Maria Creignou, Elsa Bernard, Alessandro Gasparini, Anna Tranberg, Gabriele Todisco, Pedro Luis Moura, Elisabeth Ejerblad, Lars Nilsson, Hege Garelius, Petar Antunovic, Fryderyk Lorenz, Bengt Rasmussen, Gunilla Walldin, Teresa Mortera-Blanco, Monika Jansson, Magnus Tobiasson, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Luca Malcovati, Gustaf Edgren, Michael J Crowther, Martin Jädersten, Elli Papaemmanuil, Eva Hellström-Lindberg
BACKGROUND: The Molecular International Prognostic Scoring System (IPSS-M) is the new gold standard for diagnostic outcome prediction in patients with myelodysplastic syndromes (MDS). This study was designed to assess the additive prognostic impact of dynamic transfusion parameters during early follow-up. METHODS: We retrieved complete transfusion data from 677 adult Swedish MDS patients included in the IPSS-M cohort. Time-dependent erythrocyte transfusion dependency (E-TD) was added to IPSS-M features and analyzed regarding overall survival and leukemic transformation (acute myeloid leukemia)...
April 23, 2024: Journal of Internal Medicine