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https://www.readbyqxmd.com/read/28632494/long-term-dutasteride-therapy-in-men-with-benign-prostatic-hyperplasia-alters-glucose-and-lipid-profiles-and-increases-severity-of-erectile-dysfunction
#1
Abdulmaged Traish, Karim Sultan Haider, Gheorghe Doros, Ahmad Haider
Background Dutasteride has been successfully used in treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). However, dutasteride inhibits 5α-reductase type 1 and type 2 enzymes and may compromises glucocorticoids and androgen metabolism and alters metabolic function resulting in undesirable metabolic and sexual adverse side effects. Aim The aim of this study was to investigate the long-term adverse effects of dutasteride therapy in men with BPH on: i) blood glucose, ii) glycated hemoglobin (HbA1c), iii) low density lipoprotein-cholesterol (LDL-C); high density lipoprotein-cholesterol (HDL-C) and total cholesterol (TC), iv) testosterone (T), v) liver alanine and aspartate aminotransferases (ALT and AST) and vi) erectile dysfunction (ED)...
June 21, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28626863/prolactin-correction-for-adequacy-of-petrosal-sinus-cannulation-may-diminish-diagnostic-accuracy-in-cushing-s-disease
#2
Sunita Mc De Sousa, Ann I McCormack, Shaun McGrath, David J Torpy
OBJECTIVE: Petrosal venous prolactin concentrations have been promoted to improve the diagnostic accuracy of inferior petrosal sinus sampling (IPSS), beyond that achieved with ACTH measurement alone, in diagnosing a pituitary ACTH source, and determining corticotrophinoma side (L/R). Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. DESIGN: Retrospective cohort study...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28624553/comparison-of-the-effect-of-naptopidil-and-tamsulosin-on-the-bladder-storage-symptom-with-benign-prostatic-hyperplasia-prospective-multi-institutional-study
#3
Se Yun Kwon, Kyung Seop Lee, Tag Keun Yoo, Jae Il Chung, Ji Youl Lee, Jun Hyuk Hong, Seong Il Seo, Tae Young Jung, Cheol Kwak, Taek Won Kang, Seok-Joong Yun
OBJECTIVE: To compare the efficacies of naftopidil and tamsulosin in terms of reducing storage symptoms in patients with BPH. MATERIAL & METHODS: This prospective randomized study was performed at 10 centers. Ninety-four patients that had been taking tamsulosin for more than 8 weeks, but had an OABSS of greater than 3 points were initially enrolled. After a 1 week washout period, patients were divided into two groups. Forty-five patients were treated with tamsulosin 0...
June 14, 2017: Urology
https://www.readbyqxmd.com/read/28622770/intensity-modulated-radiation-therapy-from-70gy-to-80gy-in-prostate-cancer-six-year-outcomes-and-predictors-of-late-toxicity
#4
Maria Jolnerovski, Julia Salleron, Véronique Beckendorf, Didier Peiffert, Anne-Sophie Baumann, Valérie Bernier, Sandrine Huger, Vincent Marchesi, Ciprian Chira
OBJECTIVE: To report grade ≥2 overall late rectal and urinary toxicities in patients (pts) with prostate cancer treated by intensity-modulated radiotherapy (IMRT) at 3 dose-levels. Identify predictors of radiation toxicity and report biochemical progression free survival (bPFS). METHODS: A total of 277 pts were treated with 70Gy (10.8%), 74Gy (63.9%) and 80 Gy (25.3%) using IMRT without pelvic irradiation were analyzed. Short or long-course androgen deprivation therapy (ADT) was allowed in 46...
June 16, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28612999/overactive-bladder-symptom-scores-responsiveness-before-and-after-anticholinergic-treatment-in-women-with-overactive-bladder-the-pilot-study
#5
Suvit Bunyavejchevin
AIM: The aims of this study were: (i) to evaluate change of Overactive Bladder Symptom Scores (OABSS) from before to after solifenacin treatment; and (ii) to evaluate correlation between change of OABSS and 3-day micturition diary, International Prostate Symptom Score (IPSS), and Patient Perception of Bladder Condition (PPBC). METHODS: Thirty-six women, aged > 18 years, diagnosed as having overactive bladder (OAB) at King Chulalongkorn Memorial Hospital, with the symptoms of urgency, frequency with or without urge incontinence for more than 3 months, and at least three episodes of urgency with or without incontinence during the last 3 days prior to the study, were recruited during January 2010-May 2011...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28612357/multidimensional-assessment-of-patient-condition-and-mutational-analysis-in-peripheral-blood-as-tools-to-improve-outcome-prediction-in-myelodysplastic-syndromes-a-prospective-study-of-the-spanish-mds-group
#6
Fernando Ramos, Cristina Robledo, Arturo Pereira, Carmen Pedro, Rocío Benito, Raquel de Paz, Mónica Del Rey, Andrés Insunza, Mar Tormo, María Díez-Campelo, Blanca Xicoy, Eduardo Salido, Javier Sánchez-Del-Real, Leonor Arenillas, Lourdes Florensa, Elisa Luño, Consuelo Del Cañizo, Guillermo F Sanz, Jesús María Hernández-Rivas
The International Prognostic Scoring System and its revised form (IPSS-R) are the most widely used indices for prognostic assessment of patients with myelodysplastic syndromes (MDS), but can only partially account for the observed variation in patient outcomes. This study aimed to evaluate the relative contribution of patient condition and mutational status in peripheral blood when added to the IPSS-R, for estimating overall survival and the risk of leukemic transformation in patients with MDS. A prospective cohort (2006-2015) of 200 consecutive patients with MDS were included in the study series and categorized according to the IPSS-R...
June 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28612220/individual-outcome-prediction-for-myelodysplastic-syndrome-mds-and-secondary-acute-myeloid-leukemia-from-mds-after-allogeneic-hematopoietic-cell-transplantation
#7
Michael Heuser, Razif Gabdoulline, Patrick Löffeld, Vera Dobbernack, Henriette Kreimeyer, Mira Pankratz, Madita Flintrop, Alessandro Liebich, Sabrina Klesse, Victoria Panagiota, Michael Stadler, Martin Wichmann, Rabia Shahswar, Uwe Platzbecker, Christian Thiede, Thomas Schroeder, Guido Kobbe, Robert Geffers, Brigitte Schlegelberger, Gudrun Göhring, Hans-Heinrich Kreipe, Ulrich Germing, Arnold Ganser, Nicolaus Kröger, Christian Koenecke, Felicitas Thol
We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for mutations in 54 genes. We used a Cox multivariate model and competing risk analysis with internal and cross validation to identify factors prognostic of overall survival (OS), cumulative incidence of relapse (CIR), and non-relapse mortality (NRM)...
June 13, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28612083/does-combination-therapy-with-tamsulosin-and-trospium-chloride-improve-lower-urinary-tract-symptoms-after-seeds-brachytherapy-for-prostate-cancer-compared-with-tamsulosin-alone-a%C3%A2-prospective-randomized-controlled-trial
#8
Miao Yan, Peng Xue, Kunpeng Wang, Guojun Gao, Wei Zhang, Fanghu Sun
OBJECTIVE: To compare the efficacy of combination therapy with an alpha-blocker and an anticholinergic to monotherapy with an alpha blocker on lower urinary tract symptoms (LUTS) following brachytherapy in prostate cancer patients. MATERIAL AND METHODS: A total of 124 patients that had been clinically diagnosed with localized prostate cancer and underwent prostate brachytherapy were enrolled in the present study. Patients were randomized and allocated to two groups, including 60 to the combination group (tamsulosin 0...
June 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28609136/can-the-urolift-prostatic-implant-device-treat-the-symptoms-of-benign-prostatic-hypertrophy-avoid-sexual-dysfunction-and-reduce-hospital-turp-waiting-times-a-single-centre-single-surgeon-experience-and-review-of-the-literature
#9
Antonio D Bardoli, Will St J Taylor, Wasim Mahmalji
BPH associated with LUTS and sexual dysfunction is common. We performed UroLift on 11 patients, average age 71 years (range 56-90). IPSS improved by an average of 9 points post-procedure. Pre-operatively their post-void residuals were 306.3 ml (range 120-499 ml SD [120.6]) and their QMAX was 7 ml/s (range 4-14 SD [2.8] ml/s). Post-procedure the post-void residual decreased by 35.4% at 4 months (mean difference - 106.3 ml). QMAX improved by an average of 1.7 ml/s, which was not statistically significant...
June 13, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28608963/relationship-between-lower-urinary-tract-symptoms-and-cardiovascular-risk-scores-including-framingham-risk-score-and-acc-aha-risk-score
#10
Bora Lee, Sang Wook Lee, Hye Rim Kang, Dae In Kim, Hwa Yeon Sun, Jae Heon Kim
AIMS: This study attempted to investigate the association between lower urinary tract symptoms (LUTS) and cardiovascular disease (CVD) risk using International Prostate Symptom Score (IPSS) and CVD risk scores and to overcome the limitations of previous relevant studies. METHODS: A total of 2994 ostensibly healthy males, who participated in a voluntary health check in a health promotion center from January 2010 to December 2014, were reviewed. CVD risk scores were calculated using Framingham risk score and American College of Cardiology (ACC)/American Heart Association (AHA) score...
June 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28603827/prognostic-factors-predicting-overall-survival-in-moroccan-patients-with-myelodysplastic-syndrome
#11
Selim Jennane, Sanae Amelal, Mahtat El Mehdi, Samir Ahid, Nezha Messaoudi, Kamal Doghmi, Mohammed Mikdame
BACKGROUND: Prognostic scores are an indispensable tool in the management of myelodysplastic syndromes. AIM: Identify prognostic factors influencing overall survival of patients with myelodysplastic syndromes. METHODS: We included all patients with myelodysplastic syndromes treated in the clinical hematology department of the military hospital of Rabat (Morocco). RESULTS: Seventy-four patients were included. The sex ratio [M / F] was 1...
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28601562/patterns-of-benign-prostate-hyperplasia-based-on-magnetic-resonance-imaging-are-correlated-with-lower-urinary-tract-symptoms-and-continence-in-men-undergoing-a-robot-assisted-radical-prostatectomy-for-prostate-cancer
#12
Nikolaos Grivas, Rosanne van der Roest, Corinne Tillier, Daan Schouten, Erik van Muilekom, Ivo Schoots, Henk van der Poel, Stijn Heijmink
OBJECTIVE: To investigate the association between benign prostatic hyperplasia (BPH) patterns, classified by magnetic resonance imaging (MRI), with lower urinary tract symptoms (LUTS) or continence, preoperatively and after robot-assisted laparoscopic radical prostatectomy (RARP). MATERIALS AND METHODS: This retrospective study included 49 prostate cancer patients, with prostate size >47 cm(3), who underwent an endorectal MRI followed by RARP. Five BPH patterns were identified according to Wasserman and additional prostate measurements were recorded...
June 7, 2017: Urology
https://www.readbyqxmd.com/read/28598556/can-preoperative-detrusor-underactivity-influence-surgical-outcomes-of-120%C3%A2-w-hps-vaporization-of-the-prostate-pvp-or-holmium-laser-enucleation-of-the-prostate-holep-a-serial-3-year-follow-up-study
#13
Min Chul Cho, Juhyun Park, Jung Kwon Kim, Sung Yong Cho, Hyeon Jeong, Seung-June Oh, Jae-Seung Paick, Hwancheol Son
AIMS: To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. METHODS: A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88)...
June 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28593169/atherosclerosis-is-associated-with-erectile-function-and-lower-urinary-tract-symptoms-especially-nocturia-in-middle-aged-men
#14
Akira Tsujimura, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiki Mizuno, Taiji Nozaki, Masato Shirai, Kazuhiro Kobayashi, Yoshiaki Kumamoto, Shigeo Horie
BACKGROUND: Atherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related to quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent in aging men and are significantly associated with a reduced QOL. However, few questionnaire-based studies have fully examined the relation between atherosclerosis and several urological symptoms. MATERIALS AND METHODS: The study comprised 303 outpatients who visited our clinic with symptoms of LOH...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28591503/-cytogenetics-of-myelodysplastic-syndromes-and-its-impact-as-prognostic-factor
#15
César Borjas-Gutiérrez, Martín Daniel Domínguez-Cruz, Juan Ramón González-García
Myelodysplastic syndromes (MDS) are a group of disorders of the hematopoietic stem cell. They are characterized by cytopenia(s), dysplasia of one or more cell lines, ineffective hematopoiesis, and an increased risk for developing acute myelogenous leukemia. The classification of MDS has been complicated due to the great heterogeneity in clinical phenotype as well as in the morphological and cytogenetic characteristics. The prognostic value of cytogenetic abnormalities in MDS has been analyzed in multicenter studies...
July 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28590836/photoselective-vaporization-of-the-prostate-using-120-w-high-performance-system-a-prospective-evaluation-of-results-over-2-years
#16
Alper Eken, Ergun Alma, Durmus Alparslan Demirci, Meltem Açıl, Taner Arpacı, Bülent Soyupak
PURPOSE: This study evaluated the safety and efficacy of photoselective vaporization of prostate using the 120 W High Performance System for management of symptomatic benign prostatic hyperplasia (BPH). METHODS: We prospectively obtained data from 229 patients between January 2009 and December 2012. We evaluated the serum prostate specific antigen level, International Prostate Symptom Score (IPSS), prostate volume; maximum urine flow rate (Qmax); and postvoid residual urine volume (PVR) in the patients at presentation and on follow-up at 1, 6, 12, and 24 months...
June 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28589133/comparisons-of-quality-of-life-and-functional-and-oncological-outcomes-after-orthotopic-neobladder-reconstruction-prostate-sparing-cystectomy-versus-conventional-radical-cystoprostatectomy
#17
Po Yen Chen, Po Hui Chiang
OBJECTIVES: To compare health-related quality of life and oncological and functional outcomes on erectile function, continence, and voiding function among bladder patients who underwent orthotopic neobladder reconstruction after prostate-sparing cystectomy (PSC) and conventional radical cystoprostatectomy (CRC). METHODS: This is a retrospective cohort study from a single surgeon. During 2007 to 2015, we identified 25 of 186 male patients receiving radical cystectomies due to bladder cancer who underwent orthotopic neobladder reconstruction, 14 patients with PSC and the other 11 patients with CRC...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28584504/short-term-effect-of-tamsulosin-and-finasteride-monotherapy-and-their-combination-on-nigerian-men-with-benign-prostatic-hyperplasia
#18
Benjamin O Odusanya, Kehinde H Tijani, Emmanuel A Jeje, Moses A Ogunjimi, Rufus W Ojewola
OBJECTIVE: The objective of this study was to assess the efficacy of tamsulosin and finasteride monotherapies, and their combination in men with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: This is a prospective single-blind randomized study of ninety men with BPH who were managed using drugs. The International Prostate Symptom Score (IPSS), peak urinary flow rate, and prostate volume were measured as parameters for assessment at the beginning, 3 months, and 6 months of the study...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28576667/bipolar-plasma-enucleation-of-the-prostate-b-tuep-in-benign-prostate-hypertrophy-treatment-3-year-results
#19
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Cristina Falavolti
OBJECTIVE: To numerous endoscopic techniques have been described for the treatment of benign prostate enlargement (BPE). The plasma-button enucleation of the prostate (B-TUEP) is a successful treatment option because the large surface creates a fast enucleation process, vaporization and concomitant haemostasis. The aim of this study was to evaluate the efficacy of bipolar button electrode transurethral adenoma enucleation (B-TUEP) in saline solution. The second endpoint was to determine the change of IPSS, PVR, IEFF-5, TrUS and PSA...
May 30, 2017: Urology
https://www.readbyqxmd.com/read/28576422/a-bicentric-comparative-and-prospective-study-between-classic-photovaporization-and-anatomical-greenlight-laser-vaporization-for-large-volume-prostatic-adenomas
#20
G Hibon, G Léonard, A Franceschi, V Misrai, F Bruyère
OBJECTIVE: Long-term outcome after prostate photovaporization (PVP) remains largely unknown, especially when performed on enlarged prostates. However, new vaporisation techniques (e.g., laser enucleation) are increasingly used. Our aim was to compare postoperative results after standard PVP to those of an anatomical technique. MATERIALS AND METHODS: This bicentric prospective study included males treated for enlarged prostate caused by benign prostatic hyperplasia using a GreenLight laser...
June 2017: Progrès en Urologie
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