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Xiuyun Liu, Lara L Zimmermann, Nhi Ho, Paul Vespa, Xiaoling Liao, Xiao Hu
OBJECTIVES: Intracranial pressure (ICP) monitoring is a common practice when treating intracranial pathology with risk of elevated ICP. External ventricular drain (EVD) insertion is a standard approach for both monitoring ICP and draining cerebrospinal fluid (CSF). However, the conventional EVD cannot serve these two purposes simultaneously because it cannot accurately measure ICP and its pulsatile waveform while the EVD is open to CSF drainage. A new Integra® Camino® FLEX Ventricular Catheter (Integra Lifesciences, County Offaly, Ireland) with a double-lumen construction has been recently introduced into the market, and it can monitor ICP waveforms even during CSF drainage...
December 3, 2018: Neurocritical Care
Tomonori Tabata, Nobuhiro Kaku, Hiroaki Tagomori, Hiroshi Tsumura
BACKGROUND: Acetabular component orientation, such as high placement and femoral head diameter influence joint stability in total hip arthroplasty (THA), wherein anterior inferior iliac spine (AIIS) shape could cause femoro-acetabular impingement. Little is known regarding the combined influence of these parameters, particularly in the context of developmental dysplasia of the hip. Therefore we conducted a computer simulation study based on computed tomography (CT) data to determine whether: (1) AIIS shape, (2) high placement of acetabular cups, and (3) ball head diameter influence the range of motion (ROM) after THA...
November 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Christian Backer Mogensen, Malene Bue Vilhelmsen, Johanne Jepsen, Lilian Keene Boye, Maiken Hjuler Persson, Florence Skyum
BACKGROUND: A new generation of ear thermometers with preheated tips and several measurements points should allow a more precise temperature measurement. The aim of the study was to evaluate if the ear temperature measured by this ear thermometer can be used to screen for fever and whether the thermometer is in agreement with the rectal temperature and if age, use of hearing devices or time after admission influences the temperature measurements. METHODS: Open cross-sectional clinical single site study patients, > 18 years old, who were acutely admitted to the short stay unit at the ED...
December 3, 2018: BMC Emergency Medicine
Hoang T Kim Hong, Truong T Bich Phuong, Nguyen T Thu Thuy, Matthew D Wheatley, John C Cushman
This paper presents a simultaneous isolation of pure, intact chloroplasts and mitochondria from mature leaves of Ice plant (Mesembryanthemum crystallinum) and mitochondrial protein preparation for two-dimensional electrophoresis (2DE) analysis under well watered and water -deficit stressed treatments. The washed chloroplasts and mitochondria were purified with Percoll gradients prepared using a Master flex R pump. The chloroplast and mitochondrial proteins were extracted in lysis buffer containing a protease inhibitor mix supplemented with 1 μM Leupeptin and 1 μM E64, followed by precipitation with ice-cold acetone...
November 30, 2018: Protein Expression and Purification
C Koç, K Kamburoğlu, G Sönmez, F Yılmaz, O Gülen, S Karahan
AIM: To assess observer performance in detecting endodontic complications using three different CBCT units with and without the application of artefact reduction modes. METHODOLOGY: The study involved 40 freshly extracted human mandibular teeth (n=10 per group) and divided randomly into four endodontic complication groups. Group 1) Instrument fracture; Group 2) Strip perforation; Group 3) Canal underfilling; Group 4) Canal overfilling. Images of each tooth were obtained using three different CBCT units offering artefact reduction algorithms: the ProMax 3D Max, the Pax Flex 3D, and the Dentri S...
December 2, 2018: International Endodontic Journal
L Schlickum, S Quadlbauer, Ch Pezzei, E Stöphasius, T Hausner, M Leixnering
INTRODUCTION: The standard therapy of intra-articular and extra-articular distal radius fractures consists of open reduction and stabilization using palmar osteosynthesis with an angularly stable plate. The integrity of the flexor pollicis longus tendon (FPLT) may be mechanically affected by the plate, with rupture rates between 1 and 12% reported in the literature, occurring during a postoperative time period from 4 to 120 months. The aim of this study was to investigate the position of the tendon in relation to the distal edge of the plate using high-resolution ultrasonic imaging...
December 1, 2018: Archives of Orthopaedic and Trauma Surgery
Akinori Kaneguchi, Junya Ozawa, Kengo Minamimoto, Kaoru Yamaoka
We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3 weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W + L) groups. Total and arthrogenic contractures were assessed by restrictions of passive range of motion (ROM) before (m-ROM) and after myotomy (a-ROM), respectively...
December 1, 2018: Inflammation
Hongye Zou, Mary B Sevigny, Shengquan Liu, David T Madden, Maggie C Louie
SL-1-39 [1-(4-chloro-3-methylphenyl)-3-(4-nitrophenyl)thiourea] is a new flexible heteroarotinoid (Flex-Het) analog derived from the parental compound, SHetA2, previously shown to inhibit cell growth across multiple cancer types. The current study aims to determine growth inhibitory effects of SL-1-39 across the different subtypes of breast cancer cells and delineate its molecular mechanism. Our results demonstrate that while SL-1-39 blocks cell proliferation of all breast cancer subtypes tested, it has the highest efficacy against HER2+ breast cancer cells...
November 29, 2018: Cancer Letters
Mauro C de Morais Filho, Marcelo H Fujino, Cátia M Kawamura, Carlos A Dos Santos, José A F Lopes, Francesco C Blumetti, Rames Mattar
The aim of this study was to compare semitendinosus transfer to distal femur (STTX) to semitendinosus surgical lengthening (STL) regarding the increase of anterior pelvic tilt after flexed knee gait treatment. Thirty-nine patients were evaluated, and they were divided according surgical procedures at knees: STL group (22 patients/44 knees), which included patients who received medial hamstrings surgical lengthening as part of multilevel approach, and STTX group (17 patients/34 knees), which was represented by patients who underwent orthopedic surgery including a STTX instead of STL...
November 29, 2018: Journal of Pediatric Orthopedics. Part B
Colin D Brown, Madelyn Muniz, David S Kauvar
OBJECTIVE: Functionally limiting exertional lower extremity pain and neurologic symptoms are commonly encountered in military and civilian settings. Exertional muscle compression of the popliteal artery (PA) and tibial nerve in the proximal calf (the "popliteal outlet") can be associated with these symptoms but is rarely investigated as a cause. Exertional ankle-brachial index (EABI) and dynamic PA ultrasound imaging may be suitable to screen for this syndrome of "functional" popliteal entrapment, but neither has been rigorously studied...
November 26, 2018: Journal of Vascular Surgery
Roseri J A C Roelofsen-de Beer, Bertrand D van Zelst, Aram B Vroling, Yolanda B de Rijke, Christian Ramakers
Background Failure to report a creatinine concentration, especially in icteric patients who are eligible for a liver transplant, can result in a life-threatening situation. We assessed the influence of bilirubin interference on several creatinine assays and investigated ways to circumvent icteric interference without interfering with our normal automated sample logistics. Methods Using icteric patient sera (total bilirubin >255 μmol/L) we determined creatinine concentrations using an enzymatic and Jaffé assay (Roche Diagnostics) in both normal (i...
November 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Matheus Barbalho, Victor Silveira Coswig, Rodolfo Raiol, James Steele, James Fisher, Antonio Paoli, Paulo Gentil
BACKGROUND: The present study's aim was to compare the changes in muscle performance and anthropometric measures in trained women performing RT programs composed only of MJ exercises or programmes that involve the addition of SJ exercises. METHODS: Seventeen trained women were randomised to MJ or MJ+SJ. Both groups performed the same MJ exercises following a nonlinear periodisation model for 8 weeks. The only difference was that the MJ+SJ group also performed SJ exercises...
November 28, 2018: Sports
Yuki Okazaki, Takayuki Furumatsu, Yuya Kodama, Tomohito Hino, Yusuke Kamatsuki, Yoshiki Okazaki, Shin Masuda, Shinichi Miyazawa, Hirosuke Endo, Tomonori Tetsunaga, Kazuki Yamada, Toshifumi Ozaki
BACKGROUND: Medial meniscus posterior root tear (MMPRT) results in joint overloading and degenerative changes in the knee. Favorable clinical outcomes have been reported after transtibial pullout repair of MMPRT. To date, however, in vivo tibial rotational changes before and after root repair remain poorly understood. The purpose of this study was to investigate postoperative changes in tibial rotation following MMPRT pullout repair. HYPOTHESIS: Pathological external rotation of the tibia in the knee-flexed position is caused by MMPRT and is reduced after transtibial pullout repair...
November 24, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Charles J Prestigiacomo
No abstract text is available yet for this article.
November 27, 2018: Neurosurgery
Ryoichi Ema, Momoka Suzuki, Emi Kawaguchi, Itaru Saito, Ryota Akagi
The current study tested the hypothesis that voluntary activation during maximal voluntary contraction (MVC) conditionally depends on sex and joint action. Twenty-eight healthy adults (14 of each sex) performed knee extensor MVC and plantar flexor MVC at extended and flexed knee positions. Voluntary activation during MVC was assessed using a twitch interpolation technique. The voluntary activation during plantar flexor MVC at the extended knee position was significantly lower ( P  = 0.020, 95% confidence interval 1...
2018: PeerJ
Xini Zhang, Rui Xia, Boyi Dai, Xiaole Sun, Weijie Fu
The aim of this study was to determine the effects of two fatigue protocols on lower-limb joint mechanics, stiffness and energy absorption during drop landings. Fifteen male athletes completed landing tasks before and after two fatigue protocols (constant speed running [R-FP] and repeated shuttle sprint plus vertical jump [SJ-FP]). Sagittal plane lower-limb kinematics and ground reaction forces were recorded. Compared with R-FP, SJ-FP required significantly less intervention time to produce a fatigue state...
December 2018: Journal of Sports Science & Medicine
Sandro R Freitas, André Antunes, Pierre Salmon, Bruno Mendes, Telmo Firmino, Carlos Cruz-Montecinos, Mauricio Cerda, João R Vaz
This study sought to examine the shear modulus (i.e., an force index) of three quadriceps muscles [i.e., vastus medialis (VM), vastus lateralis (VL), and rectus femoris (RF)] during passive stretching to determine whether epimuscular myofascial force transmission occurs across muscles. Secondly, this study compared the shear modulus between the quadriceps muscles, in both proximal and distal regions. Twelve healthy individuals were assessed during a passive knee flexion maneuver between 0° and 90° of knee flexion with the hip in two positions: flexed (80°) vs...
November 17, 2018: Journal of Biomechanics
Roberto Cannataro, Mariarita Perri, Luca Gallelli, Maria Cristina Caroleo, Giovambattista De Sarro, Erika Cione
BACKGROUND: The ketogenic diet (KD) promotes metabolic changes and optimizes energy metabolism. It is unknown if microRNAs (miRs) are influenced by KD in obese subjects. OBJECTIVES: The aim of this study was to evaluate 6 weeks of biphasic KD in obese subjects. We enrolled 36 obese subjects (18 females and 18 males) in stage 1 of Edmonton Obesity Staging System (EOSS) parameter. Blood biochemical parameters were dosed by ADVIA 1800. RESULT: The screening of circulating miRs was performed with the FDA approved platform n-counter flex...
November 25, 2018: MicroRNA
Firooz Salami, Julia Brosa, Stefan Van Drongelen, Matthias C M Klotz, Thomas Dreher, Sebastian I Wolf, Mirjam Thielen
AIM: To evaluate short-term (1y postoperatively; E1) and long-term (at least 4y postoperatively; E2) changes in hamstring muscle-tendon length (MTL) and lengthening velocity after hamstring lengthening in children with bilateral cerebral palsy (CP). METHOD: Three-dimensional gait analysis was performed in 19 children (16 males, 3 females; 36 limbs; mean age at surgery 9y [SD 3y]; range 6-10y) with flexed knee gait, preoperative ankle dorsiflexion lower than 20 degrees, and CP before bilateral hamstring lengthening (E0), at E1 and E2...
November 25, 2018: Developmental Medicine and Child Neurology
M Petrovic, C N Maganaris, F L Bowling, A J M Boulton, N D Reeves
People with diabetes display biomechanical gait alterations compared to controls and have a higher metabolic cost of walking (CoW), but it remains unknown whether differences in the vertical displacement of the body centre of mass (CoM) may play a role in this higher CoW. The aim of this study was to investigate vertical CoM displacement (and step length as a potential underpinning factor) as an explanatory factor in the previously observed increased CoW with diabetes. Thirty-one non-diabetic controls (Ctrl); 22 diabetic patients without peripheral neuropathy (DM) and 14 patients with moderate/severe Diabetic Peripheral Neuropathy (DPN), underwent gait analysis using a motion analysis system and force plates while walking at a range of matched speeds between 0...
November 20, 2018: Journal of Biomechanics
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