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Emergency Blood transfusion

Anis Hasnaoui, Raja Jouini, Dhafer Haddad, Haithem Zaafouri, Ahmed Bouhafa, Anis Ben Maamer, Ehsen Ben Brahim
BACKGROUND: Since the advent of immunohistochemistry for the diagnosis of stromal tumours, the incidence of leiomyosarcomas has significantly decreased. Nowadays, gastric leiomyosarcoma is an exceptionally rare tumour. We report the second case in the English literature of gastric leiomyosarcoma revealed with massive bleeding and hemodynamic instability and diagnostic pitfalls that we encountered. CASE PRESENTATION: A 63-year-old woman, with 2 years' history of dizziness and weakness probably related to an anaemic syndrome, presented to the emergency room with hematemesis, melena and hemodynamic instability...
August 17, 2018: BMC Surgery
Elliott C Fox, Venkata Manchala
BACKGROUND Retropharyngeal hematoma is a relatively rare diagnosis that requires a high clinical suspicion and stabilization of the airway to prevent rapid deterioration. We report a case of a spontaneous retropharyngeal hematoma in an elderly patient with myelodysplastic syndrome and associated thrombocytopenia. CASE REPORT A 90-year-old man with myelodysplastic syndrome was brought to the Emergency Department with complaints of difficulty swallowing and muffled voice for 24 hours. Upon arrival, his vital signs and physical exam were unremarkable, except that when he was asked to take a sip of water, he could not swallow it...
August 17, 2018: American Journal of Case Reports
Xin-Fang Zhu, Yu-Bo Wu, Li-Hui Yang, Rong Xia, Jing-Han Liu, Jiong-Cai Lan
OBJECTIVE: Through researching preoperative coagulation function in the case of ABO-identical blood insufficient for emergency rescue transfusion according to recommended programs of special emergency rescue transfusion was carried out, the relationship between volume of blood products and coagulation function was analyzed. METHODS: The surgical cases of blood transfusion more than 1 600 ml during operation were collected in our hospitals from Aug 2015 to Dec 2016(n=218), these cases were divided into the normal coagulation group(Group A) and abnormal coagulation group(Group B), and the patients of emergency rescue transfusion O type blood group(Group C)...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
George Drosos, Fotini Ampatzidou, Pantelis Sarafidis, Theodoros Karaiskos, Athanasios Madesis, Afroditi K Boutou
BACKGROUND: Most studies evaluating predictors of renal replacement therapy (RRT) following cardiac surgery use arbitrary defined limits of preoperative serum creatinine. The aim of this study was to evaluate the effect of preoperative renal function using either estimated-glomerular filtration rate (eGFR) derived using Chronic Kidney Disease-Epidemiology (CKD-EPI) or serum creatinine alone as a predictor for RRT after cardiac surgery. METHODS: In this prospective cohort study, baseline, intraoperative, and postoperative data of all patients who underwent an elective, urgent, or emergency cardiac surgery between 2012 and 2016 in a single center were analyzed in order to identify multivariate parameters determining the need for RRT after surgery...
August 15, 2018: American Journal of Nephrology
Meisheng Li, Qinghan Li, Qiucheng Lei, Jianyuan Hu, Fengjie Wang, Huanwei Chen, Zuojun Zhen
RATIONALE: Ectopic variceal bleeding due to hepaticojejunostomy (HJ) is unusual and difficult to manage. Reports on the use of side-to-side splenorenal shunt for severe bleeding from varices at HJ anastomosis are lacking. PATIENT CONCERNS: A 43-year-old man was admitted to our hospital with repeated episodes of hematemesis. He has a history of right hemihepatectomy with HJ reconstruction to the left hepatic duct for hilar cholangiocarcinoma. Two years after surgery, he presented with repeated episodes of hematemesis and underwent blood transfusion...
August 2018: Medicine (Baltimore)
Chalak Berzingi, Vinay Badhwar, Fahad Alqahtani, Sami Aljohani, Zakeih Chaker, Mohamad Alkhouli
Background: Early experience with transcatheter mitral valve replacement (TMVR) highlighted several investigational challenges related to this novel therapy. Conclusive randomised clinical trials in the field may, therefore, be years ahead. In the interim, contemporary outcomes of isolated surgical bioprosthetic mitral valve replacement (MVR) can be used as a benchmark for the emerging TMVR therapies. Methods: We used the nationwide inpatient sample to examine recent trends and outcomes of surgical bioprosthetic MVR for mitral regurgitation (isolated and combined)...
2018: Open Heart
Jose Thekkiniath, Sara Mootien, Lauren Lawres, Benjamin A Perrin, Meital Gewirtz, Peter J Krause, Scott Williams, Stone Doggett, Michel Ledizet, Choukri Ben Mamoun
Human babesiosis is an emerging zoonotic infectious disease caused by intraerythrocytic protozoan parasites of the genus Babesia Most cases of human babesiosis are caused by Babesia microti and often manifest in individuals over the age of 50 or in patients with a compromised immune system. Those who develop symptomatic B. microti infection usually experience months of asymptomatic infection after the acute infection has resolved. About a fifth of B. microti -infected adults never develop symptoms. These asymptomatically infected individuals sometimes donate blood and thereby can transmit B...
August 9, 2018: Journal of Clinical Microbiology
Kaori Ikegami, Takuma Yamagishi, Junya Tajima, Yukinori Inoue, Ken Kumagai, Yasuo Hirose, Daisuke Kondo, Koji Nikkuni
BACKGROUND: Thrombotic microangiopathy is caused by various conditions, but few cases secondary to trauma have been reported. We present the rare case of a patient with thrombotic microangiopathy-induced high-impact trauma with hemorrhagic shock. CASE PRESENTATION: An 86-year-old Japanese woman was transferred to our hospital after a traffic accident. A whole-body computed tomography scan revealed pelvic fractures with massive extravasation. She received a blood transfusion and emergency angiographic embolization...
August 9, 2018: Journal of Medical Case Reports
Masayasu Horibe, Yuki Ogura, Juntaro Matsuzaki, Tetsuji Kaneko, Takuya Yokota, Osamu Okawa, Yukihiro Nakatani, Eisuke Iwasaki, Toshihiro Nishizawa, Naoki Hosoe, Tatsuhiro Masaoka, Naohisa Yahagi, Shin Namiki, Takanori Kanai
Background: The need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis. Objective: We assessed the clinical predictive factors associated with poor short-term prognosis in patients with a low hemoglobin level. Methods: In this prospective cohort study, all consecutive patients with suspected acute UGIB at Tokyo Metropolitan Tama Medical Center were enrolled between 2008 and 2015...
June 2018: United European Gastroenterology Journal
Anoop Kumar, Manoj Kumar Rajput, Deepika Paliwal, Aakanksha Yadav, Reba Chhabra, Surinder Singh
Hepatitis C virus (HCV) infection is a blood borne and transfusion-transmitted infection (TTI). It has emerged as one of the major health challenges worldwide. In India, around 12-18 million peoples are infected with HCV, but in terms of prevalence percentage, its looks moderate due to large population. The burden of the HCV infection increases due to lack of foolproof screening of blood and blood products before transfusion. The qualified screening and quantification of HCV play an important role in diagnosis and treatment of HCV-related diseases...
May 2018: Indian Journal of Medical Research
Amirreza T Motameni, Rebekah A Hodge, William I McKinley, Jiliene M Georgel, Brian P Strollo, Matthew V Benns, Keith R Miller, Brian G Harbrecht
BACKGROUND: Hemorrhage is the most common cause of early death in trauma patients. Massive transfusion protocols (MTPs) have been designed to accelerate the release of blood products but can result in waste if activated inappropriately. The Assessment of Blood Consumption (ABC) score has become a widely accepted score for MTP activation. In this study, we compared the use of ABC criteria to physician judgment in MTP activation. METHODS: Adult trauma patients treated at University of Louisville Trauma Center from January 2016 to December 2016 were studied...
August 2018: Journal of Trauma and Acute Care Surgery
Arnaud Dupuis, Christian Gachet
Inherited platelet disorders are rare bleeding syndromes due to either platelet function abnormalities or thrombocytopenia which may be associated with functional defects. The haemorrhagic symptoms observed in these patients are mostly muco-cutaneous and of highly variable severity. Although 30 to 50% of the platelet disorders are still of unknown origin, the precise diagnosis of these pathologies by specialized laboratories together with haemorrhagic scores enables an assessment of the risk of bleeding in each patient...
August 1, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Norman J Galbraith, Stephen J O'Brien, Samuel P Walker, Sarah A Gardner, Hiram C Polk, Stephen L Barnes
BACKGROUND: Severe injury can lead to immune dysfunction and predispose patients to infection and death. Micro-RNAs regulate gene expression and may act as biomarkers for susceptibility to infection. The aim of this study was to examine the temporal and differential expression of previously identified dysregulated micro-RNAs in patients with severe injury. METHODS: Fourteen severely injured patients requiring transfusion were enrolled prospectively in this study approved by our institutional review board...
August 1, 2018: Surgery
Sharon R Lewis, Michael W Pritchard, David Jw Evans, Andrew R Butler, Phil Alderson, Andrew F Smith, Ian Roberts
BACKGROUND: Critically ill people may lose fluid because of serious conditions, infections (e.g. sepsis), trauma, or burns, and need additional fluids urgently to prevent dehydration or kidney failure. Colloid or crystalloid solutions may be used for this purpose. Crystalloids have small molecules, are cheap, easy to use, and provide immediate fluid resuscitation, but may increase oedema. Colloids have larger molecules, cost more, and may provide swifter volume expansion in the intravascular space, but may induce allergic reactions, blood clotting disorders, and kidney failure...
August 3, 2018: Cochrane Database of Systematic Reviews
Naresh Kumar, Nivetha Ravikumar, Joel Yong Hao Tan, Kutbuddin Akbary, Ravish Shammi Patel, Rajesh Kannan
Objective: To review the current status of salvaged blood transfusion(SBT) in metastatic spine tumour surgeries(MSTS), with regard to its safety&efficacy, contraindications, and adverse effects. We also aim to establish that the safety and adverse event profile of SBT is comparable and at least equal to that of allogeneic blood transfusion(ABT). Methods: Medline and Scopus were used to search for relevant articles, based on keywords such as "cancer surgery", "salvaged blood"&"circulating tumor cells"...
August 3, 2018: Neurospine
Katherine M Prioli, Julie Katz Karp, Nina M Lyons, Vera Chrebtow, Jay H Herman, Laura T Pizzi
BACKGROUND: US FDA draft guidance includes pathogen reduction (PR) or secondary rapid bacterial testing (RT) in its recommendations for mitigating risk of platelet component (PC) bacterial contamination. An interactive budget impact model was created for hospitals to use when considering these technologies. METHODS: A Microsoft Excel model was built and populated with base-case costs and probabilities identified through literature search and a survey of US hospital transfusion service directors...
July 31, 2018: Applied Health Economics and Health Policy
Alberto Conti, Daniele Molesti, Simone Bianchi, Stefania Catarzi, Mariuccia Mazzucchelli, Antonella Covelli, Andrea Tognarelli, Mafalda Ester Perrotta, Alessandro Pampana, Giovanni Orlandi, Iginio Dell'Amico, Alberto Baratta, Giuseppe Arena, Tito Torri
BACKGROUND: Clinical variables including hypertension could be linked with major bleeding events and death beyond vitamin K antagonist (warfarin) or direct oral anti-coagulants (DOACs) treatment strategy. METHODS: Subgroup analysis of major bleeding (primary endpoint) associated with clinical variables, site of bleeding, ongoing antithrombotics, reversal treatment or blood transfusion, outcomes (secondary endpoints) was performed in patients with bleeding events submitted to hard 5:1 propensity-score matching for hypertension...
September 2018: Critical Pathways in Cardiology
R I Mincu, T Rassaf, M Totzeck
BACKGROUND: Red blood cell transfusion remains controversial in patients with acute coronary syndromes and particularly in patients with ST-elevation myocardial infarction (STEMI). METHODS: We systematically searched PubMed, Cochrane, EMBASE, and Web of Science for studies published until January 2017 describing the outcomes in patients with STEMI who received red blood cell transfusion, compared with patients who did not. RESULTS: A total of 21,770 patients with STEMI from 5 cohort studies were included in the meta-analysis, 984 (4...
July 23, 2018: Netherlands Heart Journal
Laura Sotillo, Maria De la Calle, Fernando Magdaleno, Jose Luis Bartha
OBJECTIVE: This is a prospective observational study whose goal was to compare the effectiveness of carbetocin and oxytocin for prevention of postpartum hemorrhage (PPH) when they are administered in twin pregnancies undergoing a cesarean section. DESIGN: We enrolled 166 twin pregnancies at term undergoing elective or emergency cesarean section. We compared the effect of a single 100 µg dose of carbetocin with the use of oxytocin as a protocol (20 IU in Ringer lactate 500 ml in 10-15 min)...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
Hunter B Moore, Ernest E Moore, Michael P Chapman, Kevin McVaney, Gary Bryskiewicz, Robert Blechar, Theresa Chin, Clay Cothren Burlew, Fredric Pieracci, F Bernadette West, Courtney D Fleming, Arsen Ghasabyan, James Chandler, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Plasma is integral to haemostatic resuscitation after injury, but the timing of administration remains controversial. Anticipating approval of lyophilised plasma by the US Food and Drug Administration, the US Department of Defense funded trials of prehospital plasma resuscitation. We investigated use of prehospital plasma during rapid ground rescue of patients with haemorrhagic shock before arrival at an urban level 1 trauma centre. METHODS: The Control of Major Bleeding After Trauma Trial was a pragmatic, randomised, single-centre trial done at the Denver Health Medical Center (DHMC), which houses the paramedic division for Denver city...
July 28, 2018: Lancet
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