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Kshiti Singh, Nimisha Jadon, Rajeev Jain
Titanium oxide nanoparticles and 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide modified glassy carbon electrode (TiO2 /IL/GCE) has been fabricated for electrochemical sensing of flunarizine (FRH). The electrochemical properties and morphology of the prepared nanocomposite were studied by electrochemical impedance spectroscopy (EIS) and transmission electron microscopy (TEM). The response of the electrochemical sensor was found to be proportional to the concentrations of FRH in the range from 0...
March 2, 2018: Colloids and Surfaces. B, Biointerfaces
Barry M Trost, Chris Kalnmals
Herein, we report a valuable umpolung strategy that highlights the ambiphilic nature of the bis(phenylsulfonyl)methyl synthon and demonstrates its utility as a synthetic linchpin. While the bis(phenylsulfonyl)methyl group is typically introduced as an sp3 carbon nucleophile, we demonstrate that it can also function as an effective sp2 carbon electrophile in the presence of organolithium nucleophiles. Akyl- and aryllithiums couple with the central carbon of the bis(phenylsulfonyl)methyl unit to ultimately generate trisubstituted alkenes, comprising a formal sp3-sp2 and sp2-sp2 cross-coupling between organolithiums and bis(sulfones)...
March 15, 2018: Chemistry: a European Journal
Anna Koziróg, Bogumił Brycki, Katarzyna Pielech-Przybylska
This study investigates the biological activity of two cationic gemini surfactants, hexamethylene-1,6-bis-( N , N -dimethyl- N -dodecylammonium bromide) C6 and pentamethylene-1,5-bis-( N , N -dimethyl- N -dodecyla,.mmonium bromide) C5, and their two neutral analogs, hexamethylene-1,6-bis-( N -methyl- N -dodecylamine) (A6) and pentamethylene-1,5-bis-( N -methyl- N -dodecylamine) (A5). Experiments were performed with Aspergillus brasiliensis , which is used in the standard tests for biocides. The minimal inhibitory concentration (MIC) values for conidia and mycelium were determined using the dilution method...
March 15, 2018: International Journal of Molecular Sciences
Daniel C Crowley, Denis Lynch, Anita R Maguire
Enantioselective intramolecular Buchner reactions of α-diazoketones can be effected using heterogeneous copper-bis(oxazoline) catalysts in batch or using continuous flow processing in up to 83% ee. The catalyst can be reused up to 7 times without loss of activity. For α-diazoketones 3 and 4, the enantioselection achieved in flow with the immobilized catalyst was comparable with the standard homogeneous catalyzed process.
March 15, 2018: Journal of Organic Chemistry
Somali Mukherjee, Sumi Ganguly, Krishnendu Manna, Sanchaita Mondal, Supratim Mahapatra, Debasis Das
Five new coordination polymers (CPs) namely, [{Zn(μ2 -H2 O)0.5 (5N3 -IPA)(2,2'-bpe)}]∞ (1), [{Zn(μ2 -H2 O)0.5 (5N3 -IPA)(1,10-phen)}]∞ (2), [{Zn(5N3 -IPA)(1,2-bpe)}]∞ (3), [{Zn(5N3 -IPA)(1,2-bpey)}]∞ (4), and [{Zn(H2 O)(5N3 -IPA)(4,4'-tme)}(H2 O)0.5 ]∞ (5) (5N3 -H2 IPA = 5-azidoisophthalic acid, 2,2'-bpe= 2,2'-bipyridine, 1,10-phen = 1,10-phenanthroline, 1,2-bpe = 1,2-bis(4-pyridyl)ethane, 1,2-bpey = 1,2-bis(4-pyridyl)ethylene, 4,4'-tme = 4,4'-trimethylenedipyridine), have been synthesized based on a mixed ligand approach adopting a solvothermal technique...
March 15, 2018: Inorganic Chemistry
Xiaoqiang Huang, Jiahui Lin, Tianqi Shen, Klaus Harms, Marianna Marchini, Paola Ceroni, Eric Meggers
Here reported visible-light-activated catalytic asymmetric [3+2] photocycloadditions between cyclopropanes and alkenes or alkynes provide access to chiral cyclopentanes and cyclopentenes, respectively, in 63-99% yields and with excellent enantioselectivities of up to >99% ee. The reactions are catalyzed by a single bis-cyclometalated chiral-at-rhodium complex (2-8 mol%) which after coordination to the cyclopropane generates the visible-light-absorbing complex, lowers the reduction potential of the cyclopropane, and provides the asymmetric induction and overall stereocontrol...
March 15, 2018: Angewandte Chemie
Jun Zhang, Alexander Sandberg, Audun Konsmo, Xiongyu Wu, Sofie Nyström, K Peter Nilsson, Peter Konradsson, Harry LeVine, Mikael Lindgren, Per Hammarström
We revisited the Congo red analogue 2,5-bis(4'-hydroxy-3'-carboxy-styryl)benzene (X-34) to develop this highly fluorescent amyloid dye for imaging Alzheimer's disease (AD) pathology comprising Aβ and Tau fibrils. A selection of ligands with distinct optical properties were synthesized by replacing the central benzene unit of X-34, with other heterocyclic moieties. Full photophysical characterization was performed determining absorbance and fluorescence spectra, Stokes shift, quantum yield and fluorescence lifetimes...
March 15, 2018: Chemistry: a European Journal
Guisheng Li, Olga V Zatolochnaya, Xiao-Jun Wang, Sonia Rodríguez, Bo Qu, Jean-Nicolas Desrosiers, Hari P R Mangunuru, Soumik Biswas, Daniel Rivalti, Shuklendu D Karyakarte, Joshua D Sieber, Nelu Grinberg, Ling Wu, Heewon Lee, Nizar Haddad, Daniel R Fandrick, Nathan K Yee, Jinhua J Song, Chris H Senanayake
Novel bidentate phosphine ligands BABIPhos featuring a biaryl bis-dihydrobenzooxaphosphole core are presented. Their synthesis was achieved via Pd-catalyzed reductive homocoupling of dihydrobenzooxaphosphole aryl triflates. An efficient route toward various analogues was also established, giving access to phosphines with different electronic and steric properties. The newly obtained ligands demonstrated high efficiency and selectivity in Rh-catalyzed asymmetric hydrogenation of di- and trisubstituted enamides...
March 15, 2018: Organic Letters
Duong Tung Pham, Joseph Paul Baboo, Jinju Song, Sungjin Kim, Jeonggeun Jo, Vinod Mathew, Muhammad Hilmy Alfaruqi, Balaji Sambandam, Jaekook Kim
Pyrite (FeS2 ) is a promising electrode material for lithium ion batteries (LIBs) because of its high natural availability, low toxicity, cost-effectiveness, high theoretical capacity (894 mA h g-1 ) and high theoretical specific energy density (1270 W h kg-1 , 4e- /FeS2 ). Nevertheless, the use of FeS2 in electrochemical capacitors was restricted due to fast capacity fading as a result of polysulfide (S/Sn 2- ) formation during the initial electrochemical cycling. In order to avoid the formation of polysulfides, we employed the strategy of utilizing an ether based electrolyte (1...
March 15, 2018: Nanoscale
Nicholas R Andreychuk, Tara Dickie, David J H Emslie, Hilary A Jenkins
Palladium-catalyzed coupling of 1-adamantylamine (2 equiv.) with 4,5-dibromo-2,7-di-tert-butyl-9,9-dimethylxanthene afforded the proligand 4,5-bis(1-adamantylamino)-2,7-di-tert-butyl-9,9-dimethylxanthene, H2 [XAd] (1), which upon deprotonation with excess KH or KCH2 Ph in THF or dme generated [{K(THF)3 }2 (XAd)] (2a) and [K2 (XAd)(dme)] (2b). Subsequent reaction of in situ generated 2a or 2b with [ThCl4 (dme)2 ] yielded [(XAd)ThCl4 K2 ]·x(dme) (3; x = 0.5-2), which reacted with 2 equiv. of LiCH2 SiMe3 or K[allylTMS ] to afford the bis(hydrocarbyl) complexes [(XAd)Th(CH2 SiMe3 )2 (THF)] (4) and [(XAd)Th(η3 -allylTMS )2 ] {5; allylTMS = 1-(SiMe3 )C3 H4 }...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sheun Oshinbolu, Rachana Shah, Gary Finka, Mike Molloy, Mark Uden, Daniel G Bracewell
BACKGROUND: A current challenge in bioprocessing is the ability to analyse critical quality attributes such as aggregation without prior purification. This study evaluated the use of fluorescent dyes (Bis-ANS, SYPRO Orange, Thioflavin T and ProteoStat) to characterise mAb aggregates in Chinese hamster ovary clarified cultures. RESULTS: The null and mAb culture supernatants showed an increase in fluorescence intensity over the duration of the culture. The null cultures on day 14 saw a rapid increase in fluorescence intensity; day 10 to day 14, Bis-ANS and Thioflavin T had average increases of 21% and 48%, respectively, whereas ProteoStat and SYPRO Orange showed an average increase of 60%...
March 2018: Journal of Chemical Technology and Biotechnology
Surendra Kumar Mattoo, Sambhu Prasad, Abhishek Ghosh
Unhealthy substance use lies on a wide range that extends from occasional mild risky/harmful/hazardous use to severe substance use disorder. Brief intervention (BI) is a technique, used to initiate change for an unhealthy or risky substance use. It can be delivered by a vast array of trained professionals, in opportunistic settings (i.e. in people seeking help not for their substance use, but either its consequences or for completely unrelated physical or psychiatric disorders), and across substances, age and ethno-cultural groups...
February 2018: Indian Journal of Psychiatry
Beiqing Wu, Jianhui Liu, Runze Zhao, Yuju Li, Justin Peer, Alexander L Braun, Lixia Zhao, Yi Wang, Zenghan Tong, Yunlong Huang, Jialin C Zheng
BACKGROUND: Extracellular vesicles (EVs) are important in the intercellular communication of the central nervous system, and their release is increased during neuroinflammation. Our previous data demonstrated an increased release of EVs during HIV-1 infection and immune activation in glial cells. However, the molecular mechanism by which infection and inflammation increase EV release remains unknown. In the current study, we investigated the role of glutaminase 1 (GLS1)-mediated glutaminolysis and the production of a key metabolic intermediate α-ketoglutarate on EV release...
March 14, 2018: Journal of Neuroinflammation
J David Guerrero-Apolo, J Blas Navarro-Pastor, Antonio Bulbena-Vilarrasa, Julián Gabarre-Mir
OBJECTIVE: Impulsiveness has been the subject of much research, but little is known about the possible relationship between craniofacial anatomy and impulsiveness. The present study was designed to investigate the relationship between one aspect of craniofacial structure (the angle of inclination of the forehead) and impulsiveness. METHOD: Photographs in profile were obtained from 131 volunteers who had been fined for driving at high speed and were undergoing a court-mandated driving license point-recovery course...
March 12, 2018: Revista Brasileira de Psiquiatria
Xia Jin, Hua Xu, Michael S McGrath
Monocyte activation and polarization play essential roles in many chronic inflammatory diseases. An imbalance of M1 and M2 macrophage activation (pro-inflammatory and alternatively activated, respectively) is believed to be a key aspect in the etiology of these diseases, thus a therapeutic approach that regulates macrophage activation could be of broad clinical relevance. Methylglyoxal-bis-guanylhydrazone (MGBG), a regulator of polyamine metabolism, has recently been shown to be concentrated in monocytes and macrophages, and interfere with HIV integration into the DNA of these cells in vitro...
2018: PloS One
Miguel A Esteruelas, Ana M López, Enrique Oñate, Ainhoa San-Torcuato, Jui-Yi Tsai, Chuanjun Xia
The preparation and photophysical properties of heteroleptic iridium(III) complexes containing a dianionic C,C,C,C-tetradentate ligand and a cyclometalated phenylpyridine group are described. Complex [Ir(μ-OMe)(COD)]2 (1, COD = 1,5-cyclooctadiene) reacts with 1,1-diphenyl-3,3-butylenediimidazolium iodide ([PhIm(CH2 )4 ImPh]I2 ), in the presence NaOt Bu, to give [Ir(μ-I){κ4 - C, C, C, C-[C6 H4 Im(CH2 )4 ImC6 H4 ]}]2 (2), which leads to {[Ir{κ4 - C, C, C, C-[C6 H4 Im(CH2 )4 ImC6 H4 ]}]2 (μ-OH)(μ-OMe)} (3) by treatment first with silver trifluoromethanesulfonate (AgOTf) in acetone-dichloromethane and subsequently with KOH in methanol...
March 14, 2018: Inorganic Chemistry
Hirofumi Maekawa, Katsuaki Noda, Keisuke Kuramochi, Tianyuan Zhang
Vinylsilanes were directly prepared from the corresponding vinyl triflates under magnesium-promoted reductive conditions in THF with no transition metal catalyst, and gem-bis-silylated compounds were obtained in NMP. Investigation of the redox potential of starting materials and products suggested that reductive coupling reactions of vinyl triflates might be controlled by the reduction potential. A variety of gem-bis-silylated compounds and 3-silyladipic acid esters were easily synthesized in only two steps from vinyl triflates in high yields...
March 14, 2018: Organic Letters
Piotr Pander, Rachel Bulmer, Ross Martinscroft, Stuart Thompson, Frank W Lewis, Thomas J Penfold, Fernando B Dias, Valery N Kozhevnikov
This article describes a convenient method for the synthesis of ONNO-type tetradentate 6,6'-bis(2-phenoxy)-2,2'-bipyridine (bipyridine bisphenolate, BpyBph) ligands and their platinum(II) complexes. The methodology includes the synthesis of 1,2,4-triazine precursors followed by their transformation to functionalized pyridines by the Boger reaction. Two complementary routes employing 3,3'- and 5,5'-bis-triazines allow a modification of the central pyridine rings in different positions, which was exemplified by the introduction of cyclopentene rings...
March 14, 2018: Inorganic Chemistry
Chin-Yu Lee, Tao-Hsin Tung, Chia-Yu Liu, Shu-Hui Wang, Ching-Chi Chi
HINTERGRUND UND ZIEL: Lokalanästhetische Creme (LAC) wird zur Analgesie bei verschiedenen Verfahren angewendet. Ihre analgetische Wirkung bei der Kryotherapie von Warzen ist jedoch unklar. Wir untersuchten die Wirkung von LAC bei der Kryotherapie von Warzen. MATERIAL UND METHODEN: Wir erstellten eine systematische Übersicht und Meta-analyse randomisierter kontrollierter Studien (RCTs) zu Wirkungen von LAC bei der Kryotherapie von Warzen. Dazu haben wir MEDLINE, CENTRAL und EMBASE am 31...
March 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Michael Senske, Yao Xu, Alexander Bäumer, Sarah Schäfer, Hanna Wirtz, Janne Savolainen, Hermann Weingärtner, Martina Havenith
When comparing protein folding in vitro and in vivo significant differences have been found. This has been attributed to crowding and confinement effects. Using a combination of GHz- and THz-dielectric relaxation spectroscopy and MD simulations, we studied hydration dynamics and reviewed protein stability data inside sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and cetyltrimethylammonium bromide (CTAB) reverse micelles which are model systems for confinement. We find that water inside anionic AOT and cationic CTAB reverse micelles is characterized by a strong dielectric depolarization giving rise to a very low relative permittivity compared to an unconfined solution...
March 14, 2018: Physical Chemistry Chemical Physics: PCCP
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