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https://www.readbyqxmd.com/read/28109948/design-and-synthesis-of-novel-tetrandrine-derivatives-as-potential-anti-tumor-agents-against-human-hepatocellular-carcinoma
#1
Junjie Lan, Ning Wang, Lan Huang, Yazhou Liu, Xiaopan Ma, Huayong Lou, Chao Chen, Yibin Feng, Weidong Pan
Tetrandrine, a lead anti-tumor compound with a bis-benzyltetrahydroisoquinoline skeleton isolated from medicinal plant Stephania tetrandra. In order to obtain active anti-tumor agents and evaluate their structure-activity relationships, a series of novel tetrandrine derivatives were designed and synthesized in this study. Their anti-tumor activities against human hepatocellular carcinoma cell lines (HMCC97L and PLC/PRF/5) were also evaluated. The bioassay results showed that the derivatives exhibited moderate to strong inhibition against the two cell lines...
January 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28109787/synthesis-and-in-vitro-activity-of-dicationic-indolyl-diphenyl-ethers-as-novel-potent-antibiotic-agents-against-drug-resistant-bacteria
#2
Xiaofang Chen, Xinxin Hu, Yanbin Wu, Yonghua Liu, Cong Bian, Tongying Nie, Xuefu You, Laixing Hu
A series of 4,4'-bis-[2-(6-N-substituted-amidino)indolyl] diphenyl ether have been synthesized and tested for their in vitro antibacterial activity including a range of Gram-positive and Gram-negative pathogens and cytotoxicity. Most of these compounds have mainly shown anti-Gram positive bacteria activities especially against drug resistant bacterial strains MRSA, MRSE and VRE. The anti-MRSA and anti-MRSE activities of compound 7a and 7j were more potent than that of the lead compound 2, levofloxacin and vancomycin...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28107988/quantitative-assay-for-the-detection-screening-and-reactivity-evaluation-of-nanoceria-particles
#3
Ali Othman, Kristen Bear, Silvana Andreescu
Increasing use of engineered nanoparticles (NPs) in many industrial processes and consumer products requires rapid analytical methodologies to reliably detect and screen samples for the presence of NPs. Here, we report the development, analytical characterization and performance evaluation of a colorimetric assay as a comprehensive test for quantitative detection, screening and reactivity evaluation of nanoceria (cerium oxide, CeO2) particles in aqueous environments. We provide a critical discussion of the role of environmental conditions including pH, ionic composition, and presence of humic acid and particle type on the overall performance and sensitivity of this assay...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107273/influence-of-depth-of-hypnosis-on-pupillary-reactivity-to-a-standardized-tetanic-stimulus-in-patients-under-propofol-remifentanil-target-controlled-infusion-a-crossover-randomized-pilot-study
#4
Nada Sabourdin, Jean-Baptiste Peretout, Eliane Khalil, Marie-Laurence Guye, Nicolas Louvet, Isabelle Constant
BACKGROUND: Pupillometry allows the measurement of pupillary diameter variations in response to nociceptive stimuli. This technique has been used to monitor the balance between analgesia and nociception. Under general anesthesia, the amplitude of pupillary dilation is related to the amount of administered opioids. The objective of this study was to determine whether at a constant infusion rate of opioids, the pupillary response was influenced by depth of hypnosis assessed by the bispectral index (BIS)...
January 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28106793/hybrid-intelligent-system-to-perform-fault-detection-on-bis-sensor-during-surgeries
#5
José-Luis Casteleiro-Roca, José Luis Calvo-Rolle, Juan Albino Méndez Pérez, Nieves Roqueñí Gutiérrez, Francisco Javier de Cos Juez
This paper presents a new fault detection system in hypnotic sensors used for general anesthesia during surgery. Drug infusion during surgery is based on information received from patient monitoring devices; accordingly, faults in sensor devices can put patient safety at risk. Our research offers a solution to cope with these undesirable scenarios. We focus on the anesthesia process using intravenous propofol as the hypnotic drug and employing a Bispectral Index (BIS(TM)) monitor to estimate the patient's unconsciousness level...
January 18, 2017: Sensors
https://www.readbyqxmd.com/read/28106394/green-to-red-electrochromic-fe-ii-metallo-supramolecular-polyelectrolytes-self-assembled-from-fluorescent-2-6-bis-2-pyridyl-pyrimidine-bithiophene
#6
Sandesh Pai, Michael Moos, Maximilian H Schreck, Christoph Lambert, Dirk G Kurth
The structure and properties of metallo-supramolecular polyelectrolytes (MEPEs) self-assembled from rigid 2,6-bis(2-pyridyl)pyrimidine and the metal ions Fe(II) and Co(II) are presented. While FeL1-MEPE (L1 = 1,4-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]benzene) is deep blue, FeL2- and CoL2-MEPE (L2 = 5,5'-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]-2,2'-bithiophene) are intense green and red in color, respectively. These novel MEPEs display a high extinction coefficient and solvatochromism. Ligand L2 shows a high absolute fluorescence quantum yield (Φf = 82%)...
January 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28106388/mechanistic-studies-of-single-step-styrene-production-using-a-rhodium-i-catalyst
#7
Benjamin A Vaughan, Sarah K Khani, J Brannon Gary, James D Kammert, Michael S Webster-Gardiner, Bradley A McKeown, Robert J Davis, Thomas R Cundari, T Brent Gunnoe
The direct and single-step conversion of benzene, ethylene, and a Cu(II) oxidant to styrene using the Rh(I) catalyst ((Fl)DAB)Rh(TFA)(η(2)-C2H4) [(Fl)DAB = N,N'-bis(pentafluorophenyl)-2,3-dimethyl-1,4-diaza-1,3-butadiene; TFA = trifluoroacetate] has been reported to give quantitative yields (with Cu(II) as the limiting reagent) and selectivity combined with turnover numbers >800. This report details mechanistic studies of this catalytic process using a combined experimental and computational approach. Examining catalysis with the complex ((Fl)DAB)Rh(OAc)(η(2)-C2H4) shows that the reaction rate has a dependence on catalyst concentration between first- and half-order that varies with both temperature and ethylene concentration, a first-order dependence on ethylene concentration with saturation at higher concentrations of ethylene, and a zero-order dependence on the concentration of Cu(II) oxidant...
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28106382/lactide-as-the-playmaker-of-the-rop-game-theoretical-and-experimental-investigation-of-ring-opening-polymerization-of-lactide-initiated-by-aminonaphtholate-zinc-complexes
#8
Dawid Jędrzkiewicz, Grażyna Adamus, Michał Kwiecień, Łukasz John, Jolanta Ejfler
A family of homo- and heteroleptic zinc complexes bearing aminonaphtholate ligands was synthesized and fully characterized. Using NMR spectroscopy and DFT calculation, bis-alkoxy-bridged complexes [LZn(μ-OR)]2 were confirmed to have dimeric structures in solution, analogous to those obtained via X-ray crystallography. Surprisingly, a detailed experimental and theoretical study of the catalytic activity of [LZn(μ-OR)]2 in the ring-opening polymerization (ROP) of lactides showed that although well-defined alkoxy dimers possess a single-site structural motif, the most active initiator is obtained during in situ alcoholysis of the alkylzinc precursor...
January 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28106381/synthesis-of-boriranes-by-double-hydroboration-reactions-of-n-heterocyclic-carbene-boranes-and-dimethyl-acetylenedicarboxylate
#9
Timothy R McFadden, Cheng Fang, Steven J Geib, Everett Merling, Peng Liu, Dennis P Curran
Reaction of bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene borane with dimethyl acetylenedicarboxylate gives 80% yield of a stable borirane (boracyclopropane) formed by formal double hydroboration along with 5% of the (E)-alkenylborane. DFT calculations suggest a mechanism where divergence to the two products occurs after a common initial stage of hydride transfer from the NHC-borane to the acetylenedicarboxylate.
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28106362/dibenzothiophene-s-s-dioxide-and-bispyridinium-based-cationic-polyfluorene-derivative-as-an-efficient-cathode-modifier-for-polymer-solar-cells
#10
Guiting Chen, Sha Liu, Jin Xu, Ruifeng He, Zhicai He, Hongbin Wu, Wei Yang, Bin Zhang, Yong Cao
A novel n-type conjugated polymer containing dibenzothiophene-S,S-dioxide (FSO), bispyridinium, and fluorene scaffolds in the backbone (PFSOPyCl) was synthesized and used in the cathode interfacial layers (CILs) of conventional polymer solar cells (PSCs). The high electron affinities and large planar structures of the FSO and bispyridinium units endowed this polymer with good energy level alignments with [6,6]-phenyl-C71 butyric acid methyl ester (PC71BM) and metal cathode, and excellent electron transport and extraction properties...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106342/electrochemical-reduction-of-oxygen-in-aprotic-ionic-liquids-containing-metal-cations-na-o2-system-case-study
#11
Eneko Azaceta, Lukas Lutz, Alexis Grimaud, Jose Manuel Vicent-Luna, Said Hamad, Luis Yate, Geman Cabañero, Hans-Jurgen Grande, Juan Antonio Anta, Jean-Marie Tarascon, Ramon Tena-Zaera
Metal-air batteries are intensively studied because of their high theoretical energy storage capability. However, the fundamental science at work dealing with electrodes, electrolytes and reaction products still need to be better understood. In this report, the ionic liquid N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl) imide (PYR14TFSI) is chosen to study the influence of a wide range of metal cations (Mn+) on the electrochemical behavior of oxygen.. We demonstrate the relevance of the Lewis hard-soft acid-base (HSAB) theory to predict satisfactorily the reduction potential of the oxygen reduction in electrolytes containing metal cations...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28106335/competition-between-cation-solvent-and-cation-anion-interactions-in-imidazolium-ionic-liquids-with-polar-aprotic-solvents
#12
Bogdan A Marekha, Oleg N Kalugin, Marc Bria, Toshiyuki Takamuku, Slobodan Gadžurić, Abdenacer Idrissi
Subtle interplay between ion solvation and association was analyzed in mixtures of imidazolium-based ionic liquids (ILs) with polar aprotic solvents. Site-specific pattern of cation-solvent and cation-anion interactions was disclosed by means of a careful analysis of the 1H and 13C NMR chemical shift mixture composition dependence. It was established that less polar but more donating γ-butyrolactone is more prone to establish H-bonds with the imidazolium ring hydrogen atoms of IL cations than propylene carbonate, particularly at the H2 site and at high dilutions xIL < 0...
January 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28106332/copper-ii-controlled-molecular-glue-for-mismatched-dna
#13
Naoko Kotera, Régis Guillot, Marie-Paule Teulade-Fichou, Anton Granzhan
Isothermal hybridization of two DNA strands bearing three thymine-thymine (T-T) mismatches can be brought about in the presence of a stoichiometric amount of a bis-naphthalene macrocycle, 2,7-BisNP-NH. This process can be reverted by addition of a Cu(II) salt due to formation of a dinuclear metal complex which does not bind to DNA. Subsequent sequestration of Cu(II) releases the macrocycle and restores the hybridization state of DNA strands, thus allowing implementation of a fast fluorescent two-state DNA switch...
January 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28106292/23-hydroxytormentic-acid-protects-human-dermal-fibroblasts-by-attenuating-uva-induced-oxidative-stress
#14
Hae Jeong Youn, Ki Bbeum Kim, Hyo-Sun Han, In-Sook An, Kyu Joong Ahn
Ultraviolet A (UVA), one of the major components of sunlight, can penetrate the dermal layer of the skin and generate reactive oxygen species (ROS). It causes alterations in the dermal connective tissue and gene expression, inflammation, photoaging, and DNA damage. Therefore, the harmful effects of UVA and strategies to reduce it have been consistently investigated. 23-Hydroxytormentic acid (23-HTA) has been demonstrated to improve drug-induced nephrotoxicity and exhibit several free radical scavenging effects with other molecules...
January 20, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28106211/carbon-annulation-of-ortho-vinylanilines-with-dimethyl-sulfoxide-to-access-4-aryl-quinolines
#15
Jin Yuan, Jin-Tao Yu, Yan Jiang, Jiang Cheng
A palladium-catalyzed annulation of ortho-vinylanilines with dimethyl sulfoxide was developed to access 4-aryl quinolines in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a "[double bond, length as m-dash]CH-" fragment in this transformation. It represents a facile pathway leading to 4-aryl quinolines.
January 20, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28105832/sensitive-and-fast-humidity-sensor-based-on-a-redox-conducting-supramolecular-ionic-material-for-respiration-monitoring
#16
Hailong Yan, Li Zhang, Ping Yu, Lanqun Mao
Real-time monitoring of respiratory rate (RR) is highly important for human health, clinical diagnosis, and fundamental scientific research. Exhaled humidity-based RR monitoring has recently attracted increased attention because of its accuracy and portability. Here, we report a new design of an exhaled humidity sensor for the real-time monitoring of the RR based on a synthetic redox conducting supramolecular ionic material (SIM). The humidity-dependent conducting SIM is prepared by ionic self-assembly in aqueous solutions of electroactive 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,10-bis(3-methylimidazolium-1-yl) decane (C10(mim)2)...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105827/size-based-analysis-of-au-nps-by-online-monolithic-capillary-microextraction-icpms
#17
Xiaolan Liu, Beibei Chen, Yabing Cai, Man He, Bin Hu
An online hydrophilic polymer monolithic capillary microextraction (CME)-inductively coupled plasma mass spectrometry (ICPMS) analytical system was developed for the size-based analysis of Au NPs in the range of 3-40 nm. Au NPs with different particle sizes retained on the poly(acrylamide-vinylpyridine-methylene bis(acrylamide)) (poly(AA-VP-Bis)) monolithic capillary showed different elution behavior when cysteamine was used as the eluent, and the napierian logarithm of the critical eluent concentration (Ln C (cysteamine)) was linearly dependent on the particle size of Au NPs...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105660/selective-reductions-of-n-n-bis-chloro-aryl-phosphino-amines-yielding-three-five-six-and-eight-membered-cyclic-azaphosphanes
#18
Uwe Rosenthal, Martha Hoehne, Markus Joksch, Katharina Konieczny, Bernd Harald Mueller, Anke Spannenberg, Normen Peulecke
To date a plethora of λ3-P nitrogen containing-compounds is known. A large part of them is used as ligands in coordination chemistry and homogeneous catalysis. PN-containing compounds tend to build up cyclic moieties which have received less attention in regard to their application as ligands in transition metal chemistry. Hence different dehalogenation reactions of N,N-Bis{chloro(aryl)-phosphino}-amines have being developed to synthesize different P-N-P containing cyclic compounds. Their coordination behaviour to group (VI) transition metal carbonyls was explored...
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28105111/effect-of-rocuronium-on-the-bispectral-index-under-anesthesia-and-tracheal-intubation
#19
Hui Yue, Jinyu Han, Ling Liu, Kaiyuan Wang, Jincheng Li
The aim of the present study was to investigate the effect of various doses of rocuronium on bispectral index (BIS) responses to propofol induction and tracheal intubation, as well as the role of the non-depolarization muscle relaxant rocuronium on the depth of sedation. A total of 72 patients (American Society of Anesthesiologists physical status I-II) were anaesthetized with propofol using a target-controlled infusion, and randomly divided into two sedation level groups (n=36). The patients were divided into 2 groups according to the BIS value: A normal sedation group (group 1), with a stable BIS value at 40-60, and a deep sedation group (group 2), with a BIS value <20 or with burst suppression...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104235/determination-and-quantification-of-cations-in-ionic-liquids-by-capillary-electrophoresis-mass-spectrometry
#20
Marcelina Pyschik, Martin Winter, Sascha Nowak
In this study, a capillary electrophoresis (CE) method hyphenated to a high-resolution mass spectrometer is presented to detect the cations in ionic liquids (ILs) and their decomposition products. The investigated ILs were 1-methyl-1-propylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR13TFSI), 1-butyl-1-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI) and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (EMIM TFSI). With this method, it was possible to achieve baseline separation of the decomposition products from the main cations in short migration times...
January 13, 2017: Journal of Chromatography. A
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