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JOURNAL ARTICLE
Maria A Diaz-Mateus, Laura L Machuca, Hanan Farhat, Silvia J Salgar-Chaparro
The synergistic corrosion effect of acid-producing bacteria (APB) and magnetite on carbon steel corrosion was assessed using two different microbial consortia. A synergistic corrosion effect was observed exclusively with Consortium 2, which was composed of Enterobacter sp., Pseudomonas sp., and Tepidibacillus sp. When Consortium 2 was accompanied by magnetite, uniform corrosion and pitting rates were one-time higher (0.094 mm/year and 0.777 mm/year, respectively) than the sum of the individual corrosion rates promoted by the consortium and deposit separately (0...
March 5, 2024: Applied Microbiology and Biotechnology
#22
JOURNAL ARTICLE
Claudia Betancourtt, Alexis M Catalán, Diego F Morales-Torres, Daniela N Lopez, Valentina Escares-Aguilera, Luis P Salas-Yanquin, Joseline A Büchner-Miranda, Oscar R Chaparro, Jorge Nimptsch, Bernardo R Broitman, Nelson Valdivia
Anthropogenic biodiversity loss poses a significant threat to ecosystem functioning worldwide. Numerically dominant and locally rare (i.e., transient) species are key components of biodiversity, but their contribution to multiple ecosystem functions (i.e., multifunctionality) has been seldomly assessed in marine ecosystems. To fill this gap, here we analyze the effects of a dominant and a transient species on ecosystem multifunctionality. In an observational study conducted along ca. 200 km of the southeastern Pacific coast, the purple mussel Perumytilus purpuratus numerically dominated the mid-intertidal and the dwarf mussel Semimytilus patagonicus exhibited low abundances but higher recruitment rates...
February 27, 2024: Marine Environmental Research
#23
JOURNAL ARTICLE
Mariangela Allocca, Gaia Catalano, Edoardo V Savarino, María Chaparro, Asaf Levartovsky, George Michalopoulos, Nikos Viazis, Fotis S Fousekis, Andreas Psistakis, Daniele Noviello, Catarina Neto do Nascimento, Benedicte Caron, Vassiliki Kitsou, Giorgos Bamias, María José García, Eirini Zacharopoulou, Kalliopi Foteinogiannopoulou, Ferdinando D'Amico, Ioannis Koutroubakis, Pierre Ellul, Maria Tzouvala, Laurent Peyrin-Biroulet, Joana Torres, Flavio Caprioli, Konstantinos Karmiris, Angeliki Theodoropoulou, Konstantinos H Katsanos, Dimitrios K Christodoulou, Gerassimos J Mantzaris, Uri Kopylov, Javier P Gisbert, Silvio Danese, Fernando Magro, Fornari Carla, Gionata Fiorino
BACKGROUND: Ustekinumab and tofacitinib have recently been approved for the management of moderate to severe ulcerative colitis (UC). However, there is no evidence on how they should be positioned in the therapeutic algorithm. The aim of this study was to compare tofacitinib and ustekinumab as third-line therapies in UC patients in whom anti-TNF and vedolizumab had failed. METHODS: This was a multicenter retrospective observational study. The primary outcome was disease progression, defined as the need for steroids, therapy escalation, UC-related hospitalization and/or surgery...
February 28, 2024: United European Gastroenterology Journal
#24
JOURNAL ARTICLE
T Brann, A Beltramini, C Chaparro, M Berriman, S R Doyle, A V Protasio
BACKGROUND: The genomic region that lies between the telomere and chromosome body, termed the subtelomere, is heterochromatic, repeat-rich, and frequently undergoes rearrangement. Within this region, large-scale structural changes enable gene diversification, and, as such, large multicopy gene families are often found at the subtelomere. In some parasites, genes associated with proliferation, invasion, and survival are often found in these regions, where they benefit from the subtelomere's highly plastic, rapidly changing nature...
February 27, 2024: BMC Genomics
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JOURNAL ARTICLE
Carlos A Reyes-Ortiz, Eliana Marín-Vargas, José Mauricio Ocampo-Chaparro
BACKGROUND AND AIMS: Social determinants of health (SDH) are critical in health outcomes. More insight is needed on the correlation between SDH and metabolic syndrome (MetS) in the aging population. This study assessed the association between SDH and MetS scores among older adults in Colombia. METHODS AND RESULTS: This cross-sectional country-wide study includes a sample of 4085 adults aged ≥60 from the SABE Colombia Survey. MetS measurements were central obesity, hyperglycemia or diabetes, hypertriglyceridemia, arterial hypertension, and low HDL cholesterol (MetS score 0-5)...
January 26, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#26
Valerie A Seitz, Bridget B McGivern, Mikayla A Borton, Jacqueline M Chaparro, Meagan E Schipanski, Jessica E Prenni, Kelly C Wrighton
Background Cover cropping is an agricultural practice that uses secondary crops to support the growth of primary crops through various mechanisms including erosion control, weed suppression, nutrient management, and enhanced biodiversity. Cover crops may elicit some of these ecosystem services through chemical interactions with the soil microbiome via root exudation, or the release of plant metabolites from roots. Phytohormones are one metabolite type exuded by plants that activate the rhizosphere microbiome, yet managing this chemical interaction remains an untapped mechanism for optimizing plant-soil microbiome interactions...
February 16, 2024: Research Square
#27
REVIEW
D V Estrada-Osorio, Ricardo A Escalona-Villalpando, M P Gurrola, Ricardo Chaparro-Sánchez, J A Rodríguez-Morales, L G Arriaga, J Ledesma-García
This article provides an overview of the work reported in the past decade in the field of microfluidic fuel cells. To develop appropriate research, the most commonly used electrocatalytic materials were considered and a new classification was proposed based on their nature: abiotic, hybrid, or biological. This classification allowed the authors to discern the information collected. In this sense, the types of electrocatalysts used for the oxidation of the most common fuels in different environments, such as glucose, ethanol, methanol, glycerol, and lactate, were presented...
February 21, 2024: ACS Meas Sci Au
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JOURNAL ARTICLE
Nataliya A Sakharova, Jorge M Antunes, André F G Pereira, Bruno M Chaparro, Tomás G Parreira, José V Fernandes
Two-dimensional (2D) nanostructures of aluminum nitride (AlN) and gallium nitride (GaN), called nanosheets, have a graphene-like atomic arrangement and represent novel materials with important upcoming applications in the fields of flexible electronics, optoelectronics, and strain engineering, among others. Knowledge of their mechanical behavior is key to the correct design and enhanced functioning of advanced 2D devices and systems based on aluminum nitride and gallium nitride nanosheets. With this background, the surface Young's and shear moduli of AlN and GaN nanosheets over a wide range of aspect ratios were assessed using the nanoscale continuum model (NCM), also known as the molecular structural mechanics (MSM) approach...
February 7, 2024: Materials
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JOURNAL ARTICLE
Alan Otero-Carrascal, Dora Chaparro-Ortiz, Purushothaman Srinivasan, Oscar Huerta, Edmundo Gutiérrez-Domínguez, Reydezel Torres-Torres
Based on S -parameter measurements, the effect of dynamic trapping and de-trapping of charge in the gate oxide, the increase of dielectric loss due to polarization, and the impact of leakage current on the small-signal input impedance at RF is analyzed and represented. This is achieved by systematically extracting the corresponding model parameters from single device measurements at different frequency ranges, and then the methodology is applied to analyze the evolution of these parameters when the device is submitted to non-conducting electrical stress...
February 7, 2024: Micromachines
#30
REVIEW
Nelia M Rodriguez, Pía Loren, Isis Paez, Constanza Martínez, Alejandra Chaparro, Luis A Salazar
Cardiovascular diseases are the leading cause of death worldwide, and arterial hypertension is a recognized cardiovascular risk factor that is responsible for high morbidity and mortality. Arterial hypertension is the result of an inflammatory process that results in the remodeling and thickening of the vascular walls, which is associated with an immunological response. Previous studies have attempted to demonstrate the relationship between oral disease, inflammation, and the development of systemic diseases...
February 6, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Juliana Salazar, Esther Garcia-Planella, Agnès Fernández-Clotet, Maria Esteve, Javier P Gisbert, David Busquets, Alfredo Lucendo, Lucía Márquez, Jordi Guardiola, María Dolores Martín-Arranz, Eva Iglesias, David Monfort, Albert Villoria, Fiorella Cañete, Olga Bell, Elena Ricart, Yamile Zabana, María Chaparro, Eugeni Domènech, Jordi Gordillo
AIMS: Methotrexate (MTX) is used to induce and maintain remission in patients with steroid-dependent Crohn's disease (CD). Despite its proven efficacy, its use is limited due to associated adverse events. Polymorphisms involving folate pathway genes might influence MTX efficacy and toxicity. We aimed to assess the impact of certain polymorphisms on the therapeutic outcomes of MTX in CD. METHODS: Patients with CD who exclusively followed MTX monotherapy and fulfilled inclusion criteria were identified from the GETECCU ENEIDA registry...
February 18, 2024: British Journal of Clinical Pharmacology
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JOURNAL ARTICLE
Me-Linh Luong, Yoshiko Nakamachi, Fernanda P Silveira, Catherine O Morrissey, Lara Danziger-Isakov, Erik A M Verschuuren, Cameron R Wolfe, Denis Hadjiliadis, Daniel C Chambers, Jignesh K Patel, Goran Dellgren, Miranda So, Geert M Verleden, Emily A Blumberg, Robin Vos, Michael Perch, Are M Holm, Nicholas J Mueller, Cecilia Chaparro, Shahid Husain
PURPOSE: Antimicrobial misuse contributes to antimicrobial resistance in thoracic transplant (TTx) and mechanical circulatory support (MCS) recipients. This study uses a modified Delphi method to define the expected appropriate antimicrobial prescribing for the common clinical scenarios encountered in TTx and MCS recipients. METHODS: An online questionnaire on managing 10 common infectious disease syndromes was submitted to a multidisciplinary Delphi panel of 25 experts from various disciplines...
February 13, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#33
JOURNAL ARTICLE
Nestor David Caicedo Buitrago, Diana Trejos Gallego, Maria Cristina Florián Pérez, Carlos Andrés Quintero Cardona, Cristian Chaparro Botero
BACKGROUND: Patients undergoing cardiac surgery are exposed to many factors that activate catabolic and inflammatory pathways, which affect skeletal muscle and are, therefore, related to unfavorable hospital outcomes. Given the limited information on the behavior of muscle mass in critically ill patients, the objective of this study was to evaluate the impact on quantitative and qualitative measurements of quadriceps muscle mass using ultrasound after cardiac surgery. To accomplish this, a prospective, descriptive, and correlational study was conducted at a tertiary care hospital...
February 12, 2024: The ultrasound journal
#34
JOURNAL ARTICLE
Zilac Espitaleta, Alex Domínguez-Vargas, Johanna Villamizar-Martínez, Martha Carrascal-Guzmán, Gustavo Guerrero-Tinoco, Diana Silva-Díaz, Richard Baquero, Claudia Pinto-Bernal, Luz González-Chaparro, Luisa Rojas-Rosas, Pilar Amado-Niño, Mariángel Castillo-Arteaga, Yeferson Alvarez-Gómez, Laura Arguello-Muñoz, William Morales-Camacho, Oscar León-Guerra, Eduardo Egea, Ricardo Galeano-Rodríguez, Ana Quintero-Gómez, Gustavo Aroca-Martínez, Carlos G Musso
Objectives. Atypical hemolytic uremic syndrome (aHUS) is a rare complement-mediated kidney disease with genetic predisposition and represents up to 10% of pediatric hemolytic uremic syndrome (HUS) cases. Few studies have evaluated aHUS in Latin American population. We studied a Colombian pediatric cohort to delineate disease presentation and outcomes. Methods. A multicenter cohort of 27 Colombian children with aHUS were included. Patients were grouped by age at onset. Clinical features were compared using analysis of variance (ANOVA) and Fisher exact tests...
2024: Global Pediatric Health
#35
REVIEW
Pauline Rivière, Christopher Li Wai Suen, María Chaparro, Peter De Cruz, Antonino Spinelli, David Laharie
Acute severe ulcerative colitis (ASUC) is a distinctive ulcerative colitis flare presentation characterised by the presence of systemic inflammation as well as bloody diarrhoea, and occurs at least once in 25% of patients with ulcerative colitis during their disease course. Each episode carries a risk of complications, need for colectomy, and mortality. Little is known about ASUC pathogenesis, although impaired host-microbiota crosstalk involving pathobionts is suspected. In this Review, we discuss unanswered questions and results from the latest research on the medical-first-line, second-line, and potential third-line therapies-and surgical management of ASUC...
March 2024: Lancet. Gastroenterology & Hepatology
#36
JOURNAL ARTICLE
Tomás Caycho-Rodríguez, Jonatan Baños-Chaparro, José Ventura-León, Sherman A Lee, Lindsey W Vilca, Carlos Carbajal-León, Daniel E Yupanqui-Lorenzo, Pablo D Valencia, Mario Reyes-Bossio, Nicol Oré-Kovacs, Claudio Rojas-Jara, Miguel Gallegos, Roberto Polanco-Carrasco, Mauricio Cervigni, Pablo Martino, Marlon Elías Lobos-Rivera, Rodrigo Moreta-Herrera, Diego Alejandro Palacios Segura, Antonio Samaniego-Pinho, Andrés Buschiazzo Figares, Diana Ximena Puerta-Cortés, Andrés Camargo, Julio Torales, José Arkangel Monge Blanco, Pedronel González, Vanessa Smith-Castro, Olimpia Petzold-Rodriguez, Raymundo Calderón, Wendy Yamilet Matute Rivera, Daniela Ferrufino-Borja, Agueda Muñoz-Del-Carpio-Toia, Jorge Palacios, Carmen Burgos-Videla, Ana María Eduviges Florez León, Ibeth Vergara, Diego Vega, Marion K Schulmeyer, Hassell Tatiana Urrutia Rios, Arelly Esther Lira Lira, Nicol A Barria-Asenjo, Jesús Ayala-Colqui, Luis Hualparuca-Olivera
This study aimed to characterize the network structure of pandemic grief symptoms and suicidal ideation in 2174 people from eight Latin American countries. Pandemic grief and suicidal ideation were measured using the Pandemic Grief Scale and a single item, respectively. Network analysis provides an in-depth characterization of symptom-symptom interactions within mental disorders. The results indicated that, "desire to die," "apathy" and "absence of sense of life" are the most central symptoms in a pandemic grief symptom network; therefore, these symptoms could be focal elements for preventive and treatment efforts...
February 6, 2024: Psychological Reports
#37
JOURNAL ARTICLE
Md Javed Foysal, Silvia J Salgar-Chaparro
The quantity and quality of DNA isolated from environmental samples are crucial for getting robust high-throughput sequencing data commonly used for microbial community analysis. The differences in the nature and physicochemical properties of environmental samples impact DNA yields, and therefore, an optimisation of the protocols is always recommended. For instance, samples collected from corroded areas contain high concentrations of metals, salts, and hydrocarbons that can interfere with several steps of the DNA extraction protocols, thereby reducing yield and quality...
February 5, 2024: Scientific Reports
#38
JOURNAL ARTICLE
Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto
PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of PF-07209960 were evaluated following once every other week subcutaneous (SC) or intravenous (IV) administration to cynomolgus monkeys in a repeat-dose PKPD (0.01-0.3 mg/kg/dose) and GLP toxicity study (0.1-3 mg/kg/dose). PF-07209960 showed dose dependent pharmacokinetics with a terminal T1/2 of 8 and 13 hours following IV administration at 0...
2024: PloS One
#39
JOURNAL ARTICLE
Sandeep Appunni, Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Mayur Doke, Mukesh Roy, Juan Gabriel Ruiz-Pelaez, Yanjia Zhang, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Sandra Chaparro, Javier Jimenez
OBJECTIVES: Many epidemiological studies have shown that coronavirus disease 2019 (COVID-19) disproportionately affects males, compared with females, although other studies show that there were no such differences. The aim of the present study was to assess differences in the prevalence of hospitalizations and in-hospital outcomes between the sexes, using a larger administrative database. METHODS: We used the 2020 California State Inpatient Database for this retrospective analysis...
February 2024: Southern Medical Journal
#40
JOURNAL ARTICLE
Gabriele Dragoni, Tommaso Innocenti, Aurelién Amiot, Fabiana Castiglione, Laura Melotti, Stefano Festa, Edoardo Vincenzo Savarino, Marie Truyens, Konstantinos Argyriou, Daniele Noviello, Tamas Molnar, Vincent Bouillon, Cristina Bezzio, Piotr Eder, Samuel Fernandes, Anna Kagramanova, Alessandro Armuzzi, Raquel Oliveira, Anna Viola, Davide Giuseppe Ribaldone, Ioannis Drygiannakis, Chiara Viganò, Francesca Calella, Antonietta Gerarda Gravina, Daniela Pugliese, María Chaparro, Pierre Ellul, Sophie Vieujean, Monica Milla, Flavio Caprioli
BACKGROUND AND AIMS: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the risk of post-operative complications of tofacitinib exposure before colectomy in comparison with biologics. METHODS: A multicentre, retrospective, observational study was conducted in patients with UC who underwent total colectomy for medically refractory disease, exposed to tofacitinib or a biologic before surgery...
February 2, 2024: American Journal of Gastroenterology
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