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hemangioma infantil

Yuan Liang, Yun Liu Chen, Mu Tong Zhao, Zhao Yang Wang, Li Li, Bin Zhang, Chun Ping Shen, Shan Wang, Zi Gang Xu, Lin Ma
The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. The use of biologics and small molecules in children with atopic dermatitis and psoriasis, exciting advances in the use of propranolol and other beta-blockers for the treatment of infantile hemangiomas, the use of sirolimus for vascular anomalies will be discussed...
December 7, 2018: Dermatologic Therapy
Megan N Kelchen, Nicole K Brogden
Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths...
December 6, 2018: Biomedical Microdevices
Zeshan Shabbir, Ainy Javaid
Infantile hepatic hemangioma (IHH) historically called "hemangiomaendothelioma" refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Contrast enhanced CT demonstrated typical features of diffuse infantile hepatic hemangiomas.
December 2018: JPMA. the Journal of the Pakistan Medical Association
Cristina Padula, Sara Nicoli, Silvia Pescina, Patrizia Santi
BACKGROUND/AIMS: Infantile hemangioma (IH), the most common benign tumor of childhood, is currently treated with propranolol. The aim of this work was to study in vitro propranolol permeation and skin retention from an original polymeric film, composed of polyvinyl alcohol and an acrylic polymer. METHODS: Propranolol polymeric films were applied in occlusive and non-occlusive conditions, on either full thickness skin or isolated epidermis. Experiments were performed also on stripped skin, to simulate the skin permeability of damaged skin...
November 12, 2018: Colloids and Surfaces. B, Biointerfaces
Mohammad Idris, Mahfooz Hussain, Junaid Sethi, Zubairullah Khan, Muhammad Zubair Umer
A five-day baby girl presented with a large mass involving the right upper and lower eyelid obstructing the visual axis completely. She was treated with intralesional triamcinolone acetonide injection under general anesthesia but no change in size of the tumor was observed. Oral beta blocker, propranolol, 1 mg/kg body weight, was given at three months. After two months, no significant change in tumor size was seen. The tumor was managed by surgical excision. There was no effect of intralesional triamcinolone acetonide and oral beta blockers...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
(no author information available yet)
OBJECTIVEVon Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs account for significant morbidity and mortality, ultimately necessitating numerous neurological and renal surgeries. Propranolol is an FDA-approved pan-beta adrenergic antagonist with antitumor effects against infantile hemangiomas (IHs) and possibly VHL HBs...
October 1, 2018: Journal of Neurosurgery
Lidia Sacchelli, Colombina Vincenzi, Michelangelo La Placa, Bianca M Piraccini, Iria Neri
Allergic contact dermatitis (ACD) caused by timolol eyedrops is well-known (1, 2) while ACD following its use for infantile hemangiomas has hitherto not been reported.
November 28, 2018: Contact Dermatitis
Massimo Dal Monte, Maura Calvani, Maurizio Cammalleri, Claudio Favre, Luca Filippi, Paola Bagnoli
Stress plays a role in tumorigenesis through catecholamines acting at β-adrenoceptors including β1-, β2- and β3-adrenoceptors and the use of β-adrenoceptor antagonists seems to counteract tumor growth and progression. Preclinical evidence and meta-analysis data demonstrate that melanoma shows a positive response to β-adrenoceptor blockers and in particular to propranolol acting mainly at β1- and β2-adrenoceptors. Although evidence suggesting that β3-adrenoceptors may play a role as a therapeutic target in infantile hemangiomas has been recently reviewed, a comprehensive analysis of the available data from preclinical studies supporting a possible role of β3-adrenoceptors in melanoma was not available...
November 24, 2018: British Journal of Pharmacology
Jaeyoon Kim, Jong Won Hong, Tai Suk Roh, Won Jai Lee
BACKGROUND: Infantile hemangioma (IH) is a common vascular tumor in pediatric patients, and is commonly treated with propranolol. We describe our experiences with dosage, response to treatment, and side effects in 23 IH patients treated with propranolol. METHODS: For this nonrandomized comparative cohort study, the authors enrolled 23 patients treated with propranolol. Photographs were taken before propranolol administration and at 3, 6, 9, and 12 months after treatment...
November 2018: Archives of Plastic Surgery
Li Wei, Li Li, Bin Zhang, Lin Ma
BACKGROUND/AIMS: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs). METHODS: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Effects of propranolol on apoptosis and expressions of cell cycle-related genes, CDK4 and cyclin D1, were detected by flow cytometry and RT-PCR respectively...
November 16, 2018: Pharmacology
V Babic, A Schoeffler, S Moawad, L Mainard, J-L Schmutz, A-C Bursztejn
BACKGROUND: Infantile hemangioma (IH) is a common benign vascular tumor in children. In most cases, diagnosis is based entirely on clinical examination. When the diagnosis is uncertain, the first-line complementary examination is Doppler ultrasound. We report 4 cases of atypical infantile hemangiomas with delayed diagnosis and non-contributory imaging. PATIENTS AND METHODS: One child had congenital purple papules and nodules on the back of the foot, the second had inaugural ulceration of the buttocks, and the last two presented telangiectasia, either isolated or on an erythematous macula...
November 8, 2018: Annales de Dermatologie et de Vénéréologie
Hiram Álvarez-Neri, Jaime Penchyna-Grub, Gustavo Teyssier-Morales, Eduardo Morera-Serna, Carlos De La Torre, Perla Villamor
Background: Airway hemangiomas are congenital neoplasms of low incidence. Its clinical presentation consists of obstruction of the upper airway with progressive dyspnea and stridor and the life of the patient at risk. Infantile hemangiomas have an incidence at birth of 2%, increasing to 9% at 12 months of life. Almost 60% of childhood hemangiomas affect the head and neck region. However, localization in the upper airway is not as frequent and it is only reported in 1.8% of patients with cutaneous hemangiomas...
2018: Boletín Médico del Hospital Infantil de México
Xinjun Sun, Xiang Liu, Nan Lu, Shulan Yao, Xiguang Xu, Lili Niu
Short-term curative effect and safety of propranolol combined with laser in the treatment of infantile hemangiomas was studied, so as to provide reference for clinical treatment. A total of 100 cases of infantile hemangiomas admitted to the Affiliated Hospital of Jining Medical University from October 2014 to June 2016 were selected into this study. According to the random number table method, they were divided into the control group and the observation group, with 50 cases in each group. The infant patients in the control group were treated with laser alone, and the infant patients in the observation group were treated with propranolol combined with laser...
November 2018: Oncology Letters
Feng Zhao, Xiaoliang Yang, Guangqi Xu, Jianhai Bi, Renrong Lv, Ran Huo
Infantile hemangioma (IH) is a common benign tumor. Human umbilical vein endothelial cells (HUVECs) have the potential of stem cells, which has been widely used in vascular endothelial cell experiments. Oral propranolol was first reported to treat hemangioma in 2008. However, the role of propranolol in IH remains unclear. Therefore, in this study, we investigated the effects of propranolol on HUVECs in vitro, to explore the underlying mechanism of propranolol in IH. HUVECs were treated with 0.15, 1.5, and 15 μM of propranolol, and transfected with microRNA-4295 (miR-4295) mimic...
October 28, 2018: Journal of Cellular Biochemistry
Aiko Igarashi, Ikue Hata, Miori Yuasa, Takashi Okuno, Yusei Ohshima
Background Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormone inactivating enzyme by hemangioma cells, hypothyroidism has been rarely recognized in infants with cutaneous hemangioma. Case presentation A male infant born at 28 weeks of gestational age with an extremely low birth weight (775 g) developed a massive cutaneous hemangioma on his neck and severe abdominal distension. Imaging examinations detected a small mass lesion in the brain but no hepatic hemangioma...
October 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Li Xiao, Dakan Liu, Song Zuo, Xiaoshuang Zhu, Yanlin Wang, Changxian Dong
The aim of this study was to investigate the manner of urea-modulated UT-B urea transporter (UT) internalization in infantile hemangioma-derived vascular endothelial cells (HemECs). The immunohistochemistry assay was performed to identify infancy hemangioma-derived endothelial cell line (XPTS-1) cells. Cell toxicity was detected with the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. Quantitative real-time polymerase chain reaction and Western blot analysis were measured to analyze the expression of UT-B...
October 26, 2018: Journal of Cellular Biochemistry
A Lahrichi, F Hali, K Baline, F Z El Fatoiki, S Chiheb, K Khadir
Infantile hemangiomas are the most common childhood vascular tumors. Propranolol is a β-adrenergic blocker that has proven effective in the treatment of this tumor. Numerous studies around the world have been published, describing satisfactory responses in pediatric populations with a higher cure rate and fewer adverse effects than when using corticosteroids. The aim of this study was to evaluate the efficacy and adverse effects of propranolol in Moroccan pediatric patients diagnosed with infantile hemangioma who were treated with oral propranolol...
October 22, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Fang Hou, Yuemeng Dai, Chun-Yang Fan, James Y Suen, Gresham T Richter
BACKGROUND: Estrogen plays a role in infantile hemangioma (IH) development, but the underlying mechanism remains unclear. This study aimed to assess estrogen and estrogen receptor (ER) localization and expression levels in IH. In addition, the unexpected relationship between mast cells (MCs) and estrogen in human IH was discussed. METHODS: IH (n = 29), vascular malformation (VMs, n = 33) and normal skin (n = 15) specimens were assessed. IH was classified into proliferative (n = 9; age, 3...
October 19, 2018: Orphanet Journal of Rare Diseases
Zeferino Demartini, Luana A M Gatto, Roberto Oliver Lages, Alexandre Novicki Francisco, Adriano Keijiro Maeda, Gelson Luis Koppe
PHACE(S) syndrome is a neurocutaneous syndrome with a wide array of presentations. The most known and present trait is facial hemangioma > 5 cm. The name is an acronym for Posterior fossa malformations, infantile Hemangiomas, Arterial anomalies, aortic Coarctation, Eye abnormalities, and middle-line malformations of the Sternum. The exact etiopathogenic mechanism of this syndrome is not fully understood, and its treatment depends on detailed and individualized assessment. The aim of this paper is to describe a child with a throat hemangioma, vascular malformations, cognitive delay, and other anomalies to illustrate the neuroimaging found in this syndrome...
October 18, 2018: Pediatric Neurosurgery
Zhenwei Zhu, Peng Cai, Jie Zhu, Jianlei Chen, Bin Wu, Zhicheng Gu, Shungen Huang, Jian Wang
RATIONALE: Hepatic hemangioma is the third most common pediatric tumor, and it is rare in the neonatal period. This case study presents a rare case of hepatic hemangioma found in a neonate. PATIENT CONCERNS: A girl who was 18 days of age with the emergence of jaundice and an abdominal mass was admitted for physical examination in the local department. DIAGNOSES: An ultrasound showed that the hepatic left lobe was about 9 cm × 7 cm × 7 cm in size...
October 2018: Medicine (Baltimore)
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