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Thyroid teratoma treatment

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https://www.readbyqxmd.com/read/30317832/unexpected-false-positive-i-131-uptake-in-patients-with-differentiated-thyroid-carcinoma
#1
Aylin Oral, Bülent Yazıcı, Cenk Eraslan, Zeynep Burak
Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29946481/rare-clinical-entity-metastatic-malignant-struma-ovarii-diagnosed-during-pregnancy-lessons-for-management
#2
Corey J Lager, Ronald J Koenig, Richard W Lieberman, Anca M Avram
Background: Malignant struma ovarii is an ovarian teratoma containing at least 50% thyroid tissue which has the potential to metastasize and produce thyroid hormone. Given its rarity, management strategies are not well-established. We report a case of metastatic malignant struma ovarii discovered during pregnancy with lessons for evaluation and management. Case presentation: A 30-year-old woman who was two months pregnant was discovered to have struma ovarii with over half of the struma comprised of papillary thyroid cancer...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29848726/malignant-transformation-in-mature-cystic-teratomas-of-the-ovary-case-reports-and-review-of-the-literature
#3
REVIEW
Angiolo Gadducci, Sabina Pistolesi, Maria Elena Guerrieri, Stefania Cosio, Francesco Giuseppe Carbone, Antonio Giuseppe Naccarato
Malignant transformation occurs in 1.5-2% of mature cystic teratomas (MCT)s of the ovary and usually consists of squamous cell carcinoma, whereas other malignancies are less common. Diagnosis and treatment represent a challenge for gynecologic oncologists. The preoperative detection is very difficult and the diagnostic accuracy of imaging examinations is uncertain. The tumor is usually detected post-operatively based on histopathologic findings. This paper reviewed 206 consecutive patients who underwent surgery for a histologically-proven MCT of the ovary between 2010 and 2017...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29459090/-thyroid-carcinoma-on-struma-ovarii-diagnosis-and-treatment
#4
REVIEW
Coriolan Lebreton, Abir Al Ghuzlan, Anne Floquet, Michèle Kind, Sophie Leboulleux, Yann Godbert
Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, the treatment of TCSO is not consensual and should be validated in multidisciplinary team involved in rare ovarian carcinoma. The first treatment is a surgical removal, with a laparoscopic approach...
March 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29286966/isolated-scapular-metastasis-in-a-patient-with-malignant-struma-ovarii-a-case-report
#5
Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D'Almeida Costa, Américo Delgado Brilhante
CASE: We report the case of a 38-year-old woman who presented with a lytic bone lesion in the left scapula. A biopsy showed a tumor with the histologic appearance of thyroid tissue. She also was found to have a thyroid nodule and an enlarged ovary, both of which were excised. The thyroid nodule turned out to be a benign colloid nodule, and the ovary contained a monodermal teratoma composed of thyroid tissue (struma ovarii). The lesion in the scapula eventually was proven to be metastatic malignant struma ovarii...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29278520/malignant-struma-ovarii-harboring-a-unique-nras-mutation-case-report-and-review-of-the-literature
#6
REVIEW
Carlo Gobitti, Alessandro Sindoni, Chiara Bampo, Tanja Baresic, Giorgio Giorda, Lara Alessandrini, Vincenzo Canzonieri, Giovanni Franchin, Eugenio Borsatti
Struma ovarii (SO), a rare tumor containing at least 50% of thyroid tissue, represents approximately 5% of all ovarian teratomas; its malignant transformation rate is reported to occur in up to 10% of cases and metastases occur in about 5-6% of them. We describe a 36-year old woman who underwent laparoscopic left annessectomy two years earlier because of an ovarian cyst. Follow-up imaging revealed a right adnexal mass, ascitis and peritoneal nodes that were diagnosed as comprising a malignant SO with peritoneal secondary localizations at histopathology performed after intervention...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29250686/ovarian-strumal-carcinoid-case-report
#7
Delia Gabriela Ciobanu Apostol, Tudor Andrei BuŢureanu, Demetra Gabriela Socolov, Daniela Claudia Scripcaru, Oana LuminiŢa Rosin, Ludmila Lozneanu
Strumal carcinoid represents a rare form of ovarian teratoma, consisting of both thyroid tissue and carcinoid structures. The carcinoid component is a well-differentiated neuroendocrine tumor with excellent prognosis. Strumal carcinoid tumors are commonly found in peri-menopausal women who are not usually interested in preserving their fertility and who are thus open to radical surgical treatment. In this report, we present a 24-year-old, nulliparous patient with strumal carcinoid, confirmed by histopathology and a large panel of immunohistochemistry (IHC) markers, who wished to preserve her fertility...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28982046/treatment-and-follow-up-in-an-asymptomatic-malignant-struma-ovarii-a-case-report
#8
Antoni Llueca, Yasmine Maazouzi, Jose Luis Herraiz, Mari Carmen Medina, Dolors Piquer, Blanca Segarra, Raquel Del Moral, Anna Serra, Guillermo Bassols
INTRODUCTION: Struma ovarii is a rare ovarian tumor, representing 0.5-1% of all ovarian tumors and 2-5% of ovarian teratomas. It is defined as an ovarian teratoma composed mostly of thyroid tissue. The symptoms are nonspecific, and the imaging studies can help in characterize the mass; however, the definitive diagnosis is usually given by the Pathologist. Classically, the treatment is the surgical resection of the ovarian mass, however there is no consensus regarding the follow-up. PRESENTATION OF CASE: An asymptomatic malignant struma ovarii in a 43 year-old patient is presented...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28615984/papillary-thyroid-microcarcinoma-arising-within-a-mature-ovarian-teratoma-case-report-and-review-of-the-literature
#9
Maria M Pineyro, Jimena Pereda, Pamela Schou, Karina de Los Santos, Soledad de la Peña, Benedicta Caserta, Raul Pisabarro
Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28214816/-ovarian-teratomas-as-the-cause-of-diseases-of-the-nervous-endocrine-and-haematology-system
#10
REVIEW
Patrycja Ziober-Malinowska, Krzysztof Kułak, Elżbieta Witt, Matthias Korell, Jan Kotarski, Rafał Tarkowski
Teratomas are the most common tumors of the ovary occurring in girls and young women. Derived from primordial germ cell and embryonic gonads have the ability to differentiate into the three germ layers. In about 95% of cases are benign, and their most common form is a dermoid cyst of the ovary. This paper aims to present the relationship described tumors of autoimmune hemolytic anemia, anti-NMDA-dependent autoimmune inflammation of the brain and thyroid disease. It reminds us that teratomas are not always insulated disease entities and may have a significant impact on the course of coexisting diseases and their treatment...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27899309/repeated-misdiagnosis-of-a-relapsed-atypical-anti-nmda-receptor-encephalitis-without-an-associated-ovarian-teratoma
#11
Weihe Zhang, Li Yan, Jinsong Jiao
We present an atypical case of relapsed anti-NMDAR encephalitis in a young female patient without an associated ovarian teratoma. She presented with recurrent seizure attacks with muscle weakness, psychosis, dyskinesia, autonomic failure and insomnia. She was first misdiagnosed as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) then Hashimoto's encephalopathy due to diffuse cerebral lesions, elevated serum lactic acid concentration, increased amount of thyroid peroxidase and thyroglobulin antibodies in serum and diffuse lesions of the thyroid gland...
January 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27784193/successful-management-of-a-patient-with-malignant-thyroid-teratoma
#12
Guilherme Rabinowits, Justine Barletta, Lynette M Sholl, Encarnacion Reche, Jochen Lorch, Laura Goguen
BACKGROUND: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. PATIENT FINDINGS: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event...
January 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27563566/management-dilemma-of-thyroid-nodules-in-patients-with-malignant-struma-ovarii
#13
Sarah J Sternlieb, Celine Satija, David T Pointer, Byron E Crawford, Lacey Sullivan, Emad Kandil
Struma ovarii is a rare type of ovarian teratoma comprised of at least 50% thyroid tissue. While most are benign, 70% of malignant cases are diagnosed as papillary carcinoma. Management of patients with thyroid nodules following gynecologic surgery remains controversial and variable. Historically, the treatment of choice has been surgical removal to rule out ovarian carcinoma. Thyroid follow-up and further treatment options are guided by tumor characteristics. The patient in this case presented to the endocrine surgeon with multiple thyroid nodules, dysphagia and a history of struma ovarii that was surgically treated at an outside hospital...
August 2016: Gland Surgery
https://www.readbyqxmd.com/read/27478467/the-role-of-prenatal-ultrasound-assessment-in-management-of-fetal-cervicofacial-tumors
#14
Rafał Zieliński, Maria Respondek-Liberska
Ultrasound prenatal examination enables one to assess the facial skeleton and the neck from the first weeks of gestation. Cervicofacial tumors detected via prenatal ultrasound are very rarely reported fetal pathologies. They include cystic hygromas, teratomas, epulides, vascular tumors, and thyroid tumors. The tumor category, its location and vascularization pattern allow one to accurately establish a diagnosis which is usually confirmed by clinical examination of the neonate or a pathological examination (surgical specimen, biopsy, autopsy)...
August 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27258816/struma-ovarii-with-malignant-transformation-and-germline-kit-mutation-a-case-report-with-review-of-the-literature
#15
REVIEW
Deqin Ma, Natalya V Guseva, Laila Dahmoush, Robert A Robinson
Struma ovarii accounts for 5% of ovarian teratomas. Malignant transformation occurs in <0.3%, however, the underlying molecular mechanism is unknown. We report a patient with follicular variant and tall cell variant of papillary thyroid carcinoma (PTC) arising from struma ovarii and coexisting incidental PTC in the thyroid. Mutation analysis by next-generation sequencing identified a novel germline mutation, KIT p.V530I mutation in the tumors and normal ovarian and thyroid tissue. Immunohistochemical staining showed loss of KIT expression in the PTCs...
September 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27224256/metastatic-malignant-struma-ovarii-with-coexistence-of-hashimoto-s-thyroiditis
#16
Marco Russo, Ilenia Marturano, Romilda Masucci, Melania Caruso, Maria Concetta Fornito, Dario Tumino, Martina Tavarelli, Sebastiano Squatrito, Gabriella Pellegriti
UNLABELLED: Struma ovarii is a rare ovarian teratoma characterized by the presence of thyroid tissue as the major component. Malignant transformation of the thyroidal component (malignant struma ovarii) has been reported in approximately 5% of struma ovarii. The management and follow-up of this unusual disease remain controversial. We report the case of a woman with a history of autoimmune thyroiditis and a previous resection of a benign struma ovarii that underwent hystero-annexiectomy for malignant struma ovarii with multiple papillary thyroid cancer foci and peritoneal involvement...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/26997461/-benign-struma-ovarii-report-of-7-cases-and-review-of-the-literature
#17
REVIEW
G Lamblin, C Gallice, C Bournaud, B Nadaud, K Lebail-Carval, G Chene
OBJECTIVE: Struma ovarii is a monodermal teratoma composed of thyroid tissue, representing 0.85 to 1.3% of ovarian tumors. The objective of the present study is to report a continuous series of struma ovarii, with a comprehensive analysis of the literature. METHODS: A retrospective study in the gynecological surgery department of Hôpital Femme-Mère-Enfant (Hospices Civils de Lyon, Lyon, France) assessed a continuous series of struma ovarii from the Lyon East Pathology Center database...
May 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/26611341/head-and-neck-teratomas-in-children-a-series-of-23-cases-at-great-ormond-street-hospital
#18
Victoria Rebecca Carol Alexander, Joseph George Manjaly, Christopher M Pepper, Sonna N Ifeacho, Richard J Hewitt, Benjamin E J Hartley
OBJECTIVE: Head and neck teratomas are rare and malignant change is rarer still. This is a report detailing all of the teratomas treated by the ear, nose and throat or craniofacial teams over the last 28 years at our institution. Examining the common presenting and radiological features as well as our success rates compared to the current literature. METHOD: A retrospective review of all cases presenting to our institution with a head and neck teratoma were analysed...
December 2015: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/25745492/a-case-report-of-thyroid-carcinoma-confined-to-ovary-and-concurrently-occult-in-the-thyroid-is-conservative-treatment-always-advised
#19
Nunzia Brusca, Susanna Carlotta Del Duca, Rita Salvatori, Antonio D'Agostini, Pina Cannas, Maria Giulia Santaguida, Camilla Virili, Loredana Bianchi, Lucilla Gargano, Marco Centanni
INTRODUCTION: Struma ovarii is an ovarian teratoma, represented in more than 50% by thyroid tissue. Five percent of struma ovarii cases have been proven to be malignant and, as in the thyroid gland, papillary thyroid carcinoma is the most common histotype arising in struma ovarii. Because of the unusual occurrence of this tumor, its management and follow-up after pelvic surgery is still controversial. Usually, total thyroidectomy followed by radioiodine treatment is the choice treatment in metastatic malignant struma ovarii, while these procedures are still controversial in non-metastatic thyroid cancer arising in struma ovarii...
January 2015: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25600283/retrospective-chart-review-of-44-fetuses-with-cervicofacial-tumors-in-the-sonographic-assessment
#20
Rafal Zielinski, Maria Respondek-Liberska
OBJECTIVES: The aim of this retrospective study was to review and analyze ultrasonography examinations and follow-up of fetuses with cervicofacial tumors to develop bases for counseling specialist involved in perinatal treatment. METHODS: The study consisted of case series with chart review of 44 fetuses with cervicofacial tumors diagnosed in utero by ultrasonography. The study was carried in Department of Diagnosis and Prevention of Congenital Malformations, Medical University of Lodz in years 1998-2013...
March 2015: International Journal of Pediatric Otorhinolaryngology
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