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Metastatic ewing's sarcoma

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https://www.readbyqxmd.com/read/30339522/clinical-and-radiographic-presentation-of-pelvic-sarcoma-in-children
#1
Muayad Kadhim, Nariman Abol Oyoun, Richard B Womer, John P Dormans
INTRODUCTION: Pelvic sarcomas may present with vague symptoms. The aim of this study was to examine the characteristics and clinical presentations of different types of pelvic sarcoma in children. METHODS: This is a retrospective cohort study of patients up to 21 years of age with the diagnosis of pelvic sarcoma between January 2000 and June 2013. Data on demographics, tumor type and location, and clinical presentation were collected from the medical records. RESULTS: A total of 59 patients [37 males (62...
2018: SICOT-J
https://www.readbyqxmd.com/read/30275176/spinal-ewing-sarcoma-debuting-with-cord-compression-have-we-discovered-the-thread-of-ariadne
#2
REVIEW
Stergios Boussios, Catherine Hayward, Deirdre Cooke, Nikolaos Zakynthinakis-Kyriakou, Alexandros K Tsiouris, Aikaterini A Chatziantoniou, Foivos S Kanellos, Afroditi Karathanasi
Ewing's sarcoma (ES) of the spine with cord or radicular compression as an initial sign is infrequent. It is unclear, in alleviating a neurological deficit, whether decompressive laminectomy is preferred over chemotherapy. Herein, a literature review of the treatment approaches to the primary or metastatic ES of the spine has been performed. Collected data included clinical features of the patients, treatment, and outcome. There are reported 69 cases with initial presentation of cord or radicular compression of spinal cord, arising from primary or metastatic ES, treated either with initial chemotherapy and/or radiotherapy (RT) (33...
October 2018: Anticancer Research
https://www.readbyqxmd.com/read/30173130/oesophageal-narrowing-during-combination-chemotherapy-in-ewing-s-sarcoma-is-vincristine-a-culprit
#3
Kunal Das, Santosh Singh, BrahmaPrakash Kalra, Nitika Agrawal
Vincristine is a widely used chemotherapeutic agent in paediatric oncology. A 7-year-old boy was diagnosed with non-metastatic Ewing's sarcoma of the pelvis. He was started on chemotherapy with vincristine-cyclophosphamide-adriamycin alternate with ifosfamide-etoposide. He developed recurrent vomiting after three cycles of chemotherapy. Evaluation showed oesophageal stricture involving the middle and lower third part. Biopsy was non-conclusive. His symptoms improved with dilatation. A chemotherapy-induced neuropathic dysmotility was suspected, and his chemotherapy was continued with serial dilatation...
September 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30148241/extraosseous-ewing-sarcoma-arising-in-a-chronically-lymphedematous-limb
#4
David John Tobias McArdle, Louise Nott, Robin Harle, John Patrick McArdle
Ewing sarcoma is a highly aggressive small round cell malignant neoplasm of bone and soft tissue that typically is manifested in children and young adults. It is most commonly a primary bone tumor; however, extraosseous cases have been increasingly reported. We report a case of metastatic extraosseous Ewing sarcoma with the primary lesion occurring within a limb affected by primary lymphedema. Lymphedema, in this case, played a role not only in the genesis of the tumor because of the relative local immunosuppression but also in masking the development of the lower limb mass...
September 2018: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/30147091/analysis-of-bone-and-soft-tissue-sarcomas-registered-during-the-year-2012-at-tata-memorial-hospital-mumbai-with-clinical-outcomes
#5
Jyoti Bajpai, Nehal Khanna, Tushar Vora, Ashish Gulia, Siddhartha Laskar, Ajay Puri, Bhanupriya Sanduptla, Girish Chinnaswamy, Prakash Nayak, Shashikant L Juvekar, Amit Janu, Subhash Desai, Jaya Ghosh, Nilendu Purandare, Mukta Ramadwar, Venkatesh Rangarajan, Bharat Rekhi
Introduction: Primary bone and soft tissue sarcomas are rare, but diagnostically and therapeutically challenging group of tumors, requiring multidisciplinary management. There are limited documented studies from multidisciplinary teams , in the form of comprehensive analysis of these tumors, from our country. This study is an analysis of cases of osteosarcomas, Ewing sarcomas (ESs), chondrosarcomas (CSs), and soft-tissue sarcomas (STSs), registered at our institution during 2012. Methods: Clinical details, including outcomes of cases of bone and STSs, during the year 2012, were retrieved from the medical records of our institution and were further analyzed...
January 2018: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30131449/usp6-confers-sensitivity-to-ifn-mediated-apoptosis-through-modulation-of-trail-signaling-in-ewing-sarcoma
#6
Ian C Henrich, Robert Young, Laura Quick, Andre M Oliveira, Margaret M Chou
Ewing sarcoma is the second most common sarcoma of the bone, afflicting predominantly the pediatric population. Although patients with localized disease exhibit favorable survival rates, patients with metastatic disease suffer a dismal 5-year rate of approximately 25%. Thus, there is a great need to develop treatments to combat the disseminated disease. Ubiquitin-specific protease 6 (USP6/TRE17) has been implicated as the key etiologic factor in several benign mesenchymal tumors, including nodular fasciitis and aneurysmal bone cyst (ABC)...
August 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/30116912/sorafenib-in-patients-with-progressed-and-refractory-bone-tumors
#7
Anna Raciborska, Katarzyna Bilska
Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Twelve patients with refractory bone tumors (two with Ewing sarcoma, two with chondrosarcoma, and eight with osteosarcoma) received salvage treatment with sorafenib. All patients had standard tumor imaging and laboratory evaluation. All toxicities were documented...
August 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/30085939/primary-ewing-family-of-tumor-arising-in-the-ovary-a-case-report
#8
Yi-Ping Li, Koping Chang, Tom Wei-Wu Chen, Shu-Ping Lee, Chi-An Chen, Wen-Fang Cheng
Ewing sarcoma and peripheral primitive neuroectodermal tumor constitute the Ewing family of tumors (EFT). EFTs primarily arising in the ovary are extremely rare. We report the case of a 22-yr-old nulliparous woman with a primary EFT in the ovary that initially presented as a 3-cm teratoma-like ovarian tumor, with rapid progression to a 15-cm-sized tumor with liver metastasis in 3 mo. The patient underwent suboptimal debulking surgery and salvage chemotherapy with vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide...
August 6, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30084137/impact-of-the-interdisciplinary-tumor-board-of-the-cooperative-ewing-sarcoma-study-group-on-local-therapy-and-overall-survival-of-ewing-sarcoma-patients-after-induction-therapy
#9
Justus Kreyer, Andreas Ranft, Beate Timmermann, Heribert Juergens, Susanne Jung, Karsten Wiebe, Tobias Boelling, Andreas Schuck, Volker Vieth, Arne Streitbuerger, Jendrik Hardes, Melina Heinemann, Uta Dirksen
BACKGROUND: The Interdisciplinary Tumor Board (ITB) of the Cooperative Ewing Sarcoma Study (CESS) Group was investigated to assess its impact on the overall survival (OAS) of Ewing sarcoma (EwS) patients. The ITB functions as a reference center for the international institutions participating in the clinical trials of the CESS group, but is also available internationally to patients who have not been treated within an appropriate clinical trial. The value of tumor boards in terms of benefit for the patients and the health care system in general is not well documented and is also the subject of controversial discussions...
August 7, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30080131/vincristine-irinotecan-and-temozolomide-treatment-for-refractory-relapsed-pediatric-solid-tumors-a-single-center-experience
#10
Sema Büyükkapu Bay, Rejin Kebudi, Omer Görgün, Bülent Zülfikar, Emin Darendeliler, Fatma B Çakır
Background Although the survival of pediatric cancer has increased dramatically in the last decades, the survival of refractory, relapsed, and metastatic cases is still dismal. The combination of irinotecan and temozolomide has shown activity against refractory/relapsed pediatric solid tumors. Method Thirty-four children with refractory/relapsed solid tumors who had previously been heavily pretreated and who were given vincristine, irinotecan, and temozolomide as third- or further line chemotherapy during 2004-2015 were evaluated...
August 6, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/30077790/short-hypofractionated-radiotherapy-in-palliation-of-pediatric-malignancies-outcomes-and-toxicities
#11
Stanislav Lazarev, Brian H Kushner, Suzanne L Wolden
PURPOSE: Treatment strategies in palliation of pediatric cancer remain a significant challenge. In this study, we aimed to assess efficacy and safety of a short course of hypofractionated RT for metastatic, or recurrent childhood tumors. METHODS AND MATERIALS: A total of 104 lesions in 62 pediatric patients with metastatic or recurrent cancer were treated with a short hypofractionation schedule (>1 but ≤5 fractions; ≥3 Gy per fraction) between 2007 and 2017 in our institution...
August 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30048248/survival-outcome-and-prognostic-factors-after-pulmonary-metastasectomy-in-sarcoma-patients-a-18-year-experience-at-a-single-high-volume-referral-center
#12
Umberto Cariboni, Rita De Sanctis, Marta Giaretta, Emanuele Voulaz, Emanuela Morenghi, Piergiuseppe Colombo, Pierluigi Novellis, Edoardo Bottoni, Valentina Errico, Alessandro Crepaldi, Andrea Marrari, Pierina Navarria, Anna M Ascolese, Alberto Testori, Marta Scorsetti, Vittorio Quagliuolo, Armando Santoro, Marco Alloisio
BACKGROUND: Metastatic sarcoma patients have a poor prognosis with 3-year survival rate of 25%. About 30% of them present isolated lung metastases. We aimed to analyze the clinical outcome of sarcoma patients undergoing pulmonary metastasectomy (PM) and prognostic factors associated with local control, disease-free, and overall survival (OS). PATIENTS AND METHODS: All sarcoma patients undergoing PM at Humanitas Cancer Center were retrospectively reviewed. Analyzed variables included clinicopathologic, surgical, and survival data...
July 25, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29977059/ewing-sarcoma
#13
REVIEW
Thomas G P Grünewald, Florencia Cidre-Aranaz, Didier Surdez, Eleni M Tomazou, Enrique de Álava, Heinrich Kovar, Poul H Sorensen, Olivier Delattre, Uta Dirksen
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease. Treatment comprises local surgery, radiotherapy and polychemotherapy, which are associated with acute and chronic adverse effects that may compromise quality of life in survivors. Histologically, Ewing sarcomas are composed of small round cells expressing high levels of CD99...
July 5, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29949650/reconstructing-diaphyseal-tumors-using-radiated-50-gy-autogenous-tumor-bone-graft
#14
Ajay Puri, Suman Byregowda, Ashish Gulia, Vijayraj Patil, Saniya Crasto, Siddharth Laskar
AIMS: Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS: Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32)...
July 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29936064/phase-i-results-of-a-phase-i-ii-study-of-weekly-nab-paclitaxel-in-paediatric-patients-with-recurrent-refractory-solid-tumours-a-collaboration-with-innovative-therapies-for-children-with-cancer
#15
Lucas Moreno, Michela Casanova, Julia C Chisholm, Pablo Berlanga, Pascal B Chastagner, Sylvain Baruchel, Loredana Amoroso, Soledad Gallego Melcón, Nicolas U Gerber, Gianni Bisogno, Franca Fagioli, Birgit Geoerger, Julia L Glade Bender, Isabelle Aerts, Christophe Bergeron, Pooja Hingorani, Ileana Elias, Mathew Simcock, Stefano Ferrara, Yvan Le Bruchec, Ruta Slepetis, Nianhang Chen, Gilles Vassal
BACKGROUND: nab-Paclitaxel has demonstrated efficacy in adults with solid tumours and preclinical activity in paediatric solid tumour models. Results from phase I of a phase I/II study in paediatric patients with recurrent/refractory solid tumours treated with nab-paclitaxel are reported. PATIENTS AND METHODS: Patients with recurrent/refractory extracranial solid tumours received nab-paclitaxel on days 1, 8 and 15 every 4 weeks at 120, 150, 180, 210, 240, or 270 mg/m2 (rolling-6 dose-escalation) to establish the maximum tolerated dose (MTD) and recommended phase II dose (RP2D)...
September 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29891750/ewing-sarcoma-peripheral-primitive-neuroectodermal-tumor-in-the-adrenal-gland-of-a-child
#16
Kourosh Goudarzipour, Farzaneh Farahmandi, Ahmad Mohammadi, Reza Taherian
Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29851332/-application-of-three-dimensional-printing-technology-in-bone-tumor-surgery
#17
Leilei Xu, Zheng Tian, Akbar Yunus, Xiaoshuai Wang, Jiangtao Chen, Chong Wang, Xinghua Song
Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery. Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). There were 1 case of cystic echinococcosis at left pelvis and pathological fracture of the proximal femur; 1 case of left iliac bone osteoblastoma associated with aneurysmal bone cyst; 1 case of fibrous dysplasia of the left femur (sheep horn deformity) with pathological fracture; 1 case of metastatic carcinoma of right calcaneus (tumor staging was T 2 N 0 M 0 ); and 1 case of Ewing sarcoma of left femur (tumor staging was T 2 N 0 M 0 )...
September 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29850398/small-animal-models-for-the-study-of-bone-sarcoma-pathogenesis-characteristics-therapeutic-interests-and-limitations
#18
REVIEW
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29782348/renal-ewing-sarcoma-treated-with-apatinib
#19
Yang Zhao, Ye Chen, Ke Cheng, Zhi-Ping Li, Hao Zeng, Ji-Yan Liu
Renal Ewing sarcoma (RES) is an extremely rare disease. The standard treatment for this disease is lacking, and clinical experience needs to be accumulated. Here, we report a case of RES that rapidly developed to metastatic disease and was refractory to radiotherapy and chemotherapy; however, the case obtained a partial response based on Choi criteria by orally taking antiangiogenic drug apatinib. Our case suggests that apatinib may be a therapeutic option for RES.
August 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29780156/the-successful-treatment-of-metastatic-extraosseous-ewing-sarcoma-with-pazopanib
#20
Yoshinori Mori, Shiori Kinoshita, Takashi Kanamori, Hiromi Kataoka, Takashi Joh, Shinsuke Iida, Masashi Takemoto, Masahiro Kondo, Junko Kuroda, Hirokazu Komatsu
The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib...
September 15, 2018: Internal Medicine
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