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minghui zhao

Yi Pan, Lu Zhang, Minghui Duan, Hong Yang, Duoduo Zhao, Weifeng Li
OBJECTIVE: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay. CLINICAL PRESENTATION AND INTERVENTION: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. CONCLUSION: Given that growth retardation and pubertal delay are rare in BRBNS patients, this case reminds us to include BRBNS in the differential diagnosis of growth retardation...
December 10, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Ning Zhang, Yuting Chen, Feiyang Zhao, Qing Yang, Franco L Simonetti, Minghui Li
Protein-DNA interactions play important roles in regulations of many vital cellular processes, including transcription, translation, DNA replication and recombination. Sequence variants occurring in these DNA binding proteins that alter protein-DNA interactions may cause significant perturbations or complete abolishment of function, potentially leading to diseases. Developing a mechanistic understanding of impacts of variants on protein-DNA interactions becomes a persistent need. To address this need we introduce a new computational method PremPDI that predicts the effect of single missense mutation in the protein on the protein-DNA interaction and calculates the quantitative binding affinity change...
December 11, 2018: PLoS Computational Biology
Guangqiang Wang, Minghui Zhang, Jianxin Zhao, Yongjun Xia, Phoency F-H Lai, Lianzhong Ai
Adhesion to epithelial cells is considered important for Lactobacillus to exert probiotic effects. In this study, we found that trypsin treatment decreased the adhesion ability of Lactobacillus plantarum AR326 and AR269, which exhibit good adhesion ability, and surface proteins extracts increased the adhesion of the strains with poor adhesion ability. By SDS-polyacrylamide gel electrophoresis and mass spectrometry analysis, the main component of the surface proteins was detected and identified as a protein of approximately 37 kDa...
2018: Frontiers in Microbiology
Yuan An, Yunshan Zhou, Liqi Bi, Bo Liu, Hong Wang, Jin Lin, Danyi Xu, Mei Wang, Jing Zhang, Yongfu Wang, Yan An, Ping Zhu, Ronghua Xie, Zhiyi Zhang, Yifang Mei, Xiangyuan Liu, Xiaoli Deng, Zhongqiang Yao, Zhuoli Zhang, Yu Wang, Weiguo Xiao, Hui Shen, Xiuyan Yang, Hanshi Xu, Feng Yu, Guochun Wang, Xin Lu, Yang Li, Yingnan Li, Xiaoxia Zuo, Yisha Li, Yi Liu, Yi Zhao, Jianping Guo, Lingyun Sun, Minghui Zhao, Zhanguo Li
OBJECTIVES: The standard strategy for treating lupus nephritis comprises glucocorticoids together with either intravenous cyclophosphamide or oral mycophenolate mofetil, but the low remission rate is still a challenge in practice. This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy. METHOD: A 24-week trial was conducted in 17 rheumatology or nephrology centers in China. A total of 191 lupus nephritis patients were randomized to follow a combined immunosuppressive treatment (CIST) with intravenous cyclophosphamide, an oral immunosuppressive agent, namely mycophenolate mofetil, azathioprine or leflunomide, and hydroxychloroquine (n = 95), or receive intravenous cyclophosphamide alone (n = 96) for 24 weeks...
November 28, 2018: Clinical Rheumatology
Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang, Xiaoxu Han
BACKGROUND: The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not been fully understood. Circular RNAs (circRNAs) have been verified as "microRNA sponges" that regulate gene expression through competing endogenous RNA (ceRNA) networks, but circRNA expression profiles and their contribution to EHI pathogenesis are still unclear. METHODS: Two different libraries were constructed with RNA from human peripheral blood mononuclear cells from 3 HARRT-naive EHI patients and 3 healthy controls (HCs)...
November 29, 2018: Journal of Translational Medicine
Bixia Gao, Shouling Wu, Jinwei Wang, Chao Yang, Shuohua Chen, Jinhong Hou, Junjuan Li, Yaozheng Yang, Kevin He, Minghui Zhao, Min Chen, Luxia Zhang
BACKGROUND: Information regarding the clinical phenotypes of diabetic kidney disease (DKD) might guide better practice for clinicians. We aim to compare the clinical features and long-term outcomes of proteinuric and non-proteinuric phenotypes of DKD, based on a prospective cohort of Chinese population. METHODS: Altogether 8811 Chinese participants with diabetes were included. Kidney function decline was defined as estimated glomerular filtration rate <60 mL/min·1...
October 12, 2018: Journal of Diabetes and its Complications
Ying Shi, Minghui Zhao, Si Chen, Shouqi Wang, Huanhuan Li, Jie Ying, Meiling Zhang, Yuan Li, Zhuangjie Xing, Jiao Sun
The aim of this review is to examine the efficacy of cognitive behavioral therapy (CBT) on people living with HIV (PLWH) and depression. A literature search from five electronic databases was conducted, and articles published until July 2017 were collected. The inclusion criteria included randomized controlled trials (RCTs) of CBT that were conducted among PLWH with clinically relevant depression. Comprehensive Meta-Analysis 2 was used to obtain pooled results. Seven RCTs, with a total sample size of 388 participants, met the inclusion criteria...
November 27, 2018: Psychology, Health & Medicine
Congcong Shen, Shuping Liu, Xiaoqing Li, Dan Zhao, Minghui Yang
The authors describe an adapted rolling circle amplification (RCA) method for the determination of human epidermal growth factor receptor 2 (HER2). This method (which is termed immunoRCA) combines an immunoreaction with DNA based signal amplification. Gold nanoparticles (AuNPs) were loaded with antibodies against HER2 and DNA, and then fulfill the functions of recognizing HER2 and achieving signal amplification. The DNA serves as a primer to trigger RCA. This results in formation of a long DNA containing hundreds of copies of circular DNA sequence on the electrode surface...
November 13, 2018: Mikrochimica Acta
Shixin Guan, Quan Xu, Dianrong Ma, Wenzhong Zhang, Zhengjin Xu, Minghui Zhao, Zhifu Guo
Weedy rice is an important germplasm resource for rice improvement because it has useful genes for many abiotic stresses including cold tolerance. We identified the cold tolerance and cold sensitivity of two weedy rice lines (WR 03-35 and WR 03-26) and two cultivated rice lines (Kongyu 131 and 9311). During the seedling stage of these lines, we used RNA-seq to measure changes in weedy rice and cultivated rice whole-genome transcriptome before and after cold treatment. We identified 14,213 and 14,730 differentially expressed genes (DEGs) in cold-tolerant genotypes (WR 03-35, Kongyu 131), and 9219 and 720 DEGs were observed in two cold-sensitive genotypes (WR 03-26, 9311)...
October 30, 2018: Gene
Ling Chen, Yurong Mao, Minghui Ding, Le Li, Yan Leng, Jiangli Zhao, Zhiqin Xu, Dong Feng Huang, Wai Leung Ambrose Lo
Background: Stroke survivors may lack the cognitive ability to anticipate the required control for palmar grasp execution. The cortical mechanisms involved in motor anticipation of palmar grasp movement and its association with post-stroke hand function remains unknown. Aims: To investigate the cognitive anticipation process during a palmar grasp task in subacute stroke survivors and to compare with healthy individuals. The association between cortical excitability and hand function was also explored. Methods: Twenty-five participants with hemiparesis within 1-6 months after first unilateral stroke were recruited...
2018: Frontiers in Neurology
Shaoxuan Hu, Daobin Zhou, Yongji Wu, Yongqiang Zhao, Shujie Wang, Bing Han, Minghui Duan, Jian Li, Tienan Zhu, Junling Zhuang, Xinxin Cao, Huacong Cai, Jun Feng, Yan Zhang, Fengchun Zhang, Xiaofeng Zeng, Yan Zhao, Qian Wang, Wei Zhang
The incidence and clinical implications of autoimmune diseases (ADs) in patients with non-Hodgkin's lymphoma(NHL) remain unclear. The aim of this study was to examine the prevalence of ADs in NHL and define the clinical characteristics and prognosis of AD-associated NHL patients. Patients diagnosed with NHL in our institute between 1995 and 2017 were retrospectively reviewed to assess the incidence of ADs. Of 4880 patients with NHL, 140 (2.9%) presented with autoimmunity, with a total of 24 ADs. The most common AD was Sjögren syndrome, followed by autoimmune cytopenia, psoriasis, rheumatoid arthritis, etc...
October 29, 2018: Annals of Hematology
Jianli Ma, Decai Chi, Yan Wang, Yubo Yan, Shu Zhao, Hang Liu, Jing Jing, Haihong Pu, Minghui Zhang
Background: The prognostic role of PD-L1 expression in surgically resected lung adenocarcinoma (ADC) remains controversial. The present study was aimed to clarify the role of PD-L1 expression in predicting prognosis and to investigate its biological function in ADC. Materials and Methods: The association between PD-L1 expression and clinical outcomes in patients with resected ADC was analyzed using immunohistochemistry (IHC) in our cohort (n=104), externally validated by a meta-analysis of 13 published studies...
2018: Journal of Cancer
Huaqiang Ouyang, Weidong Ma, Ti Zhang, Fang Liu, Lujun Zhao, Minghui Fang, Manman Quan, Zhanyu Pan
OBJECTIVES: We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM). METHODS: We reviewed the medical records of 184 patients treated with SCT ± LDT at Tianjin Medical University Cancer Hospital from 2001 to 2015. Overall survival (OS) was the primary end-point. The role of treatment modality and other clinical factors was evaluated by univariate and Cox regression analyses...
September 29, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Xiaoxue Wang, Xu Zhang, Lei Sun, Dongwook Lee, Sunghwan Lee, Minghui Wang, Junjie Zhao, Yang Shao-Horn, Mircea Dincă, Tomás Palacios, Karen K Gleason
Air-stable, lightweight, and electrically conductive polymers are highly desired as the electrodes for next-generation electronic devices. However, the low electrical conductivity and low carrier mobility of polymers are the key bottlenecks that limit their adoption. We demonstrate that the key to addressing these limitations is to molecularly engineer the crystallization and morphology of polymers. We use oxidative chemical vapor deposition (oCVD) and hydrobromic acid treatment as an effective tool to achieve such engineering for conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT)...
September 2018: Science Advances
Panpan Li, Wei Sun, Limin Zuo, Zhiling Zhu, Ting Zhao, Ran Wang, Minghui Zhu, Xiaoyun Leng, Xiaodan Qiu, Liping Bai, Guangzhi Shan
This study describes an analytical method to control the quality of potassium aspartate and magnesium aspartate (PAMA) injection based on the simultaneous detection of the main components (K+ , Mg2+ and Asp) and impurities (Na+ ) using a mixed-mode chromatography coupled with charged aerosol detector. To obtain optimal chromatographic separation, the effects of organic content, column temperature, buffer types, pH and concentrations were evaluated. A Response Surface Methodology (RSM) optimal design was performed after single factor experiment...
November 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Shu Zhao, Minghui Zhang, Yu Zhang, Hongxue Meng, Yan Wang, Yupeng Liu, Jing Jing, Lan Huang, Mengqi Sun, Yue Zhang, Qingyuan Zhang
Objective: Although the prognostic value of programmed cell death-ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis. Methods: The PubMed, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio (HR), 95% confidence interval (CI), and odds ratios (OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival (OS) and clinicopathological features...
August 2018: Cancer Biology & Medicine
Zhongfu Ying, Ge Xiang, Lingjun Zheng, Haite Tang, Lifan Duan, Xiaobing Lin, Qiuge Zhao, Keshi Chen, Yi Wu, Guangsuo Xing, Yiwang Lv, Linpeng Li, Liang Yang, Feixiang Bao, Qi Long, Yanshuang Zhou, Xueying He, Yaofeng Wang, Minghui Gao, Duanqing Pei, Wai-Yee Chan, Xingguo Liu
Reprogramming of somatic cells to induced pluripotent stem cells reconfigures chromatin modifications. Whether and how this process is regulated by signals originating in the mitochondria remain unknown. Here we show that the mitochondrial permeability transition pore (mPTP), a key regulator of mitochondrial homeostasis, undergoes short-term opening during the early phase of reprogramming and that this transient activation enhances reprogramming. In mouse embryonic fibroblasts, greater mPTP opening correlates with higher reprogramming efficiency...
August 23, 2018: Cell Metabolism
Shutang Wang, Minghui He, Bingjuan Weng, Lihui Gan, Yingru Zhao, Ning Li, Yannan Xie
Recently, wearable, self-powered, active human motion sensors have attracted a great deal of attention for biomechanics, physiology, kinesiology, and entertainment. Although some progress has been achieved, new types of stretchable and wearable devices are urgently required to promote the practical application. In this article, targeted at self-powered active human motion sensing, a stretchable, flexible, and wearable triboelectric nanogenerator based on kinesio tapes (KT-TENG) haven been designed and investigated systematically...
August 24, 2018: Nanomaterials
Ying Zhao, Feng Luo, Minghui Chen, Yingchao Wang, Jiazhi Xia, Fangfang Zhou, Yunhai Wang, Yi Chen, Wei Chen
Fuzzy clustering assigns a probability of membership for a datum to a cluster, which veritably reflects real-world clustering scenarios but significantly increases the complexity of understanding fuzzy clusters. Many studies have demonstrated that visualization techniques for multi-dimensional data are beneficial to understand fuzzy clusters. However, no empirical evidence exists on the effectiveness and efficiency of these visualization techniques in solving analytical tasks featured by fuzzy clusters. In this paper, we conduct a controlled experiment to evaluate the ability of fuzzy clusters analysis to use four multi-dimensional visualization techniques, namely, parallel coordinate plot, scatterplot matrix, principal component analysis, and Radviz...
August 20, 2018: IEEE Transactions on Visualization and Computer Graphics
Zhangcheng Liu, Dan Zhao, Jinping Ao, Xiaohui Chang, Yanfeng Wang, Jiao Fu, Minghui Zhang, Hongxing Wang
In this study, a Ti-diamond-Ti structured ultraviolet photodetector was fabricated on a homoepitaxial diamond layer with an oxygen-terminated surface. The properties of the Ti/diamond schottky contact were measured using X-ray photoelectron spectroscopy, and the barrier height was found to be 1.15 eV. At a bias of 3 V, the responsivity at 210 nm was only 4.29 mA/W, while at 12 V, the responsivity increased rapidly to 51 mA/W. The increase can be ascribed to the photocurrent gain. With the further increase in voltage, an avalanche effect was produced, and the responsivity could reach 1...
June 25, 2018: Optics Express
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