu Cui
OBJECTIVES: Long non-coding RNAs (lncRNAs), a group of transcripts with length greater than 200 nucleotides, have been involved in multiple pathophysiological processes of the human body, especially in tumorigenesis and progression of cancers. The aberrant expression of lncRNAs processes crucial functions involved in proliferation, apoptosis and metastatic capacity of cancers. Recent studies have revealed that small nucleolar RNA host gene 1 (SNHG1), a long non-coding RNA transcribed from UHG, was located in chromosome 11...
September 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30096220/plncrna-1-is-overexpressed-in-retinoblastoma-and-regulates-retinoblastoma-cell-proliferation-and-motility-through-modulating-cbr3
#4
Shuna Wang, Jianwei Liu, Yang Yang, Fengqin Hao, Laixia Zhang
PlncRNA-1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, and gastric cancer. The expression pattern of PlncRNA-1 in retinoblastoma remained unknown. Therefore, the aim of this study was to explore the clinical significance of PlncRNA-1 in retinoblastoma patient and the biological function and molecular mechanism of PlncRNA-1 in regulating retinoblastoma cell proliferation, migration, and invasion. The results showed the level of PlncRNA-1 expression was obviously increased in retinoblastoma tissues and cell lines compared with compared with normal retina tissues and retina cell lines, respectively...
October 2018: IUBMB Life
https://www.readbyqxmd.com/read/29903571/role-of-cxcl12-and-cxcr4-in-the-pathogenesis-of-hematological-malignancies
#5
Amnon Peled, Shiri Klein, Katia Beider, Jan A Burger, Michal Abraham
The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in many type of tumors including lymphoma, leukemia, glioma, and prostate, breast, colorectal, renal, and hepatocellular carcinomas...
September 2018: Cytokine
https://www.readbyqxmd.com/read/29880086/the-effect-of-biochanin-a-on-cell-growth-apoptosis-and-migration-in-osteosarcoma-cells
#6
Ying Zhao, Ling Wang, Xueying Zhai, Tao Cui, Guijiang Wang, Qijun Pang
Biochanin A has been reported to be associated to tumour cell proliferation, apoptosis and drug resistance in hepatocellular carcinoma, prostate cancer, and colorectal cancer, etc, while the relation of biochanin A on osteosarcoma is not clear. Hence, in this study, we examined the effects of biochanin A treatment on osteosarcoma cell lines MG63 and U2OS on proliferation, apoptosis, invasion and migration. We then investigated the involved molecular mechanism and found a time- and dose-dependent inhibition of cell viability in MG63 and U2OS cells with biochanin A treatment...
June 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29804238/are-non-hiv-malignancies-increased-in-the-hiv-infected-population
#7
REVIEW
Aaron P Thrift, Elizabeth Y Chiao
PURPOSE OF REVIEW: The introduction of antiretroviral therapy (ART) has revolutionized HIV infection management, resulting in improved outcomes and survival for people living with HIV (PLWH). However, as PLWH are living longer and aging, non-AIDS-defining cancers (NADCs) represent a significant source of morbidity and mortality in the HIV-infected population. Here, we review the epidemiology of NADCs in PLWH. RECENT FINDINGS: Cancer mortality among PLWH is much higher than that among the general population...
May 26, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29786110/multi%C3%A2-layered-prevention-and-treatment-of-chronic-inflammation-organ-fibrosis-and-cancer-associated-with-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-activation-review
#8
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
August 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29763615/anticancer-activity-study-of-a-3-adenosine-receptor-agonists
#9
Gabriella Marucci, Claudia Santinelli, Michela Buccioni, Aleix Martí Navia, Catia Lambertucci, Anastasia Zhurina, Olli Yli-Harja, Rosaria Volpini, Meenakshisundaram Kandhavelu
AIMS: A3 adenosine receptor (A3 AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of potent and selective A3 AR agonists could be crucial for cancer drug development. MATERIALS AND METHODS: In the present study was determined the in vitro activity of known 1-3 and newly 4-6 synthesized compounds with high A3 AR affinity and selectivity (Ki in the low nanomolar range) in binding studies...
July 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29692736/the-function-and-mechanism-of-long-non-coding-rna-atb-in-cancers
#10
REVIEW
Huizhong Xiao, Fuyou Zhang, Yifan Zou, Jianfa Li, Yuchen Liu, Weiren Huang
Long non-coding RNAs (lncRNAs) are a class of transcriptional RNA molecules with a length of greater than 200 nucleotides that function as regulatory factors in many human diseases. Studies have shown that lncRNAs are involved in multiple cellular processes, including proliferation, apoptosis, migration, and invasion. In this report, a long non-coding RNA-ATB that is overexpressed in various tumor tissues and cell lines was investigated. Recent evidence suggests that ATB is dysfunctional in a variety of cancers, including hepatocellular carcinoma, gastric cancer (GC), colorectal cancer (CRC), breast cancer (BC), prostate cancer, renal cell carcinoma, non-small cell lung cancer (NSCLC), pancreatic cancer, osteosarcoma, and glioma...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29164842/tumor-suppressor-role-of-mir-503
#11
Gaurav Gupta, Dinesh K Chellappan, Terezinha de Jesus Andreoli Pinto, Philip M Hansbro, Mary Bebawy, Kamal Dua
MicroRNAs (miRNAs) are non-coding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate post-transcriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR‑503, an associate of the "canonical" miRNA-16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR‑503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells...
March 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29115416/annexin-a2-and-cancer-a-systematic-review
#12
REVIEW
Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall
Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated...
January 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29050933/foxk1-plays-an-oncogenic-role-in-the-development-of-esophageal-cancer
#13
Di Chen, Kai Wang, Xiaowei Li, Mingzuo Jiang, Lu Ni, Bing Xu, Yi Chu, Weijie Wang, Hua Wang, Huijie Kang, Kaichun Wu, Jie Liang, Gui Ren
Forkhead box k1 (FOXK1) is a member of the FOX class of transcription factors and it is dysregulated in many solid tumors including hepatocellular carcinoma, gastric cancer, colorectal cancer and prostate cancer. However, the expression status of FOXK1 and its clinical significance in esophageal cancer (EC) is still uncertain. Our study aimed at investigating the significance of FOXK1 expression in human EC and its biological function in the development of EC. We found that FOXK1 was overexpressed in EC tissues compared with corresponding non-tumor tissues using immunohistochemistry...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29031818/camptothecin-and-its-analog-sn-38-the-active-metabolite-of-irinotecan-inhibit-binding-of-the-transcriptional-regulator-and-oncoprotein-fubp1-to-its-dna-target-sequence-fuse
#14
Sabrina Khageh Hosseini, Stefanie Kolterer, Marlene Steiner, Viktoria von Manstein, Katharina Gerlach, Jörg Trojan, Oliver Waidmann, Stefan Zeuzem, Jörg O Schulze, Steffen Hahn, Dieter Steinhilber, Volker Gatterdam, Robert Tampé, Ricardo M Biondi, Ewgenij Proschak, Martin Zörnig
The transcriptional regulator FUSE Binding Protein 1 (FUBP1) is overexpressed in more than 80% of all human hepatocellular carcinomas (HCCs) and other solid tumor entities including prostate and colorectal carcinoma. FUBP1 expression is required for HCC tumor cell expansion, and it functions as an important pro-proliferative and anti-apoptotic oncoprotein that binds to the single-stranded DNA sequence FUSE to regulate the transcription of a variety of target genes. In this study, we screened an FDA-approved drug library and discovered that the Topoisomerase I (TOP1) inhibitor camptothecin (CPT) and its derivative 7-ethyl-10-hydroxycamptothecin (SN-38), the active irinotecan metabolite that is used in the clinics in combination with other chemotherapeutics to treat carcinoma, inhibit FUBP1 activity...
December 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28852726/phytochemistry-cytotoxicity-and-apoptosis-studies-of-b-sitosterol-3-o-glucoside-and-%C3%AE-amyrin-from-prunus-africana
#15
F Maiyo, R Moodley, M Singh
BACKGROUND: Prunus africana is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia. MATERIALS AND METHODS: In this study, compounds from the leaves and bark of this plant were isolated and tested for their cytotoxicity and apoptosis induction in two human cancer cell lines (hepatocellular carcinoma (HepG2) and colorectal carcinoma (Caco-2)) and a non-cancer cell line (embryonic kidney (HEK293)). GC-MS profiling of the extract was also conducted...
2016: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28759178/mutations-in-axin2-gene-as-a-risk-factor-for-tooth-agenesis-and-cancer-a-review
#16
REVIEW
Alena Hlouskova, Peter Bielik, Ondrej Bonczek, Vladimir J Balcar, Omar Šerý
AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer...
July 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28428642/-technology-and-prevention-in-the-era-of-mobile-health-applications-for-cancer-screening-programs
#17
Fabrizio Bert, Maria Rosaria Gualano, Salvatore Clemente, Giulia Villa, Roberta Siliquini
The Italian national health system provides screening to detect breast, colorecatal and cervical cancers, however, population adherence is not as high as expected. Smartphones and their applications (apps) could be used as a tool to communicate with the population and to help improve adherence. The aim of this study was to analyze the features and functions of smartphone applications aimed at secondary prevention of oncological diseases. In February 2016, we reviewed online app stores, using specific key-words, to search for available apps for cancer screening...
January 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28245474/mir-543-promotes-proliferation-and-epithelial-mesenchymal-transition-in-prostate-cancer-via-targeting-rkip
#18
Yang Du, Xiu-Heng Liu, Heng-Cheng Zhu, Lei Wang, Jin-Zhuo Ning, Cheng-Cheng Xiao
BACKGROUND/AIMS: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in the pathogenesis of prostate cancer has not been fully understood. METHODS: Expression of miR-543 and Raf Kinase Inhibitory Protein (RKIP) in clinical prostate cancer specimens, two prostate cancer cell lines, namely LNCAP and C4-2B, were determined...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28174483/dual-effect-of-wisp-1-in-diverse-pathological-processes
#19
Mengmeng Feng, Shuqin Jia
Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, belongs to the connective tissue growth factor (CTGF) family. WISP-1 is primarily expressed in embryonic stem cells and is involved in adult organ development. WISP-1 participates in many cellular processes, including proliferation, differentiation, apoptosis and adhesion. In addition, WISP-1 plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repairs and cancers. Recent studies showed that WISP-1 was highly correlated with tumor progression and malignant transformation, whereas it played an oncogenic role in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma and breast cancer...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28117699/synthesis-and-anticancer-activity-of-new-1-thia-4-azaspiro-4-5-decane-their-derived-thiazolopyrimidine-and-1-3-4-thiadiazole-thioglycosides
#20
Eman M Flefel, Wael A El-Sayed, Ashraf M Mohamed, Walaa I El-Sofany, Hanem M Awad
New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines and a number of compounds showed moderate to high inhibition activities...
January 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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