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Induction labor

Yan-Ping Xing, Xin-Ying Qi, Xue-Zhen Wang, Feng-Zhen Yang
This study was designed to establish a modified prediction score system to improve the safety and success rate of vaginal birth after cesarean delivery (VBAC). We recruited 406 patients (between January 2012 and December 2016) and generated a modified score system in predicting the success rate of VBAC. All patients were required to sign informed consent forms. 87.2% of patients had successful VBAC and 12.8% patients had repeated cesarean section. We conducted multivariable logistic regression, and found seven variables that were associated with VBAC success, including previous primary indication of cesarean delivery [odds ratio (OR) 2...
December 10, 2018: Clinical and Translational Science
Ahmet Eser, Enis Ozkaya, Cigdem Yayla Abide, Tugba Eser, Gulcin Yildirim Eser, Faruk Abike, Ahter Tanay Tayyar, Mustafa Eroglu
PURPOSE: To analyze the effect of combined application of intravaginal PGE2 insert and intracervical Foley balloon catheter for induction of labor. METHODS: Patients with unfavorable cervices who required induction of labor from August 2017 to December 2017 were evaluated for the study. Three hundred and ten participants were randomly assigned to study (n:155) and control group (n:155). Nine patients in study group and seven patients in control group were excluded, because they declined to participate in the study...
December 7, 2018: Archives of Gynecology and Obstetrics
Liselotte E M van Kempen, Augustinus S van Teeffelen, Annemijn A de Ruigh, Dick Oepkes, Monique C Haak, Elisabeth van Leeuwen, Mallory Woiski, Martina M Porath, Caroline J Bax, Aleid G van Wassenaer-Leemhuis, Antonius L Mulder, David P van der Ham, Christine Willekes, Maureen T Franssen, Jan B Derks, Ewoud Schuit, Ben W Mol, Eva Pajkrt
OBJECTIVE: To assess the effectiveness of amnioinfusion in women with second-trimester preterm prelabor rupture of membranes. METHODS: We performed a nationwide, multicenter, open-label, randomized controlled trial, the PPROM: Expectant Management versus Induction of Labor-III (PPROMEXIL-III) trial, in women with singleton pregnancies and preterm prelabor rupture of membranes at 16 0/7 to 24 0/7 weeks of gestation with oligohydramnios (single deepest pocket less than 20 mm)...
December 4, 2018: Obstetrics and Gynecology
Frieda-Elsje Dreyer, Ganiy Opeyemi Abdulrahman, Gareth Waring, Kim Hinshaw
Placental steroid sulphatase deficiency (SSD) is an X-linked inborn error of metabolism. Congenital X-linked ichthyosis (XLI) is a genetic disorder of keratinisation caused by steroid sulphatase (STS) deficiency, which results in a scaling skin condition in male infants shortly after birth. It may be associated with failed induction of labor and prolonged labor leading to cesarean delivery due to 'cervical dystocia'. We present two cases of congenital ichthyosis. Thorough counselling of women with a previously affected pregnancy during the antenatal period should include discussion about mode of delivery and a critical review of the complexities of prenatal diagnosis in this condition...
November 2018: Annals of Saudi Medicine
Laura Seikku, Vedran Stefanovic, Petri Rahkonen, Kari Teramo, Jorma Paavonen, Minna Tikkanen, Leena Rahkonen
OBJECTIVE: Erythropoietin - a hormone regulating erythropoiesis - is a biomarker of chronic fetal hypoxia. High erythropoietin levels in fetal plasma and amniotic fluid are associated with increased risk of adverse neonatal outcome. Since the risk of perinatal morbidity and mortality is increased in pregnancies beyond 41 gestational weeks, we evaluated erythropoietin levels in amniotic fluid and umbilical cord serum in apparently low-risk term (≥ 37 gestational weeks) and prolonged pregnancies (≥ 41 gestational weeks) with labor induction...
December 3, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Apala Priyadarshini, Shyam P Jaiswar, Apoorva Singh, Swati Singh
AIM: To evaluate the comparative outcome of induced labor by intracervical Foley catheter with misoprostol versus misoprostol alone. MATERIALS & METHODS: A total of 1306 women were enrolled over 4 years, induced with either intracervical Foley with misoprostol or misoprostol alone and compared in terms of induction-delivery interval, mode of delivery, the presence of uterine tachysystole, postpartum hemorrhage and perinatal outcome. RESULTS: Induction to delivery interval, the duration between induction to active labor was significantly reduced, deliveries within 24 h were significantly higher and the number of misoprostol doses used was significantly less in Foley with misoprostol group...
December 10, 2018: Journal of Comparative Effectiveness Research
Jouni Havukainen, Jaana Hiltunen, Liisa Puro, Mika Horttanainen
Determining the chemical properties of waste is crucial to ensure the most effective utilization of waste. The standard laboratory measurements can produce accurate results, but analysis is labor- and time-consuming. The variety of elements that field portable X-ray fluorescence spectrometry (FPXRF) can detect from selected waste materials was studied, including how the results compared with those of inductively coupled plasma mass spectrometry (ICP-MS) measurements. The selected materials were fine fraction reject from solid recovered fuel production, fly ash, biowaste, and compost...
January 2019: Waste Management
Worku Taye Getahun, Abayneh Aklilu Solomon, Fisseha Yetewale Kassie, Habtamu Kebebe Kasaye, Habtamu Temesgen Denekew
BACKGROUND: Maternal morbidity and mortality have been one of the most challenging health problems that concern the globe over the years. Uterine rupture is one of the peripartum complications, which cause nearly about one out of thirteen maternal deaths. This study aimed to assess the prevalence and associated factors of uterine rupture among obstetric case in referral hospitals of Amhara Regional State, Northern Ethiopia. METHODS: Institution based cross sectional study was conducted from Dec 5-2017-Jan 5-2018 on uterine rupture...
2018: PloS One
Ibinabo Ibiebele, Jennifer R Bowen, Tanya A Nippita, Jonathan M Morris, Jane B Ford
INTRODUCTION: There is debate about optimal management of pregnancies with a large-for-gestational age baby. A recent randomized controlled trial reported that early term induction of labor reduced cesarean section rates and infant morbidity. However, long term childhood outcomes have not been assessed. The aim of this study was to assess maternal, neonatal and child health and education outcomes for large-for-gestational age babies induced at 37-38 weeks gestation. MATERIAL AND METHODS: Population-based record linkage study of term (37+ weeks), cephalic-presenting singleton pregnancies with a large-for-gestational age baby in New South Wales, Australia, 2002-2006...
December 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
Martin Audet, Kate L White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A Hanson, Raymond C Stevens
Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of administration and clinical efficacy. However, misoprostol lacks receptor and tissue selectivities, and thus its use is accompanied by a number of serious side effects. The development of pharmacological agents combining the advantages of misoprostol with improved selectivity is hindered by the absence of atomic details of misoprostol action in labor induction...
January 2019: Nature Chemical Biology
Lixia Zhu, Cong Zhang, Fang Cao, Qin Liu, Xing Gu, Jianhao Xu, Jianqing Li
BACKGROUND: Successful labor induction depends on the cervical status at the time of induction. Currently, both a Foley catheter and a dinoprostone insert are used for effective cervical ripening. This study compared the efficacy and safety of the intracervical Foley catheter and dinoprostone insert for cervical ripening to achieve successful labor induction. METHODS: PubMed, Embase, and the Cochrane Library were searched from January 2000 to February 2017 for relevant articles...
November 2018: Medicine (Baltimore)
Rebecca F Hamm, Katheryne L Downes, Sindhu K Srinivas, Lisa D Levine
OBJECTIVE:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix. STUDY DESIGN:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis)...
December 3, 2018: American Journal of Perinatology
Lu Chen, Gaia Pocobelli, Onchee Yu, Susan M Shortreed, Sarah S Osmundson, Sharon Fuller, Paige D Wartko, David Mcculloch, Susan Warwick, Katherine M Newton, Sascha Dublin
OBJECTIVES:  Women with prediabetes are identified from screening for overt diabetes in early pregnancy, but the clinical significance of prediabetes in pregnancy is unclear. We examined whether prediabetes in early pregnancy was associated with risks of adverse outcomes. STUDY DESIGN:  We conducted a retrospective cohort study of pregnant women enrolled in Kaiser Permanente Washington from 2011 to 2014. Early pregnancy hemoglobin A1C (A1C) values, covariates, and outcomes were ascertained from electronic medical records and state birth certificates...
November 30, 2018: American Journal of Perinatology
Malin Dögl, Pål Romundstad, Line Dahlgaard Berntzen, Oliv Camilla Fremgaarden, Katrine Kirial, Anne Molne Kjøllesdal, Benedicte S Nygaard, Line Robberstad, Thorbjørn Steen, Christian Tappert, Cecilie Fredvik Torkildsen, Magdalena R Vaernesbranden, Alexander Vietheer, Runa Heimstad
The aim of the present study was to assess indications for induction and describe the characteristics and delivery outcome in medical compared to non-medical/elective inductions. During a three-month period, 1663 term inductions were registered in 24 delivery units in Norway. Inclusion criteria were singleton pregnancies with cephalic presentation at gestational age 37+0 and beyond. Indications, pre-induction Bishop scores, mode of delivery and adverse maternal and fetal outcomes were registered, and compared between the medically indicated and elective induction groups...
2018: PloS One
Maja Dolanc Merc, Miha Lučovnik, Andreja Trojner Bregar, Ivan Verdenik, Nataša Tul, Isaac Blickstein
Objective To determine the association between pre-gravid obesity and stillbirth. Methods A retrospective study of a population-based dataset of births at ≥34 weeks' gestation. We excluded fetal deaths due to lethal anomalies and intrapartum fetal deaths. We calculated the incidence of stillbirths, neonatal respiratory distress syndrome (RDS) and neonatal intensive care unit (NICU) admissions per ongoing pregnancies for each gestational week in the two body mass index (BMI) categories (≥30 vs.<30). Results Pre-pregnancy obesity (BMI≥30), pre-pregnancy diabetes, oligo- and polyhydramnios, being small for gestational age (SGA) and preeclampsia were significantly associated with stillbirth...
November 29, 2018: Journal of Perinatal Medicine
Tamar Eshkoli, Tamar Wainstock, Eyal Sheiner, Ofer Beharier, Merav Fraenkel, Asnat Walfisch
OBJECTIVE:  Previous studies suggested maternal hypothyroidism during pregnancy to be associated with cognitive impairment of the offspring. Scarce data exist regarding long-term endocrine health of the offspring. This study was aimed to assess whether children born to mothers with hypothyroidism during pregnancy are at an increased risk for long-term endocrine morbidity. STUDY DESIGN:  A retrospective population-based cohort study compared long-term endocrine morbidity of children born between the years 1991 and 2014 to mothers with and without hypothyroidism...
November 26, 2018: American Journal of Perinatology
Mathilde Firmin, Gabriel Carles, Bénédicte Mence, Nikila Madhusudan, Emilie Faurous, Anne Jolivet
INTRODUCTION: Postpartum hemorrhage remains the leading cause of maternal death in France. Parturients in western French Guiana have specific sociodemographic features and a high rate of pathological pregnancies. The objective of this study was to determine the incidence of immediate postpartum hemorrhage (IPPH) in western French Guiana, and to describe the etiologies and risk factors. METHODS: A case control study with incident cases was conducted in the Maternity Department of the Western French Guiana Hospital over a period of one year...
November 23, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Lena Sagi-Dain, Moti Bardicef, Reuven Kedar, Ron Gonen, Ofer Lavie, Shlomi Sagi
No abstract text is available yet for this article.
November 2018: Harefuah
Sansan Rodrigue Sib, Issa Ouédraogo, Moussa Sanogo, Sibraogo Kiemtoré, Yobi Alexis Sawadogo, Hyacinthe Zamané, Blandine Bonané
BACKGROUND: Abdominal pregnancy is defined as the partial or total insertion of the embryo into the abdominal cavity. It is rare, and can evolve towards the full term if it is not recognized in the early pregnancy. It carries a high risk of maternal-fetal morbidity and mortality. CASE PRESENTATION: We report a case of a 22 year-old gravida IV, para II with an asymptomatic and undiagnosed abdominal pregnancy presumed full term, in a context of health centers under-equipment...
November 19, 2018: BMC Pregnancy and Childbirth
Nicole N Lønfeldt, Frank C Verhulst, Katrine Strandberg-Larsen, Kerstin J Plessen, Eli R Lebowitz
Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood...
November 16, 2018: Psychological Medicine
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