Nathalie Søderhamn Bülow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Rønn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grøndahl, Sven Olaf Skouby, Nicholas Stephen Macklon
STUDY QUESTION: Does letrozole (LZ) co-treatment during ovarian stimulation with gonadotropins for in IVF impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR)? SUMMARY ANSWER: No impact of LZ was found in follicle recruitment, number of oocytes, quality of embryos, or LBR. WHAT IS KNOWN ALREADY: Multi-follicle stimulation for IVF produces supra-physiological oestradiol levels. LZ is an aromatase inhibitor that lowers serum oestradiol thus reducing negative feedback and increasing the endogenous gonadotropins in both the follicular and the luteal phases, effectively normalizing the endocrine milieu during IVF treatment...
November 2, 2023: Human Reproduction