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https://www.readbyqxmd.com/read/30310505/prognostic-value-of-pd-l1-expression-in-resected-lung-adenocarcinoma-and-potential-molecular-mechanisms
#1
Jianli Ma, Decai Chi, Yan Wang, Yubo Yan, Shu Zhao, Hang Liu, Jing Jing, Haihong Pu, Minghui Zhang
Background: The prognostic role of PD-L1 expression in surgically resected lung adenocarcinoma (ADC) remains controversial. The present study was aimed to clarify the role of PD-L1 expression in predicting prognosis and to investigate its biological function in ADC. Materials and Methods: The association between PD-L1 expression and clinical outcomes in patients with resected ADC was analyzed using immunohistochemistry (IHC) in our cohort (n=104), externally validated by a meta-analysis of 13 published studies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30287168/systemic-chemotherapy-in-combination-with-liver-directed-therapy-improves-survival-in-patients-with-pancreatic-adenocarcinoma-and-synchronous-liver-metastases
#2
Huaqiang Ouyang, Weidong Ma, Ti Zhang, Fang Liu, Lujun Zhao, Minghui Fang, Manman Quan, Zhanyu Pan
OBJECTIVES: We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM). METHODS: We reviewed the medical records of 184 patients treated with SCT ± LDT at Tianjin Medical University Cancer Hospital from 2001 to 2015. Overall survival (OS) was the primary end-point. The role of treatment modality and other clinical factors was evaluated by univariate and Cox regression analyses...
September 29, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30225366/high-electrical-conductivity-and-carrier-mobility-in-ocvd-pedot-thin-films-by-engineered-crystallization-and-acid-treatment
#3
Xiaoxue Wang, Xu Zhang, Lei Sun, Dongwook Lee, Sunghwan Lee, Minghui Wang, Junjie Zhao, Yang Shao-Horn, Mircea Dincă, Tomás Palacios, Karen K Gleason
Air-stable, lightweight, and electrically conductive polymers are highly desired as the electrodes for next-generation electronic devices. However, the low electrical conductivity and low carrier mobility of polymers are the key bottlenecks that limit their adoption. We demonstrate that the key to addressing these limitations is to molecularly engineer the crystallization and morphology of polymers. We use oxidative chemical vapor deposition (oCVD) and hydrobromic acid treatment as an effective tool to achieve such engineering for conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT)...
September 2018: Science Advances
https://www.readbyqxmd.com/read/30216789/fast-simultaneous-determination-of-main-components-and-impurity-sodium-ion-in-pama-injection-by-mixed-mode-chromatography
#4
Panpan Li, Wei Sun, Limin Zuo, Zhiling Zhu, Ting Zhao, Ran Wang, Minghui Zhu, Xiaoyun Leng, Xiaodan Qiu, Liping Bai, Guangzhi Shan
This study describes an analytical method to control the quality of potassium aspartate and magnesium aspartate (PAMA) injection based on the simultaneous detection of the main components (K+ , Mg2+ and Asp) and impurities (Na+ ) using a mixed-mode chromatography coupled with charged aerosol detector. To obtain optimal chromatographic separation, the effects of organic content, column temperature, buffer types, pH and concentrations were evaluated. A Response Surface Methodology (RSM) optimal design was performed after single factor experiment...
November 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30197796/the-prognostic-value-of-programmed-cell-death-ligand-1-expression-in-non-hodgkin-lymphoma-a-meta-analysis
#5
Shu Zhao, Minghui Zhang, Yu Zhang, Hongxue Meng, Yan Wang, Yupeng Liu, Jing Jing, Lan Huang, Mengqi Sun, Yue Zhang, Qingyuan Zhang
Objective: Although the prognostic value of programmed cell death-ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis. Methods: The PubMed, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio (HR), 95% confidence interval (CI), and odds ratios (OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival (OS) and clinicopathological features...
August 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/30174306/short-term-mitochondrial-permeability-transition-pore-opening-modulates-histone-lysine-methylation-at-the-early-phase-of-somatic-cell-reprogramming
#6
Zhongfu Ying, Ge Xiang, Lingjun Zheng, Haite Tang, Lifan Duan, Xiaobing Lin, Qiuge Zhao, Keshi Chen, Yi Wu, Guangsuo Xing, Yiwang Lv, Linpeng Li, Liang Yang, Feixiang Bao, Qi Long, Yanshuang Zhou, Xueying He, Yaofeng Wang, Minghui Gao, Duanqing Pei, Wai-Yee Chan, Xingguo Liu
Reprogramming of somatic cells to induced pluripotent stem cells reconfigures chromatin modifications. Whether and how this process is regulated by signals originating in the mitochondria remain unknown. Here we show that the mitochondrial permeability transition pore (mPTP), a key regulator of mitochondrial homeostasis, undergoes short-term opening during the early phase of reprogramming and that this transient activation enhances reprogramming. In mouse embryonic fibroblasts, greater mPTP opening correlates with higher reprogramming efficiency...
August 23, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/30149583/stretchable-and-wearable-triboelectric-nanogenerator-based-on-kinesio-tape-for-self-powered-human-motion-sensing
#7
Shutang Wang, Minghui He, Bingjuan Weng, Lihui Gan, Yingru Zhao, Ning Li, Yannan Xie
Recently, wearable, self-powered, active human motion sensors have attracted a great deal of attention for biomechanics, physiology, kinesiology, and entertainment. Although some progress has been achieved, new types of stretchable and wearable devices are urgently required to promote the practical application. In this article, targeted at self-powered active human motion sensing, a stretchable, flexible, and wearable triboelectric nanogenerator based on kinesio tapes (KT-TENG) haven been designed and investigated systematically...
August 24, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30136966/evaluating-multi-dimensional-visualizations-for-understanding-fuzzy-clusters
#8
Ying Zhao, Feng Luo, Minghui Chen, Yingchao Wang, Jiazhi Xia, Fangfang Zhou, Yunhai Wang, Yi Chen, Wei Chen
Fuzzy clustering assigns a probability of membership for a datum to a cluster, which veritably reflects real-world clustering scenarios but significantly increases the complexity of understanding fuzzy clusters. Many studies have demonstrated that visualization techniques for multi-dimensional data are beneficial to understand fuzzy clusters. However, no empirical evidence exists on the effectiveness and efficiency of these visualization techniques in solving analytical tasks featured by fuzzy clusters. In this paper, we conduct a controlled experiment to evaluate the ability of fuzzy clusters analysis to use four multi-dimensional visualization techniques, namely, parallel coordinate plot, scatterplot matrix, principal component analysis, and Radviz...
August 20, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/30119526/responsivity-improvement-of-ti-diamond-ti-structured-uv-photodetector-through-photocurrent-gain
#9
Zhangcheng Liu, Dan Zhao, Jinping Ao, Xiaohui Chang, Yanfeng Wang, Jiao Fu, Minghui Zhang, Hongxing Wang
In this study, a Ti-diamond-Ti structured ultraviolet photodetector was fabricated on a homoepitaxial diamond layer with an oxygen-terminated surface. The properties of the Ti/diamond schottky contact were measured using X-ray photoelectron spectroscopy, and the barrier height was found to be 1.15 eV. At a bias of 3 V, the responsivity at 210 nm was only 4.29 mA/W, while at 12 V, the responsivity increased rapidly to 51 mA/W. The increase can be ascribed to the photocurrent gain. With the further increase in voltage, an avalanche effect was produced, and the responsivity could reach 1...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30102662/rapid-cd4-t-cell-decline-is-associated-with-coreceptor-switch-among-men-who-have-sex-with-men-primarily-infected-with-hiv-1-crf01_ae-in-northeast-china
#10
Hualu Cui, Wenqing Geng, Hong Sun, Xiaoxu Han, Minghui An, Yongjun Jiang, Zining Zhang, Zhiwei Chen, Junjie Xu, Qinghai Hu, Bin Zhao, Bennan Zhou, Hong Shang
OBJECTIVE: CRF01_AE is the most prevalent human immunodeficiency virus-1 (HIV-1) subtype among men who have sex with men (MSM) in China. However, the characteristics and underlying mechanism of the accelerated CD4 T-cell decline in CRF01_AE-infected MSM remain incompletely understood. DESIGN: A long-term prospective follow-up study was conducted with 1338 MSM at risk of HIV-1 infection in Northeast China. MSM with primary HIV-1 CRF01_AE infection were identified and followed for 3-6 years to explore the determinants of rapid CD4 T-cell decline...
August 9, 2018: AIDS
https://www.readbyqxmd.com/read/30100242/clinical-characteristics-of-patients-with-ochrobactrum-anthropi-bloodstream-infection-in-a-chinese-tertiary-care-hospital-a-7-year-study
#11
Minghui Zhu, Xiaoyan Zhao, Qiang Zhu, Zhaorui Zhang, Yu Dai, Liangan Chen, Zhixin Liang
BACKGROUND: Ochrobactrum anthropi has become an emerging pathogen for bloodstream infection (BSI). METHODS: From January 1st 2010 to June 30th 2017, inpatients with one or more blood cultures positive for O. anthropi isolates at Chinese People's Liberation Army General Hospital in Beijing, China, were enrolled in this study. Clinical and laboratory data were collected by reviewing electronic records. RESULTS: A total of 11 patients with O...
August 9, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/30090532/effects-of-ambient-pm-2-5-and-9-nitroanthracene-on-dna-damage-and-repair-oxidative-stress-and-metabolic-enzymes-in-the-lungs-of-rats
#12
Ruijin Li, Lifang Zhao, Li Zhang, Minghui Chen, Jing Shi, Chuan Dong, Zongwei Cai
Ambient fine particulate matter (PM2.5 ) is a complex mixture associated with lung cancer risk. PM2.5 -bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM2.5 induced DNA damage, whereas there is little knowledge of whether 9-nitroanthracene (9-NA), a typical compound of NPAHs in PM2.5 , causes DNA damage. Also, the regulating mechanisms of PM2.5 and 9-NA in DNA damage and repair are not yet fully established...
September 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/30037003/computational-approaches-to-prioritize-cancer-driver-missense-mutations
#13
REVIEW
Feiyang Zhao, Lei Zheng, Alexander Goncearenco, Anna R Panchenko, Minghui Li
Cancer is a complex disease that is driven by genetic alterations. There has been a rapid development of genome-wide techniques during the last decade along with a significant lowering of the cost of gene sequencing, which has generated widely available cancer genomic data. However, the interpretation of genomic data and the prediction of the association of genetic variations with cancer and disease phenotypes still requires significant improvement. Missense mutations, which can render proteins non-functional and provide a selective growth advantage to cancer cells, are frequently detected in cancer...
July 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30027380/the-pregnancy-outcomes-in-patients-with-stage-3-4-chronic-kidney-disease-and-the-effects-of-pregnancy-in-the-long-term-kidney-function
#14
Yingdong He, Jing Liu, Qingqing Cai, Jicheng Lv, Feng Yu, Qian Chen, Minghui Zhao
OBJECTIVE: To investigate the pregnancy outcomes for patients with stage 3-4 chronic kidney disease (CKD) and the effects of pregnancy on kidney function. METHODS: Clinical data of pregnant women with CKD in the Peking University First Hospital between January 1st 2005 and October 1st 2016 were retrospectively analysed. The pregnancy outcomes of patients with different stages of CKD were compared. Patients with stage 3-4 CKD were followed up by telephone interview, and non-pregnant patients with stage 3-4 CKD were selected using the propensity score method to analyse the effects of pregnancy on kidney function...
July 19, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30013584/genome-wide-association-mapping-for-cold-tolerance-in-a-core-collection-of-rice-oryza-sativa-l-landraces-by-using-high-density-single-nucleotide-polymorphism-markers-from-specific-locus-amplified-fragment-sequencing
#15
Jiayu Song, Jinqun Li, Jian Sun, Tao Hu, Aiting Wu, Sitong Liu, Wenjia Wang, Dianrong Ma, Minghui Zhao
Understanding the genetic mechanism of cold tolerance in rice is important to mine elite genes from rice landraces and breed excellent cultivars for this trait. In this study, a genome-wide association study (GWAS) was performed using high-density single nucleotide polymorphisms (SNPs) obtained using specific-locus amplified fragment sequencing (SLAF-seq) technology from a core collection of landraces of rice. A total of 67,511 SNPs obtained from 116,643 SLAF tags were used for genotyping the 150 accessions of rice landraces in the Ting's rice core collection...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29964364/the-effectiveness-of-aromatherapy-and-massage-on-stress-management-in-nurses-a-systematic-review
#16
REVIEW
Huanhuan Li, Minghui Zhao, Ying Shi, Zhuangjie Xing, Yuan Li, Shouqi Wang, Jie Ying, Meiling Zhang, Jiao Sun
AIMS AND OBJECTIVES: To assess the effectiveness of aromatherapy and massage on relieving stress in nurses. BACKGROUND: Nurses face uncommon levels of stress in medical settings. Stress has a negative impact on nurses' well-being and the organisation where they work. Aromatherapy and massage are important strategies for stress reduction. However, the effectiveness of aromatherapy and massage on relieving stress in nurses currently lacks understanding. DESIGN: Systematic review...
July 2, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29887858/the-heme-transporter-htsabc-of-group-a-streptococcus-contributes-to-virulence-and-innate-immune-evasion-in-murine-skin-infections
#17
Yingli Song, Xiaolan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
Group A Streptococcus (GAS) requires iron for growth, and heme is an important source of iron for GAS. Streptococcus heme transporter A (HtsA) is the lipoprotein component of the GAS heme-specific ABC transporter (HtsABC). The objective of this study is to examine the contribution of HtsABC to virulence and host interaction of hypervirulent M1T1 GAS using an isogenic htsA deletion mutant (Δ htsA ). The htsA deletion exhibited a significantly increased survival rate, reduced skin lesion size, and reduced systemic GAS dissemination in comparison to the wild type strain...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29880878/publisher-correction-n-6-methyladenosine-rna-modification-regulates-embryonic-neural-stem-cell-self-renewal-through-histone-modifications
#18
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar, Robert J Wechsler-Reya, Zhaolei Zhang, Yuya Ogawa, Manolis Kellis, Gregg Duester, Jing Crystal Zhao
In the version of this article initially published online, there were errors in URLs for www.southernbiotech.com, appearing in Methods sections "m6A dot-blot" and "Western blot analysis." The first two URLs should be https://www.southernbiotech.com/?catno=4030-05&type=Polyclonal#&panel1-1 and the third should be https://www.southernbiotech.com/?catno=6170-05&type=Polyclonal. In addition, some Methods URLs for bioz.com, www.abcam.com and www.sysy.com were printed correctly but not properly linked...
June 7, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29850676/ratiometric-fluorescence-detection-of-trace-water-in-organic-solvents-based-on-aggregation-induced-emission-enhanced-cu-nanoclusters
#19
Shanliang Song, Yuping Zhang, Yizhou Yang, Chuanxi Wang, Ying Zhou, Chuan Zhang, Yueqi Zhao, Minghui Yang, Quan Lin
A fast, sensitive, and convenient dual-emission water detector was robustly fabricated. This detector was prepared with blue fluorescent carbon dots (CDs) and red fluorescent Cu nanoclusters (NCs), and showed two well-resolved and intensity-comparable fluorescence peaks under a single excitation wavelength. Moreover, it showed strong red fluorescence in organic solvent due to the aggregation-induced emission enhancement (AIEE) properties of the Cu NCs, but the red fluorescence was gradually quenched with an increasing amount of water, whereas the blue fluorescence remained constant...
June 25, 2018: Analyst
https://www.readbyqxmd.com/read/29844348/hmgb1-released-by-irradiated-tumor-cells-promotes-living-tumor-cell-proliferation-via-paracrine-effect
#20
Sijia He, Jin Cheng, Lianhui Sun, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, Minghui Zhao, Yuntao Luo, Ling Tian, Chuanyuan Li, Qian Huang
Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation...
May 29, 2018: Cell Death & Disease
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