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Matthias Florian Geiger, Nicola Bongartz, Christian Blume, Hans Clusmann, Christian Andreas Müller
BACKGROUND:  To evaluate whether decompression in lumbar spinal stenosis without fusion leads to sufficient improvement of back pain and leg pain and whether re-decompression alone is sufficient for recurrent lumbar spinal stenosis for patients without signs of instability. MATERIAL AND METHODS:  A successive series of 102 patients with lumbar spinal stenosis (with and without previous lumbar surgery) were treated with decompression alone during a 3-year period...
December 5, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Chen Zou, Xuan Zhou, Shuhan Zhuang, Guowei Huang, Hongwu Wang
Objective. This study aimed to compare the physical and mental states and the clinical effects of parenteral nutrition combined with enteral nutrition (PN+EN), total enteral nutrition (TEN), and total parenteral nutrition (TPN) after surgery in patients with maxillofacial malignant tumors. Methods. A total of 112 patients were divided into three groups, with 58, 33, and 21 patients in the PN+EN, TPN, and TEN groups, respectively. The psychological survey contained the Faces Pain Scale-Revised (FRS-R), visual analog scale (VAS), numerical rating scale (NRS), Hamilton anxiety rating scale (HAMA), and short-form 36 health survey questionnaire (SF-36)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
L B Sørensen, S A Boudreau, P Gazerani, T Graven-Nielsen
Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia without immediate pain. This double-blinded, randomized study assessed pain and muscle hypersensitivity after a single-site bolus NGF injection (5µg) compared with five spatially distributed, low-dose NGF injections (1µg, 4cm distance) into the tibialis anterior (TA) muscles in 20 healthy subjects. Injection-pain was rated on a visual analogue scale (VAS). Reports of muscle pain with functional tasks (Likert scale score) and presence of spontaneous pain were collected daily using a diary...
December 1, 2018: Journal of Pain: Official Journal of the American Pain Society
Meng Lan, Jia Zipu, Shen Ying, Ren Hao, Luo Fang
Background: There is a lack of prospective studies for the long-term results of percutaneous pulsed radiofrequency (PRF) of the Gasserian ganglion in the treatment of patients with medically refractory trigeminal neuralgia (TN). Methods and results: We prospectively observed the outcomes of 28 idiopathic TN patients (between July 2013 and July 2016) who received CT-guided percutaneous PRF treatment of the Gasserian ganglion. All of the patients had stopped responding to drug therapy before PRF treatment...
2018: Journal of Pain Research
Amol Patwardhan, Ryan Matika, Janalee Gordon, Brian Singer, Michelle Salloum, Mohab Ibrahim
BACKGROUND: The management of chronic nonmalignant pain with high-dose opioids has partially contributed to the current opioid epidemic, with some responsibility shared by chronic pain clinics. Traditionally, both primary care providers and patients used chronic pain clinics as a source for continued medical management of patients on high-dose opioids, often resulting in tolerance and escalating doses. Although opioids continue to be an important component of the management of some chronic pain conditions, improvement in function and comfort must be documented...
November 2018: Pain Physician
Vivek Mehta, Kavita Poply, Michael Husband, Sibtain Anwar, Richard Langford
BACKGROUND: Radiofrequency neurotomy (RFN) is a therapy aimed at providing lasting back pain relief for sacroiliac joint (SIJ) pain. A recent advancement in RFN is a strip lesioning technique that involves placement of a single curved electrode and a 3-pole design that facilitates the creation of 5 overlapping lesions. These lesions form one long strip lesion accessible through a single entry point, without the need for multiple punctures. Although the early case series data looks promising, there is lack of long-term, randomized, controlled study evaluating the strip-lesioning system for SIJ pain...
November 2018: Pain Physician
Myong-Hwan Karm, Seong-Soo Choi, Doo-Hwan Kim, Jun-Young Park, Sukyung Lee, Jin Kyu Park, Young Joong Suh, Jeong-Gil Leem, Jin Woo Shin
BACKGROUND: When conventional interventional procedures fail, percutaneous epidural adhesiolysis (PEA), which has moderate evidence for successful treatment of lumbar spinal stenosis (LSS), has been recommended over surgical treatments. In a previous study, we demonstrated the efficacy of a newly developed inflatable balloon catheter for overcoming the access limitations of pre-existing catheters for patients with severe stenosis or adhesions. OBJECTIVES: This study compared the treatment response of combined PEA with balloon decompression and PEA only in patients with central LSS over 6 months of follow-up...
November 2018: Pain Physician
Peng Guo, Jian-Wei Wang, An Tong
This retrospective study investigated the effectiveness and safety of neuromuscular electrical stimulation (NMES) for patients with chronic low back pain (CLBP).A total of 72 patients with CLBP were included in this retrospective study. All patients received usual care, and were assigned to a NMES group (n = 36) and a control group (n = 36). In addition, patients in the NMES group also received NMES for a total of 4 weeks. The primary outcome was pain intensity, measured by numerical rating scale (NRS)...
November 2018: Medicine (Baltimore)
Jilan Adel, Ghada Koura, Hamada Ahmed, Amal A El Borady, Hala El-Habashy, Alaa Eldin Balbaa, Ibtissam M Saab
BACKGROUND: Patellofemoral osteoarthritis is a common presentation in the outpatients' physical therapy clinics. The muscle imbalance between the vastus medialis oblique and vastus lateralis muscles is one of the main factors that lead to the development of this condition. OBJECTIVE: To compare the effect of a squatting versus squatting with hip adduction in management of patellofemoral osteoarthritis. METHODS: Patients in group A received a traditional physical therapy program in addition to squatting exercise and those in group B received a traditional physical therapy program in addition to squatting with hip adduction exercise for four weeks...
November 23, 2018: Journal of Back and Musculoskeletal Rehabilitation
Sandi M Tenfelde, Dina Tell, Cynthia Brincat, Colleen M Fitzgerald
OBJECTIVE: To characterize sexual function in women with and without musculoskeletal pelvic pain during the first year after childbirth. DESIGN: Cross-sectional descriptive study. SETTING: Outpatient women's health clinic in a Midwestern U.S. academic medical center. PARTICIPANTS: Women who gave birth to singleton infants within the past year. METHODS: Women were recruited from various outpatient settings...
November 29, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Diandian Deng, Hong Yang, Chang Liu, Kang Zhao, Jianguo Li, Anping Deng
An immunochromatographic assay (ICA) based on surface-enhanced Raman scattering (SERS) for ultrasensitive determination of Sudan I in food samples was reported. Gold-silver core-shell bimetallic nanorods (referred to as Au@Ag NRs) were synthesized, characterized and used as the substrate for preparation of the ICA. Polyclonal antibody against Sudan I was immobilized on the surface of the Au@Ag NRs carrying the Raman reporter 5,5'-dithiobis (2-nitrobenzoic acid). The Raman scattering intensity on the test line was used for quantitation of Sudan I...
March 30, 2019: Food Chemistry
Dan Xu, Songqiang Huang, Hui Wang, Wen Xie
Nuclear receptors (NRs) belong to a family of ligand dependent transcription factors. The target genes of NRs include many drug metabolizing enzymes and transporters. The central nervous system (CNS) bears the expression of NRs, drug metabolizing enzymes and transporters. NRs that express in the brain can be divided into three groups according to their characteristics of ligand binding: steroid hormone receptors, non-steroid hormone receptors, and orphan receptors. The NR-mediated regulation of drug metabolizing enzymes and transporters plays important roles in the metabolism and disposition of drugs in the CNS and the penetration of endogenous and exogenous substances through the blood-brain barrier (BBB)...
December 2, 2018: Drug Metabolism Reviews
Ho Jeong Do, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jae-Heung Cho, Koh-Woon Kim, In-Hyuk Ha
BACKGROUND: Neck pain is a highly prevalent medical condition that incurs substantial social burden. Although manual therapy is widely used for treatment of neck pain, the body of evidence supporting its effectiveness and safety is not conclusive. The aim of this study is to examine the effect, safety, and cost-effectiveness of Chuna manual therapy, a traditional Korean manual therapy for treatment of various musculoskeletal complaints. METHODS/DESIGN: This study is the protocol for a two-armed parallel, assessor-blinded, multicenter, randomized controlled trial...
November 29, 2018: Trials
Michael J McCarthy, Heather Wei, Caroline M Nievergelt, Andrea Stautland, Adam X Maihofer, David K Welsh, Paul Shilling, Martin Alda, Ney Alliey-Rodriguez, Amit Anand, Ole A Andreasson, Yokesh Balaraman, Wade H Berrettini, Holli Bertram, Kristen J Brennand, Joseph R Calabrese, Cynthia V Calkin, Ana Claasen, Clara Conroy, William H Coryell, David W Craig, Nicole D'Arcangelo, Anna Demodena, Srdjan Djurovic, Scott Feeder, Carrie Fisher, Nicole Frazier, Mark A Frye, Fred H Gage, Keming Gao, Julie Garnham, Elliot S Gershon, Kara Glazer, Fernando Goes, Toyomi Goto, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Elizabeth Karberg, Marisa Kelly, Susan G Leckband, Falk Lohoff, Melvin G McInnis, Francis Mondimore, Gunnar Morken, John I Nurnberger, Sarah Obral, Ketil J Oedegaard, Abigail Ortiz, Megan Ritchey, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Candice Schwebel, Martha Shaw, Tatyana Shekhtman, Claire Slaney, Emma Stapp, Szabolcs Szelinger, Bruce Tarwater, Peter P Zandi, John R Kelsoe
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs...
November 16, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Zhengze Yu, Ping Zhou, Wei Pan, Na Li, Bo Tang
Photodynamic therapy (PDT) is ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Herein, we developed a biomimetic nanoreactor (bio-NR) to achieve synergistic chemiexcited photodynamic-starvation therapy against tumor metastasis. Photosensitizers on the hollow mesoporous silica nanoparticles (HMSNs) are excited by chemical energy in situ of the deep metastatic tumor to generate singlet oxygen (1 O2 ) for PDT, and glucose oxidase (GOx) catalyzes glucose into hydrogen peroxide (H2 O2 )...
November 28, 2018: Nature Communications
Jingyu Zhi, Yajing Li, Zhongyi Zhang, Chaofei Yang, Xiaotong Geng, Miao Zhang, Xinrong Li, Xin Zuo, Mingjie Li, Yong Huang, Fengqing Wang, Caixia Xie
Rehmannia glutinosa L., a perennial plant of Scrophulariaceae, is one of the most commonly used herbs in traditional Chinese medicine (TCM) that have been widely cultivated in China. However, to date, the biosynthetic pathway of its two quality-control components, catalpol and acteoside, are only partially elucidated and the mechanism for their tissue-specific accumulation remains unknown. To facilitate the basic understanding of the key genes and transcriptional regulators involved in the biosynthesis of catalpol and acteoside, transcriptome sequencing of radial striation (RS) and non-radial striation (nRS) from four R...
November 26, 2018: International Journal of Molecular Sciences
Giovanni Cacciamani, Nicola Menestrina, Marco Pirozzi, Alessandro Tafuri, Paolo Corsi, Davide De Marchi, Davide Inverardi, Tania Processali, Niccolò Trabacchin, Mario De Michele, Marco Sebben, Maria Angela Cerruto, Vincenzo de Marco, Filippo Migliorini, Antonio Benito Porcaro, Walter Artibani
OBJECTIVE To determinate benefits of the combination of local anaesthetic wounds infiltration and Ultrasound Transversus Abdominal Plane (US-TAP) block with ropivacaine on postoperative pain, early recovery and hospital stay in patients undergoing robot assisted radical prostatectomy (RARP). METHODS The study is double-blinded randomized controlled trial. Our hypothesis was that the combination of wound infiltration and US-TAP block with Ropivacaine would decrease immediate post-operative pain and opioids use...
November 28, 2018: Journal of Endourology
Allard R J V Vossen, Martijn B A van Doorn, Hessel H van der Zee, Errol P Prens
BACKGROUND: Effective anti-inflammatory treatments for hidradenitis suppurativa (HS) are limited. OBJECTIVE: To evaluate the efficacy and short-term safety of apremilast in patients with moderate HS. METHODS: A total of 20 patients with moderate HS were randomized in a 3:1 ratio to receive blinded treatment with apremilast, 30 mg twice daily, or placebo for 16 weeks. The primary outcome was the Hidradenitis Suppurativa Clinical Response at week 16...
July 3, 2018: Journal of the American Academy of Dermatology
Yingli Chen, Feng Yang, Jun Yang, Yali Hou, Leilei He, Houxiang Hu, FengLin Lv
Bacterial vaccines have been widely used to prevent infectious diseases, especially in veterinary medicine. Although there are many reports on bacterin adjuvants, only a few contain innovations in bacterin adjuvants. Taking this into consideration, in this study, we designed and synthesized a new aluminum (oxy) hydroxide (AlOOH) nanorod (Al-NR) with a diameter of 200 ± 80 nm and a length of 1.1 ± 0.6 μm. Using whole-Pseudomonas aeruginosa PAO1 as antigens, we showed that the bacterial antigens of P. aeruginosa PAO1 adsorbed on the Al-NRs induced a quick and stronger antigen-specific antibody response than those of the other control groups, especially in the early stage of immunization...
November 27, 2018: ACS Applied Materials & Interfaces
Lorenzo Dutto, Amar Ahmad, Katerina Urbanova, Christian Wagner, Andreas Schuette, Mustafa Addali, John D Kelly, Ashwin Shridhar, Senthil Nathan, Timothy P Briggs, Joern H Witt, Gregory Shaw
BACKGROUND: Active surveillance is recommended for insignificant prostate cancer (PCa). Tools exist to identify suitable candidates using clinical variables. We aimed to develop and validate a novel risk score (NRS) predicting which patients are harbouring insignificant PCa. METHODS: We used prospectively collected data from 8040 consecutive unscreened patients who underwent radical prostatectomy between 2006 and 2016. Of these, data from 2799 patients with Gleason 3 + 3 on biopsy were used to develop a multivariate model predicting the presence of insignificant PC at radical prostatectomy (ERSPC updated definition3 : Gleason 3 + 3 only, index tumour volume < 1...
November 27, 2018: British Journal of Cancer
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