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Bone regeneration

Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D Johnson, E Antonio Chiocca, Xin Wang
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland in animals. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS) in brain injury, liver damage, and bone health...
October 10, 2018: Free Radical Biology & Medicine
Xu Li, Mingjie Wang, Xiaoguang Jing, Weimin Guo, Chunxiang Hao, Yu Zhang, Shuang Gao, Mingxue Chen, Zengzeng Zhang, Xueliang Zhang, Shi Shen, Bin Zhang, Hai Xian, Zehao Wang, Yu Wang, Xiang Sui, Aiyuan Wang, Jiang Peng, Shibi Lu, Shuyun Liu, Quanyi Guo
Articular cartilage defects have very limited self-repair potential, and traditional bone marrow-stimulating therapy is not effective. Cartilage tissue engineering using bone marrow mesenchymal stem cells (BMSCs) and adipose tissue-derived mesenchymal stem cells (ADSCs) is considered an attractive treatment for cartilage lesions and osteoarthritis. However, studies proved that both BMSCs and ADSCs have their own advantages and shortcomings, including their sources, isolation methods, characterizations and differentiation potential...
2018: Critical Reviews in Eukaryotic Gene Expression
Sachin Kulkarni, Mohammed Meer, Roy George
Post-extraction healing of the socket may take up to 24 weeks to complete. This systematic review aims to evaluate whether photobiomodulation accelerates bone healing in those sockets. A search strategy was developed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Cochrane Library, and Scopus electronic databases were searched for in vivo studies with restrictions on the year (< 50 years old) and language (English). After applying the inclusion criteria, ten studies were selected for review...
October 11, 2018: Lasers in Medical Science
Ilaria Roato, Dimas Carolina Belisario, Mara Compagno, Aurora Lena, Alessandro Bistolfi, Luca Maccari, Federico Mussano, Tullio Genova, Laura Godio, Giuseppe Perale, Matteo Formica, Irene Cambieri, Carlotta Castagnoli, Tiziana Robba, Lamberto Felli, Riccardo Ferracini
PURPOSE: Osteoarthritis (OA) is characterized by articular cartilage degeneration and subchondral bone sclerosis. OA can benefit of non-surgical treatments with collagenase-isolated stromal vascular fraction (SVF) or cultured-expanded mesenchymal stem cells (ASCs). To avoid high manipulation of the lipoaspirate needed to obtain ASCs and SVF, we investigated whether articular infusions of autologous concentrated adipose tissue are an effective treatment for knee OA patients. METHODS: The knee of 20 OA patients was intra-articularly injected with autologous concentrated adipose tissue, obtained after centrifugation of lipoaspirate...
October 11, 2018: International Orthopaedics
Deting Xue, Erman Chen, Huiming Zhong, Wei Zhang, Shengdong Wang, Muhammad Umar Joomun, Tianyi Yao, Yanbin Tan, ShiSheng Lin, Qiang Zheng, Zhijun Pan
Background: The osteo-immunomodulatory properties of biomaterials play an important role in the outcomes of bone regeneration. Graphene oxide (GO) has been widely applied in many research fields due to its unique properties. However, the immunomodulatory properties of GO as a biomaterial for bone tissue engineering are still unclear. Materials and methods: In this study, we evaluated the Inflammatory response of RAW264.7 cells influenced by GO. Then the osteogenic differentiation of BMSCs, and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs) by stimulation with GO/RAW 264...
2018: International Journal of Nanomedicine
Elvira De Giglio, Maria A Bonifacio, Ana M Ferreira, Stefania Cometa, Zhi Yuan Ti, Antonella Stanzione, Kenny Dalgarno, Piergiorgio Gentile
The development of in vitro 3D models to get insights into the mechanisms of bone regeneration could accelerate the translation of experimental findings to the clinic, reducing costs and duration of experiments. This work explores the design and manufacturing of multi-compartments structures in poly(ε-caprolactone) (PCL) 3D-printed by Fused Filament Fabrication technique. The construct was designed with interconnected stalls to host stem cells and endothelial cells. Cells were encapsulated within an optimised gellan gum (GG)-based hydrogel matrix, crosslinked using strontium (Sr2+ ) ions to exploit its bioactivity and finally, assembled within compartments with different sizes...
October 11, 2018: Scientific Reports
Marija Đ Vukelić-Nikolić, Stevo J Najman, Perica J Vasiljević, Tatjana M Jevtović-Stoimenov, Vladimir J Cvetković, Milica N Andrejev, Žarko J Mitić
Platelet-rich plasma (PRP) with normal and below-normal physiological concentrations of platelets is designated as diluted PRP (dPRP). The aims of this study are to evaluate whether bone mineral matrix in combination with dPRP possesses osteogenic capacity; and whether the differences in dynamics and osteogenic process pattern depend on different platelet concentrations, to what extent, and also what could be benefits for bone regeneration in clinical practice. Three types of implants were made: BMM-bone mineral matrix alone; dPRP/10-bone mineral matrix mixed with dPRP (concentration of platelets 10 times lower than physiological level) and dPRP/3-bone mineral matrix mixed with dPRP (concentration of platelets 3 times lower than physiological level)...
September 19, 2018: Journal of Cranio-maxillo-facial Surgery
Abeer I Abd El-Fattah, M S Zaghloul, N A Eltablawy, L A Rashed
Cardiac injury is a dangerous disease and become a greater issue in the forthcoming decades. The ultimate goal is to prevent the progression of heart failure and apoptotic processes. Cardiac tissue may regenerate itself but to certain extent depending on the number of resident stem cells that is limited. Thus, research had been focused on bone marrow derived stem cells (BM-MSCs) as a promising therapy in different types of tissues, including the heart. This study is designed not only to assess the therapeutic effect of BM-MSCs but also to improve their therapeutic effect in combination with antioxidant α-lipoic acid (ALA) and antihypertensive therapeutic drug form (AP) against isoproterenol-induced cardiac injury and compared with that of BM-MSCs alone...
October 8, 2018: Biochimie
Li-Jun Deng, Yan-Lin Wu, Xian-Hua He, Ke-Nan Xie, Lu Xie, Yi Deng
The strategy of a functional biomimetic system built to obtain the positive cellular response remains a field of topical interest. In this study, a hydrogel covered simvastatin-loaded polyetheretherketone (PEEK) bio-composites was constructed with the purpose of bone tissue regeneration therapy. Briefly, a three-dimensional (3D) porous structure was fabricated on PEEK surface; then the substrate was functionalized with the poly(L-lactic acid)/simvastatin porous film and hyaluronic acid hydrogel subsequently...
October 11, 2018: Journal of Biomaterials Science. Polymer Edition
Amir Reza Rokn, Abbas Monzavi, Mehrdad Panjnoush, Hamid Mahmood Hashemi, Mohammad Javad Kharazifard, Tahereh Bitaraf
BACKGROUND: Short implants have been proposed as an alternative for the rehabilitation of atrophic edentulous areas. PURPOSE: To evaluate the efficacy of 4-mm implants vs longer implants in the atrophic posterior mandibles. MATERIALS AND METHODS: Eleven patients with bilateral atrophic mandibles were rehabilitated with two to four 4-mm implants and 10 or 8-mm long implants in augmented bone using Guided Bone Regeneration procedure. One side of the mandibles was randomly allocated to vertical augmentation with mixed autogenous bone and allograft...
October 11, 2018: Clinical Implant Dentistry and related Research
Franz Josef Strauss, Alexandra Stähli, Reinhard Gruber
OBJECTIVE: To assess the impact of platelet-rich fibrin (PRF) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRF administration for bone regeneration and implant therapy? METHOD: A systematic literature search comprised three databases: MEDLINE, EMBASE, and Cochrane followed by a hand search of relevant scientific journals. Human studies using PRF for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included...
October 2018: Clinical Oral Implants Research
Alexandra Stähli, Franz Josef Strauss, Reinhard Gruber
OBJECTIVE: To assess the effect of platelet-rich plasma (PRP) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRP administration for bone regeneration and implant therapy? METHODS: A literature search was conducted involving three databases: MEDLINE, EMBASE and Cochrane database followed by a hand search of relevant scientific journals. Human studies using PRP for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included...
October 2018: Clinical Oral Implants Research
Shuyun Wang, Shan Huang, Lianghui Gong, Zhize Yuan, Joshua Wong, Jeffrey Lee, Ming-Sing Si
Newborns with critical congenital heart disease are at significant risk of developing heart failure later in life. Because treatment options for end-stage heart disease in children are limited, regenerative therapies for these patients would be of significant benefit. During neonatal cardiac surgery, a portion of the thymus is removed and discarded. This discarded thymus tissue is a good source of MSCs that we have previously shown to be proangiogenic and to promote cardiac function in an in vitro model of heart tissue...
2018: Stem Cells International
Yasuo Miura
Mesenchymal stromal/stem cells (MSCs) exhibit various biological characteristics, including immunomodulation, tissue regeneration, anti-inflammation, and hematopoietic support. Extensive efforts have been made toward the development of cell therapy using MSCs to treat various diseases. In Japan, off-the-shelf allogeneic human bone marrow-derived MSC products from third-party donors are clinically available for treating patients with steroid-resistant/refractory acute graft-versus-host disease (GVHD). In this manuscript, we present an overview of the current status of clinical development of MSC-based cell therapy and the basic understanding of MSCs...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Dejian Li, Wei Nie, Liang Chen, David McCoul, Dinghua Liu, Xu Zhang, Ying Ji, Baoqing Yu, Chuanglong He
Repairing large tumor-related bone defects remains a difficult clinical problem because of the significant risk of locoregional relapse after surgical curettage. In this study, a composite scaffold of nano-hydroxyapatite (nHA) and reduced graphene oxide (rGO) sheets was fabricated by self-assembly, and a 20 wt% nHA-rGO sheet solution formed the most stable hydrogel. In vitro , nHA-rGO scaffolds killed all but 8% of osteosarcoma cells (MG-63) under 808 nm near-infrared laser irradiation for 20 min. SEM images and live/dead staining of MG-63 cells in nHA-rGO also confirmed the therapeutic efficacy of the scaffolds...
December 1, 2018: Journal of Biomedical Nanotechnology
Patrick Haubruck, Anja Solte, Raban Heller, Volker Daniel, Michael Tanner, Arash Moghaddam, Gerhard Schmidmaier, Christian Fischer
BACKGROUND: Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible. Chemokines play an important role in promoting the formation of new bone and remodeling existing bone. Despite their importance regarding the regulation of bone biology, the potential of chemokines as biological markers reflecting osseous regeneration is unknown. The purpose of this study was to determine (1) if serum chemokine expression levels correlate with the outcome of non-union surgery and (2) if chemokine expression analysis can be used to identify patients at risk for treatment failure...
October 10, 2018: Journal of Orthopaedic Surgery and Research
Aya Tal, Reshef Tal, Shafiq Shaikh, Stephanie Gidicsin, Ramanaiah Mamillapalli, Hugh S Taylor
Cell fusion is involved in the development of some adult organs, is implicated in the pathogenesis of specific types of cancer, and is known to participate in repair/regeneration processes mediated by bone-marrow derived cells (BMDCs). Endometriosis is a disease characterized by growth of functional endometrial tissue outside of the uterine cavity. Endometriosis shares some molecular properties with cancer and BMDCs home to endometriosis lesions in a mouse model. Our objective was to determine if cell fusion can occur in endometriosis and establish whether bone marrow derived cells participate in cell fusion events in lesions...
October 9, 2018: Biology of Reproduction
Seigo Ohba, Yoshinori Sumita, Yuya Nakatani, Sawako Noda, Izumi Asahina
OBJECTIVE: The aim of this study was to assess the effectiveness of a hydroxyapatite/collagen composite material (HAp/Col) for preservation of alveolar bone after tooth extraction. MATERIALS AND METHODS: HAp/Col was applied to the alveolus bone ridge preservation after tooth extraction, because of subsequent dental implant placement in 35 regions of 24 patients (mean age, 59.3 years; range, 25-81 years). Cone beam computed tomography was used to assess changes in alveolar bone at the extraction site before and at 3 months (mean, 13...
October 9, 2018: Clinical Oral Investigations
Jeanne Adiwinata Pawitan
Traditional Chinese and Korean medicine uses various manipulations on acupuncture points/acupoints that are located along imaginary lines on the surface of a human body, which are called 'meridians'. Acupuncture has been used from the ancient time till now to cure various diseases, including for the purpose of regenerative medicine. In various studies, meridians are alternatively called as Bong-Han ducts, primo vessels, or hyaluronic-acid rich ducts, while acupoints are called Bong-Han corpuscles, primo nodes, or hyaluronic-acid rich nodes...
October 2018: Journal of Traditional and Complementary Medicine
John Nowlin, Mehzubh A Bismi, Baptiste Delpech, Patrick Dumas, Yingge Zhou, George Z Tan
Tendon injuries can be difficult to heal and have high rates of relapse due to stress concentrations caused by scar formation and the sutures used in surgical repair. Regeneration of the tendon/ligament-to-bone interface is critical to provide functional graft integration after injury. The objective of this study is to recreate the tendon-to-bone interface using a gradient scaffold which is fabricated by a one-station electrospinning process. Two cell phenotypes were grown on a poly- ε -caprolactone nanofiber scaffold which possesses a gradual transition from random to aligned nanofiber patterns...
January 2018: Nanobiomedicine
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