Vivi-Nelli Mäkinen, Stine Horskær Madsen, Mette Ji Riis-Vestergaard, Mette Bjerre, Steen Bønløkke Pedersen, Sylvia L Asa, Lars Rolighed, Jens Otto Lunde Jørgensen, Marie Juul Ornstrup
SUMMARY: This case report describes a rare presentation of ectopic Cushing's syndrome (CS) due to ectopic corticotropin-releasing hormone (CRH) production from a medullary thyroid carcinoma (MTC). The patient, a 69-year-old man, presented with symptoms of muscle weakness, facial plethora, and easy bruising. An inferior petrosal sinus sampling test (IPSS) demonstrated pituitary adrenocorticotrophic hormone (ACTH) secretion, but a whole-body somatostatin receptor scintigraphy (68Ga-DOTATOC PET/CT) revealed enhanced uptake in the right thyroid lobe which, in addition to a grossly elevated serum calcitonin level, was indicative of an MTC...
July 1, 2023: Endocrinology, Diabetes & Metabolism Case Reports