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Erico Masala, Ana Valencia-Martinez, Serena Pillozzi, Tommaso Rondelli, Alice Brogi, Alessandro Sanna, Antonella Gozzini, Annarosa Arcangeli, Persio Dello Sbarba, Valeria Santini
Myelodysplastic Syndromes (MDS) are clonal neoplasms where stem/progenitor cells endowed with self-renewal and capable of perpetuating the disease have been demonstrated. It is known that oxygen tension plays a key role in driving normal hematopoiesis and that hematopoietic stem cells are maintained in hypoxic areas of the bone marrow (BM). Hypoxia could also regulate leukemic/dysplastic hematopoiesis. We evaluated the stem cell potential of MDS cells derived from the BM of 39 MDS patients and selected under severe hypoxia...
February 13, 2018: Oncotarget
L Klotz, A Loblaw, R Siemens, P Ouellette, A Kapoor, M Kebabdjian, L Zhang, F Saad
BACKGROUND: In men initiating intermittent androgen deprivation therapy (IADT), a range of induction durations, between 3 and 12 months, have been employed. OBJECTIVE: To determine if the duration of induction ADT influences the duration of the off treatment interval and the recovery of serum testosterone (T). MANEUVER: This was a prospective, randomized, open label study. Men with biochemical recurrence after local therapy for prostate cancer, with a negative bone scan, were randomized between 4 and 10 months of monthly Degarelix...
March 10, 2018: Journal of Urology
Limin Liao, Yao-Chi Chuang, Shih-Ping Liu, Kyu-Sung Lee, Tag Keun Yoo, Romeo Chu, Budiwan Sumarsono, Jian-Ye Wang
OBJECTIVE: Lower urinary tract symptoms (LUTS) in males can reduce patients' quality of life (QoL) and affect sexual function and satisfaction. Although this has been documented in the US, Canada, Germany, Italy, UK, and Sweden, data are limited on the effects of LUTS on QoL and sexual function in Asian men. The present subgroup analysis of an Internet-based survey correlated the incidence of male LUTS by severity and category with self-assessed QoL and sexual function and satisfaction measures...
March 11, 2018: Lower Urinary Tract Symptoms
Guillermo Montalban-Bravo, Koichi Takahashi, Keyur Patel, Feng Wang, Song Xingzhi, Graciela M Nogueras, Xuelin Huang, Ana Alfonso Pierola, Elias Jabbour, Simona Colla, Irene Gañan-Gomez, Gautham Borthakur, Naval Daver, Zeev Estrov, Tapan Kadia, Naveen Pemmaraju, Farhad Ravandi, Carlos Bueso-Ramos, Ali Chamseddine, Marina Konopleva, Jianhua Zhang, Hagop Kantarjian, Andrew Futreal, Guillermo Garcia-Manero
The prognostic and predictive value of sequencing analysis in myelodysplastic syndromes (MDS) has not been fully integrated into clinical practice. We performed whole exome sequencing (WES) of bone marrow samples from 83 patients with MDS and 31 with MDS/MPN identifying 218 driver mutations in 31 genes in 98 (86%) patients. A total of 65 (57%) patients received therapy with hypomethylating agents. By univariate analysis, mutations in BCOR, STAG2, TP53 and SF3B1 significantly influenced survival. Increased number of mutations (≥ 3), but not clonal heterogeneity, predicted for shorter survival and LFS...
February 9, 2018: Oncotarget
Il-Young Jang, Chang Ki Lee, Hee-Won Jung, Sang Soo Yu, Young Soo Lee, Eunju Lee, Dae Hyun Kim
Purpose: Frailty is an important consideration in the management of lower urinary tract symptoms and erectile dysfunction in older men; frailty increases vulnerability to treatment-related adverse outcomes, but its burden is not known. The authors aimed to examine the burden of frailty and associated geriatric conditions in community-dwelling older men. Patients and methods: A cross-sectional study was conducted with 492 community-dwelling older men (mean age, 74...
2018: Clinical Interventions in Aging
Emilio Sacco, Carlo Gandi, Luigi Vaccarella, Salvatore Recupero, Marco Racioppi, Francesco Pinto, Angelo Totaro, Nazario Foschi, Giuseppe Palermo, Francesco Pierconti, Pierfrancesco Bassi
OBJECTIVE: To evaluate prospectively midterm outcomes of a new titanium-coated fixed polypropylene sling for male stress urinary incontinence. MATERIALS AND METHODS: From 01/2013 to 06/2016, 44 consecutive patients with incontinence caused by radical prostatectomy (39) or TURP (5) underwent transobturator two-arm titanium-coated sling (TiLOOP Male® ) implantation with an inside-out, single-incision technique, leaving the bulbourethral muscle in place. Patients have been assessed postoperatively with uroflowmetry, pad count, ICIQ-SF, IIQ-7, PGI-I, OABq, IPSS, satisfaction (yes/no)...
March 1, 2018: Urology
Saturnino Napal Lecumberri, Iñigo Insausti Gorbea, Ana Sáez de Ocáriz García, Saioa Solchaga Álvarez, José Luis Cebrián Lostal, Raquel Monreal Beortegui, Pedro José Giral Villalta, Fermín Urtasun Grijalba
Background: Benign prostatic hyperplasia (BPH) is a prevalent disease associated with lower urinary tract symptoms (LUTS). The standard of care for moderate-to-severe LUTS unresponsive to pharmacological treatment is the transurethral resection of the prostate (TURP). However, this intervention is not exempt from complications. Prostatic artery embolization (PAE) has been described as a new, effective and safe procedure for the treatment of LUTS secondary to BPH. To date, only one clinical trial has been published on the use of PAE for LUTS, but the study was methodologically flawed in terms of safety monitoring...
2018: Research and Reports in Urology
Jae Hoon Chung, Cheol Young Oh, Jae Heon Kim, U-Syn Ha, Tae Hyo Kim, Seung Hwan Lee, Jun Hyun Han, Jae Hyun Bae, In Ho Chang, Deok Hyun Han, Tag Keun Yoo, Jae Il Chung, Sae Woong Kim, Jina Jung, Yong-Il Kim, Seung Wook Lee
OBJECTIVE: To verify the efficacy and safety of tamsulosin 0.4 mg and tamsulosin 0.2 mg compared with those of placebo in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). METHODS: A total of 494 patients from multiple centers participated in this double-blind, randomized, phase 3 trial. The eligible patients were randomly assigned to the tamsulosin 0.4 mg group, tamsulosin 0.2 mg group, or placebo group...
February 28, 2018: Current Medical Research and Opinion
D Maclean, M Harris, T Drake, B Maher, S Modi, J Dyer, B Somani, N Hacking, T Bryant
INTRODUCTION: As prostate artery embolisation (PAE) becomes an established treatment for benign prostatic obstruction, factors predicting good symptomatic outcome remain unclear. Pre-embolisation prostate size as a predictor is controversial with a handful of papers coming to conflicting conclusions. We aimed to investigate if an association existed in our patient cohort between prostate size and clinical benefit, in addition to evaluating percentage volume reduction as a predictor of symptomatic outcome following PAE...
February 26, 2018: Cardiovascular and Interventional Radiology
Marc Gaudet, Mathieu Pharand-Charbonneau, Marie-Pierre Desrosiers, Debbie Wright, Alain Haddad
PURPOSE: To determine the acute toxicity and effect on health-related quality of life of a two-fraction regimen of high-dose-rate (HDR) prostate brachytherapy. METHODS AND MATERIALS: Patients with low- or intermediate-risk prostate cancer were treated with HDR brachytherapy as monotherapy in two implants of 13.5 Gy spaced 7-14 days apart. Patients completed International Prostate Symptom Score (IPSS) and Expanded Prostate Index Composite (EPIC) questionnaires at 1, 3, 6, 9, 12, 16, 20, and 24 months after brachytherapy...
February 23, 2018: Brachytherapy
Cosimo DE Nunzio, Giovanni Truscelli, Fabrizio Presicce, Mariangela Bellangino, Mauro Gacci, Carlo Gaudio, Andrea Tubaro
BACKGROUND: To assess the association between cardiovascular risk (CVR) and Lower Urinary Tract Symptoms (LUTS) in men with Benign Prostatic Enlargement (BPE). METHODS: We enrolled a consecutive series of men with LUTS/BPE. International Prostate Symptom Score (IPSS), voiding (vIPSS) and storage (sIPSS) subscore and prostate volume were evaluated. We defined CVR according to the European Association of Cardiologist Guidelines and Metabolic syndrome (MetS) according to Adult Treatment Panel III (ATP III)...
February 22, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Colleen A C Wong, Shannon A Y Wong, Heather A Leitch
BACKGROUND: An increased incidence of infections and infectious mortality has been reported in myelodysplastic syndromes (MDS) patients receiving red blood cell (RBC) transfusions. METHODS: We examined incidence of infections requiring antibiotics, antifungal or antiviral medications in transfused lower International Prognostic Scoring System (IPSS) risk MDS patients and whether this differed with iron chelation therapy (ICT). RESULTS: 138 transfused MDS patients were lower IPSS risk...
February 10, 2018: Leukemia Research
Musa Alzahrani, Maryse Power, Yasser Abou Mourad, Michael Barnett, Raewyn Broady, Donna Forrest, Alina Gerrie, Donna Hogge, Stephen Nantel, David Sanford, Kevin Song, Heather Sutherland, Cynthia Toze, Thomas Nevill, Sujaatha Narayanan
BACKGROUND: The natural history of patients with myelodysplastic syndromes (MDS) is variable. The revised international prognostic score (IPSS-R) is commonly used in practice to predict outcome in patients with MDS both at diagnosis and pre-transplant. However the effect of change in IPSS-R pre-allogeneic stem cell transplant with chemotherapy or hypomethylating agents on post-transplant outcomes is currently unknown. AIM: We assessed if improvement in IPSS-R prognostic score pre HSCT would result in improvement in clinical outcomes post-transplant...
February 20, 2018: Biology of Blood and Marrow Transplantation
Minoru Kobayashi, Yuumi Tokura, Tsunehito Kambara, Akinori Nukui, Takao Kamai
OBJECTIVE: The aim of the present study was to examine the clinical features and implications of a feeling of incomplete emptying despite little post-void residual (PVR), because it remains unclear why patients are bothered by such an undefined feeling. METHODS: Data were collected prospectively from 173 consecutive patients (135 men, 38 women) with a complaint of a feeling of incomplete emptying with PVR <50 mL at an initial visit. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, overactive bladder symptom score (OABSS), prostate volume, and PVR were determined...
February 22, 2018: Lower Urinary Tract Symptoms
Tomohiro Matsuo, Yasuyoshi Miyata, Tatsufumi Nakamura, Katsuya Satoh, Hideki Sakai
OBJECTIVE: Mirabegron is widely considered as an effective and safe drug for patients with overactive bladder (OAB). However, there is no evidence regarding the efficacy of mirabegron in human T cell lymphotropic virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients with OAB symptoms. The aim of the present study was to clarify the efficacy of mirabegron in HAM/TSP patients with OAB symptoms. METHODS: The present study evaluated the efficacy of mirabegron treatment (50 mg, once daily) in nineteen HAM/TSP patients with OAB symptoms by assessing subjective symptoms using the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) before and 12 weeks after administration...
February 22, 2018: Lower Urinary Tract Symptoms
Mehmet Sarier, Ibrahim Duman, Suleyman Kilic, Yucel Yuksel, Meltem Demir, Mesut Aslan, Levent Yucetin, Sabri Tekin, Asuman Havva Yavuz, Mestan Emek
PURPOSE: The aim of this study is to compare the results of transurethral incision of the prostate (TUIP) and transurethral resection of the prostate (TURP) for the surgical treatment of benign prostate hyperplasia (BPH) in patients with renal transplantation. MATERIALS AND METHODS: Between April 2009 and May 2016, BPH patients with renal transplants whose prostate volumes were less than 30 cm3 were treated surgically. Forty-seven patients received TURP and 32 received TUIP...
February 18, 2018: Urology Journal
Zhihui Zou, Abai Xu, Shaobo Zheng, Binshen Chen, Yawen Xu, Hulin Li, Chongyang Duan, Junhong Zheng, Jiasheng Chen, Chaoming Li, Yiming Wang, Yubo Gao, Chaozhao Liang, Chunxiao Liu
PURPOSE: Bipolar endoscopic enucleation of the prostate (BEEP) was recommended by the 2016 EAU guidelines as the first choice of surgical treatment in men with a substantially enlarged prostate and moderate-to-severe lower urinary tract symptoms. The main aim of this study was to compare a modified diode laser enucleation of the prostate (DiLEP) to BEEP. METHODS: A total of 114 patients with prostate (20-160 mL) were randomized 1:1 into either DiLEP or BEEP in a dual-centre, non-inferiority-design randomized-controlled trial...
February 19, 2018: World Journal of Urology
Martin Schoenthaler, Karl-Dietrich Sievert, Dominik Stefan Schoeb, Arkadiusz Miernik, Thomas Kunit, Simon Hein, Thomas R W Herrmann, Konrad Wilhelm
PURPOSE: The aim of the study was to evaluate the feasibility and safety of combining prostatic urethral lift (PUL) and a limited resection of the prostatic middle lobe or bladder neck incision in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). METHODS: Twenty-eight patients were treated at two tertiary centers and followed prospectively. Patient evaluations included patient characteristics, relief of LUTS symptoms, erectile and ejaculatory function, continence, operative time and adverse events...
February 15, 2018: World Journal of Urology
Livio Mordasini, Carlo Di Bona, Jacques Klein, Agostino Mattei, Gregory Wirth, Christophe E Iselin
OBJECTIVES: To assess long term functional and safety follow-up data after 80-W GreenLight photoselective vaporization (GL PV) of the prostate and transurethral resection of the prostate (TURP). MATERIALS AND METHODS: Prospective randomized trial at a single tertiary referral center (Geneva, Switzerland). Patients were recruited in the outpatient clinic if they met the criteria for surgical treatment of BPO. At baseline, 238 patients were treated either with the 80-W GL PV or monopolar TURP...
February 12, 2018: Urology
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