keyword
https://read.qxmd.com/read/38534883/uncommon-presentation-of-sarcoidosis-with-severe-thrombocytopenia-and-hemorrhagic-diathesis
#1
Dorela Lame, Michelangelo Pianelli, Shahram Kordasti, Erika Morsia, Attilio Olivieri, Antonella Poloni
Sarcoidosis, a multi-organ system disease, often presents insidiously. Thrombocytopenia in sarcoidosis is frequent because of hypersplenism, granulomas infiltrating the bone marrow, or immune thrombocytopenia (ITP). The diagnosis of ITP relies on exclusionary criteria, given the absence of a definitive laboratory diagnostic feature. In the era prior to modern ITP management, sarcoidosis-associated ITP was known to manifest severely, often showing resistance to treatment and an increased risk of mortality. In this case, we present a young male who was admitted to a district hospital's emergency room, displaying symptoms of hematuria, gingival bleeding, and a petechial rash...
March 4, 2024: Hematology Reports
https://read.qxmd.com/read/38531812/whole-blood-resuscitation-for-injured-patients-requiring-transfusion-a-systematic-review-meta-analysis-and-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma
#2
JOURNAL ARTICLE
Jonathan P Meizoso, Bryan A Cotton, Ryan A Lawless, Lisa M Kodadek, Jennifer M Lynde, Nicole Russell, John Gaspich, Adrian Maung, Christofer Anderson, John M Reynolds, Krista L Haines, George Kasotakis, Jennifer J Freeman
INTRODUCTION: Whole blood resuscitation has reemerged as a resuscitation strategy for injured patients. However, the effect of whole blood-based resuscitation on outcomes has not been established. The primary objective of this guideline was to develop evidence-based recommendations on whether whole blood should be considered in civilian trauma patients receiving blood transfusions. METHODS: An EAST working group performed a systematic review and meta-analysis utilizing the GRADE methodology...
March 27, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38530410/management-of-pancreatic-and-duodenal-trauma-in-childhood-a-university-hospital-experience-over-a-10-year-period
#3
JOURNAL ARTICLE
Agah Koray Mansiroglu, Emrullah Cesur, Binali Firinci, Ozgur Caglar, Murat Yigiter, Ahmet Bedii Salman
PURPOSE: Duodenal/pancreatic injuries occur in less than 10% of intra-abdominal injuries in pediatric blunt trauma. Isolated duodenal/pancreatic injuries occur in two-thirds of cases, while combined injuries occur in the remaining. This study aimed to investigate pediatric patients with pancreatic and duodenal trauma. METHODS: Data from 31 patients admitted to Atatürk University, Medical Faculty, Department of Pediatric Surgery for pancreatic/duodenal trauma between 2010 and 2019 were retrospectively analyzed...
March 26, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38528572/characteristics-of-traumatic-major-haemorrhage-in-a-tertiary-trauma-center
#4
JOURNAL ARTICLE
Pieter van Wyk, Marcus Wannberg, Anna Gustafsson, Jane Yan, Agneta Wikman, Louis Riddez, Carl-Magnus Wahlgren
BACKGROUND: Major traumatic haemorrhage is potentially preventable with rapid haemorrhage control and improved resuscitation techniques. Although advances in prehospital trauma management, haemorrhage is still associated with high mortality. The aim of this study was to use a recent pragmatic transfusion-based definition of major bleeding to characterize patients at risk of major bleeding and associated outcomes in this cohort after trauma. METHODS: This was a retrospective cohort study including all trauma patients (n = 7020) admitted to a tertiary trauma center from January 2015 to June 2020...
March 25, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38528484/umbilical-cord-blood-cell-characteristics-in-very-preterm-neonates-for-autologous-cell-therapy-of-preterm-associated-complications
#5
JOURNAL ARTICLE
Ren Zhuxiao, Han Jiangxue, Li Yongsheng, Pei Jingjun, Yang Shuo, Xu Fang, Zhang Qi, Zhang Shandan, Nie Chuan, Yang Jie
BACKGROUND: There are emerging clinical evidence for umbilical cord blood mononuclear cells (UCBMNCs) intervention to improve preterm complications. The first critical step in cell therapy is to obtain high-quality cells. This retrospective study aimed to investigate the quantity and quality of UCBMNCs from very preterm infants (VPIs) for the purpose of autologous cell therapy in prevention and treatment of preterm complications. METHODS: Very preterm infants (VPIs) born in Guangdong Women and Children Hospital from January 1, 2017, to December 8, 2022, from whom cord blood was successfully collected and separated for public or private banking, were enrolled...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38524802/second-trimester-spontaneous-fundal-rupture-of-unscarred-bicornuate-uterus-in-primipara-a-case-report-and-literature-review-jigjiga-university-sheik-hassen-yabare-comprehensive-specialized-hospital-jigjiga-ethiopia
#6
Hassen Mohammed Areys, Nour Hies Omer, Osman Ali Osman
BACKGROUND: Primary rupture of an unscarred uterus is rare. Spontaneous rupture of an unscarred bicornuate uterus is a life-threatening obstetric emergency with high morbidity and mortality in the mother and fetus; however, it most commonly occurs in the first trimester of pregnancy. CASE: A 20-year-old primigravid woman at 22 weeks of gestation, with no prior surgery, presented with severe abdominal pain, anemia, and hemodynamic instability. With a preoperative diagnosis of uterine rupture, she was transfused with three units of cross-matched whole blood and underwent emergency laparotomy...
2024: International Medical Case Reports Journal
https://read.qxmd.com/read/38524357/implementation-of-a-prehospital-whole-blood-program-lessons-learned
#7
JOURNAL ARTICLE
Matthew J Levy, Eric M Garfinkel, Robert May, Eric Cohn, Zachary Tillett, Christopher Wend, Robert A Sikorksi, Ruben Troncoso, J Lee Jenkins, Timothy P Chizmar, Asa M Margolis
Early blood administration by Emergency Medical Services (EMS) to patients suffering from hemorrhagic shock improves outcomes. Prehospital blood programs represent an invaluable resuscitation capability that directly addresses hemorrhagic shock and mitigates subsequent multiple organ dysfunction syndrome. Prehospital blood programs must be thoughtfully planned, have multiple safeguards, ensure adequate training and credentialing processes, and be responsible stewards of blood resources. According to the 2022 best practices model by Yazer et al, the four key pillars of a successful prehospital program include the following: (1) the rationale for the use and a description of blood products that can be transfused in the prehospital setting, (2) storage of blood products outside the hospital blood bank and how to move them to the patient in the prehospital setting, (3) prehospital transfusion criteria and administration personnel, and (4) documentation of prehospital transfusion and handover to the hospital team...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38524021/intraoperative-acute-cardiac-tamponade-as-a-result-of-intracardiac-perforation-requiring-emergency-continuous-pericardiocentesis-and-open-sternotomy-a-case-report-and-literature-review-of-a-rare-but-fatal-complication
#8
Christopher M Russo, Mitchell E Harrison, Nathaniel M Harry, John R Benjamin, Christian Popa
Intraoperative acute cardiac tamponade associated with iatrogenic intracardiac perforation from percutaneous interventional cardiac procedures is a rare but potentially catastrophic complication. We report a case of intraoperative acute hemopericardium caused by a left atrial (LA) perforation resulting in cardiac tamponade in a patient undergoing a baffling procedure for the correction of two anomalous pulmonary veins draining into her superior vena cava (SVC) that required continuous pericardiocentesis with autologous blood transfusion via the femoral vein and an emergency intraoperative transfer from the interventional cardiology cath lab to the cardiac operating room for an open sternotomy and primary repair...
February 2024: Curēus
https://read.qxmd.com/read/38517320/assessing-the-one-month-mortality-impact-of-civilian-setting-prehospital-transfusion-a-systematic-review-and-meta-analysis
#9
REVIEW
David W Schoenfeld, Carlo L Rosen, Tim Harris, Stephen H Thomas
BACKGROUND: Based on convincing evidence for outcomes improvement in the military setting, the past decade has seen evaluation of prehospital transfusion (PHT) in the civilian emergency medical services (EMS) setting. Evidence synthesis has been challenging, due to study design variation with respect to both exposure (type of blood product administered) and outcome (endpoint definitions and timing). The goal of the current meta-analysis was to execute an overarching assessment of all civilian-arena randomized controlled trial (RCT) evidence focusing on administration of blood products compared to control of no blood products...
March 22, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38517201/review-article-upper-gastrointestinal-bleeding-review-of-current-evidence-and-implications-for-management
#10
REVIEW
Dennis L Shung, Loren Laine
BACKGROUND: Acute upper gastrointestinal bleeding (UGIB) is a common emergency requiring hospital-based care. Advances in care across pre-endoscopic, endoscopic and post-endoscopic phases have led to improvements in clinical outcomes. AIMS: To provide a detailed, evidence-based update on major aspects of care across pre-endoscopic, endoscopic and post-endoscopic phases. METHODS: We performed a structured bibliographic database search for each topic...
March 22, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38513795/presumptive-spontaneous-hemothorax-associated-to-thymic-involution-in-a-dog-with-steroid-responsive-meningitis-arteritis-srma
#11
B Alcocer, P Bou, L Bosch, C Torrente
OBJECTIVE: To describe an unusual case of spontaneous hemothorax resulting from thymic involution in a dog with suspected acquired bleeding dyscrasia associated with steroid-responsive meningitis-arteritis (SRMA). CASE DESCRIPTION: A 6-month-old spayed female Golden Retriever was referred due to the sudden onset of lethargy, fever (pyrexia), loss of appetite (anorexia), and moderate neck pain. These symptoms emerged six days after an ovariohysterectomy performed by the primary veterinarian...
March 19, 2024: Topics in Companion Animal Medicine
https://read.qxmd.com/read/38512418/evaluation-of-management-of-ct-scan-proved-solid-organ-injury-in-blunt-injury-abdomen-a-prospective-study
#12
JOURNAL ARTICLE
Sourodip Mukharjee, Dinesh B V, Bharath S V
BACKGROUND: Trauma especially road traffic injury is one of the major health-related issues throughout the world, especially in developing countries like India (Mattox 2022). Solid organ injury is the most common cause of morbidity and mortality in patients with blunt abdominal trauma. The non-operative management (NOM) is being consistently followed for hemodynamically stable patients with respect to solid organ injuries. This study aims to provide an evidence base for management modalities of solid organ injuries in blunt abdominal trauma...
March 21, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38511866/factors-affecting-physicians-decision-to-start-prehospital-blood-product-transfusion-in-blunt-trauma-patients-a-cohort-study-of-helsinki-trauma-registry
#13
JOURNAL ARTICLE
Timo Jama, Rolf Lefering, Jouni Lauronen, Lauri Handolin
BACKGROUND: Prehospital blood transfusions are increasing as a treatment for bleeding trauma patients at risk for exsanguination. Triggers for starting transfusion in the field are less studied. We analyzed the factors affecting the decision of physicians to start prehospital blood product transfusion (PHBT) in blunt adult trauma patients. STUDY DESIGN AND METHODS: Data of all adult blunt trauma patients from the Helsinki Trauma Registry between March 2016 and July 2021 were retrospectively analyzed...
March 21, 2024: Transfusion
https://read.qxmd.com/read/38508946/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management
#14
JOURNAL ARTICLE
Juan Carlos Montano-Pedroso, Silvana Biagini, Maria Cristina Martins de Almeida Macedo, Glaciano Ribeiro, José Franciscos Comenalli Marques Junior, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Patient Blood Management (PBM) is a multidimensional approach that seeks to optimize the use of blood and its components in patients. This matter emerged as a response to the need to reduce unnecessary exposure to blood transfusions and their potential risks. In the past, blood transfusion was often overused resulting in complications and high costs. The advent of Patient Blood Management has caused a paradigm shift, highlighting anemia prevention, bleeding control and maximizing the production of blood cells by the organism itself...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38508489/life-threatening-hemorrhage-associated-with-a-dentigerous-cyst-in-a-dog-case-report
#15
Taylor Curley, Jenna K Rooks, Adesola Odunayo
Dentigerous cysts are the most common type of odontogenic cysts and arise from an unerupted tooth. These cysts have stereotypical radiographic and clinical findings. They can be extremely invasive but rarely present as a life-threatening emergency. This case report describes the stabilization and treatment of a 6-year-old mixed breed dog with a dentigerous cyst with concurrent life-threatening hemorrhage. The dog presented with severe oral hemorrhage from the mandibular artery and required multiple blood transfusions...
March 18, 2024: Topics in Companion Animal Medicine
https://read.qxmd.com/read/38507942/the-impact-of-anticoagulant-medications-on-fragility-femur-fracture-care-the-hip-and-femoral-fracture-anticoagulation-surgical-timing-evaluation-haste-study
#16
JOURNAL ARTICLE
M M Farhan-Alanie, R Chinweze, R Walker, W G P Eardley
INTRODUCTION: Due to their hypocoagulable state on presentation, anticoagulated patients with femoral fragility fractures typically experience delays to surgery. There are no large, multicentre studies previously carried out within the United Kingdom (UK) evaluating the impact of anticoagulant use in this patient population. This study aimed to evaluate the current epidemiology and compare the perioperative management of anticoagulated and non-anticoagulated femoral fragility fracture patients...
February 27, 2024: Injury
https://read.qxmd.com/read/38504263/effectiveness-and-safety-of-tourniquet-utilization-for-civilian-vascular-extremity-trauma-in-the-pre-hospital-settings-a-systematic-review-and-meta-analysis
#17
REVIEW
Ying-Chih Ko, Tou-Yuan Tsai, Chien-Kai Wu, Kai-Wei Lin, Ming-Ju Hsieh, Tzu-Pin Lu, Tasuku Matsuyama, Wen-Chu Chiang, Matthew Huei-Ming Ma
BACKGROUND: Tourniquets (TQ) have been increasingly adopted in pre-hospital settings recently. This study examined the effectiveness and safety of applying TQ in the pre-hospital settings for civilian patients with traumatic vascular injuries to the extremities. MATERIALS AND METHODS: We systematically searched the Ovid Embase, PubMed, and Cochrane Central Register of Controlled Trials databases from their inception to June 2023. We compared pre-hospital TQ (PH-TQ) use to no PH-TQ, defined as a TQ applied after hospital arrival or no TQ use at all, for civilian vascular extremity trauma patients...
March 19, 2024: World Journal of Emergency Surgery: WJES
https://read.qxmd.com/read/38501706/emergence-of-novel-circoviruses-in-humans-and-pigs-and-their-possible-importance-for-xenotransplantation-and-blood-transfusions
#18
JOURNAL ARTICLE
Tanja Opriessnig, Chao-Ting Xiao, Nicolas J Mueller, Joachim Denner
BACKGROUND: As sequencing is becoming more broadly available, virus discovery continues. Small DNA viruses contribute to up to 60% of the overall virus load in pigs. Porcine circoviruses (PCVs) are small DNA viruses with a single-stranded circular genome. They are common in pig breeds and have not been properly addressed for their potential risk in xenotransplantation. Whereas PCV1 is non-pathogenic in pigs, PCV2 has been associated with various disease manifestations. Recently two new circoviruses have been described, PCV3 and PCV4...
2024: Xenotransplantation
https://read.qxmd.com/read/38501231/survey-of-policies-at-us-hospitals-on-the-selection-of-rhd-type-of-low-titer-o-whole-blood-for-use-in-trauma-resuscitation
#19
JOURNAL ARTICLE
Skye Clayton, Christine M Leeper, Mark H Yazer, Philip C Spinella
BACKGROUND: Low-titer group O whole blood (LTOWB) use is increasing due to data suggesting improved outcomes and safety. One barrier to use is low availability of RhD-negative LTOWB. This survey examined US hospital policies regarding the selection of RhD type of blood products in bleeding emergencies. STUDY DESIGN AND METHODS: A web-based survey of blood bank directors was conducted to determine their hospital's RhD-type selection policies for blood issued for massive bleeding...
March 19, 2024: Transfusion
https://read.qxmd.com/read/38498943/a-novel-approach-to-retrograde-autologous-priming-for-infant-pediatric-and-adult-populations-undergoing-congenital-heart-surgery
#20
JOURNAL ARTICLE
Joseph Deptula, Vincent Olshove, Molly Oldeen, Deborah Kozik, Bahaaldin Alsoufi
INTRODUCTION: Retrograde Autologous Priming (RAP) of cardiopulmonary bypass (CPB) circuits is an effective way to reduce prime volume, commonly through the transfer of prime into separate reservoirs or circuit manipulation. We describe a simple and safe technique for RAP without the need for any circuit modifications or manipulations. METHODS: For this technique, a separate roller pump for ultrafiltration (UF) is used. After adequate heparinization and arterial cannulation, the UF pump is initiated slowly, removing prime through the effluent of the UF, replacing with the patient's blood from the aortic cannula...
March 18, 2024: Perfusion
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