keyword
https://read.qxmd.com/read/37213666/recombinant-klotho-attenuates-ifn%C3%AE-receptor-signaling-and-samhd1-expression-through-blocking-nf-%C3%AE%C2%BAb-translocation-in-glomerular-mesangial-cells
#21
JOURNAL ARTICLE
Kuen-Daw Tsai, Yi-Chao Lee, Bo-Yu Chen, Li-Syuan Wu, Shan-Yuan Liang, Ming-Yuan Liu, Yu-Wen Hung, Hui-Ling Hsu, Pei-Qi Chen, Jia-Ching Shieh, Yi-Ju Lee, Ting-Hui Lin
Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) is an IFNγ-inducible protein that modulates cellular dNTP levels. Mutations in the human SAMHD1 gene cause Aicardi-Goutières (AG) syndrome, an autoimmune disease sharing similar clinical features with systemic lupus erythematosus (SLE). Klotho is an anti-inflammatory protein which suppresses aging through multiple mechanisms. Implication of Klotho in autoimmune response is identified in rheumatologic diseases such as SLE...
2023: International Journal of Medical Sciences
https://read.qxmd.com/read/37204469/tetraspanin-tspan8-restrains-interferon-signaling-to-stabilize-intestinal-epithelium-by-directing-endocytosis-of-interferon-receptor
#22
JOURNAL ARTICLE
Jiang Min, Shenglan Yang, Yang Cai, David R Vanderwall, Zhiping Wu, Shuping Li, Songlan Liu, Beibei Liu, Jie Wang, Yingjun Ding, Junxiong Chen, Chao Jiang, Jonathan D Wren, Anna Csiszar, Zoltan Ungvari, Céline Greco, Tomoharu Kanie, Junmin Peng, Xin A Zhang
Inflammation can impair intestinal barrier, while increased epithelial permeability can lead to inflammation. In this study, we found that the expression of Tspan8, a tetraspanin expressed specifically in epithelial cells, is downregulated in mouse model of ulcerative disease (UC) but correlated with those of cell-cell junction components, such as claudins and E-cadherin, suggesting that Tspan8 supports intestinal epithelial barrier. Tspan8 removal increases intestinal epithelial permeability and upregulates IFN-γ-Stat1 signaling...
May 19, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37013128/cxcl8-promotes-glioma-progression-by-activating-the-jak-stat1-hif-1-%C3%AE-snail-signaling-axis-retraction
#23
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S224721.].
2023: OncoTargets and Therapy
https://read.qxmd.com/read/36934584/usp18-promotes-endometrial-receptivity-via-the-jak-stat1-and-the-isgylation-pathway
#24
JOURNAL ARTICLE
Xinyan Zhang, Suhua Gong, Haijing Li, Jiaqi Jiang, Yanni Jia, Ruixue Zhang, Haokun Liu, Aihua Wang, Yaping Jin, Pengfei Lin
Interferon-tau (IFNT), a pregnancy recognition signal in ruminants, promotes the establishment of endometrial receptivity by inducing the expression of interferon-stimulated genes (ISGs) via the Janus kinase/signal transducer and activator of transcription (JAK/STATs) signaling pathway. However, the precise mechanisms remain largely unknown. Ubiquitin-specific protease 18 (USP18) acts specifically on the ISGylation modification system to exert deubiquitination and participates in the regulation of the type I IFN signaling pathway...
March 11, 2023: Theriogenology
https://read.qxmd.com/read/36838711/-centipeda-minima-extract-inhibits-inflammation-and-cell-proliferation-by-regulating-jak-stat-signaling-in-macrophages-and-keratinocytes
#25
JOURNAL ARTICLE
Yuanqiang Ma, Byoung Ha Kim, Sang Kyu Yun, Yoon-Seok Roh
Psoriasis, a chronic inflammation-mediated skin disease, affects 2-3% of the global population. It is characterized by keratinocyte hyperproliferation and immune cell infiltration. The JAK/STAT3 and JAK/STAT1 signaling pathways play an important role in the development of psoriasis when triggered by IL-6 and IFN-γ, which are produced by dendritic cells and T-lymphocytes. Thus, blocking JAK/STAT signaling may be a potential strategy for treating psoriasis. Therefore, we examined the effects of CMX, an extract of Centipeda minima enriched in Brevilin A, Arnicolide D, Arnicolide C, and Microhelenin C, on macrophages and keratinocytes...
February 11, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36766197/the-protective-role-of-scorias-spongiosa-polysaccharide-based-microcapsules-on-intestinal-barrier-integrity-in-dss-induced-colitis-in-mice
#26
JOURNAL ARTICLE
Yingyin Xu, Huiyu Feng, Zhiyuan Zhang, Qian Zhang, Jie Tang, Jie Zhou, Yong Wang, Weihong Peng
Scorias spongiosa , a type of edible fungus, is beneficial for intestinal health. However, the mechanisms by which polysaccharides derived from S . spongiosa contribute to the integrity of the intestinal barrier have been little investigated. In the present study, 40 C57BL/6J mice were assigned into five groups: (1) Normal; (2) Dextran sulfate sodium (DSS)Administration; (3) DSS + Uncapped polysaccharides; (4) DSS + Low microcapsules; (5) DSS + High microcapsules. After one week of administration of S. spongiosa polysaccharides, all mice, excluding the Normal group, had free access to the drinking water of 3...
February 3, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36738214/-dickkopf-1-inhibits-the-secretion-of-muc5ac-induced-by-mycoplasma-pneumoniae-p1-c-in-mouse-lung-epithelial-cells
#27
JOURNAL ARTICLE
Juan Shi, Chunji Ma, Xiujing Hao, Haixia Luo, Min Li
Mycoplasma pneumoniae is the most common pathogen of respiratory tract infection in children and adults. Clinical observation shows that M . pneumoniae infection can cause massive mucus secretion in the respiratory tract, which makes the breathing of patients difficult. Studies have shown that M . pneumoniae infection can cause massive secretion of mucin 5AC (MUC5AC). Adhesin P1 plays an important role in the pathogenesis of M . pneumoniae infection by mediating the adhesion of pathogens to host cells, and the C-terminal residues of P1 (P1-C) are immunogenic...
January 25, 2023: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/36584854/ifi44l-as-a-novel-epigenetic-silencing-tumor-suppressor-promotes-apoptosis-through-jak-stat1-pathway-during-lung-carcinogenesis
#28
JOURNAL ARTICLE
Yong Zeng, Hong-Qiang Chen, Zhe Zhang, Jun Fan, Jing-Zhi Li, Shi-Meng Zhou, Na Wang, Su-Peng Yan, Jia Cao, Jin-Yi Liu, Zi-Yuan Zhou, Wen-Bin Liu
Numerous evidence showed that the occurrence and development of lung cancer is closely related to environmental pollution. Therefore, new environmental response predictive markers are urgently needed for early diagnosis and screening of lung cancer. Interferon-induced protein 44-like (IFI44L) has been shown to be related in a variety of tumors, but its function and mechanism during lung carcinogenesis still have remained largely unknown. In this study, gene expression and methylation status were analyzed through online tools and malignant transformation models...
December 27, 2022: Environmental Pollution
https://read.qxmd.com/read/36550792/structural-elucidation-and-anti-inflammatory-activity-of-a-proteoglycan-from-spent-substrate-of-lentinula-edodes
#29
JOURNAL ARTICLE
Zhong Zhang, Di Wu, Wen Li, Wanchao Chen, Yanfang Liu, Jingsong Zhang, Jianing Wan, Hailong Yu, Shuai Zhou, Yan Yang
A proteoglycan LEPS1 was firstly isolated and purified from the spent substrate of Lentinula edodes, an agricultural waste that may cause environmental pollution. The average molecular weight of LEPS1 was 1.18 × 104  g/mol, and carbohydrate moiety (88.9 %) was composed of glucose, arabinose, galactose, xylose and mannose at a molar ratio of 1.2:1.2:1.0:2.3:1.1. The protein moiety (8.5 %) of LEPS1 was bonded to the polysaccharide chain via O-glycosidic linkage. LEPS1 could significantly improve the inflammatory injury of LPS stimulated RAW264...
January 1, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/36535573/targeting-type-i-ifn-stat1-signaling-inhibited-and-reversed-corneal-squamous-metaplasia-in-aire-deficient-mouse
#30
JOURNAL ARTICLE
Yaoyao Yu, Shengqian Dou, Peng Peng, Li Ma, Xia Qi, Ting Liu, Yang Yu, Chao Wei, Weiyun Shi
Corneal transparency and integrity are essential for obtaining good vision; nevertheless, squamous metaplasia (SQM) of ocular epithelium is a kind of serious blinding corneal diseases, without therapeutic medication in clinic. Here, we found that deficiency of the autoimmune regulator (AIRE) in corneas spontaneously developed corneal plaques. Using corneal abrasion model, we revealed that deletion of Aire not only resulted in delayed corneal re-epithelialization, but also promoted a cell-fate transition from transparent corneal epithelium to keratinized epithelium,histopathologically characterized with SQM based on the transcriptomic analysis...
December 16, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/36499045/integrated-transcriptome-and-metabolome-analysis-reveals-the-regulatory-mechanisms-of-fasn-in-geese-granulosa-cells
#31
JOURNAL ARTICLE
Xi Chen, Kailiang Huang, Shenqiang Hu, Gang Lan, Xiang Gan, Shanyan Gao, Yan Deng, Jiwei Hu, Liang Li, Bo Hu, Hua He, Hehe Liu, Lu Xia, Jiwen Wang
FASN plays a critical role in lipid metabolism, which is involved in regulating ovarian follicular development. However, the molecular mechanisms of how FASN regulate the function of ovarian follicular cells still remain elusive. In this study, by overexpression or interference of FASN in pre-hierarchical follicle granulosa cells (phGCs) and hierarchical follicle granulosa cells (hGCs), we analyzed their effects on the granulosa cell transcriptome and metabolome profiles using RNA-Seq and LC-MS/MS, respectively...
November 25, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36475797/genome-wide-gain-of-function-screening-characterized-lncrna-regulators-for-tumor-immune-response
#32
JOURNAL ARTICLE
Yifei Wang, Yueshan Zhao, Weiwei Guo, Ghanshyam Singh Yadav, Chetana Bhaskarla, Zehua Wang, Xiaofei Wang, Sihan Li, Yue Wang, Yuang Chen, Dhamotharan Pattarayan, Wen Xie, Song Li, Binfeng Lu, Udai S Kammula, Min Zhang, Da Yang
The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8+ T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed that IL10RB-DT and LINC01198 are significantly correlated with tumor immune response and survival in melanoma and breast cancer. Specifically, IL10RB-DT suppresses CD8+ T cells activation via inhibiting IFN-γ-JAK-STAT1 signaling and antigen presentation in melanoma and breast cancer cells...
December 9, 2022: Science Advances
https://read.qxmd.com/read/36455758/macrophage-specific-xct-deficiency-drives-immune-activation-and-boosts-responses-to-immune-checkpoint-blockade-in-lung-cancer
#33
JOURNAL ARTICLE
Bufu Tang, Yajie Wang, Wangting Xu, Jinyu Zhu, Qiaoyou Weng, Weiqian Chen, Shiji Fang, Yang Yang, Rongfang Qiu, Minjiang Chen, Weiyang Mao, Min Xu, Zhongwei Zhao, Songhua Cai, Hongbing Zhang, Jiansong Ji
Tumor-associated macrophages (TAMs) play an important role in remodeling the tumor microenvironment (TME), which promotes tumor growth, immunosuppression and angiogenesis. Because of the high plasticity of macrophages and the extremely complex tumor microenvironment, the mechanism of TAMs in cancer progression is still largely unknown. In this study, we found that xCT (SLC7A11) was overexpressed in lung cancer-associated macrophages. Higher xCT in TAMs was associated with poor prognosis and was an independent predictive factor in lung cancer...
November 28, 2022: Cancer Letters
https://read.qxmd.com/read/36448712/exosomal-circnfix-promotes-angiogenesis-in-ovarian-cancer-via-mir-518a-3p-trim44-axis
#34
JOURNAL ARTICLE
Hui Ye, Rui-Yu Wang, Xiu-Zhang Yu, Yu-Ke Wu, Bo-Wen Yang, Meng-Yin Ao, Ming-Rong Xi, Min-Min Hou
Ovarian cancer (OC) is a gynecological cancer with high mortality. OC-derived exosomal circRNAs can regulate angiogenesis. This study aims to explore the role and mechanism of exosomal circRNA nuclear factor I X (CircNFIX) derived from OC cells in angiogenesis. Quantitative real-time polymerase chain reaction was employed to evaluate the levels of circNFIX, miR-518a-3p, and tripartite motif protein 44 (TRIM44) in OC and adjacent tissues. Exosomes from the ovarian surface epithelial cell (HOSEpiC) and OC cells (SKOV3 or OVCAR3) were isolated by differential centrifugation...
November 30, 2022: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/36426362/delamanid-suppresses-cxcl10-expression-via-regulation-of-jak-stat1-signaling-and-correlates-with-reduced-inflammation-in-tuberculosis-patients
#35
JOURNAL ARTICLE
Min Qiao, Shanshan Li, Jinfeng Yuan, Weicong Ren, Yuanyuan Shang, Wei Wang, Rongmei Liu, Fuzhen Zhang, Qing Li, Xiao Wu, Jie Lu, Mengqiu Gao, Yu Pang
BACKGROUND: Apart from bactericidal effects, anti-tuberculosis drugs can interfere with the host's immune system. In this study, we analyzed the role of delamanid (DLM), an inhibitor of mycolic acid synthesis of mycobacterial cell wall, on human macrophages. METHODS: Based on a cohort of multidrug-resistant tuberculosis (MDR-TB) patients treated with DLM, the levels of C-reaction protein (CRP) and cytokines in the plasma were monitored using immunoturbidimetric assay and flow cytometry, respectively...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36419754/zdhhc9-promotes-colon-tumor-growth-by-inhibiting-effector-t-cells
#36
JOURNAL ARTICLE
Xiaodan Chong, Lingxi Zhu, Dong Yu, Shasha Chen, Guang Wang, Qingzhuo Yu, Xianwei Ma, Jing Xu, Haitao Chen, Huazhang An
Zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) has been reported to play an important role in the occurrence and development of several types of cancer. However, its effects on colon cancer growth remain unclear. Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis...
January 2023: Oncology Letters
https://read.qxmd.com/read/36384075/candida-tropicalis-induces-nlrp3-inflammasome-activation-via-glycogen-metabolism-dependent-glycolysis-and-jak-stat1-signaling-pathway-in-myeloid-derived-suppressor-cells-to-promote-colorectal-carcinogenesis
#37
JOURNAL ARTICLE
Zhiyong Zhang, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Ziqian Bing, Yaojun Zheng, Yayi Hou, Sunan Shen, Yitian Chen, Tingting Wang
Our previous studies showed that Candida tropicalis promoted colorectal cancer (CRC) by activating the function of MDSCs. However, underlying molecular mechanisms remains to be further investigated. In the present study, we indicated that C. tropicalis induced NLRP3 inflammasome activation through Dectin-3 in myeloid-derived suppressor cells (MDSCs). Mechanistically, we identified that C. tropicalis significantly enhanced the levels of glycolysis dependent on glycogen metabolism in MDSCs, which was required for NLRP3 inflammasome activation...
November 13, 2022: International Immunopharmacology
https://read.qxmd.com/read/36374433/transcriptional-expression-of-cxcl10-and-stat1-in-lupus-nephritis-and-the-intervention-effect-of-triptolide
#38
JOURNAL ARTICLE
Dongliang Shi, Yan Li, Xiaomei Shi, Meihong Yao, Dan Wu, Yuhui Zheng, Qing Lin, Yinghong Yang
OBJECTIVE: This study screened out the key genes associated with the occurrence and development of lupus nephritis (LN) using bioinformatics methods, and then explored the expression of key genes in LN and the inhibitory effect of triptolide. METHODS: The GEO2R online tool in the GEO database was used to perform differential analysis of gene expression in LN tissues and normal kidney tissues. The GO function and KEGG pathway enrichment analysis of differentially expressed genes (DEGs), STRING, and Cytoscape software were used to build a protein-protein interaction network (PPI) to screen out the Hub gene...
November 14, 2022: Clinical Rheumatology
https://read.qxmd.com/read/36356302/a-novel-ripk1-inhibitor-reduces-gvhd-in-mice-via-a-non-immunosuppressive-mechanism-that-restores-intestinal-homeostasis
#39
JOURNAL ARTICLE
Xiaoliang Yu, Haikuo Ma, Bohan Li, Yuting Ji, Yayun Du, Siying Liu, Zhanhai Li, Yongjin Hao, Sheng Tian, Cong Zhao, Qian Du, Zhongqin Jin, Xueming Zhu, Yuanyuan Tian, Xin Chen, Xue Sun, Chengkui Yang, Fang Zhu, Jie Ju, Yunjing Zheng, Wei Zhang, Jingrui Wang, Tao Yang, Xinhui Wang, Jingjing Li, Xiangping Xu, Shujing Du, Haohao Lu, Feng Ma, Haibing Zhang, Yi Zhang, Xiaohu Zhang, Shaoyan Hu, Sudan He
Intestinal epithelial cells (IECs) are implicated in the propagation of T cell-mediated inflammatory diseases including graft-versus-host disease (GVHD), but the underlying mechanism remains poorly defined. Here, we report that IECs require receptor-interacting protein kinase-3 (RIPK3) to drive both gastrointestinal (GI) tract and systemic GVHD following allogeneic hematopoietic stem cell transplantation. Selectively inhibiting RIPK3 in IECs markedly reduces GVHD in murine intestine and liver. IEC RIPK3 cooperates with RIPK1 to trigger MLKL-independent production of T cell-recruiting chemokines and MHC class II molecules which amplify and sustain alloreactive T cell responses...
November 10, 2022: Blood
https://read.qxmd.com/read/36185620/the-interaction-of-the-ifn-%C3%AE-jak-stat1-and-jak-stat3-signalling-pathways-in-egfr-mutated-lung-adenocarcinoma-cells
#40
JOURNAL ARTICLE
Yaguang Han, Yan Zhang, Ying Tian, Miao Zhang, Cheng Xiang, Qiang Zhen, Jiabao Liu, Yanhong Shang, Yiyi Zhao, Huarui Si, Aixia Sui
Purpose: It was reported that the EGFR (epidermal growth factor receptor) mutation status was related to primary immune resistance in NSCLC (non-small-cell lung cancer). ICIs (immune checkpoint inhibitors) have poor efficacy and large side effects for people with EGFR mutation. EGFR mutation was considered as a sign of immune therapeutic resistance, but its underlying mechanism is difficult to be determined. Combined with our research basis, we tried to explore the possible mechanism of primary drug resistance in EFGR mutant lung adenocarcinoma through the interaction between the JAK/STAT1 and JAK/STAT3 pathway...
2022: Journal of Oncology
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