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https://www.readbyqxmd.com/read/30118761/accuracy-of-quick-sequential-organ-failure-assessment-score-to-predict-mortality-in-hospitalized-patients-with-suspected-infection-in-an-hiv-aids-reference-center-in-rio-de-janeiro-brazil
#1
José Moreira, Ariane Paixão, Juliana Oliveira, Waldir Jaló, Ofélio Manuel, Rafaela Rodrigues, Alexandra Oliveira, Leonardo Tinoco, João Lima, Beatriz Grinsztejn, Valdiléa G Veloso, André M Japiassú, Cristiane C Lamas
OBJECTIVES: To compare the discriminatory capacity of the quick Sequential Organ Failure Assessment (qSOFA) versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting 30-day mortality and intensive care unit (ICU) admission in patients with suspicion of infection at an HIV reference center. METHODS: Prospective cohort study including consecutive adult patients who had suspected infection and subsequently admitted to the medical ward. Variables related to qSOFA and SIRS were measured at admission...
August 14, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30112500/effects-of-ozone-and-prophylactic-antimicrobial-applications-on-shear-bond-strength-of-orthodontic-brackets
#2
Özer Alkan, Burcu Oktay Çöven, Betül Özçopur, Fatih Kazancı, Yeşim Kaya, Cihan Aydoğan, Gürcan Eskitaşçıoğlu
Objective: The present study aimed to evaluate the effects of ozone and prophylactic antimicrobial applications on the shear bond strengths and bond failure interfaces of orthodontic brackets. Methods: Sixty human canine teeth were randomly divided into three groups (n=20), receiving the following treatments: Group I-pumice prophylaxis (Isler Dental, Ankara, Turkey)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+Transbond XT primer and adhesive (3M Unitek, Monrovia, USA); Group II-prophylaxis paste (Topex, NJ, USA)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+ Transbond XT primer and adhesive paste (3M Unitek, Monrovia, USA); and Group III-ozone application (Biozonix GmbH, Munich, Germany)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+Transbond XT primer and adhesive (3M Unitek, Monrovia, USA)...
December 2017: Turkish journal of orthodontics
https://www.readbyqxmd.com/read/30105290/peroral-endoscopic-myotomy-is-effective-and-safe-in-non-achalasia-esophageal-motility-disorders-an-international-multicenter-study
#3
Mouen A Khashab, Pietro Familiari, Peter V Draganov, Hanaa Dakour Aridi, Joo Young Cho, Michael Ujiki, Ricardo Rio Tinto, Hubert Louis, Pankaj N Desai, Vic Velanovich, Eduardo Albéniz, Amyn Haji, Jeffrey Marks, Guido Costamagna, Jacques Devière, Yaseen Perbtani, Mason Hedberg, Fermin Estremera, Luis A Martin Del Campo, Dennis Yang, Majidah Bukhari, Olaya Brewer, Omid Sanaei, Lea Fayad, Amol Agarwal, Vivek Kumbhari, Yen-I Chen
Background and study aims : The efficacy of per oral endoscopic myotomy (POEM) in non-achalasia esophageal motility disorders such as esophagogastric junction outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and jackhammer esophagus (JE) has not been well demonstrated. The aim of this international multicenter study was to assess clinical outcomes of POEM in patients with non-achalasia disorders, namely DES, JE, and EGJOO, in a large cohort of patients. Patients and methods : This was a retrospective study at 11 centers...
August 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/30104921/bone-mineral-density-t-scores-derived-from-ct-attenuation-numbers-hounsfield-units-clinical-utility-and-correlation-with-dual-energy-x-ray-absorptiometry
#4
Nathan R Hendrickson, Perry J Pickhardt, Alejandro Munoz Del Rio, Humberto G Rosas, Paul A Anderson
Background: Clinical computed tomography (CT) studies performed for other indications can be used to opportunistically assess vertebral bone without additional radiation or cost. Reference values for young women are needed to evaluate diagnostic accuracy and track changes in CT bone mineral density values across the lifespan. The purpose of this study was to determine reference values for lumbar trabecular CT attenuation (Hounsfield units [HU]) and determine the diagnostic accuracy of HU T-scores (T-scoreHU ) for identifying individuals with osteoporosis...
2018: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/30104688/analysis-of-sequencing-strategies-and-tools-for-taxonomic-annotation-defining-standards-for-progressive-metagenomics
#5
Alejandra Escobar-Zepeda, Elizabeth Ernestina Godoy-Lozano, Luciana Raggi, Lorenzo Segovia, Enrique Merino, Rosa María Gutiérrez-Rios, Katy Juarez, Alexei F Licea-Navarro, Liliana Pardo-Lopez, Alejandro Sanchez-Flores
Metagenomics research has recently thrived due to DNA sequencing technologies improvement, driving the emergence of new analysis tools and the growth of taxonomic databases. However, there is no all-purpose strategy that can guarantee the best result for a given project and there are several combinations of software, parameters and databases that can be tested. Therefore, we performed an impartial comparison, using statistical measures of classification for eight bioinformatic tools and four taxonomic databases, defining a benchmark framework to evaluate each tool in a standardized context...
August 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30101996/nutritional-risk-screening-2002-cut-off-to-identify-high-risk-is-a-good-predictor-of-icu-mortality-in-critically-ill-patients
#6
Laura Rafaela Monteiro de Almeida Maciel, Oellen Stuani Franzosi, Diego Silva Leite Nunes, Sérgio Henrique Loss, Audrey Machado Dos Reis, Bibiana de Almeida Rubin, Silvia Regina Rios Vieira
BACKGROUND: The Nutritional Risk Screening 2002 (NRS-2002) is a widely recommended nutrition risk indicator. Two cut-offs have been proposed for intensive care unit (ICU) patients to classify nutrition risk: ≥3-<5, at risk and ≥5, high risk. To date, no study has directly compared these cut-offs. The aim of this study is to compare the NRS-2002 ICU nutrition risk cut-offs as predictors of clinical outcomes including infections, ICU and hospital mortality, length of stay (LOS), duration of mechanical ventilation (MVd), weaning failure, tracheotomy for prolonged MVd, and chronic critical illness (CCI)...
August 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30034104/contributions-to-the-team-score-by-male-wheelchair-basketball-players-with-different-physical-capacities-at-the-rio-2016-paralympics
#7
Takashi Doi, Hirotaka Mutsuzaki, Kaori Tachibana, Yasuyoshi Wadano, Koichi Iwai
[Purpose] The contributions of male wheelchair basketball players with different capability classifications to the team score at the Rio 2016 Paralympics were evaluated. The roles required for team members belonging to each such classification were determined. [Participants and Methods] Statistics obtained from the official box scores of all 42 games included at the Rio 2016 Paralympics were used in this study. Players who participated for >20 minutes in each game were included in the analysis. Players were divided into 3 groups (low, middle, and high) based on their capability classification...
July 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/30025999/claudin-4-expression-is-associated-with-disease-free-survival-in-breast-carcinoma-in-situ-mean-follow-up-of-8-2-years
#8
Giuliano M Duarte, Natalie Rios Almeida, Fernando Tocchet, Juliana Espinola, Carolina Teixeira de Resende Barreto, Glauce Aparecida Pinto, Fernando Augusto Soares, Priscila Marshall, Geisilene Russano de Paiva Silva
INTRODUCTION: Claudins are tight junctions associated with breast cancer prognosis. The claudin-low intrinsic subtype of invasive carcinoma is associated with high-grade carcinoma, low junction molecule expression, and worse response to chemotherapy. However, it is not known whether the expression of claudins may provide clues as to carcinoma-in-situ (CIS) prognosis. The aim of this study was evaluate claudin-4 expression in CIS and its association with disease-free survival and histologic type of local recurrence (in situ or invasive)...
June 18, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30020437/extracting-chemical-protein-relations-with-ensembles-of-svm-and-deep-learning-models
#9
Yifan Peng, Anthony Rios, Ramakanth Kavuluru, Zhiyong Lu
Mining relations between chemicals and proteins from the biomedical literature is an increasingly important task. The CHEMPROT track at BioCreative VI aims to promote the development and evaluation of systems that can automatically detect the chemical-protein relations in running text (PubMed abstracts). This work describes our CHEMPROT track entry, which is an ensemble of three systems, including a support vector machine, a convolutional neural network, and a recurrent neural network. Their output is combined using majority voting or stacking for final predictions...
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/30009967/validation-of-two-pain-assessment-tools-utilizing-a-standardized-nociceptive-stimulation-in-critically-ill-adults
#10
Cristini Klein, Wolnei Caumo, Céline Gélinas, Valéria Patines, Tatiana Pilger, Alexandra Lopes, Fabiane Neiva Backes, Débora Feijó Villas-Boas, Silvia Regina Rios Vieira
CONTEXT: The Behavioral Pain Scale (BPS) or the Critical-Care Pain Observation Tool (CPOT) are recommended in practice guidelines for pain assessment in critically ill adults unable to self-report. However, their use in another language requires cultural adaptation and validation testing. OBJECTIVES: Cross-cultural adaptation of the CPOT and the BPS English versions into Brazilian Portuguese, and their validation by comparing behavioral scores during rest, standardized nociceptive stimulation by pressure algometry (SNSPA) and turning were completed...
July 12, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30003535/egos-has-a-reduced-capacity-to-predicts-gbs-prognosis-in-northeast-brazil
#11
Mário E T Dourado Júnior, Ugor T Fernandes, Eugênio S Ramos, Ana L F Vital, João C C Urbano, José W Queiroz, Selma M B Jeronimo
OBJECTIVE: The Erasmus Guillain Barre Outcome Score (EGOS) is a prognostic model that predicts the chance of being able to walk independently at 6 months after Guillain Barré syndrome (GBS). This study was conducted aiming to determine the validity of EGOS in a Brazilian population. MATERIAL AND METHODS: Data collected from GBS patients in Rio Grande do Norte, Brazil, were used to determine the validity of EGOS. GBS disability score was assessed in the second week of disease and at 6 months...
July 12, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29980522/implementation-of-a-regional-network-for-st-segment-elevation-myocardial-infarction-stemi-care-and-30-day-mortality-in-a-low-to-middle-income-city-in-brazil-findings-from-salvador-s-stemi-registry-resisst
#12
Nivaldo Menezes Filgueiras Filho, Gilson Soares Feitosa Filho, Davi Jorge Fontoura Solla, Felipe Coelho Argôlo, Patrícia Oliveira Guimarães, Ivan de Mattos Paiva Filho, Larissa Gordilho Mutti Carvalho, Larissa Silva Teixeira, Marcos Nogueira de Oliveira Rios, Sergio Figueiredo Câmara, Victor Oliveira Novais, Leonardo de Souza Barbosa, Constance Silva Ballalai, Carolina Vitoria De Lúcia, Christopher B Granger, L Kristin Newby, Renato D Lopes
BACKGROUND: Few data exist on regional systems of care for the treatment of ST-segment-elevation myocardial infarction (STEMI) in developing countries. Our objective was to describe temporal trends in 30-day mortality and identify predictors of mortality among STEMI patients enrolled in a prospective registry in Brazil. METHODS AND RESULTS: From January 2011 to June 2013, 520 patients who received initial STEMI care at 23 nonspecialized public health units or hospitals, some of whom were transferred to a public cardiology referral center, were identified through a regional STEMI network supported by telemedicine and the local prehospital emergency medical service...
July 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29968546/the-matrix-metalloproteinases-panel-in-multiple-sclerosis-patients-treated-with-natalizumab-a-possible-answer-to-natalizumab-non-responders
#13
R Balasa, B Ciurba, S Voidezan, I Simu, A Hutanu, S Andone, A Romaniuc, A Motataianu, S Maier
BACKGROUND: In the lymphocyte migration across the blood-brain barrier (BBB) in multiple sclerosis (MS), matrix metalloproteinases (MMPs) play an important role in the degradation of the basal membrane. Natalizumab (NAT), a monoclonal antibody, binds to the alpha-4 (α4) integrin leading to BBB impermeability. Approximately 30% of NAT-treated patients show clinical or MRI signs of BBB disruption. OBJECTIVE: To determine whether NAT significantly influences the MMPs serum levels and to what extent these could be used as biomarkers in relapsing-remitting MS (RRMS) patients...
July 2, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29955659/the-alzheimer-s-prevention-initiative-autosomal-dominant-alzheimer-s-disease-trial-a-study-of-crenezumab-versus-placebo-in-preclinical-psen1-e280a-mutation-carriers-to-evaluate-efficacy-and-safety-in-the-treatment-of-autosomal-dominant-alzheimer-s-disease-including
#14
Pierre N Tariot, Francisco Lopera, Jessica B Langbaum, Ronald G Thomas, Suzanne Hendrix, Lon S Schneider, Silvia Rios-Romenets, Margarita Giraldo, Natalia Acosta, Carlos Tobon, Claudia Ramos, Alejandro Espinosa, William Cho, Michael Ward, David Clayton, Michael Friesenhahn, Howard Mackey, Lee Honigberg, Sandra Sanabria Bohorquez, Kewei Chen, Trisha Walsh, Carolyn Langlois, Eric M Reiman
Introduction: Autosomal-dominant Alzheimer's disease (ADAD) represents a crucial population for identifying prevention strategies that might modify disease course for cognitively unimpaired individuals at high imminent risk for developing symptoms due to Alzheimer's disease (AD), that is, who have "preclinical" AD. Crenezumab is an antiamyloid monoclonal antibody that binds monomeric and aggregated forms of amyloid β, with highest affinity for oligomers; it is in development for early stages of sporadic AD and for ADAD...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29950276/usefulness-of-the-vibration-perception-thresholds-measurement-as-a-diagnostic-method-for-diabetic-peripheral-neuropathy-results-from-the-rio-de-janeiro-type-2-diabetes-cohort-study
#15
Thainá Rodrigues Melo Santos, Juliana Valeria Melo, Nathalie Carvalho Leite, Gil Fernando Salles, Claudia Regina Lopes Cardoso
AIMS: To investigate the associated factors with the vibration threshold perception (VPT) in patients with type 2 diabetes and to assess whether it is useful for detection of diabetic peripheral neuropathy (DPN). METHODS: VPTs were measured with Vibration Sensory Analyzer (VSA-3000) in 426 diabetic patients. The diagnosis of DPN was based on Neuropathy Symptom Score and Neuropathy Disability Score (NDS). ROC curve analysis and multiple linear and logistic regressions were performed to investigate the associations between VPT and DPN...
August 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29928468/tolerability-and-safety-profile-of-a-new-brand-generic-product-of-glatiramer-acetate-in-iranian-patients-with-relapsing-remitting-multiple-sclerosis-an-observational-cohort-study
#16
Roya Abolfazli, Shirin Pournourmohammadi, Ahmadreza Shamshiri, Sara Samadzadeh
Background: The aim of this study was to evaluate the safety, tolerability, and efficacy of a brand-generic glatiramer acetate product in patients with relapsing-remitting multiple sclerosis over a 12-month period. A noninterventional cohort study was conducted on 185 patients. The patients had a confirmed and documented diagnosis of relapsing-remitting multiple sclerosis as defined by the Revised McDonald Criteria (2010), were ambulatory with a Kurtzke Expanded Disability Status Scale score of 0 to 5...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29924166/longitudinality-in-primary-health-care-a-comparison-between-care-models
#17
Marciane Kessler, Suzinara Beatriz Soares de Lima, Teresinha Heck Weiller, Luís Felipe Dias Lopes, Lucimare Ferraz, Elaine Thumé
OBJECTIVE: to evaluate the attribute longitudinality in different models of assistance in Primary Health Care and observe its association with demographic, socioeconomic and health care characteristics. METHOD: a cross-sectional study, carried out in 2015 with 1076 adult users of primary care services in the 32 cities of the 4th Regional Health Care Core of Rio Grande do Sul State. The Primary Care Assessment Tool was used with definition of low (<6.6) or high (≥6...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29912978/mediterranean-diet-and-quality-of-life-baseline-cross-sectional-analysis-of-the-predimed-plus-trial
#18
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
https://www.readbyqxmd.com/read/29906470/the-effect-of-intracerebroventricular-allopregnanolone-on-depressive-like-behaviors-of-rats-selectively-bred-for-high-and-low-immobility-in-the-forced-swim-test
#19
Felipe Borges Almeida, Alan Rios Fonseca, Núbia Heidrich, Maurício Schüler Nin, Helena Maria Tannhauser Barros
Depression is a highly incapacitating disorder known to have a multifactorial etiology, including a hereditary genetic background. The neurosteroid allopregnanolone (ALLO) is a positive allosteric modulator of the GABAA receptor and has been shown to have an antidepressant-like effect in animals. This study aimed to assess the behavioral effect of ALLO in animals with different backgrounds of depressive-like activity. An initial population (F0) of male and female Wistar rats was screened for immobility behavior utilizing the Forced Swim Test (FST)...
October 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29903598/trial-protocol-cognitive-functional-therapy-compared-with-combined-manual-therapy-and-motor-control-exercise-for-people-with-non-specific-chronic-low-back-pain-protocol-for-a-randomised-controlled-trial
#20
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
July 2018: Journal of Physiotherapy
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