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Schizophrenia depression

Hiroaki Hori, Seiji Nakamura, Fuyuko Yoshida, Toshiya Teraishi, Daimei Sasayama, Miho Ota, Kotaro Hattori, Yoshiharu Kim, Teruhiko Higuchi, Hiroshi Kunugi
Etiology of depression and its vulnerability remains elusive. Using a latent profile analysis on dimensional personality traits, we previously identified 3 different phenotypes in the general population, namely stress-resilient, -vulnerable, and -resistant groups. Here we performed microarray-based blood gene expression profiling of these 3 groups (n = 20 for each group) in order to identify genes involved in stress vulnerability as it relates to the risk of depression. Identified differentially expressed genes among the groups were most markedly enriched in ribosome-related pathways...
August 6, 2018: Journal of Psychiatric Research
Lorena Oliveira de Matos, Ana Luiza de Araujo Lima Reis, Lorena Terene Lopes Guerra, Leonardo de Oliveira Guarnieri, Muiara Aparecida Moraes, Nayara Soares Sena Aquino, Raphael E Szawka, Grace Schenatto Pereira, Bruno Rezende Souza
Alterations in dopaminergic signaling and neurodevelopment are associated with many neuropsychiatric disorders, such as attention deficit and hyperactivity disorder (ADHD), autism, and schizophrenia. Imbalances in dopamine levels during prenatal development are associated with behavioral alterations later in life, like hyperactivity and addiction, and it is possible that dopaminergic imbalances may have diverse effects during different neurodevelopmental windows. In this study, we investigate whether an increase in dopamine levels during the perinatal developmental window affects behavior of juvenile male and female Swiss mice...
August 10, 2018: Pharmacology, Biochemistry, and Behavior
Gülser Şenses-Dinç, Uğur Özçelik, Tuna Çak, Deniz Doğru-Ersöz, Esra Çöp, Ebru Yalçın, Ebru Çengel-Kültür, Sevgi Pekcan, Nural Kiper, Fatih Ünal
Şenses-Dinç G, Özçelik U, Çak T, Doğru-Ersöz D, Çöp E, Yalçın E, Çengel-Kültür E, Pekcan S, Kiper N, Ünal F. Psychiatric morbidity and quality of life in children and adolescents with cystic fibrosis. Turk J Pediatr 2018; 60: 32-40. The aim of this study was to investigate psychiatric disorders, depression and anxiety levels, and quality of life in children and adolescents with cystic fibrosis (CF), and to compare them with those of children with non-cystic fibrosis (non-CF) bronchiectasis and healthy controls...
2018: Turkish Journal of Pediatrics
Adriano H Moffa, Andre R Brunoni, Stevan Nikolin, Colleen K Loo
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that has been gaining favor as a viable tool in Psychiatry. The purpose of this review is to summarize the evidence of tDCS as a treatment of disorders such as depression, schizophrenia, and obsessive-compulsive disorder (OCD). Current findings indicate that tDCS is probably effective in non-treatment-resistant depressive patients. Regarding schizophrenia and OCD, present evidence is not robust enough, although preliminary results indicate that tDCS is a promising technique...
September 2018: Psychiatric Clinics of North America
Peter B Rosenquist, Nagy A Youssef, Sandarsh Surya, William V McCall
The use of electroconvulsive therapy (ECT) for those suffering from major depressive disorder is well-evidenced, time-honored, and recognized by most treatment guidelines. However, since its inception ECT has been used by practitioners for a broader range of neuropsychiatric conditions. This article reviews the highly variable evidence supporting the use of ECT in conditions other than depression, such as schizophrenia, bipolar manic states, catatonia, Parkinson disease, and post-traumatic stress disorder.
September 2018: Psychiatric Clinics of North America
Jaśmina Arabska, Anna Łucka, Dominik Strzelecki, Adam Wysokiński
AIM: Neurotrophin-3 (NT-3) is a neurotrophic factor responsible for promoting development, survival and function of neurons. NT-3 may be involved in the etiopathology of schizophrenia and mood disorders. However it must be cleared up if changes of NT-3 level are associated with schizophrenia itself or are secondary to certain symptoms (e.g. negative or depressive). The aim of this study was to examine whether the presence of negative or depressive symptoms affects peripheral NT-3 concentration in patients with schizophrenia...
August 8, 2018: Neuroscience Letters
Merel Prikken, Mette J Konings, Wan U Lei, Marieke J H Begemann, Iris E C Sommer
BACKGROUND: Computerized methods for improving cognitive functioning in schizophrenia have gained popularity during the past decades. Therefore, this study evaluates the available evidence for the efficacy of computerized cognitive drill and practice training for patients with schizophrenia-spectrum disorders. METHODS: A systematic search was carried out using PubMed, Embase, Cochrane Database of Systematic Reviews, and PsycINFO. A meta-analysis was performed to compare cognitive drill and practice training in patients with a schizophrenia-spectrum disorder with non-cognitively oriented control conditions...
August 7, 2018: Schizophrenia Research
Lakshmi Rajagopal, Mei Huang, Eric Michael, Sunoh Kwon, Herbert Y Meltzer
GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABAA α2,3 subtype-selective GABAA partial agonist and α1/5 antagonist, and the neurosteroid, pregnenolone sulfate, a GABAA antagonist, may improve CIAS in pilot clinical trials...
July 23, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Connie Svob, Priya J Wickramaratne, Linda Reich, Ruixin Zhao, Ardesheer Talati, Marc J Gameroff, Rehan Saeed, Myrna M Weissman
Importance: Previous studies have shown an inverse association between offspring religiosity and suicidal ideation/attempts, but the association of parent religiosity on offspring suicidal ideation/attempts has not been examined. Objective: To examine associations of parent and offspring religiosity with suicide ideation and attempts in offspring. Design, Setting, and Participants: The study is based on offspring (generation 3) from a 3-generation family study at New York State Psychiatric Institute and Columbia University, in which generations 2 and 3 were defined as being at high risk or low risk for major depressive disorder because of the presence or absence of major depressive disorder in generation 1...
August 8, 2018: JAMA Psychiatry
Kärt Mätlik, Vootele Võikar, Carolina Vilenius, Natalia Kulesskaya, Jaan-Olle Andressoo
Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson's disease (PD). However, how endogenous GDNF influences dopamine system function and animal behavior is not fully understood. We recently generated GDNF hypermorphic mice that express increased levels of endogenous GDNF from the native locus, resulting in augmented function of the nigrostriatal dopamine system...
August 8, 2018: Scientific Reports
Hannah J Jones, Jon Heron, Gemma Hammerton, Jan Stochl, Peter B Jones, Mary Cannon, George Davey Smith, Peter Holmans, Glyn Lewis, David E J Linden, Michael C O'Donovan, Michael J Owen, James Walters, Stanley Zammit
Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modelling comorbidity across psychopathology. We examine how genetic risk for schizophrenia relates to adolescent psychosis-related and internalizing psychopathology using a latent modelling approach, and compare this to genetic risk for other psychiatric disorders, to gain a more comprehensive understanding of the developmental pathways at this age...
August 8, 2018: Translational Psychiatry
Ya-Ting Ke, I-Jung Feng, Chien-Chin Hsu, Jhi-Joung Wang, Shih-Bin Su, Chien-Cheng Huang, Hung-Jung Lin
Nurses have high work stress that may contribute to an increased overdose for sedatives, hypnotics, and antipsychotics (OSHA). We conducted this nationwide population-based cross-sectional study to clarify this still unclear issue. We used a nationwide database to identify 110,379 nurses, 22,032 other healthcare providers (HCPs), and an identical number of individuals from the general population matched by age and sex. We compared the period prevalence of OSHA between nurses and the general population, other HCPs and the general population, and nurses and other HCPs, among nurse subgroups from 2006 to 2012...
2018: PloS One
Karen E Swietek, Marisa Elena Domino, Christopher Beadles, Alan R Ellis, Joel F Farley, Lexie R Grove, Carlos Jackson, C Annette DuBard
OBJECTIVE: To examine the association between medical home enrollment and receipt of recommended care for Medicaid beneficiaries with multiple chronic conditions (MCC). DATA SOURCES/STUDY SETTING: Secondary claims data from fiscal years 2008-2010. The sample included nonelderly Medicaid beneficiaries with at least two of eight target conditions (asthma, chronic obstructive pulmonary disease, diabetes, hypertension, hyperlipidemia, seizure disorder, major depressive disorder, and schizophrenia)...
August 7, 2018: Health Services Research
Yongfeng Yang, Lu Wang, Lingyi Li, Wenqiang Li, Yan Zhang, Hong Chang, Xiao Xiao, Ming Li, Luxian Lv
Previous genome-wide association studies (GWAS) suggest that rs10489202 in the intron of MPC2 (mitochondrial pyruvate carrier 2) is a risk locus for schizophrenia in Han Chinese populations. To validate this discovery, we conducted a replication analysis in an independent case-control sample of Han Chinese ancestry (437 cases and 2031 controls), followed by a meta-analytic investigation in multiple East Asian samples. In the replication analysis, rs10489202 showed marginal association with schizophrenia (two-tailed P = 0...
August 7, 2018: Translational Psychiatry
A Schandrin, J Norton, S Raffard, B Aouizerate, F Berna, L Brunel, I Chereau-Boudet, T D'Amato, H Denizot, C Dubertret, J Dubreucq, C Faget, G Fond, F Gabayet, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, F Schurhoff, M Urbach, S Bonnet, D Capdevielle
BACKGROUND: Aggressiveness is a stigma frequently associated with schizophrenia. The role of insight as a risk factor of aggressiveness remains contradictory; mainly because single measures of these states mask their complexity and heterogeneity. METHODS: This study was conducted on 666 patients aged 15 and above with a DSM-IV-TR diagnosis of schizophrenia spectrum disorder, drawn from the French national network of schizophrenia expert center database. Collected data comprised socio-demographics and standardized psychiatric assessments...
August 3, 2018: Schizophrenia Research
Siv Hege Lyngstad, Erlend Strand Gardsjord, Carmen Simonsen, Magnus Johan Engen, Kristin Lie Romm, Ingrid Melle, Ann Færden
BACKGROUND: Apathy and depression are prevalent in first-episode psychosis (FEP), have overlapping clinical features and are linked to social dysfunction, with indications that persisting symptoms have an even more negative impact. Our objective was to investigate the prevalence of persisting depression (PD), persisting apathy (PA), to what extent they overlap and their relative associations to functioning during a one-year follow-up. METHODS: One hundred and twenty-five participants with a FEP were recruited, and 88 (70%) were reassessed at follow-up...
July 29, 2018: Comprehensive Psychiatry
Christine L McKibbin, Aaron Lee, Dale Glaser, Stephanie Kanuch, Kristin Cassidy, Charles Thomas, Douglas Gunzler, Richard McCormick, Neal V Dawson, Martha Sajatovic
Objective Adults with serious mental illness are at increased risk for diabetes mellitus and diabetes-related complications. This article classifies subgroups among people with serious mental illness and comorbid diabetes with respect to functional status and examines differences among those groups. Methods This analysis used a baseline sample of 157 adults with serious mental illness and diabetes mellitus enrolled in a National Institute of Health-funded research study. Latent profile analysis was used to distinguish health status profiles and investigate how these subgroups differed across assessment domains...
August 4, 2018: International Journal of Psychiatry in Medicine
R B Bassey, S N Chapman, M Pessu, A Jayam-Trouth, M C Gondré-Lewis
Background: Human immunodeficiency virus (HIV) infection remains a serious immunological disease with new infections in the U.S. disproportionately reported in minority populations. For many years, the District of Columbia (DC) has reported the highest HIV infection rate in the nation. Drug abuse and addiction is also prevalent in DC and has traditionally been linked to HIV/AIDS because of the likelihood for opportunistic infections. Despite this data, the relationship between HIV status, drugs of abuse, and the incidence of neurological disorders are scarcely reported for minority populations...
2018: Journal of Neurology and Neuroscience
Juan Fernández-Candil, Laura Castelltort Mascó, Neus Fàbregas Julià, Mikel Urretavizcaya Sarachaga, Miquel Bernardo Arroyo, Ricard Valero Castells
OBJECTIVES: Electroconvulsive therapy (ECT) is one of the main techniques available for the treatment of such serious mental illnesses as schizophrenia and drug-resistant depression. The pre-anaesthetic assessment appropriate for patients with various mental disorders or pathologies does not differ substantially from that of any patient prior to undergoing anaesthesia for a surgical procedure. The present review aims to propose guidelines to achieve a higher level of safety and effectiveness during ECT in the most frequent situations, in accordance with the current literature...
August 2, 2018: Revista de Psiquiatrí́a y Salud Mental
G Fond, M Faugere, C Faget-Agius, M Cermolacce, R Richieri, L Boyer, C Lançon
Hypovitaminosis D has been associated with, respectively, major depressive disorder, schizophrenia (SZ), and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objective was to determine the prevalence of hypovitaminosis D and associated factors in a non-selected multicentric sample of SZ subjects in day hospital. Hypovitaminosis D was defined by blood vitamin D level < 25 nM. Depressive symptoms were assessed by the Calgary Depression Rating Scale Score and Positive and Negative Syndrome Scale Score...
August 4, 2018: European Archives of Psychiatry and Clinical Neuroscience
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