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https://www.readbyqxmd.com/read/28322900/structural-variations-of-the-prostatic-urethra-within-the-prostate-predict-the-severities-of-obstructive-symptoms-a-prospective-multicenter-observational-study
#1
Young Hwii Ko, Tae-Hwan Kim, Phil Hyun Song, Byung Hoon Kim, Bum Soo Kim, Ki Ho Kim, Jaeho Cho
OBJECTIVE: To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract symptom (LUTS). MATERIALS AND METHODS: After standardizing measurements, seven ultrasonography determined variables, that is, prostate volume, transitional zone volume, transitional zone to total volume ratio, presence of intraprostatic protrusion, prostatic urethral angle, prostatic urethral length (PUL), and PUL-to-volume ratio (rPUL), were obtained prospectively in 293 men that had not taken LUTS medication during the 3 months prior to initial visits...
March 17, 2017: Urology
https://www.readbyqxmd.com/read/28321924/infectious-complications-in-patients-with-myelodysplastic-syndromes-a-review-of-the-literature-with-emphasis-on-patients-treated-with-5-azacitidine
#2
REVIEW
Markus Radsak, Uwe Platzbecker, Cornelia S Schmidt, Wolf-Karsten Hofmann, Florian Nolte
Myelodysplastic syndromes (MDS) are oligo-clonal diseases of the hematopoietic stem cell compartment resulting in peripheral cytopenias and a tendency of developing acute myeloid leukemia (AML). MDS show an incidence of approximately 4/100.000/year. However, MDS are mainly a disease of the elderly with a sharp increase in incidence in the age decade above 70 years. Due to the demographic change in western countries, it is expected that the MDS will play an increasing role for these health systems. Although anemia is the predominant cytopenia in the majority of patients, about 30-50% of patients suffer from neutropenia of varying severity...
March 21, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28321120/decision-analysis-of-allogeneic-hematopoietic-stem-cell-transplantation-for-patients-with-myelodysplastic-syndrome-stratified-according-to-the-revised-international-prognostic-scoring-system-ipss-r
#3
M G Della Porta, C H Jackson, E P Alessandrino, M Rossi, A Bacigalupo, M T van Lint, M Bernardi, B Allione, A Bosi, S Guidi, V Santini, L Malcovati, M Ubezio, C Milanesi, E Todisco, M T Voso, P Musto, F Onida, A P Iori, R Cerretti, G Grillo, A Molteni, P Pioltelli, L Borin, E Angelucci, E Oldani, S Sica, C Pascutto, V Ferretti, A Santoro, F Bonifazi, M Cazzola, A Rambaldi
Allogeneic hematopoietic stem cell transplantation (allo-SCT) represents the only curative treatment for patients with myelodysplastic syndrome (MDS), but involves non-negligible morbidity and mortality. Crucial questions in clinical decision making include the definition of optimal timing of the procedure and the benefit of cytoreduction before transplant in high risk patients. We carried out a decision analysis on 1728 MDS who received supportive care, transplantation or hypomethylating agents (HMAs). Risk assessment was based on the revised International Prognostic Scoring System (IPSS-R)...
March 21, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28321087/myelodysplastic-syndrome-diagnosed-on-the-occasion-of-fournier-s-gangrene
#4
Masaaki Adachi, Kimiyoshi Mitsuhashi, Hiroyuki Matsuda, Junko Watanabe, Katsuya Nakanishi
Fournier's gangrene (FG) is a fulminant infective necrotizing fasciitis, which includes the genital, perineal, and perianal regions. A 77-year-old man had previously been diagnosed as having diabetes mellitus (DM) and was treated with pioglitazone (15 mg) and miglitol (150 mg). He developed sudden perineal discomfort, fever with painful penile, and scrotal edema, subsequently leading to urinary retention. According to physical examination and CT scan results for the swollen penis and scrotum, he was diagnosed with FG...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28303843/photoselective-vaporesection-of-the-prostate-with-an-end-firing-lithium-triborate-crystal-laser
#5
Xin Wang, Ming Liu, Yao-Guang Zhang, Sheng-Cai Zhu, Ben Wan, Jian-Ye Wang
BACKGROUND: Photoselective vaporization of the prostate is a technique that is widely used for the treatment of benign prostatic hyperplasia (BPH) and has pronounced advantages compared to the traditional transurethral resection of the prostate. Following the recent introduction of end-firing lithium triborate lasers, we have created a new technique called photoselective vaporesection of the prostate (PVRP). This study described our initial experience using the PVRP technique for the treatment of BPH...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28301527/associations-between-the-severity-of-obstructive-lower-urinary-tract-symptoms-and-care-seeking-behavior-in-rural-africa-a-cross-sectional-survey-from-uganda
#6
Lynn Stothers, Andrew J Macnab, Francis Bajunirwe, Sharif Mutabazi, Jonathan Berkowitz
STUDY TYPE: A cross sectional survey. BACKGROUND: Global estimates indicate that by 2018 2.3 billion individuals worldwide will suffer from lower urinary tract symptoms (LUTS), with 1.1 billion having LUTS related to bladder outlet obstruction (BOO). Left untreated BOO in men causes irreversible changes to the urinary tract leading to urinary retention, the need for catheterization, renal failure and even death. Estimates suggest that Africa will be one of the continents with the greatest increase in (LUTS) by 2018 however direct measures in Africa are lacking...
2017: PloS One
https://www.readbyqxmd.com/read/28295051/six-out-of-ten-women-with-recurrent-urinary-tract-infections-complain-of-distressful-sexual-dysfunction-a-case-control-study
#7
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Roberta Scano, Alessandra Graziottin, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
Uncomplicated recurrent urinary tract infections (rUTIs) are common among reproductive-aged women. We aimed to assess the prevalence and predictors of sexual dysfunction (FSD) in a cohort of women with rUTIs and compare their psychometric scores to those of matched controls. Data from 147 rUTIs women and 150 healthy controls were analysed. Participants completed the International Prostatic Symptoms Score (IPSS), the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (SDS). Descriptive statistics and logistic regression models tested prevalence and predictors of distressful FSD...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293871/greenlight-laser-photoselective-vaporization-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia-lower-urinary-tract-symptoms-in-patients-with-different-post-void-residual-urine
#8
Fei Luo, Hong-Hong Sun, Yan-Hui Su, Zhi-Hua Zhang, Ya-Shen Wang, Zhen Zhao, Jian Li
The purpose of this study is to assess the safety and efficacy of GreenLight laser photoselective vaporization of the prostate (PVP) for the treatment of benign prostate hyperplasia/lower urinary tract symptoms (BPH/LUTS) in patients with different post-void residual urine (PVR). BPH/LUTS patients treated with PVP from January 2014 to January 2016 were enrolled in the present study. All patients were divided into PVR > 50, 50 ≤ PVR < 400, and PVR ≥ 400 ml groups, and standard general and urological methods for BPH/LUTS were carried out...
March 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28288952/outcomes-after-umbilical-cord-blood-transplantation-for-myelodysplastic-syndromes
#9
Aaron T Gerds, Kwang Woo Ahn, Zhen-Huan Hu, Hisham Abdel-Azim, Gorgun Akpek, Mahmoud Aljurf, Karen K Ballen, Amer Beitinjaneh, Ulrike Bacher, Jean-Yves Cahn, Saurabh Chhabra, Corey Cutler, Andrew Daly, Zachariah DeFilipp, Robert Peter Gale, Usama Gergis, Michael R Grunwald, Gregory A Hale, Betty Ky Hamilton, Madan Jagasia, Rammurti T Kamble, Tamila Kindwall-Keller, Taiga Nishihori, Richard F Olsson, Muthalagu Ramanathan, Ayman A Saad, Melhem Solh, Celalettin Ustun, David Valcárcel, Erica Warlick, Baldeep M Wirk, Matt Kalaycio, Edwin Alyea, Uday Popat, Ronald Sobecks, Wael Saber
For patients with hematologic malignancies undergoing allogeneic hematopoietic cell transplantation, umbilical cord blood transplantation (UCBT) has become an acceptable alternative donor source in the absence of a matched sibling or unrelated donor. However, there have been few published series dedicated solely to describing the outcomes of adult patients with myelodysplastic syndrome (MDS) who have undergone UCBT. From 2004 to 2013, 176 adult MDS patients underwent UCBT as reported to the Center for International Blood and Marrow Transplant Research...
March 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28285780/-validation-of-visual-prostate-symptom-score-vpss-in-the-evaluation-of-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-550-patients
#10
A Descazeaud, P Coloby, J L Davin, A De La Taille, G Karsenty, G Kouri, D Rossi, J C Pouteau, M Zerbib
OBJECTIVES: Our objective was to validate the VPSS (visual prostatic symptom score) score in the French language for the identification and monitoring of BPH-related LUTS in urological practice. METHODS: A prospective observational survey was carried out between September the 15th 2014 and July the 30th 2015 in urology practices. The first 4 consecutive patients aged over 60 years, with BPH-related LUTS requiring prescription of an alpha-blocker, were enrolled. We translated a "visual prostatic symptom score" (VPSS) into French and adapted it slightly...
March 9, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28281047/acute-and-late-complications-after-hypofractionated-intensity-modulated-radiotherapy-in-prostate-cancer
#11
Takuyo Kozuka, Masahiro Nakano, Masatoshi Hashimoto, Kotaro Gomi, Keiko Nemoto Murofushi, Minako Sumi, Junji Yonese, Masahiko Oguchi
PURPOSE: The present study compared the complications associated with hypofractionated intensity-modulated radiation therapy (Hypo-IMRT) of prostate cancer to conventionally fractionated IMRT (Conv-IMRT). MATERIALS AND METHODS: Hypo-IMRT delivered 70 Gy in 28 fractions, whereas Conv-IMRT delivered 78 Gy in 39 fractions. Toxicity was graded with the Common Terminology Criteria for Adverse Events, version 4.0, weekly during radiotherapy, 1 month after radiotherapy, and annually in both patient groups...
March 9, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28279036/-predict-response-to-decitabine-in-patients-with-myelodysplastic-syndrome-and-related-neoplasms
#12
Y S Zhao, J Guo, F Xu, D Wu, L Y Wu, L L Song, C Xiao, X Li, C K Chang
Objective: To identify clinical and molecular signatures for predicting response to decitabine (DAC) in patients with myelodysplastic syndrome (MDS) and related neoplasms. Methods: The clinical characteristics of 109 patients with MDS and related neoplasms who were treated with DAC were analyzed retrospectively and the next target sequencing was performed to define recurrently mutated genes in these disease samples, to examine the association of the clinical and molecular signatures with response to DAC treatment...
February 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28278704/incidence-etiology-and-timing-of-infections-following-azacitidine-therapy-for-myelodysplastic-syndromes
#13
Jason A Trubiano, Michael Dickinson, Karin A Thursky, Timothy Spelman, John F Seymour, Monica A Slavin, Leon J Worth
We examine the infective complications occurring during azacitidine (AZA) therapy in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). A retrospective review of patients receiving ≥1 cycle of AZA for MDS or AML was performed. Patient demographics, infection prophylaxis/episodes and outcomes were evaluated. Sixty eight patients received 884 AZA cycles. Bacterial infections occurred in 25% of cycle-1 and 27% of cycle-2 AZA therapy. Febrile neutropenia complicated 5.3% of AZA cycles, bacteremia 2% and invasive Aspergillosis 0...
February 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28275519/sildenafil-citrate-in-combination-with-tamsulosin-versus-tamsulosin-monotherapy-for-management-of-male-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-a-randomised-double-blind-placebo-controlled-trial
#14
Amr Fawzi, Mostafa Kamel, Emad Salem, Esam Desoky, Mohamed Omran, Hazem Elgalaly, Ahmed Sakr, Aref Maarouf, Salem Khalil
OBJECTIVE: To assess the additive effect of sildenafil citrate to tamsulosin in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) in men with or without erectile dysfunction (ED). PATIENTS AND METHODS: In all, 150 men with untreated LUTS/BPH with or without ED were randomised to receive sildenafil 25 mg once daily (OD) or placebo OD (night time) combined with tamsulosin 0.4 mg OD (day time) for 6 months. Changes from pre-treatment scores in International Prostate Symptom Score (IPSS), IPSS-quality of life (QoL) score, maximum urinary flow rate (Qmax), and the five-item version of the International Index of Erectile Function questionnaire (IIEF-5) were assessed at 3 and 6 months...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28261619/the-long-term-effect-of-radical-prostatectomy-on-erectile-function-urinary-continence-and-lower-urinary-tract-symptoms-a-comparison-to-age-matched-healthy-controls
#15
Badereddin Mohamad Al-Ali, Anton Ponholzer, Herbert Augustin, Stephan Madersbacher, Karl Pummer
Introduction. To analyze the impact of radical prostatectomy (RPE) on erectile function and lower urinary tract function in comparison to age-matched healthy men. Materials and Methods. Patients who underwent radical retropubic prostatectomy completed questionnaires containing the IIEF-5, the Bristol female LUTS questionnaire, and the International Prostate Symptom Score (IPSS). Results. Patients after RPE were included (n = 363). Age-matched healthy men (n = 363) were included. The mean IIEF-5 of patients aged 61-70 yrs after RPE was 10...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28261572/effect-of-triptorelin-on-lower-urinary-tract-symptoms-in-australian-prostate-cancer-patients
#16
Henry H Woo, Declan G Murphy, Gerard M Testa, Jeremy P Grummet, Michael Chong, Andrew P Stork
PURPOSE: Prostate cancer is often comorbidly associated with lower urinary tract symptoms (LUTS), but few studies have assessed the effects of androgen deprivation therapy on LUTS in this patient group. PATIENTS AND METHODS: We conducted a prospective, noninterventional, multicenter, observational study to assess the effectiveness of triptorelin (11.25 mg every 12 weeks) over 48 weeks in men presenting with local stage T3/4 prostate cancer and moderate to severe LUTS (International Prostate Symptom Score [IPSS] >7) in a routine practice setting in Australia...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28257560/dutasteride-add-on-therapy-reduces-detrusor-mass-in-patients-with-benign-prostatic-enlargement-not-satisfied-with-alpha-adrenergic-antagonist-monotherapy-a-single-center-prospective-study
#17
Cosimo De Nunzio, Aldo Brassetti, Flavia Proietti, Mauro Gacci, Sergio Serni, Francesco Esperto, Andrea Tubaro
AIMS: The ultrasound assessment of bladder wall thickness (BWT) and intravesical prostatic protrusion (IPP) have emerged as a non-invasive, inexpensive, time-saving alternatives to pressure-flow studies to assess benign prostatic obstruction (BPO). Aim of our study was to evaluate the effect on detrusor mass of dutasteride add-on therapy in men with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: A consecutive series of BPE patients with a prostate volume (PV) ≥30 mL and an international prostate symptoms score (IPSS) ≥8 not satisfied with Tamsulosin monotherapy were enrolled...
March 3, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28249090/performance-of-vascular-exposure-and-fasciotomy-among-surgical-residents-before-and-after-training-compared-with-experts
#18
Colin F Mackenzie, Evan Garofalo, Adam Puche, Hegang Chen, Kristy Pugh, Stacy Shackelford, Samuel Tisherman, Sharon Henry, Mark W Bowyer
Importance: Surgical patient outcomes are related to surgeon skills. Objective: To measure resident surgeon technical and nontechnical skills for trauma core competencies before and after training and up to 18 months later and to compare resident performance with the performance of expert traumatologists. Design, Setting, and Participants: This longitudinal study performed from May 1, 2013, through February 29, 2016, at Maryland State Anatomy Board cadaver laboratories included 40 surgical residents and 10 expert traumatologists...
March 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28248016/-ipss-qol-questionnaire-in-assessing-symptoms-and-quality-of-life-in-patients-with-anterior-urethral-stricture
#19
V V Bazaev, A N Shibaev, Yu V Pavlova
RELEVANCE: The IPSS-QOL questionnaire is frequently used to assess symptoms and quality of life of men with urethral strictures. However, the psychometric properties of the questionnaire in assessing these patients have not been evaluated. AIM: To test the psychometric properties of the IPSS-QoL questionnaire in assessing patients with anterior urethral strictures. MATERIAL AND METHODS: Thirty five men with anterior urethral strictures self-completed the IPSS-QoL questionnaire...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247729/-monopolar-transurethral-enucleation-of-benign-prostatic-hyperplasia-our-initial-experience
#20
D G Tsarichenko, R R Simberdeev, P V Glybochko, Y G Alyaev, L M Rapoport, R B Sukhanov, N I Sorokin, D V Enikeev, D S Davydov
INTRODUCTION: The choice of surgical treatment in patients with BPH is one of the most discussed issues in urology. In recent years, the surgical treatment of prostates of medium and large sizes by means of enucleation has become increasingly popular. OBJECTIVE: The emergence of special loops to perform bipolar and monopolar enucleation using standard equipment for TURP has opened up new possibilities for the treatment of patients with BPH-transurethral monopolar enucleation BPH...
August 2016: Urologii︠a︡
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