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hemangioma infantil

Chongqing Huang, Jingyong Huang, Guanfeng Yu
Vascular endothelial growth factor A (VEGF-A) plays a critical role in the development and progression of Infantile hemangioma (IH), the most common vascular tumor occurring during infancy. However, a role of VEGF-C in IH remains unclear. Here, we addressed this question. The expression of VEGF family members in hemangiomas at involuting-phase and at proliferating-phase was compared, by RT-qPCR and by ELISA. VEGF-A and VEGF-C were suppressed by specific short-hairpin interfering RNA (shRNA), respectively. Cell growth was determined in an MTT assay...
2018: American Journal of Translational Research
Zuzana Sipkova, Kanmin Xue, Hardeep S Mudhar, Bart Wagner, Göran Darius Hildebrand
Background: Infantile capillary hemangiomas (IHs) affect approximately 4-5% of infants. The systemic nonselective β-adrenergic antagonist, propranolol, has become the standard first-line treatment for severe IHs. The topical β-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. Despite their therapeutic success and prevalent use, the mechanism of action of β-adrenergic antagonists in the treatment of IHs is not well understood...
September 2018: Ocular Oncology and Pathology
Jose M Martin, Sara Sanchez, Víctor González, Pilar Cordero, Dolores Ramon
BACKGROUND/OBJECTIVES: Infantile hemangiomas (IH) with minimal or arrested growth (MAG) constitute a distinctive subset of IH based on their clinical characteristics and natural history. They are often confused with capillary malformations. METHODS: A retrospective observational study has been carried out in which clinical and perinatal characteristics have been evaluated in all IH-MAG evaluated in our Dermatology Department in a 5-year period (January 2013-December 2017)...
October 15, 2018: Pediatric Dermatology
Mana Alharbi, Ariel E Eber, Marina Perper, Maisa ALFalah, Sultan Al-Khenaizan, Ibrahim A Alomair, Abdulkareem Alfuraih, Keyvan Nouri, Jeong Hee Cho-Vega
Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. We describe a case of DCPG effectively treated with propranolol.
October 15, 2018: Pediatric Dermatology
Yuki Naruke, Hiroshi Horie, Yuichiro Nagai, Ryo Ando
Filar lipomas are a subtype of spinal lipomas wherein adipose tissue accumulation is restricted to the filum terminale. Embryologically, filar lipomas are considered to occur because of the failure of secondary neurulation, although the precise mechanism is not yet completely understood. Involvement of ectopic mesodermal, ectodermal, and endodermal tissues in spinal lipomas has been occasionally reported, and the origin of these ectopic tissues has been supposed to be migration of pluripotent tissues, which exist during secondary neurulation...
October 12, 2018: Clinical Neuropathology
Megan N Kelchen, Nicole K Brogden
PURPOSE: Topical beta-blockers are efficacious for treating infantile hemangiomas, but no formulations have been specifically optimized for skin delivery. Our objective was to quantify skin concentrations and drug permeation of propranolol (a nonselective beta-blocker) after application of microemulsions to intact and microneedle pretreated skin. METHODS: Four propranolol-loaded microemulsions were characterized for droplet size, surface charge, conductivity, pH, drug solubility, and drug release...
October 9, 2018: Pharmaceutical Research
Brooke Hanson, Logan G Spector, Christina Boull, Ingrid Polcari, Kristen Hook, Sheilagh Maguiness
No abstract text is available yet for this article.
October 5, 2018: Journal of the American Academy of Dermatology
Kathleen F O'Brien, Sonal D Shah, Elena Pope, Roderic J Phillips, Francine Blei, Eulalia Baselga, Maria C Garzon, Catherine McCuaig, Anita N Haggstrom, Peter H Hoeger, James R Treat, Marissa J Perman, Jane S Bellet, Xavier Cubiró, Jeffrey Poole, Ilona J Frieden
BACKGROUND: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. OBJECTIVE: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. METHODS: A multicenter, retrospective cohort study. RESULTS: In total, 59 patients, 85% of which were female, met the inclusion criteria...
October 4, 2018: Journal of the American Academy of Dermatology
Myo-Sabai Aye, Maheshwar Mahaseth, Arlene Rozzelle, Indira Bhagat, Prashant Agarwal
Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back.
2018: Global Pediatric Health
Erina Lie, Kevin J Psoter, Katherine B Püttgen
BACKGROUND: Early specialist evaluation during rapid proliferative growth of complicated infantile hemangiomas (IH) is crucial. Health disparities and barriers of access-to-care for children with IH have not been examined. OBJECTIVE: Investigate whether socioeconomic status (SES) is associated with age at subspecialist presentation for IH evaluation. METHOD: Retrospective cohort study of 804 children presenting to a large academic hospital...
October 1, 2018: Journal of the American Academy of Dermatology
Liat Samuelov, Michael Kinori, Anthony J Mancini, Lacey L Kruse, Annette Wagner, Hawke Yoon, Sarah L Chamlin
OBJECTIVE: To characterize the risk for ocular complications in patients with PHACE syndrome. STUDY DESIGN: This study included consecutive patients with PHACE syndrome who were seen at Lurie Children's Hospital of Chicago from January 2000 through May 2017. A complete ophthalmic examination was performed in all patients, with extra attention for findings typically associated with PHACE syndrome. RESULTS: Thirty patients (67% female, median age of onset 0...
September 27, 2018: Journal of Pediatrics
Stephanie F Polites, Miho Watanabe, Thomas Crafton, Todd M Jenkins, Carlos R Alvarez-Allende, Adrienne M Hammill, Roshni Dasgupta
PURPOSE: There has been a paradigm shift from corticosteroid to propranolol treatment for infantile hemangiomas (IHs), with surgical resection reserved for complicated or persistent IHs. The purpose of this study was to determine if propranolol treatment was associated with decreased utilization of surgical resection compared to corticosteroids. METHODS: A single center retrospective chart review of all corticosteroid or propranolol treated IHs between 2005 and 2014 was performed...
September 5, 2018: Journal of Pediatric Surgery
Ionela Iacobas, Thuy L Phung, Denise M Adams, Cameron C Trenor, Francine Blei, Douglas S Fishman, Adrienne Hammill, Prakash M Masand, Steven J Fishman
OBJECTIVE: To define the types of hepatic hemangiomas using the updated International Society for the Study of Vascular Anomalies classification and to create a set of guidelines for their diagnostic evaluation and monitoring. STUDY DESIGN: We used a rigorous, transparent consensus protocol defined by an approved methodology, with input from multiple pediatric experts in vascular anomalies from hematology-oncology, surgery, pathology, radiology, and gastroenterology...
September 21, 2018: Journal of Pediatrics
Michael J Wagner, Lee D Cranmer, Elizabeth T Loggers, Seth M Pollack
Vascular sarcomas are abnormal proliferations of endothelial cells. They range from benign hemangioma to aggressive angiosarcoma, and are characterized by dysregulated angiogenic signaling. Propranolol is a β-adrenergic receptor inhibitor that has demonstrated clinical efficacy in benign infantile hemangioma, and is now being used experimentally for more aggressive vascular sarcomas and other cancers. In this review, we discuss the use of propranolol in targeting these receptors in vascular tumors and other cancers...
2018: Journal of Experimental Pharmacology
Zhenying Lin, Luanhong Wang, Guang Huang, Wenyan Wang, Han Lin
PURPOSE: We sought to evaluate effect of propranolol in the treatment of infantile hemangiomas by quantifying the amount of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and hypoxia-inducible factor-1α (HIF-1α). METHODS: Hemangioma tissue was isolated from an infant patient and implanted into nude mice to establish a hemangioma model. Twenty-four hemangioma-model nude mice were divided into two groups including a control group (saline, by gastrogavage) and an experimental group (propranolol, by gastrogavage)...
November 2018: Pediatric Surgery International
Shangbin Li, Guangqi Xu, Feng Gao, Jianhai Bi, Ran Huo
[This corrects the article DOI: 10.3892/etm.2017.4943.].
October 2018: Experimental and Therapeutic Medicine
Jennifer J Schoch, Manrup K Hunjan, Katelyn R Anderson, Christine M Lohse, Jennifer L Hand, Dawn M R Davis, Megha M Tollefson
BACKGROUND/OBJECTIVES: Specific maternal risk factors have recently been identified in the development of infantile hemangiomas (IH), including gestational diabetes (GDM), maternal antihypertensive medication use or gestational hypertension (GHTN), maternal progesterone use, and artificial reproductive technologies (ART). We sought to explore the change in incidence of these risk factors over time and determine their association with the increased incidence of hemangiomas over 35 years, as previously reported...
September 6, 2018: Pediatric Dermatology
Jennifer Aileen Tangtatco, Carolyn Freedman, John Phillips, Elena Pope
First-line treatment for problematic infantile hemangiomas (IH) consists of systemic corticosteroids or, more recently, beta-blockers, while treatment failures or residual lesions may require surgical intervention. There is limited knowledge if prior medical intervention is associated with a better surgical outcome. This retrospective cohort study revealed that medical intervention, whether systemic steroids or beta-blockers, did not influence ultimate surgical outcomes when compared with patients who were not medically treated...
September 6, 2018: Pediatric Dermatology
Cristina Padula, Sara Nicoli, Silvia Pescina, Patrizia Santi
The objective of this work was to study in vitro propranolol permeation and skin retention after topical application of different semisolid vehicles, with the final aim of developing new topical formulations intended for the treatment of infantile hemangioma, able to produce therapeutic drug levels in the skin, avoiding systemic absorption. Propranolol ointments, creams, and gels were prepared and tested on pig skin, an accepted model of human skin. From the results obtained in the present work it is clear that the permeation of propranolol across the skin is a poor predictor of its skin retention, at least in the time-frame considered...
2018: BioMed Research International
Andrew A McCormick, Tony Tarchichi, Christopher Azbell, Lorelei Grunwaldt, Noel Jabbour
OBJECTIVE: A subglottic hemangioma (SGH) is a benign tumor of infancy that can cause severe obstruction of the airway. Infantile hemangiomas, in general, are the most common head and neck tumor in children, affecting 4-5% of the pediatric population. This retrospective cohort study characterizes subglottic infantile hemangiomas at a single vascular anomaly center over a 5-year period (2013-2017) during the era of propranolol treatment. METHODS: Queried the Vascular Anomaly Database at Children's Hospital of Pittsburgh for all infantile hemangioma(s) and then identified case of subglottic hemangiomas...
October 2018: International Journal of Pediatric Otorhinolaryngology
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