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hemangioma infantil

Lauren Brin Hermans, Bridget E Shields, Catharine B Garland, Beverly Aagaard-Kienitz, David Wargowski, Carrie Kovarik, Lisa M Arkin
Most infantile hemangiomas (IHs), the most common vascular tumors of childhood, evolve without complications; however 10% to 12% require specialty referral for treatment. To emphasize the complications of late referral, we present a case of necrotizing infection within a segmental IH leading to sepsis. Early evaluation by a pediatric dermatologist could have prevented this life-threatening and disfiguring complication. We discuss how teledermatology would enable rapid triage of such critical cases in underserved areas, increasing access to high-value care and optimizing outcomes for our most vulnerable patients...
August 10, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Eulalia Baselga, Bozenna Dembowska-Baginska, Przemysław Przewratil, María Antonia González-Enseñat, Dariusz Wyrzykowski, Antonio Torrelo, Juan-Carlos López Gutiérrez, Magdalena Rychłowska-Pruszyńska, Raúl de Lucas-Laguna, Altea Esteve-Martinez, Esther Roé, Mohammed Zaim, Yoann Menon, Stéphanie Gautier, Geneviève Lebbé, Athmane Bouroubi, Alain Delarue, Jean-Jacques Voisard
BACKGROUND AND OBJECTIVES: There is no consensus on optimal treatment duration for propranolol in infantile hemangioma (IH). We evaluated the efficacy and safety of oral propranolol solution administered for a minimum of 6 months up to a maximum of 12 months of age in high-risk IH. METHODS: This single-arm, open-label, phase 3 study was conducted in patients aged 35 to 150 days with high-risk IH in 10 hospitals between 2015 and 2017. The study comprised a 6-month initial treatment period (ITP) plus continuation up to 12 months of age if complete success was not achieved, a follow-up, and a retreatment period...
August 6, 2018: Pediatrics
Meng-Nan Xu, Min Zhang, Yuan Xu, Min Wang, Si-Ming Yuan
Infantile hemangioma can grow dramatically or typically locate on the face, which may lead to functional impairment, cosmetically disfiguring and exhibiting complications such as ulceration, bleeding, or infection. Early intervention is necessary. In this study, the authors chose individual treatment for different patients. From January 2012 to December 2016, 185 patients with hemangioma were enrolled into this study. Lesion area ranged from 0.5 cm × 0.5 cm to 9 cm × 12 cm. The initial treatment age ranged from 1 to 7 months with an average age of 3...
July 26, 2018: Journal of Craniofacial Surgery
Carlos Giugliano, Francisca Reculé, Kenneth Guler, José Tomás Gantz, Trinidad Hasbún
Treatment of infantile hemangioma is usually medical. The nose is one of the most important aesthetic and functional units of the face; therefore, surgical management is preferred in persistent lesions (fibro-fatty tissue component) that do not respond to medical treatment. Herein, the authors analyze the results of surgical nasal hemangioma treatment in their center, a literature review and propose an algorithm for surgical management. A retrospective analysis of 23 persistent nasal hemangioma operated between 1996 and 2014 at our institution was made...
July 26, 2018: Journal of Craniofacial Surgery
Shinji Kagami, Tatsuo Katori
Infantile hemangiomas grow rapidly during infancy followed by gradual involution. After involution, residual lesions sometimes remain. Despite the prognosis for eventual involution, infantile hemangiomas often cause great psychosocial morbidity that affects patients and their parents. Oral propranolol usually induces earlier involution and redness reduction in infantile hemangiomas in the proliferative phase. However, to evaluate the effectiveness of oral propranolol for infantile hemangiomas beyond the proliferative phase is difficult because of spontaneous regression...
July 27, 2018: Journal of Dermatology
Rehan Rais, Iván González, Jacqueline M Saito, Louis P Dehner
Infantile hemangioma (IH) is one of the most common vascular anomalies of early childhood and is usually recognized in the first few weeks to months of life as a solitary cutaneous lesion. This report documents our experience with a GLUT-1 positive IH presenting as the pathologic lead point in a colocolic intussusception in a 10-week-old infant who had no skin lesions. Literature suggests approximately 2% of all children presenting with an intussusception require surgical intervention; however, an IH as the pathologic lead point is unique...
2018: Case Reports in Pediatrics
Moumita Biswas, Malay Kumar Sinha, Mrinal Kanti Das, Sumantra Sarkar
Background Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile primary hypothyroidism, delayed bone age and isosexual incomplete precocious puberty with reversal to the prepubertal state following thyroid hormone replacement. Case presentation In this case, an 18-month-old girl presented with premature menarche since 9 months of age, delayed bone age and enlarged bilateral multicystic ovaries along with a superficial infantile hemangioma over the upper anterior chest. VWGS was diagnosed based on the clinical features...
July 20, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Andre V Moyakine, Saskia Spillekom-van Koulil, Elselien M Küpers, Catharina J M van der Vleuten
BACKGROUND: Quality of life (QoL) data are lacking in children with infantile hemangioma (IH) and their parents/caregivers. Available data are conflicting. OBJECTIVES: To determine QoL of (parents of) patients with IH in the proliferative phase related to IH-severity and activity. METHODS: Parents of 59 IH-patients (≤ 6 months) were asked to fill in the Dutch IH-specific QoL-questionnaire (D-IH-QoL) within 1 month after their first visit to our tertiary referral center...
July 17, 2018: Pediatric Dermatology
Marta Valdivielso-Ramos, Antonio Torrelo, Ana Martin-Santiago, Minia Campos, Elena Conde, Pablo de la Cueva, Juan Carlos Lopez-Gutierrez
BACKGROUND: Infantile hemangiomas with minimal or arrested growth are vascular tumors with a proliferative component involving < 25% of their total surface area. They are commonly described as localized lesions and are mainly located on the lower body. Little has been described about segmental forms on the face and their associations with PHACE syndrome. METHODS: We carried out a multicenter, retrospective, case-series study involving 5 hospitals in Spain. Information was collected on cases of PHACE syndrome featuring infantile hemangiomas with minimal or arrested growth...
July 9, 2018: Pediatric Dermatology
Katarzyna Oszajca, Janusz Szemraj, Dariusz Wyrzykowski, Barbara Chrzanowska, Aneta Salamon, Przemyslaw Przewratil
BACKGROUND: Infantile hemangioma (IH) is the most common vascular tumor of childhood and infancy. It is distinguished by rapid proliferation of endothelial cells during the first year of life followed by spontaneous regression thereafter. One of the possible factors responsible for the IH development is vascular endothelial grow factor (VEGF). The purpose of this study was to evaluate the influence of selected polymorphisms in the genes coding for VEGF-A (+405 G/C, rs2010963; +936 C/T, rs3025039) and its receptor VEGFR-2 (+1416 T/A, rs1870377; -271 G/A, rs7667298) on the susceptibility to infantile hemangioma...
July 9, 2018: International Journal of Dermatology
Y Tian, X S Guo, J Nan, X L Wang, G Shen
Hemangioma is the most common vascular tumor in infantile period, and propranolol is the first choice, but there are still a few patients with poor curative effect. Seven cases of infant parotid hemangioma with no response to oral propranolol were treated with transcatheter arterial sclerosing embolization combined with cortisol and satisfactory results achievod. The treatment and efficacy are disccused in this paper.
January 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
L L Sun, B Sun, Y C Ma, H Z Lei, C X Dong
PHACE syndrome is a syndrome of multiple organ and multisystem abnormalities associated with infantile segmental hemangioma, characterized by abnormal posterior fossa development, infant hemangioma, aortic abnormalities, aortic coarctation and heart defects, eye anomalies and other symptoms. The incidence of the disease is low, but there exist life-threatening factors. Once clinically diagnosed, it should be highly valued and multidisciplinary consultation must be conducted. This article reviews the diagnostic criteria of PHACE syndrome and its associated facial segmental hemangioma, as well as the treatment and prognosis of brain abnormalities...
November 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Ming Xu, Fu-Shun Pan, Wei Wang, Xiao-Er Zhang, Xiao-Ju Li, Yu Hong, Lu-Yao Zhou, Xiao-Yan Xie, Ming-de Lyu
OBJECTIVES: To investigate the combined use of ultrasound together with clinical features to differentiate infantile hepatic hemangioma (IHH) from other focal liver lesions (FLLs) in children and to compare the efficacy of the combined method to that of CECT/MRI. METHODS: The location, number, size and appearance of the tumors were evaluated in 45 children with IHH. Another 45 children with FLL were randomly selected as a control group. Independent factors for predicting IHH versus FLLs were evaluated...
June 21, 2018: Clinical Imaging
Shinji Kagami, Masahide Kaneko, Akiko Kishi, Tatsuo Katori
Infantile hemangiomas are the most common tumor of childhood and undergo rapid growth during early infancy followed by gradual involution. After involution, residual lesions sometimes remain. Oral propranolol usually induces earlier involution and redness reduction of infantile hemangiomas. However, the optimal treatment duration is unknown and infantile hemangiomas sometimes recur after cessation of treatment. We report three Japanese patients with recurrent infantile hemangiomas on their cheek. These patients were a 1-month-old female baby with a superficial infantile hemangioma, a 3-month-old female baby with a mixed infantile hemangioma and a 4-month-old male baby with a mixed infantile hemangioma...
June 28, 2018: Journal of Dermatology
Hannes Hudalla, Christian Karmen, Thomas Bruckner, Stephanie Wallwiener, Herbert Fluhr, Zoe Michael, Alexander Freis, Holger Maul, Thomas Strowitzki, Johannes Pöschl, Ruben-J Kuon
PURPOSE: β2 -sympathomimetics are used in obstetrics as tocolytic agents, despite a remarkable profile of side effects. Recently, the β2 -sympathomimetic tocolytic drug hexoprenaline was identified as an independent risk factor for the development of infantile hemangioma (IH) in preterm infants. The aim of this study was to evaluate whether this observed effect was applicable to other β2 -mimetic tocolytic agents like fenoterol. METHODS: Clinical prospectively collected data of all infants born between 2001 and 2012 and admitted to the neonatal intensive care unit (NICU) at Heidelberg University Hospital and respective maternal data were merged...
June 25, 2018: Archives of Gynecology and Obstetrics
Carlos E Escarcega González, Abimael González Hernández, Carlos M Villalón, Martin G Rodríguez, Bruno A Marichal Cancino
Infantile hemangiomas (IH) are frequent (4-5% of the childhood population) benign vascular tumors that involve accumulation, proliferation, and differentiation of aberrant vascular cells. Typically, IH are innocuous and spontaneously disappear, but they represent a potential risk for harmful effects in the body (e.g., permanent disfigurement) and health (e.g., ulcerations) in some patients. From a serendipitous discovery, the nonselective β-adrenoceptor blocker propranolol (which blocks β1-adrenoceptors, β2-adrenoceptors, and β3-adrenoceptors) emerged as an alternative therapy to treat this pathology and it quickly became a first-line treatment for IH...
2018: Journal of Vascular Research
Stephanie F Polites, Bentley B Rodrigue, Carol Chute, Adrienne Hammill, Roshni Dasgupta
BACKGROUND: There has been a paradigm shift from steroids to propranolol for the pharmacologic treatment of infantile hemangiomas (IH); however, the outcomes for ulcerated IH are not well studied. The purpose of this study was to compare the efficacy of steroids and propranolol specifically for ulcerated IH. METHODS: A retrospective review was conducted on patients with ulcerated IH treated with propranolol or steroids at a single tertiary care institution between 2007 and 2014...
June 22, 2018: Pediatric Blood & Cancer
Weili Xu, Suolin Li, Fengxue Yu, Yongting Zhang, Xiaofeng Yang, Wenting An, Wenbo Wang, Chi Sun
BACKGROUND: Propranolol (PRO) is the first-line drug for infantile hemangioma treatment. However, its mechanism of action remains unclear. Nuclear factor-kappa B (NF-κB) is highly expressed in tumors, directly or indirectly promoting angiogenesis. Thrombospondin-1 (TSP-1) is the most important anti-angiogenesis protein in vivo. These proteins mediate signaling pathways, probably playing an important role in hemangioma treatment. This study explored the synergistic regulation of TSP-1 and NF-κB signaling pathways in the treatment of hemangioma with PRO...
June 12, 2018: Plastic and Reconstructive Surgery
Anita Rotter, Luciana Paula Samorano, Maria Cecília Rivitti-Machado, Zilda Najjar Prado Oliveira, Bernardo Gontijo
Infantile hemangioma can be linked to other organ malformations. In 1996, PHACE syndrome was first defined as the association of large and segmental infantile hemangioma, usually on the face, head, or cervical region, with malformations of the posterior fossa of the brain, arterial anomalies of the central nervous system, coarctation of the aorta, cardiac defects, and ocular abnormalities. Over 300 cases of PHACE syndrome have been reported, and it is cconsidered one of the most common neurocutaneous vascular disorders in childhood...
June 2018: Anais Brasileiros de Dermatologia
Toshihiko Itesako, Rumiko Eura, Yasuhiro Okamoto, Shuichi Tatarano, Hirofumi Yoshino, Hiroaki Nishimura, Yasutoshi Yamada, Hideki Enokida, Masayuki Nakagawa
Infantile hemangiomas (IH) are the most common in the head and neck region.1 They can occur anywhere in the skin, however, urethral hemangiomas are very rare. We describe a case report of a three years old boy with extensive lesions of IH in the anterior urethra. Urethral IH were disappeared during one year of oral administration of propranolol though it brought on urinary retention. This is the first report about oral propranolol treatment in a child with urethral IH. Oral administration of propranolol may be effective for urethral IH and beneficial especially for lesions requiring extensive surgical resection and reconstruction...
June 14, 2018: Urology
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