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https://www.readbyqxmd.com/read/28432612/evaluation-of-the-analgesia-nociception-index-ani-in-healthy-awake-volunteers
#1
Rami Issa, Marco Julien, Elizabeth Décary, Olivier Verdonck, Louis-Philippe Fortier, Pierre Drolet, Philippe Richebé
BACKGROUND: Analgesia might be evaluated with simple changes in vital signs, a non-specific and non-sensitive method. Heart rate variability (HRV) correlates with autonomous nervous system activity and can be used to evaluate painful stimuli. Heart rate variability is then transformed into a numeric scale called the analgesia nociception index (ANI), where higher values represent predominant parasympathetic tone, thus low nociception. Under general anesthesia, the ANI decreases following painful stimuli and increases after administration of analgesia, but significant interindividual variability is present...
April 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28268478/comparison-of-pulse-rate-variability-and-heart-rate-variability-for-high-frequency-content-estimation
#2
R Logier, J De Jonckheere, A Dassonneville, M Jeanne
Heart Rate Variability (HRV) analysis can be of precious help in most of clinical situations because it is able to quantify the Autonomic Nervous System (ANS) activity. The HRV high frequency (HF) content, related to the parasympathetic tone, reflects the ANS response to an external stimulus responsible of pain, stress or various emotions. We have previously developed the Analgesia Nociception Index (ANI), based on HRV high frequency content estimation, which quantifies continuously the vagal tone in order to guide analgesic drug administration during general anesthesia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261288/the-relationship-between-pharmacokinetic-parameters-of-carbamazepine-and-therapeutic-response-in-epileptic-patients
#3
Chahra Chbili, Anis Hassine, Aicha Laouani, Sana Ben Amor, Manel Nouira, Sofiène Ben Ammou, Saad Saguem
INTRODUCTION: The prescribed dose and carbamazepine plasma concentration to achieve the optimal therapeutic efficacy are highly variable from one patient to the other. Our study aimed to determine whether biological parameters may be used as plasma markers that can individually adjust the carbamazepine dose necessary to optimize therapeutic efficacy. MATERIAL AND METHODS: Ninety-four epileptic patients under carbamazepine monotherapy and who have never used combination therapy were recruited from the consecutive admissions at the Department of Neurology "CHU Sahloul" of Sousse Central Hospital in Tunisia from February 2010 to April 2011...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28255433/adverse-drug-reactions-due-to-cancer-chemotherapy-in-a-tertiary-care-teaching-hospital
#4
Julie Birdie Wahlang, Purnima Devi Laishram, Dhriti Kumar Brahma, Chayna Sarkar, Joonmoni Lahon, Banylla Shisha Nongkynrih
BACKGROUND: An adverse drug reaction (ADR) is defined by World Health Organization (WHO) as 'Any response to a drug which is noxious, unintended and occurs at doses used in man for prophylaxis, diagnosis or therapy'. ADRs associated with cancer chemotherapy warrant analysis on their severity and preventability. The outcome would create awareness among health care providers and prevent their recurrence. We have performed a hospital-based prospective observational study designed to analyze the pattern of ADRs to chemotherapeutic agents in cancer patients of a tertiary care hospital...
February 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28226651/comparison-of-pulse-rate-variability-and-heart-rate-variability-for-high-frequency-content-estimation
#5
R Logier, J De Jonckheere, A Dassonneville, M Jeanne, R Logier, J De Jonckheere, A Dassonneville, M Jeanne, A Dassonneville, J De Jonckheere, R Logier, M Jeanne
Heart Rate Variability (HRV) analysis can be of precious help in most of clinical situations because it is able to quantify the Autonomic Nervous System (ANS) activity. The HRV high frequency (HF) content, related to the parasympathetic tone, reflects the ANS response to an external stimulus responsible of pain, stress or various emotions. We have previously developed the Analgesia Nociception Index (ANI), based on HRV high frequency content estimation, which quantifies continuously the vagal tone in order to guide analgesic drug administration during general anesthesia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/27957370/refractory-obstructive-sleep-apnea-in-a-patient-with-diffuse-idiopathic-skeletal-hyperostosis
#6
Ara Darakjian, Ani B Darakjian, Edward T Chang, Macario Camacho
Diffuse Idiopathic Skeletal Hyperostosis (DISH) can cause ossification of ligaments and may affect the spine. We report a case of obstructive sleep apnea in a patient with significant upper airway narrowing secondary to cervical DISH. This patient had an initial apnea-hypopnea index (AHI) of 145 events/hour and was treated with uvulopalatopharyngoplasty, genial tubercle advancement, hyoid suspension, septoplasty, inferior turbinoplasties, and radiofrequency ablations to the tongue base which reduced his AHI to 40 events/hour...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27886590/pelvic-floor-dynamics-during-high-impact-athletic-activities-a-computational-modeling-study
#7
Nicholas Dias, Yun Peng, Rose Khavari, Nissrine A Nakib, Robert M Sweet, Gerald W Timm, Arthur G Erdman, Timothy B Boone, Yingchun Zhang
BACKGROUND: Stress urinary incontinence is a significant problem in young female athletes, but the pathophysiology remains unclear because of the limited knowledge of the pelvic floor support function and limited capability of currently available assessment tools. The aim of our study is to develop an advanced computer modeling tool to better understand the dynamics of the internal pelvic floor during highly transient athletic activities. METHODS: Apelvic model was developed based on high-resolution MRI scans of a healthy nulliparous young female...
November 18, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27871583/sugammadex-given-for-rocuronium-induced-neuromuscular-blockade-in-infants-a-retrospect%C3%A4-ve-study
#8
Ozlem Ozmete, Cagla Bali, Oya Yalcin Cok, Hatice Evren Eker Turk, Nesrın Bozdogan Ozyilkan, Soner Civi, Anıs Aribogan
STUDY OBJECTIVE: To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients. DESIGN: Retrospective observational study. SETTING: University teaching hospital. PATIENTS: Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27861313/is-trough-concentration-of-vancomycin-predictive-of-the-area-under-the-curve-a-clinical-study-in-elderly-patients
#9
Anis Bel Kamel, Laurent Bourguignon, Micaela Marcos, Michel Ducher, Sylvain Goutelle
BACKGROUND: Current guidelines suggest that vancomycin trough concentrations (Cmin) between 15 and 20 mg/L should be achieved to optimize vancomycin exposure and effect. The objective of this study was to analyze the correlation between vancomycin Cmin and the area under the concentration-time curve (AUC) and assess the ability to predict an AUC target of 400 mg·h/L based on Cmin. METHODS: A retrospective analysis of vancomycin therapeutic drug monitoring data collected in 95 elderly patients treated with intermittent intravenous vancomycin was performed...
February 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27815816/a-decreasing-cd4-cd8-ratio-over-time-and-lower-csf-penetrating-antiretroviral-regimens-are-associated-with-a-higher-risk-of-neurocognitive-deterioration-independently-of-viral-replication
#10
Matteo Vassallo, R Fabre, J Durant, C Lebrun-Frenay, H Joly, M Ticchioni, F DeSalvador, A Harvey-Langton, B Dunais, M Laffon, J Cottalorda, P Dellamonica, C Pradier
Persistent immune activation is one of the suspected causes of HIV-associated neurocognitive disorders (HAND) in cART era. The CD4/CD8 ratio has been recently showed as a marker of immune activation and HAND. Our aim was to analyze if a decrease in the CD4/CD8 ratio over time could have an impact on neurocognitive deterioration. Randomly selected HIV-infected patients were followed for neuropsychological (NP) testing during a period of almost 2 years. Tests were adjusted for age, gender, and education. Patients were divided into 5 groups: normal tests (NT), neuropsychological deficit (ND, one impaired cognitive domain), asymptomatic neurocognitive disorders (ANI), mild neurocognitive disorders (MND), and HIV-associated dementia (HAD)...
November 4, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27503596/nutrition-and-health-claims-on-healthy-and-less-healthy-packaged-food-products-in-new-zealand
#11
Haya H Al-Ani, Anandita Devi, Helen Eyles, Boyd Swinburn, Stefanie Vandevijvere
Nutrition and health claims are displayed to influence consumers' food choices. This study assessed the extent and nature of nutrition and health claims on the front-of-pack of 'healthy' and 'less-healthy' packaged foods in New Zealand. Foods from eight categories, for which consumption may affect the risk of obesity and diet-related chronic diseases, were selected from the 2014 Nutritrack database. The internationally standardised International Network for Food and Obesity/Non-Communicable Diseases Research, Monitoring and Action Support (INFORMAS) taxonomy was used to classify claims on packages...
September 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27448190/changes-over-time-in-ige-sensitization-to-allergens-of-the-fish-parasite-anisakis-spp
#12
Noelia Carballeda-Sangiao, Ana I Rodríguez-Mahillo, Mercedes Careche, Alfonso Navas, Ignacio Moneo, Miguel González-Muñoz
BACKGROUND: Sensitization to Anisakis spp. can produce allergic reactions after eating raw or undercooked parasitized fish. Specific IgE is detected long after the onset of symptoms, but the changes in specific IgE levels over a long follow-up period are unknown; furthermore, the influence of Anisakis spp. allergen exposure through consumption of fishery products is also unknown. OBJECTIVE: To analyse the changes in IgE sensitization to Anisakis spp. allergens over several years of follow-up and the influence of the consumption of fishery products in IgE sensitization...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27346686/platelet-related-variants-identified-by-exomechip-meta-analysis-in-157-293-individuals
#13
John D Eicher, Nathalie Chami, Tim Kacprowski, Akihiro Nomura, Ming-Huei Chen, Lisa R Yanek, Salman M Tajuddin, Ursula M Schick, Andrew J Slater, Nathan Pankratz, Linda Polfus, Claudia Schurmann, Ayush Giri, Jennifer A Brody, Leslie A Lange, Ani Manichaikul, W David Hill, Raha Pazoki, Paul Elliot, Evangelos Evangelou, Ioanna Tzoulaki, He Gao, Anne-Claire Vergnaud, Rasika A Mathias, Diane M Becker, Lewis C Becker, Amber Burt, David R Crosslin, Leo-Pekka Lyytikäinen, Kjell Nikus, Jussi Hernesniemi, Mika Kähönen, Emma Raitoharju, Nina Mononen, Olli T Raitakari, Terho Lehtimäki, Mary Cushman, Neil A Zakai, Deborah A Nickerson, Laura M Raffield, Rakale Quarells, Cristen J Willer, Gina M Peloso, Goncalo R Abecasis, Dajiang J Liu, Panos Deloukas, Nilesh J Samani, Heribert Schunkert, Jeanette Erdmann, Myriam Fornage, Melissa Richard, Jean-Claude Tardif, John D Rioux, Marie-Pierre Dube, Simon de Denus, Yingchang Lu, Erwin P Bottinger, Ruth J F Loos, Albert Vernon Smith, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Digna R Velez Edwards, Eric S Torstenson, Yongmei Liu, Russell P Tracy, Jerome I Rotter, Stephen S Rich, Heather M Highland, Eric Boerwinkle, Jin Li, Ethan Lange, James G Wilson, Evelin Mihailov, Reedik Mägi, Joel Hirschhorn, Andres Metspalu, Tõnu Esko, Caterina Vacchi-Suzzi, Mike A Nalls, Alan B Zonderman, Michele K Evans, Gunnar Engström, Marju Orho-Melander, Olle Melander, Michelle L O'Donoghue, Dawn M Waterworth, Lars Wallentin, Harvey D White, James S Floyd, Traci M Bartz, Kenneth M Rice, Bruce M Psaty, J M Starr, David C M Liewald, Caroline Hayward, Ian J Deary, Andreas Greinacher, Uwe Völker, Thomas Thiele, Henry Völzke, Frank J A van Rooij, André G Uitterlinden, Oscar H Franco, Abbas Dehghan, Todd L Edwards, Santhi K Ganesh, Sekar Kathiresan, Nauder Faraday, Paul L Auer, Alex P Reiner, Guillaume Lettre, Andrew D Johnson
Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively...
July 7, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27249526/an-outbreak-of-dermatophilosis-and-caseous-lymphadenitis-mixed-infection-in-camels-camelus-dromedaries-in-jordan
#14
Yaser Hamadeh Tarazi, Falah Khalil Al-Ani
INTRODUCTION: This study describes and reports, for the first time, an outbreak of dermatophilosis that occurred concurrently with caseous lymphadenitis involving two camel herds (Camelus dromedaries) in north Jordan. METHODOLOGY: The affected animals were part of two herds comprising 52 Arabian camels in herd 1 and 65 camels in herd 2. The age of infected camels ranged from 18 months to 5 years. Pus and skin scab samples were aseptically collected and bacteriologically examined...
May 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27200358/robotic-surgery-in-gynecology
#15
REVIEW
Jean Bouquet de Joliniere, Armando Librino, Jean-Bernard Dubuisson, Fathi Khomsi, Nordine Ben Ali, Anis Fadhlaoui, J M Ayoubi, Anis Feki
Minimally invasive surgery (MIS) can be considered as the greatest surgical innovation over the past 30 years. It revolutionized surgical practice with well-proven advantages over traditional open surgery: reduced surgical trauma and incision-related complications, such as surgical-site infections, postoperative pain and hernia, reduced hospital stay, and improved cosmetic outcome. Nonetheless, proficiency in MIS can be technically challenging as conventional laparoscopy is associated with several limitations as the two-dimensional (2D) monitor reduction in-depth perception, camera instability, limited range of motion, and steep learning curves...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27200193/thoracic-paravertebral-block-multimodal-analgesia-and-monitored-anesthesia-care-for-breast-cancer-surgery-in-primary-lateral-sclerosis
#16
Anis Dizdarevic, Anthony Fernandes
Objective. Primary lateral sclerosis (PLS) is a rare idiopathic neurodegenerative disorder affecting upper motor neurons and characterized by spasticity, muscle weakness, and bulbar involvement. It can sometimes mimic early stage of more common and fatal amyotrophic lateral sclerosis (ALS). Surgical patients with a history of neurodegenerative disorders, including PLS, may be at increased risk for general anesthesia related ventilatory depression and postoperative respiratory complications, abnormal response to muscle relaxants, and sensitivity to opioids, sedatives, and local anesthetics...
2016: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/27035710/comparative-genomic-analysis-reveals-a-possible-novel-non-tuberculous-mycobacterium-species-with-high-pathogenic-potential
#17
Siew Woh Choo, Avirup Dutta, Guat Jah Wong, Wei Yee Wee, Mia Yang Ang, Cheuk Chuen Siow
Mycobacteria have been reported to cause a wide range of human diseases. We present the first whole-genome study of a Non-Tuberculous Mycobacterium, Mycobacterium sp. UM_CSW (referred to hereafter as UM_CSW), isolated from a patient diagnosed with bronchiectasis. Our data suggest that this clinical isolate is likely a novel mycobacterial species, supported by clear evidence from molecular phylogenetic, comparative genomic, ANI and AAI analyses. UM_CSW is closely related to the Mycobacterium avium complex. While it has characteristic features of an environmental bacterium, it also shows a high pathogenic potential with the presence of a wide variety of putative genes related to bacterial virulence and shares very similar pathogenomic profiles with the known pathogenic mycobacterial species...
2016: PloS One
https://www.readbyqxmd.com/read/26889618/assessment-of-procedural-pain-in-children-using-analgesia-nociception-index-a-pilot-study
#18
Justine Avez-Couturier, Julien De Jonckheere, Mathieu Jeanne, Louis Vallée, Jean M Cuisset, Régis Logier
OBJECTIVES: The Analgesia Nociception Index (ANI), based on heart rate variability analysis, is known to decrease after a painful stimulus during surgery under general anesthesia in adults. It is measured continuously and noninvasively. We studied ANI response to procedural pain in a pediatric population and ANI measurement's feasibility in this context, across age. METHODS: A prospective, noninterventional pilot study was performed. All children (between 6 mo and under 18 y) undergoing muscle biopsy conducted under analgesia and light sedation were included...
February 17, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/26872085/preparation-of-microvolume-anion-exchange-cartridge-for-inductively-coupled-plasma-mass-spectrometry-based-determination-of-237-np-content-in-spent-nuclear-fuel
#19
Shiho Asai, Yukiko Hanzawa, Miki Konda, Daisuke Suzuki, Masaaki Magara, Takaumi Kimura, Ryo Ishihara, Kyoichi Saito, Shinsuke Yamada, Hideyuki Hirota
Microvolume anion-exchange porous polymer disk-packed cartridges were prepared for Am/Np separation, which is required prior to the measurement of Neptunium-237 ((237)Np) with inductively coupled plasma mass spectrometry (ICPMS). Disks with a volume of 0.08 cm(3) were cut out from porous sheets having anion-exchange-group-containing polymer chains densely attached on the pore surface. Four different amine-based groups, N,N-dimethylaminoethyl methacrylate, trimethylammonium, diethylamine, and triethylenediamine (TEDA), were selected as the anion-exchange groups to be introduced into the porous sheets...
March 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/26663402/prediction-of-adverse-perinatal-outcome-of-small-for-gestational-age-pregnancy-using-size-centiles-and-conditional-growth-centiles
#20
H O Karlsen, S L Johnsen, S Rasmussen, T Kiserud
OBJECTIVE: To test whether adding conditional growth centiles to size centiles of estimated fetal weight (EFW) improves prediction of adverse perinatal outcome in pregnancies with or at risk of having a small-for-gestational-age (SGA) fetus. METHODS: This prospective longitudinal study included pregnant women at risk of or diagnosed with an SGA (≤ 5(th) centile) fetus. They underwent serial ultrasound measurements and the final two were included in the analyses for this study...
August 2016: Ultrasound in Obstetrics & Gynecology
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