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James Anderson, George Tay, George Denby, Jan Robinson, James Douglas, Peter Robinson, Deanne Curtin
Patients with neuromuscular diseases benefit from coordinated multidisciplinary care to achieve best outcomes. The integration of multi-specialty healthcare delivered in a single clinic can be challenging for service providers due to cost and resource limitation. Our cross-sectional survey of 53 adult patients with neuromuscular disease across Queensland revealed only 27% support the introduction of an integrated multidisciplinary clinic. The most cited reason for opposition to a multidisciplinary clinic was a perceived loss of contact with one's usual doctor...
December 2018: Internal Medicine Journal
Jan Löhler, Martin Lehmann, Veronika Segler, Stefan Volkenstein, Rolf-Dieter Battmer, Arneborg Ernst, Frederike Gräbner, Peter Schlattmann, Rainer Schönweiler, Barbara Wollenberg, Stefan Dazert
BACKGROUND: In Germany, about 15 million people are suffering from hearing loss (HL), whereas only 16 % are using hearing aids. Untreated hearing loss may lead to severe complications (e. g. social isolation, depression, progress of dementia). An early and widespread screening, beginning at the age of 50, is meant to improve this shortage in medical care. By this study, the Mini-Audio-Test (MAT), a six-question and three-step answers containing questionnaire on subjective HL, should be verified on a normal collective of subjects (sensitivity (Se), specificity (Sp), positive predictive value (Ppv))...
December 5, 2018: Laryngo- Rhino- Otologie
Oana A Tatucu-Babet, Emma J Ridley
Outpatients who receive hyperbaric oxygen treatment (HBOT) may represent a group at significant risk of malnutrition owing to the underlying conditions that are often treated with HBOT (e.g., non-healing diabetic wounds and radiation-induced skin injury). In this issue, See and colleagues provide new, preliminary evidence of the prevalence of malnutrition in a small group of HBOT outpatients treated in an Australian hospital, reporting that approximately one-third of patients receiving HBOT were at risk of malnutrition...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Nada Ahmed, Mohamed Ismail Nounou, Alaa Abouelfetouh, Amal El-Kamel
OBJECTIVES: Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity according to label claim and pharmaceutical quality, of herbal slimming products in between 2015 and 2017...
December 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Charles Chazot, Guillaume Jean
Recently the concept that prescription of chronic hemodialysis (HD) start should be tailored based on residual renal function (RRF) and urine output (UO) has been revived from the past and called infrequent or incremental dialysis. It mainly consists in prescribing 1 or 2 HD sessions per week instead of what has become the standard thrice-weekly HD. It is both surprising and fascinating that almost 60 years after the first end-stage kidney disease patient was treated by Scribner et al. [Trans Am Soc Artif Intern Organs 1960; 6: 114-122], the nephrology community still questions the best way to start HD therapy...
December 5, 2018: Blood Purification
Wen-Ping Wang, Long-Qi Chen, Han-Lu Zhang, Yu-Shang Yang, Song-Lin He, Yong Yuan, Yun Wang
BACKGROUND: Intrathoracic esophagogastrostomy plays an important role in minimally invasive Ivor-Lewis esophagectomy for cancer. Intrathoracic anastomosis with robot-assisted Ivor-Lewis esophagectomy (RAILE) includes hand-sewn and circular stapler methods, which remain technically challenging. In this study, we modified the techniques for intrathoracic anastomosis at RAILE, in order to simplify the complex procedures. METHODS: "Side-insertion" technique was used for anvil placement and purse string suture for intrathoracic anastomosis at RAILE...
December 5, 2018: Digestive Surgery
Simone Tassani, Josep M Font-Llagunes, Miguel Ángel González Ballester, Jérôme Noailly
BACKGROUND: Muscular co-contraction is a strategy commonly used by elders with the aim to increase stability. However, co-contraction leads to stiffness which in turns reduces stability. Some literature seems to suggest an opposite approach and to point out relaxation as a way to improve stability. Teaching relaxation is therefore becoming the aim of many studies letting unclear whether tension or relaxation are the most effective muscular strategy to improve stability. Relaxation is a misleading concept in our society...
November 28, 2018: Gait & Posture
Guillaume Bompard, Juliette van Dijk, Julien Cau, Yoann Lannay, Guillaume Marcellin, Aleksandra Lawera, Siem van der Laan, Krzysztof Rogowski
Tubulin glutamylation is a reversible posttranslational modification that accumulates on stable microtubules (MTs). While abnormally high levels of this modification lead to a number of disorders such as male sterility, retinal degeneration, and neurodegeneration, very little is known about the molecular mechanisms underlying the regulation of glutamylase activity. Here, we found that CSAP forms a complex with TTLL5, and we demonstrate that the two proteins regulate their reciprocal abundance. Moreover, we show that CSAP increases TTLL5-mediated glutamylation and identify the TTLL5-interacting domain...
December 4, 2018: Cell Reports
Laura H Rosenberg, Anne-Laure Cattin, Xavier Fontana, Elizabeth Harford-Wright, Jemima J Burden, Ian J White, Jacob G Smith, Ilaria Napoli, Victor Quereda, Cristina Policarpi, Jamie Freeman, Robin Ketteler, Antonella Riccio, Alison C Lloyd
The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated with neuropathies. The histone deacetylases histone deacetylase 1 (HDAC1) and HDAC2 are required for the myelination transcriptional program. Here, we show a distinct role for HDAC3, in that, while dispensable for the formation of mSCs, it is essential for the stability of the myelin sheath once formed-with loss resulting in progressive severe neuropathy in adulthood...
December 4, 2018: Cell Reports
Amber M Brochetti, Steven W Brose, Angela M Kuemmel, David J Dang, Dennis J Bourbeau
OBJECTIVE: Persons with spinal cord injury (SCI) have a higher prevalence of being overweight than the general population, which is thought to be due to a variety of metabolic, physiologic and psychological changes. The quality improvement project described in this work was designed to help overweight persons with SCI lose bodyweight through nutrition, exercise, and behavioral management strategies. METHODS: Eighteen persons with SCI who were overweight were enrolled in a 12-week interdisciplinary weight management program...
December 5, 2018: Journal of Spinal Cord Medicine
I Allayarov, S Upendar, M A Schmidt, T Weiss
Based on the resonant-state expansion with analytic mode normalization, we derive a general master equation for the nonlinear pulse propagation in waveguide geometries that is valid for bound and leaky modes. In the single-mode approximation, this equation transforms into the well-known nonlinear Schrödinger equation with a closed expression for the Kerr nonlinearity parameter. The expression for the Kerr nonlinearity parameter can be calculated on the minimal spatial domain that spans only across the regions of spatial inhomogeneities...
November 23, 2018: Physical Review Letters
Kenta Takata, Masaya Notomi
We reveal a one-dimensional topological insulating phase induced solely by gain and loss control in non-Hermitian optical lattices. The system comprises units of four uniformly coupled cavities, where the successive two have loss; the others experience gain, and they are balanced under two magnitudes. The gain and loss parts are effectively dimerized, and a bulk band gap, topological transition, midgap topological edge, and interface states in finite systems can all be achieved by controlled pumping. We also clarify non-Hermitian topological invariants and edge states in gapless conditions...
November 23, 2018: Physical Review Letters
Helena Sandoval-Insausti, Raúl F Pérez-Tasigchana, Esther López-García, José R Banegas, Fernando Rodríguez-Artalejo, Pilar Guallar-Castillón
BACKGROUND: The prospective association between protein intake and falls has been little studied. We assessed this association in a Spanish community-dwelling cohort. METHODS: We performed a prospective cohort study of 2464 men and women 60 years or older who were recruited in 2008-2010 and followed up through 2012. At baseline, the habitual protein intake was determined with a validated dietary history. At the end of follow-up, participants reported the number of falls experienced in the preceding year...
December 5, 2018: Journal of the American Geriatrics Society
Paolo Armando Gagliardi, Luca Primo
Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCKα) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by proteases. How caspases acquired the ability to control these proteins during evolution of vertebrates is still unknown. Here, we report a phylogenetic and molecular study on the acquisition of caspase-cleavage sites in the family of Rho-activated kinases (RaKs). We demonstrate that the acquisition of such sites has more frequently occurred in identifiable intrinsically disordered regions (IDRs) within or flanking the coiled-coil domain...
December 4, 2018: Molecular Biology and Evolution
Arthur R Gorter de Vries, Lucas G F Couwenberg, Marcel van den Broek, Pilar de la Torre Cortés, Jolanda Ter Horst, Jack T Pronk, Jean-Marc G Daran
Targeted DNA double-strand breaks (DSBs) with CRISPR-Cas9 have revolutionized genetic modification by enabling efficient genome editing in a broad range of eukaryotic systems. Accurate gene editing is possible with near-perfect efficiency in haploid or (predominantly) homozygous genomes. However, genomes exhibiting polyploidy and/or high degrees of heterozygosity are less amenable to genetic modification. Here, we report an up to 99-fold lower gene editing efficiency when editing individual heterozygous loci in the yeast genome...
December 5, 2018: Nucleic Acids Research
Sebastian Walpole, Antonia L Pritchard, Colleen M Cebulla, Robert Pilarski, Meredith Stautberg, Frederick H Davidorf, Arnaud de la Fouchardière, Odile Cabaret, Lisa Golmard, Dominique Stoppa-Lyonnet, Erin Garfield, Ching-Ni Njauw, Mitchell Cheung, Joni A Turunen, Pauliina Repo, Reetta-Stiina Järvinen, Remco van Doorn, Martine J Jager, Gregorius P M Luyten, Marina Marinkovic, Cindy Chau, Miriam Potrony, Veronica Höiom, Hildur Helgadottir, Lorenza Pastorino, William Bruno, Virginia Andreotti, Bruna Dalmasso, Giulia Ciccarese, Paola Queirolo, Luca Mastracci, Karin Wadt, Jens Folke Kiilgaard, Michael R Speicher, Natasha van Poppelen, Emine Kilic, Rana'a T Al-Jamal, Irma Dianzani, Marta Betti, Carsten Bergmann, Sandro Santagata, Sonika Dahiya, Saleem Taibjee, Jo Burke, Nicola Poplawski, Sally J O'Shea, Julia Newton-Bishop, Julian Adlard, David J Adams, Anne-Marie Lane, Ivana Kim, Sonja Klebe, Hilary Racher, J William Harbour, Michael L Nickerson, Rajmohan Murali, Jane M Palmer, Madeleine Howlie, Judith Symmons, Hayley Hamilton, Sunil Warrier, William Glasson, Peter Johansson, Carla Daniela Robles-Espinoza, Raul Ossio, Annelies de Klein, Susana Puig, Paola Ghiorzo, Maartje Nielsen, Tero T Kivelä, Hensin Tsao, Joseph R Testa, Pedram Gerami, Marc-Henri Stern, Brigitte Bressac-de Paillerets, Mohamed H Abdel-Rahman, Nicholas K Hayward
Background: The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 encoding a tumor suppressor associated with uveal melanoma, mesothelioma, cutaneous melanoma, renal cell carcinoma, and cutaneous BAP1-inactivated melanocytic tumors. However, the full spectrum of tumors associated with the syndrome is yet to be determined. Improved understanding of the BAP1-TPDS is crucial for appropriate clinical management of BAP1 germline variant carriers and their families, including genetic counseling and surveillance for new tumors...
December 4, 2018: Journal of the National Cancer Institute
Nicolas Richard, Marie Hudson, Mianbo Wang, Geneviève Gyger, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Murray Baron
Objectives: To examine the incidence, predictors and outcomes associated with severe gastrointestinal (GI) disease in a large inception SSc cohort. Methods: SSc subjects with <2 years of disease duration were identified from two multicentre cohorts. Severe GI disease was defined as: malabsorption, hyperalimentation, pseudo-obstruction and/or ⩾10% weight loss in association with the use of antibiotics for bacterial overgrowth or oesophageal stricture. Kaplan-Meier, multivariate logistic regression and Cox proportional hazard analyses were performed to determine the cumulative incidence rate, independent clinical correlates and mortality rate associated with severe GI disease...
December 4, 2018: Rheumatology
Lijun Zhao, Jianzhong Cao, Kexin Hu, Penghui Wang, Guodong Li, Xiaodong He, Tanjun Tong, Limin Han
Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions and mechanisms remain to be determined. By performing bioinformatics analysis using well-established hepatocellular carcinoma (HCC) datasets, we identified a set of HCC progression-associated RBPs (HPARBPs) and found that the global expression of HPARBPs was significantly correlated with patient prognosis. Among the 42 HPARBPs, human ribosomal protein S3 (RPS3) was one of the most abundant genes whose role remains uncharacterized in HCC...
December 4, 2018: Nucleic Acids Research
Judith Ilhan, Anne Kupczok, Christian Woehle, Tanita Wein, Nils F Hülter, Philip Rosenstiel, Giddy Landan, Itzhak Mizrahi, Tal Dagan
The ubiquity of plasmids in all prokaryotic phyla and habitats and their ability to transfer between cells marks them as prominent constituents of prokaryotic genomes. Many plasmids are found in their host cell in multiple copies. This leads to an increased mutational supply of plasmid-encoded genes and genetically heterogeneous plasmid genomes. Nonetheless, the segregation of plasmid copies into daughter cells during cell division is considered to occur in the absence of selection on the plasmid alleles. We investigate the implications of random genetic drift of multicopy plasmids during cell division - termed here segregational drift - to plasmid evolution...
December 4, 2018: Molecular Biology and Evolution
David X Liu, Donna L Perry, Lisa Evans DeWald, Yingyun Cai, Katie R Hagen, Timothy K Cooper, Louis M Huzella, Randy Hart, Amanda Bonilla, John G Bernbaum, Krisztina B Janosko, Ricky Adams, Reed F Johnson, Jens H Kuhn, Matthias J Schnell, Ian Crozier, Peter B Jahrling, Juan C de la Torre
Lassa fever (LF) survivors develop various clinical manifestations including polyserositis, myalgia, epididymitis, and hearing loss weeks to months after recovery from acute infection. We demonstrate a systemic lymphoplasmacytic and histiocytic arteritis and periarteritis in guinea pigs more than 2 months after recovery from acute Lassa virus (LASV) infection. LASV was detected in the arterial tunica media smooth muscle cells by immunohistochemistry, in situ hybridization, and transmission electron microscopy...
December 5, 2018: Journal of Infectious Diseases
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