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Metastatic ewing's sarcoma

Anna Raciborska, Katarzyna Bilska
Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Twelve patients with refractory bone tumors (two with Ewing sarcoma, two with chondrosarcoma, and eight with osteosarcoma) received salvage treatment with sorafenib. All patients had standard tumor imaging and laboratory evaluation. All toxicities were documented...
August 16, 2018: Medical Oncology
Yi-Ping Li, Koping Chang, Tom Wei-Wu Chen, Shu-Ping Lee, Chi-An Chen, Wen-Fang Cheng
Ewing sarcoma and peripheral primitive neuroectodermal tumor constitute the Ewing family of tumors (EFT). EFTs primarily arising in the ovary are extremely rare. We report the case of a 22-yr-old nulliparous woman with a primary EFT in the ovary that initially presented as a 3-cm teratoma-like ovarian tumor, with rapid progression to a 15-cm-sized tumor with liver metastasis in 3 mo. The patient underwent suboptimal debulking surgery and salvage chemotherapy with vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide...
August 6, 2018: International Journal of Gynecological Pathology
Justus Kreyer, Andreas Ranft, Beate Timmermann, Heribert Juergens, Susanne Jung, Karsten Wiebe, Tobias Boelling, Andreas Schuck, Volker Vieth, Arne Streitbuerger, Jendrik Hardes, Melina Heinemann, Uta Dirksen
BACKGROUND: The Interdisciplinary Tumor Board (ITB) of the Cooperative Ewing Sarcoma Study (CESS) Group was investigated to assess its impact on the overall survival (OAS) of Ewing sarcoma (EwS) patients. The ITB functions as a reference center for the international institutions participating in the clinical trials of the CESS group, but is also available internationally to patients who have not been treated within an appropriate clinical trial. The value of tumor boards in terms of benefit for the patients and the health care system in general is not well documented and is also the subject of controversial discussions...
August 7, 2018: Pediatric Blood & Cancer
Sema Büyükkapu Bay, Rejin Kebudi, Omer Görgün, Bülent Zülfikar, Emin Darendeliler, Fatma B Çakır
Background Although the survival of pediatric cancer has increased dramatically in the last decades, the survival of refractory, relapsed, and metastatic cases is still dismal. The combination of irinotecan and temozolomide has shown activity against refractory/relapsed pediatric solid tumors. Method Thirty-four children with refractory/relapsed solid tumors who had previously been heavily pretreated and who were given vincristine, irinotecan, and temozolomide as third- or further line chemotherapy during 2004-2015 were evaluated...
August 6, 2018: Journal of Oncology Pharmacy Practice
Stanislav Lazarev, Brian H Kushner, Suzanne L Wolden
PURPOSE: Treatment strategies in palliation of pediatric cancer remain a significant challenge. In this study, we aimed to assess efficacy and safety of a short course of hypofractionated RT for metastatic, or recurrent childhood tumors. METHODS AND MATERIALS: A total of 104 lesions in 62 pediatric patients with metastatic or recurrent cancer were treated with a short hypofractionation schedule (>1 but ≤5 fractions; ≥3 Gy per fraction) between 2007 and 2017 in our institution...
August 2, 2018: International Journal of Radiation Oncology, Biology, Physics
Umberto Cariboni, Rita De Sanctis, Marta Giaretta, Emanuele Voulaz, Emanuela Morenghi, Piergiuseppe Colombo, Pierluigi Novellis, Edoardo Bottoni, Valentina Errico, Alessandro Crepaldi, Andrea Marrari, Pierina Navarria, Anna M Ascolese, Alberto Testori, Marta Scorsetti, Vittorio Quagliuolo, Armando Santoro, Marco Alloisio
BACKGROUND: Metastatic sarcoma patients have a poor prognosis with 3-year survival rate of 25%. About 30% of them present isolated lung metastases. We aimed to analyze the clinical outcome of sarcoma patients undergoing pulmonary metastasectomy (PM) and prognostic factors associated with local control, disease-free, and overall survival (OS). PATIENTS AND METHODS: All sarcoma patients undergoing PM at Humanitas Cancer Center were retrospectively reviewed. Analyzed variables included clinicopathologic, surgical, and survival data...
July 25, 2018: American Journal of Clinical Oncology
Thomas G P Grünewald, Florencia Cidre-Aranaz, Didier Surdez, Eleni M Tomazou, Enrique de Álava, Heinrich Kovar, Poul H Sorensen, Olivier Delattre, Uta Dirksen
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease. Treatment comprises local surgery, radiotherapy and polychemotherapy, which are associated with acute and chronic adverse effects that may compromise quality of life in survivors. Histologically, Ewing sarcomas are composed of small round cells expressing high levels of CD99...
July 5, 2018: Nature Reviews. Disease Primers
Ajay Puri, Suman Byregowda, Ashish Gulia, Vijayraj Patil, Saniya Crasto, Siddharth Laskar
AIMS: Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS: Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32)...
June 27, 2018: Journal of Surgical Oncology
Lucas Moreno, Michela Casanova, Julia C Chisholm, Pablo Berlanga, Pascal B Chastagner, Sylvain Baruchel, Loredana Amoroso, Soledad Gallego Melcón, Nicolas U Gerber, Gianni Bisogno, Franca Fagioli, Birgit Geoerger, Julia L Glade Bender, Isabelle Aerts, Christophe Bergeron, Pooja Hingorani, Ileana Elias, Mathew Simcock, Stefano Ferrara, Yvan Le Bruchec, Ruta Slepetis, Nianhang Chen, Gilles Vassal
BACKGROUND: nab-Paclitaxel has demonstrated efficacy in adults with solid tumours and preclinical activity in paediatric solid tumour models. Results from phase I of a phase I/II study in paediatric patients with recurrent/refractory solid tumours treated with nab-paclitaxel are reported. PATIENTS AND METHODS: Patients with recurrent/refractory extracranial solid tumours received nab-paclitaxel on days 1, 8 and 15 every 4 weeks at 120, 150, 180, 210, 240, or 270 mg/m2 (rolling-6 dose-escalation) to establish the maximum tolerated dose (MTD) and recommended phase II dose (RP2D)...
September 2018: European Journal of Cancer
Kourosh Goudarzipour, Farzaneh Farahmandi, Ahmad Mohammadi, Reza Taherian
Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET...
May 2018: Iranian Journal of Kidney Diseases
Leilei Xu, Zheng Tian, Akbar Yunus, Xiaoshuai Wang, Jiangtao Chen, Chong Wang, Xinghua Song
Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery. Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). There were 1 case of cystic echinococcosis at left pelvis and pathological fracture of the proximal femur; 1 case of left iliac bone osteoblastoma associated with aneurysmal bone cyst; 1 case of fibrous dysplasia of the left femur (sheep horn deformity) with pathological fracture; 1 case of metastatic carcinoma of right calcaneus (tumor staging was T 2 N 0 M 0 ); and 1 case of Ewing sarcoma of left femur (tumor staging was T 2 N 0 M 0 )...
September 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
Yang Zhao, Ye Chen, Ke Cheng, Zhi-Ping Li, Hao Zeng, Ji-Yan Liu
Renal Ewing sarcoma (RES) is an extremely rare disease. The standard treatment for this disease is lacking, and clinical experience needs to be accumulated. Here, we report a case of RES that rapidly developed to metastatic disease and was refractory to radiotherapy and chemotherapy; however, the case obtained a partial response based on Choi criteria by orally taking antiangiogenic drug apatinib. Our case suggests that apatinib may be a therapeutic option for RES.
August 2018: Anti-cancer Drugs
Yoshinori Mori, Shiori Kinoshita, Takashi Kanamori, Hiromi Kataoka, Takashi Joh, Shinsuke Iida, Masashi Takemoto, Masahiro Kondo, Junko Kuroda, Hirokazu Komatsu
The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib...
May 18, 2018: Internal Medicine
Ömer Kasalak, Amelie Dammann, Hugo J A Adams, Jelle Overbosch, Rudi A J O Dierckx, Paul C Jutte, Thomas C Kwee
PURPOSE: To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients. MATERIALS AND METHODS: This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016. RESULTS: Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5...
May 11, 2018: Skeletal Radiology
Casey E Bohl, Sara M Federico, Giles W Robinson, Armita Bahrami, Barry L Shulkin
PURPOSE: Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid-pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Secondary malignancies of the pancreas occur more frequently than primary pancreatic malignancies in children and are most commonly seen with non-Hodgkin lymphomas (NHL) and mesenchymal sarcomas...
May 11, 2018: Pediatric Blood & Cancer
Alejandra Toquica, Xavier Rueda, Sergio Cervera, Adriana Reina, Carolina Pozzobon, Samuel D Morales, Rafael Parra-Medina
No abstract text is available yet for this article.
May 6, 2018: International Journal of Dermatology
Ruchita Tyagi, Aminder Singh, Bhavna Garg, Neena Sood
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current study was to analyse the clinico-haematological presentation and morphological pattern of infiltration of solid tumours detected first as metastatic deposits on bone marrow examination...
2018: Iranian Journal of Pathology
Miriam Schlegel, Martina Zeumer, Peter Michael Prodinger, Klaus Woertler, Marc Steinborn, Rüdiger von Eisenhart-Rothe, Stefan Burdach, Hans Rechl, Irene von Luettichau
BACKGROUND: The purpose of this study was to investigate whether pathological fractures (PF) influence the prognosis of patients with osteosarcoma (OS) or Ewing tumor (ET) regarding 5-year survival, occurrence of metastases, and local recurrence. METHODS: We retrospectively analyzed 205 patients with metastatic and nonmetastatic OS or ET. Survival analysis was performed for all patients and differentiated for patients with OS (n = 127) and ET (n = 78) as well as for adults (n = 101) and children (n = 104)...
2018: Oncology
Sevastián S Medina-Ornelas, Herlinda Vera-Hermosillo, Rafael Delgado-Espín, Francisco O García-Pérez
Background: Imaging studies, particularly simple and contrast-enhanced tomography, constitute the first diagnostic approach to detect recurrence of musculoskeletal tumors. The aim of the present retrospective study was to demonstrate the usefulness of scintigraphy plus SPECT/CT (single photon emission computed tomography) with thallium-201 (201 Tl) in the evaluation of malignant musculoskeletal tumors with suspicion of recurrence or metastatic disease. Methods: Eight weeks after the last therapy, 72 scintigraphy and SPECT/CT studies were performed to assess regional recurrence and metastatic disease in 42 patients with different types of malignant musculoskeletal tumors, such as osteosarcoma, Ewing's sarcoma, rhabdomyosarcoma, retinoblastoma, synovial sarcoma, and Wilms tumor at the Hospital Infantil de México Federico Gómez...
2018: Boletín Médico del Hospital Infantil de México
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