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https://www.readbyqxmd.com/read/30106682/a-novel-interpretation-of-sample-entropy-in-surface-electromyographic-examination-of-complex-neuromuscular-alternations-in-subacute-and-chronic-stroke
#1
Xiao Tang, Xu Zhang, Xiaoping Gao, Xiang Chen, Ping Zhou
The objective of this study was to develop sample entropy (SampEn) as a novel surface electromyogram (EMG) biomarker to quantitatively examine post-stroke neuromuscular alternations. The SampEn method was performed on surface EMG interference patterns recorded from biceps brachii muscles of nine healthy control subjects, fourteen subjects with subacute stroke, and eleven subjects with chronic stroke, respectively. Measurements were collected during isometric contractions of elbow flexion at different constant force levels...
August 8, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/30101255/thermodynamic-and-kinetic-isotope-effects-on-the-order-disorder-transition-of-ice-xiv-to-ice-xii
#2
Violeta Fuentes-Landete, Karsten W Köster, Roland Böhmer, Thomas Loerting
Isotope effects accompanying the order-disorder transition of ice XIV to ice XII are studied using calorimetry, X-ray diffraction, and dielectric spectroscopy. Particular emphasis is placed on the impact of the cooling rate applied during high-pressure production and during ambient-pressure recooling on the degree of hydrogen order in the low-temperature ice XIV phase. For specimens from D2O, ordering is harder to achieve in the sense that despite smaller cooling rates, the degree of order is less than in crystals produced from H2O...
August 13, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30098178/test-retest-reliability-of-non-linear-methods-to-assess-walking-dynamics
#3
Peter Raffalt, Tine Alkjaer, Bjarki Brynjólfsson, Louise J Rgensen, Cecilie R Bartholdy, Marius Henriksen
The present study investigated the day-to-day reliability (quantified by the absolute and relative reliability) of nonlinear methods that assess human locomotion dynamics. Twenty-four participants completed 5 minutes of treadmill walking at self-selected preferred speed on two separate days. Lower limb kinematics were recorded at 100Hz and hip, knee and ankle joint angles, three dimensional sacrum marker displacement and stride time intervals were extracted for 170 consecutive strides. The largest Lyapunov exponent and correlation dimension were calculated for the joint angle and sacrum displacement data using three different state space reconstruction methods (group average, test-retest average, individual time delay and embedding dimension)...
August 4, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/30095435/association-of-characteristics-of-hbv-quasispecies-with-hepatitis-b-surface-antigen-seroconversion-after-pegylated-interferon-alpha-2a-treatment-in-child-patients
#4
Juncheng Yang, Guifeng Yang, Haitang He, Lu Ning, Zhihua Liu, Qunfang Fu, Haitao Chen, Haohui Deng, Zhanhui Wang, Kangxian Luo
BACKGROUND: The correlation between hepatitis B surface antigen (HBsAg) seroconversion and the characteristics of hepatitis B virus (HBV) quasispecies (QS) before and during pegylated interferon alpha-2a (Peg-IFN-α-2a) treatment in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) children has not yet been reported. METHODS: Thirty-five patients, including 18 HBsAg seroconverters (SS) and 17 non-seroconverters (SN), were enrolled. Serum samples were collected before treatment and at weeks 12 and 24 of treatment...
August 10, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/30094475/mechanosensitivity-of-the-bk-channels-in-human-glioblastoma-cells-kinetics-and-dynamical-complexity
#5
Agata Wawrzkiewicz-Jałowiecka, Paulina Trybek, Łukasz Machura, Beata Dworakowska, Zbigniew J Grzywna
BK channels are potassium selective and exhibit large single-channel conductance. They play an important physiological role in glioma cells: they are involved in cell growth and extensive migrating behavior. Due to the fact that these processes are accompanied by changes in membrane stress, here, we examine mechanosensitive properties of BK channels from human glioblastoma cells (gBK channels). Experiments were performed by the use of patch-clamp method on excised patches under membrane suction (0-40 mmHg) at membrane hyper- and depolarization...
August 9, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/30079601/response-to-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectum-cancer-texture-analysis-of-dynamic-contrast-enhanced-mri
#6
Hai-Hua Zou, Jing Yu, Yun Wei, Jiang-Fen Wu, Qing Xu
BACKGROUND: Tumor heterogeneity can be assessed by texture analysis (TA). TA has been applied using diffusion-weighted imaging and apparent diffusion coefficient maps to predict pathological responses to preoperative chemoradiation therapy (CRT) in patients with locally advanced rectal cancer (LARC). PURPOSE: To evaluate the texture parameters obtained from K trans maps derived from dynamic contrast-enhanced (DCE)-MRI for predicting pathological responses to preoperative CRT for LARCs...
August 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30072603/variations-of-the-elastic-properties-of-the-cocrfemnni-high-entropy-alloy-deformed-by-groove-cold-rolling
#7
Paul Lohmuller, Laurent Peltier, Alain Hazotte, Julien Zollinger, Pascal Laheurte, Eric Fleury
The variations of the mechanical properties of the CoCrFeMnNi high entropy alloy (HEA) during groove cold rolling process were investigated with the aim of understanding their correlation relationships with the crystallographic texture. Our study revealed divergences in the variations of the microhardness and yield strength measured from samples deformed by groove cold rolling and conventional cold rolling processes. The crystallographic texture analyzed by electron back scattered diffraction (EBSD) revealed a hybrid texture between those obtained by conventional rolling and drawing processes...
August 2, 2018: Materials
https://www.readbyqxmd.com/read/30072204/an-acoustic-signal-based-preventive-program-for-university-lecturers-vocal-health
#8
M Sandra Paniagua, Carlos J Pérez, Fernando Calle-Alonso, Carmen Salazar
INTRODUCTION: Professional activities of university lecturers involve continued and sustained use of the voice, leading in many cases to increased risk of developing voice disorders. Risk identification followed by the fast application of preventive or corrective measures is a key issue in this context. OBJECTIVE: Define and implement a preventive program for the vocal health of university lecturers by using acoustic features automatically extracted from voice recordings to identify risk groups and manage preventive or corrective actions MATERIAL AND METHODS: A total of 170 subjects, aged between 18 and 65, were recruited at the San Pedro de Alcántara Hospital and at the University of Extremadura in Cáceres (Spain)...
July 30, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/30066648/using-natural-language-processing-methods-to-classify-use-status-of-dietary-supplements-in-clinical-notes
#9
Yadan Fan, Rui Zhang
BACKGROUND: Despite widespread use, the safety of dietary supplements is open to doubt due to the fact that they can interact with prescribed medications, leading to dangerous clinical outcomes. Electronic health records (EHRs) provide a potential way for active pharmacovigilance on dietary supplements since a fair amount of dietary supplement information, especially those on use status, can be found in clinical notes. Extracting such information is extremely significant for subsequent supplement safety research...
July 23, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/30065509/high-intensity-focused-ultrasound-thermal-lesion-detection-using-entropy-imaging-of-ultrasound-radio-frequency-signal-time-series
#10
Maryam Mohammadi Monfared, Hamid Behnam, Parisa Rangraz, Jahan Tavakkoli
Background: During the past few decades, high-intensity focused ultrasound (HIFU) modality has been gaining surging interest in various therapeutic applications such as non- or minimally-invasive cancer treatment. Among other attributes, robust and real-time HIFU treatment monitoring and lesion detection have become essential issues for successful clinical acceptance of the modality. More recently, ultrasound radio frequency (RF) time series imaging has been studied by a number of researchers...
January 2018: Journal of Medical Ultrasound
https://www.readbyqxmd.com/read/30059494/ecological-niche-modelling-and-predicted-geographic-distribution-of-lutzomyia-cruzi-vector-of-leishmania-infantum-in-south-america
#11
Everton Falcão de Oliveira, Eunice Aparecida Bianchi Galati, Alessandra Gutierrez de Oliveira, Elizabeth Ferreira Rangel, Bruno Moreira de Carvalho
In some transmission foci of Leishmania infantum in Brazil, Lutzomyia cruzi could be considered the main vector of this pathogen. In addition, L. cruzi is a permissive vector of L. amazonensis. Its geographical distribution seems to be restricted and limited to Cerrado and Pantanal biomes, which includes some areas in Brazil and Bolivia. Considering that predicting the distribution of the species involved in transmission cycles is an effective approach for assessing human disease risk, this study aims to predict the spatial distribution of L...
July 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30053539/the-effect-of-walking-speed-on-quality-of-gait-in-older-adults
#12
B Huijben, K S van Schooten, J H van Dieën, M Pijnappels
BACKGROUND: Gait quality characteristics can contribute to the identification of individuals at risk of falls. Since older adults with high fall risk tend to walk slower than older adults with a lower fall risk, walking speed may underlie differences in gait quality characteristics. RESEARCH QUESTION: How does walking speed affect gait quality characteristics in older people? METHODS: We investigated the effect of walking speed on gait characteristics in 11 older adults (aged 69...
July 10, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30043454/personalized-prediction-model-for-seizure-free-epilepsy-with-levetiracetam-therapy-a-retrospective-data-analysis-using-support-vector-machine
#13
Jia-Hui Zhang, Xiong Han, Hong-Wei Zhao, Di Zhao, Na Wang, Ting Zhao, Gui-Nv He, Xue-Rui Zhu, Ying Zhang, Jiu-Yan Han, Dian-Ling Huang
AIMS: To predict the probability of a seizure-free (SF) state in patients with epilepsy (PWEs) after treatment with levetiracetam and to identify the clinical and electroencephalographic (EEG) factors that affect outcomes. METHODS: Retrospective analysis of PWEs treated with levetiracetam for 3 years identified 22 patients who were SF and 24 who were not (NSF). Before starting levetiracetam, 11 clinical factors and 4 EEG features (sample entropy of α, β, θ, δ) were identified...
July 24, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30042878/attentional-demands-associated-with-augmented-visual-feedback-during-quiet-standing
#14
Krzysztof Kręcisz, Michał Kuczyński
To investigate how additional visual feedback (VFB) affects postural stability we compared 20-sec center-of-pressure (COP) recordings in two conditions: without and with the VFB. Seven healthy adult subjects performed 10 trials lasting 20 seconds in each condition. Simultaneously, during all trials the simple auditory reaction time (RT) was measured. Based on the COP data, the following sway parameters were computed: standard deviation (SD), mean speed (MV), sample entropy (SE), and mean power frequency (MPF)...
2018: PeerJ
https://www.readbyqxmd.com/read/30041017/how-does-normalization-impact-rna-seq-disease-diagnosis
#15
Henry Han, Ke Men
With the surge of next generation high-throughput technologies, RNA-seq data is playing an increasingly important role in disease diagnosis, in which normalization is assumed as an essential procedure to produce comparable samples. Recent studies have seen different normalization methods proposed to remove various technical biases in RNA sequencing. However, there are no previous studies evaluating the impacts of normalization on RNA-seq disease diagnosis. In this study, we investigate this problem by analyzing structured big data: RNA-seq data acquired from the TCGA portal for its popularity in RNA-seq disease diagnosis...
July 21, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/30040631/focal-loss-for-dense-object-detection
#16
Tsung-Yi Lin, Priyal Goyal, Ross Girshick, Kaiming He, Piotr Dollar
The highest accuracy object detectors to date are based on a two-stage approach popularized by R-CNN, where a classifier is applied to a sparse set of candidate object locations. In contrast, one-stage detectors that are applied over a regular, dense sampling of possible object locations have the potential to be faster and simpler, but have trailed the accuracy of two-stage detectors thus far. In this paper, we investigate why this is the case. We discover that the extreme foreground-background class imbalance encountered during training of dense detectors is the central cause...
July 23, 2018: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/30036639/determination-of-the-conformational-states-of-strychnine-using-nmr-residual-dipolar-couplings-in-a-tensor-free-approach
#17
Giulia Tomba, Carlo Camilloni, Michele Vendruscolo
Small molecules with rotatable bonds can occupy different conformational states as a consequence of their thermal fluctuations. The accurate determination of the structures of such states, as well as of their statistical weights, has been challenging because of the technical difficulties in extracting information from experimental measurements, which are normally averaged over the conformational space available. Here, to achieve this objective, we present an approach based on a recently proposed tensor-free method for incorporating NMR residual dipolar couplings as structural restraints in replica-averaged molecular dynamics simulations...
July 20, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/30035022/brain-function-characteristics-of-chronic-fatigue-syndrome-a-task-fmri-study
#18
Zack Y Shan, Kevin Finegan, Sandeep Bhuta, Timothy Ireland, Donald R Staines, Sonya M Marshall-Gradisnik, Leighton R Barnden
The mechanism underlying neurological dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is yet to be established. This study investigated the temporal complexity of blood oxygenation level dependent (BOLD) changes in response to the Stroop task in CFS patients. 43 CFS patients (47.4 ± 11.8 yrs) and 26 normal controls (NCs, 43.4 ± 13.9 yrs) were included in this study. Their mental component summary (MCS) and physical component summary (PCS) from the 36-item Short Form Health Survey (SF-36) questionnaire were recorded...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30028140/anomalous-fraunhofer-patterns-in-gated-josephson-junctions-based-on-the-bulk-insulating-topological-insulator-bisbtese-2
#19
Subhamoy Ghatak, Oliver Breunig, Fan Yang, Zhiwei Wang, Alexey A Taskin, Yoichi Ando
One-dimensional Majorana modes are predicated to form in Josephson junctions based on three-dimensional topological insulators (TIs). While observations of supercurrents in Josephson junctions made on bulk-insulating TI samples have been reported recently, the Fraunhofer patters observed in such TI-based Josephson junctions, which sometimes present anomalous features, are still not well-understood. Here, we report our study of highly gate-tunable TI-based Josephson junctions made of one of the most bulk-insulating TI materials, BiSbTeSe2 , and Al...
August 8, 2018: Nano Letters
https://www.readbyqxmd.com/read/30027316/an-optimized-band-target-entropy-minimization-for-mass-spectral-reconstruction-of-severely-co-eluting-and-trace-level-components
#20
Chun Kiang Chua, Bo Lu, Yunbo Lv, Xiao Yu Gu, Ai Di Thng, Hua Jun Zhang
Gas chromatography-mass spectrometry (GC-MS) is a versatile analytical method but its data is usually complicated by the presence of severely co-eluting and trace-level components. In this work, we introduce an optimized band-target entropy minimization approach for the analysis of complex mass spectral data. This new approach enables an automated mass spectral analysis which does not require any user-dependent inputs. Moreover, the approach provides improved sensitivity and accuracy for mass spectral reconstruction of severely co-eluting and trace-level components...
July 19, 2018: Analytical and Bioanalytical Chemistry
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