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https://www.readbyqxmd.com/read/30102662/rapid-cd4-t-cell-decline-is-associated-with-coreceptor-switch-among-men-who-have-sex-with-men-primarily-infected-with-hiv-1-crf01_ae-in-northeast-china
#1
Hualu Cui, Wenqing Geng, Hong Sun, Xiaoxu Han, Minghui An, Yongjun Jiang, Zining Zhang, Zhiwei Chen, Junjie Xu, Qinghai Hu, Bin Zhao, Bennan Zhou, Hong Shang
OBJECTIVE: CRF01_AE is the most prevalent human immunodeficiency virus-1 (HIV-1) subtype among men who have sex with men (MSM) in China. However, the characteristics and underlying mechanism of the accelerated CD4 T-cell decline in CRF01_AE-infected MSM remain incompletely understood. DESIGN: A long-term prospective follow-up study was conducted with 1338 MSM at risk of HIV-1 infection in Northeast China. MSM with primary HIV-1 CRF01_AE infection were identified and followed for 3-6 years to explore the determinants of rapid CD4 T-cell decline...
August 9, 2018: AIDS
https://www.readbyqxmd.com/read/30100242/clinical-characteristics-of-patients-with-ochrobactrum-anthropi-bloodstream-infection-in-a-chinese-tertiary-care-hospital-a-7-year-study
#2
Minghui Zhu, Xiaoyan Zhao, Qiang Zhu, Zhaorui Zhang, Yu Dai, Liangan Chen, Zhixin Liang
BACKGROUND: Ochrobactrum anthropi has become an emerging pathogen for bloodstream infection (BSI). METHODS: From January 1st 2010 to June 30th 2017, inpatients with one or more blood cultures positive for O. anthropi isolates at Chinese People's Liberation Army General Hospital in Beijing, China, were enrolled in this study. Clinical and laboratory data were collected by reviewing electronic records. RESULTS: A total of 11 patients with O...
August 9, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/30090532/effects-of-ambient-pm-2-5-and-9-nitroanthracene-on-dna-damage-and-repair-oxidative-stress-and-metabolic-enzymes-in-the-lungs-of-rats
#3
Ruijin Li, Lifang Zhao, Li Zhang, Minghui Chen, Jing Shi, Chuan Dong, Zongwei Cai
Ambient fine particulate matter (PM2.5 ) is a complex mixture associated with lung cancer risk. PM2.5 -bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM2.5 induced DNA damage, whereas there is little knowledge of whether 9-nitroanthracene (9-NA), a typical compound of NPAHs in PM2.5 , causes DNA damage. Also, the regulating mechanisms of PM2.5 and 9-NA in DNA damage and repair are not yet fully established...
September 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/30037003/computational-approaches-to-prioritize-cancer-driver-missense-mutations
#4
REVIEW
Feiyang Zhao, Lei Zheng, Alexander Goncearenco, Anna R Panchenko, Minghui Li
Cancer is a complex disease that is driven by genetic alterations. There has been a rapid development of genome-wide techniques during the last decade along with a significant lowering of the cost of gene sequencing, which has generated widely available cancer genomic data. However, the interpretation of genomic data and the prediction of the association of genetic variations with cancer and disease phenotypes still requires significant improvement. Missense mutations, which can render proteins non-functional and provide a selective growth advantage to cancer cells, are frequently detected in cancer...
July 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30027380/the-pregnancy-outcomes-in-patients-with-stage-3-4-chronic-kidney-disease-and-the-effects-of-pregnancy-in-the-long-term-kidney-function
#5
Yingdong He, Jing Liu, Qingqing Cai, Jicheng Lv, Feng Yu, Qian Chen, Minghui Zhao
OBJECTIVE: To investigate the pregnancy outcomes for patients with stage 3-4 chronic kidney disease (CKD) and the effects of pregnancy on kidney function. METHODS: Clinical data of pregnant women with CKD in the Peking University First Hospital between January 1st 2005 and October 1st 2016 were retrospectively analysed. The pregnancy outcomes of patients with different stages of CKD were compared. Patients with stage 3-4 CKD were followed up by telephone interview, and non-pregnant patients with stage 3-4 CKD were selected using the propensity score method to analyse the effects of pregnancy on kidney function...
July 19, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/30013584/genome-wide-association-mapping-for-cold-tolerance-in-a-core-collection-of-rice-oryza-sativa-l-landraces-by-using-high-density-single-nucleotide-polymorphism-markers-from-specific-locus-amplified-fragment-sequencing
#6
Jiayu Song, Jinqun Li, Jian Sun, Tao Hu, Aiting Wu, Sitong Liu, Wenjia Wang, Dianrong Ma, Minghui Zhao
Understanding the genetic mechanism of cold tolerance in rice is important to mine elite genes from rice landraces and breed excellent cultivars for this trait. In this study, a genome-wide association study (GWAS) was performed using high-density single nucleotide polymorphisms (SNPs) obtained using specific-locus amplified fragment sequencing (SLAF-seq) technology from a core collection of landraces of rice. A total of 67,511 SNPs obtained from 116,643 SLAF tags were used for genotyping the 150 accessions of rice landraces in the Ting's rice core collection...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29964364/the-effectiveness-of-aromatherapy-and-massage-on-stress-management-in-nurses-a-systematic-review
#7
REVIEW
Huanhuan Li, Minghui Zhao, Ying Shi, Zhuangjie Xing, Yuan Li, Shouqi Wang, Jie Ying, Meiling Zhang, Jiao Sun
AIMS AND OBJECTIVES: To assess the effectiveness of aromatherapy and massage on relieving stress in nurses. BACKGROUND: Nurses face uncommon levels of stress in medical settings. Stress has a negative impact on nurses' well-being and the organisation where they work. Aromatherapy and massage are important strategies for stress reduction. However, the effectiveness of aromatherapy and massage on relieving stress in nurses currently lacks understanding. DESIGN: Systematic review...
July 2, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29887858/the-heme-transporter-htsabc-of-group-a-streptococcus-contributes-to-virulence-and-innate-immune-evasion-in-murine-skin-infections
#8
Yingli Song, Xiaolan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
Group A Streptococcus (GAS) requires iron for growth, and heme is an important source of iron for GAS. Streptococcus heme transporter A (HtsA) is the lipoprotein component of the GAS heme-specific ABC transporter (HtsABC). The objective of this study is to examine the contribution of HtsABC to virulence and host interaction of hypervirulent M1T1 GAS using an isogenic htsA deletion mutant (Δ htsA ). The htsA deletion exhibited a significantly increased survival rate, reduced skin lesion size, and reduced systemic GAS dissemination in comparison to the wild type strain...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29880878/publisher-correction-n-6-methyladenosine-rna-modification-regulates-embryonic-neural-stem-cell-self-renewal-through-histone-modifications
#9
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar, Robert J Wechsler-Reya, Zhaolei Zhang, Yuya Ogawa, Manolis Kellis, Gregg Duester, Jing Crystal Zhao
In the version of this article initially published online, there were errors in URLs for www.southernbiotech.com, appearing in Methods sections "m6A dot-blot" and "Western blot analysis." The first two URLs should be https://www.southernbiotech.com/?catno=4030-05&type=Polyclonal#&panel1-1 and the third should be https://www.southernbiotech.com/?catno=6170-05&type=Polyclonal. In addition, some Methods URLs for bioz.com, www.abcam.com and www.sysy.com were printed correctly but not properly linked...
June 7, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29850676/ratiometric-fluorescence-detection-of-trace-water-in-organic-solvents-based-on-aggregation-induced-emission-enhanced-cu-nanoclusters
#10
Shanliang Song, Yuping Zhang, Yizhou Yang, Chuanxi Wang, Ying Zhou, Chuan Zhang, Yueqi Zhao, Minghui Yang, Quan Lin
A fast, sensitive, and convenient dual-emission water detector was robustly fabricated. This detector was prepared with blue fluorescent carbon dots (CDs) and red fluorescent Cu nanoclusters (NCs), and showed two well-resolved and intensity-comparable fluorescence peaks under a single excitation wavelength. Moreover, it showed strong red fluorescence in organic solvent due to the aggregation-induced emission enhancement (AIEE) properties of the Cu NCs, but the red fluorescence was gradually quenched with an increasing amount of water, whereas the blue fluorescence remained constant...
June 25, 2018: Analyst
https://www.readbyqxmd.com/read/29844348/hmgb1-released-by-irradiated-tumor-cells-promotes-living-tumor-cell-proliferation-via-paracrine-effect
#11
Sijia He, Jin Cheng, Lianhui Sun, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, Minghui Zhao, Yuntao Luo, Ling Tian, Chuanyuan Li, Qian Huang
Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation...
May 29, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29807723/active-and-passive-immunizations-with-htsa-a-streptococcal-heme-transporter-protein-protect-mice-from-subcutaneous-group-a-streptococcus-infection
#12
Yingli Song, XiaoLan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
BACKGROUND/PURPOSE: HtsA (Streptococcus heme transporter A) is the lipoprotein component of the streptococcal heme ABC transporter (HtsABC). The aim of this study is to investigate whether the HtsA protein has immunoprotective effect against group A Streptococcus (GAS) infection in mice. METHODS: The HtsA protein was purified by sequential chromatography on Ni-sepharose, DEAE-sepharose and Phenyl-sepharose, CD-1 mice were actively immunized with ALUM (control) or HtsA/ALUM, and passively immunized with control or anti-HtsA serum...
May 17, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29777791/ticagrelor-protects-against-angii-induced-endothelial-dysfunction-by-alleviating-endoplasmic-reticulum-stress
#13
Xiaoyu Wang, Xuejie Han, Minghui Li, Yu Han, Yun Zhang, Shiqi Zhao, Yue Li
Ticagrelor has been reported to decrease cardiovascular mortality compared with clopidogrel. This benefit cannot be fully explained by the more efficient platelet inhibition. Many studies demonstrated that ticagrelor improved endothelial function, leaving the mechanism elusive though. The present study aims to investigate whether ticagrelor protects against endothelial dysfunction induced by angiotensinII (AngII) through alleviating endoplasmic reticulum (ER) stress. Male Sprague Dawley rats were infused with AngII or vehicle and administrated with ticagrelor or vehicle for 14 days...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29774080/microrna-193b-3p-regulates-chondrogenesis-and-chondrocyte-metabolism-by-targeting-hdac3
#14
Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao
Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expression was assessed in a human mesenchymal stem cell (hMSC) model of chondrogenesis, in interleukin-1β (IL-1β)-treated primary human chondrocytes (PHCs), and in non-degraded and degraded cartilage...
2018: Theranostics
https://www.readbyqxmd.com/read/29773748/3d-charge-and-2d-phonon-transports-leading-to-high-out-of-plane-zt-in-n-type-snse-crystals
#15
Cheng Chang, Minghui Wu, Dongsheng He, Yanling Pei, Chao-Feng Wu, Xuefeng Wu, Hulei Yu, Fangyuan Zhu, Kedong Wang, Yue Chen, Li Huang, Jing-Feng Li, Jiaqing He, Li-Dong Zhao
Thermoelectric technology enables the harvest of waste heat and its direct conversion into electricity. The conversion efficiency is determined by the materials figure of merit ZT Here we show a maximum ZT of ~2.8 ± 0.5 at 773 kelvin in n-type tin selenide (SnSe) crystals out of plane. The thermal conductivity in layered SnSe crystals is the lowest in the out-of-plane direction [two-dimensional (2D) phonon transport]. We doped SnSe with bromine to make n-type SnSe crystals with the overlapping interlayer charge density (3D charge transport)...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29764587/-role-of-pd-0332991-on-the-proliferation-and-apoptosis-of-vascular-endothelial-cells
#16
Chenlong Zhao, Minghui Liu, Yongwen Li, Hongbing Zhang, Ying Li, Hao Gong, Yin Yuan, Weiting Li, Hongyu Liu, Jun Chen
BACKGROUND: Angiogenesis is an important process in the development of tumor. PD 0332991, a cell cycle inhibitor, can specifically inhibit CD4/6 phosphorylation and cell cycle progression. In xeongraft mice models, PD 0332991 treated mice had significantly decreased angiogenesis and vascular density compared with the control group, but the mechanism remains unknown. The purpose of this study is to investigate the role and molecular mechanism of PD 0332991 on vascular endothelial cells...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29738505/preschoolers-technology-assessed-physical-activity-and-cognitive-function-a-cross-sectional-study
#17
Minghui Quan, Hanbin Zhang, Jiayi Zhang, Tang Zhou, Jinming Zhang, Guanggao Zhao, Hui Fang, Shunli Sun, Ru Wang, Peijie Chen
Early childhood is a critical period for development of cognitive function, but research on the association between physical activity and cognitive function in preschool children is limited and inconclusive. This study aimed to examine the association between technology-assessed physical activity and cognitive function in preschool children. A cross-sectional analysis of baseline data from the Physical Activity and Cognitive Development Study was conducted in Shanghai, China. Physical activity was measured with accelerometers for 7 consecutive days, and cognitive functions were assessed using the Chinese version of Wechsler Young Children Scale of Intelligence (C-WYCSI)...
May 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29728060/genome-wide-profiling-of-long-non-coding-rnas-from-tomato-and-a-comparison-with-mrnas-associated-with-the-regulation-of-fruit-ripening
#18
Minghui Wang, Weihua Zhao, Lei Gao, Lingxia Zhao
BACKGROUND: Long non-coding RNAs (lncRNAs) are involved in multiple biological processes in both mammals and plants. There is growing evidence that they are associated with development; but their expression and regulation during fruit ripening in the model plant tomato (Solanum lycopersicum) has yet to be described. RESULTS: Following integration of 134 RNA-seq data sets, we identified 79,322 putative lncRNAs, consisting of 70,635 lincRNAs, 8085 antisense non-coding RNAs (ancRNAs) and 602 sense lncRNAs (slncRNAs)...
May 4, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29689313/alpha-lactose-reverses-liver-injury-via-blockade-of-tim-3-mediated-cd8-apoptosis-in-sepsis
#19
Zhengping Wei, Pingfei Li, Yao Yao, Hai Deng, Shengwu Yi, Cong Zhang, Han Wu, Xiuxiu Xie, Minghui Xia, Ran He, Xiang-Ping Yang, Zhao-Hui Tang
In sepsis, the liver plays a crucial role in regulating immune responses and is also a target organ for immune-related injury. Despite the critical function of CD8+ T cells against opportunistic viral infections, the CD8 immune response in the liver during sepsis remains elusive. Here we found that Tim-3 is highly up-regulated in liver CD8+ T cells in a mouse cecal ligation and puncture model and in peripheral blood CD8+ T cells of human patients with sepsis. The expression of Tim-3 in liver CD8+ T cells displayed a bi-phasic pattern and deletion of Tim-3 led to reduction of CD8+ T cell apoptosis...
July 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29671148/identification-of-a-cold-tolerant-locus-in-rice-oryza-sativa-l-using-bulked-segregant-analysis-with-a-next-generation-sequencing-strategy
#20
Jian Sun, Luomiao Yang, Jingguo Wang, Hualong Liu, Hongliang Zheng, Dongwei Xie, Minghui Zhang, Mingfang Feng, Yan Jia, Hongwei Zhao, Detang Zou
BACKGROUND: Cold stress can cause serious abiotic damage that limits the growth, development and yield of rice. Cold tolerance during the booting stage of rice is a key factor that can guarantee a high and stable yield under cold stress. The cold tolerance of rice is controlled by quantitative trait loci (QTLs). Based on the complex genetic basis of cold tolerance in rice, additional efforts are needed to detect reliable QTLs and identify candidate genes. In this study, recombinant inbred lines (RILs) derived from a cross between a cold sensitive variety, Dongnong422, and strongly cold-tolerant variety, Kongyu131, were used to screen for cold-tolerant loci at the booting stage of rice...
April 18, 2018: Rice
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