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maternal outcomes 45 years

Holly A Swartz, Jill M Cyranowski, Yu Cheng, Marlissa Amole
OBJECTIVE: Treatment of maternal depression with psychotherapy has been shown to confer indirect benefits to school-age offspring with psychiatric disorders. The current study sought to understand mechanisms by which improvement in depressed mothers, with and without histories of trauma and treated with psychotherapy, produce changes in children who struggle with psychiatric illnesses themselves. We hypothesized that maternal history of childhood trauma would moderate the relationship between maternal and child outcomes and that increased positive and decreased negative parenting behaviors would mediate the relationship between maternal and child outcomes...
August 3, 2018: Comprehensive Psychiatry
Alanna E F Rudzik, Lyn Robinson-Smith, Helen L Ball
OBJECTIVES: Many studies of infant sleep rely solely on parentally-reported data, assuming that parents accurately report their infant's sleep parameters. The objective of this paper is to examine whether night-time sleep parameters of exclusively breastfed or exclusively formula-fed infants differ, and whether correspondence between parental reports and objective measures varies by feeding type. METHODS: Mother-infant dyads intending to breastfeed or formula-feed exclusively for 18 weeks were recruited...
June 30, 2018: Sleep Medicine
Willem Verpoest, Catherine Staessen, Patrick M Bossuyt, Veerle Goossens, Gheona Altarescu, Maryse Bonduelle, Martha Devesa, Talia Eldar-Geva, Luca Gianaroli, Georg Griesinger, Georgia Kakourou, Georgia Kokkali, Jana Liebenthron, Maria-Cristina Magli, Monica Parriego, Andreas G Schmutzler, Monica Tobler, Katrin van der Ven, Joep Geraedts, Karen Sermon
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis? SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid embryos for transfer does not substantially increase the live birth rate in women aged 36-40 years...
August 6, 2018: Human Reproduction
Hyo Kyozuka, Keiya Fujimori, Mitsuaki Hosoya, Seiji Yasumura, Tadahiko Yokoyama, Akiko Sato, Koichi Hashimoto
BACKGROUND: In Japan, mean maternal age at first childbirth is increasing. The aim of this study was to investigate whether maternal age at the first childbirth is a risk factor for preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). METHODS: We used the results of Japan Environment and Children's Study (JECS) who gave birth in 2011-2014. Cases of primiparous singleton pregnancies where the subject was ≥20 years and delivered after 22 weeks were included...
August 4, 2018: Journal of Epidemiology
X Zhang, K B Liu, F J Liu, H J Yang, Y Yu
Objective: To investigate the influence of maternal age on the health status of pregnant women and the pregnant outcomes. Methods: Data obtained from "Beijing perinatal health management registration system" was analyzed, 263 157 pregnant women with age information were included from October 1st, 2015 to September 30th, 2016, in which 43 594 women delivered at the age of 35 or above (advanced age) . According to the age of maternal age, there were 5 groups. (1) Proper age: 219 563 (83.43%, 219 563/263 157) cases of the age of 18-34 years, including 122 735 cases (46...
July 25, 2018: Zhonghua Fu Chan Ke za Zhi
Brhane G/Kidan Ayele, Tesfay Gebrehiwot Gebregzabher, Tesfay Tekle Hailu, Belete Abera Assefa
BACKGROUND: Approximately 16 million teenagers aged 15-19 years and 2 million teenagers under the age of 15 years give birth annually, with 95% of these births occurring in developing countries. Ethiopia has one of the highest teenage fertility rates in Sub-Saharan Africa; however determinants of teenage pregnancy are not well studied. Therefore, this study aimed to identify determinants of teenage pregnancy among female teenagers in Degua Tembien district, Tigray, Northern Ethiopia, in 2015...
2018: PloS One
S Osborne, A Biaggi, T E Chua, A Du Preez, K Hazelgrove, N Nikkheslat, G Previti, P A Zunszain, S Conroy, C M Pariante
INTRODUCTION: Antenatal depression is associated with a broad range of suboptimal outcomes in offspring, although the underlying mechanisms are not yet understood. Animal studies propose inflammation and glucocorticoids as mediators of the developmental programming effect of prenatal stress on offspring stress responses, but studies in humans are not yet at this stage. Indeed, to date no single study has examined the effects of a rigorously defined, clinically significant Major Depressive Disorder (MDD) in pregnancy on maternal antenatal inflammatory biomarkers and hypothalamic-pituitary (HPA) axis, as well as on offspring HPA axis, behavior and developmental outcomes in the first postnatal year...
July 13, 2018: Psychoneuroendocrinology
Jaime C Slaughter-Acey, Lloyd M Talley, Howard C Stevenson, Dawn P Misra
The majority of studies investigating the relationship between racism/racial discrimination and birth outcomes have focused on perceived experiences of racism/racial discrimination directed at oneself (personal racism). However, evidence suggests individuals report with greater frequency racism/racial discrimination directed at friends, family members, or other members of their racial/ethnic group (group racism). We examined how much African American (AA) women report lifetime experiences of perceived racism or racial discrimination, both personal and group, varied by maternal age...
July 19, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Enoch Odame Anto, William K B A Owiredu, Samuel Asamoah Sakyi, Cornelius Archer Turpin, Richard K D Ephraim, Linda Ahenkorah Fondjo, Christian Obirikorang, Eric Adua, Emmanuel Acheampong
BACKGROUND: Advanced maternal age (AMA) has been associated with negative pregnancy outcomes. Oxidative stress (OS) and defective placental dysfunction are contributing factors. This study determined the association between AMA and adverse pregnancy outcomes, OS biomarkers and angiogenic growth mediators (AGMs) in normal pregnancies. METHODS: This prospective cohort study conducted at the Obstetrics and Gynaecology (O&G) Department of the Komfo Anokye Teaching Hospital (KATH) finally included 175 normal pregnant women comprising, 58 AMA (35-45 years), 55 (30-34 years) and 62 optimal childbearing age (20-29 years)...
2018: PloS One
Sushila Arya, Zuber D Mulla, Sanja Kupesic Plavsic
BACKGROUND: The purpose of this study was to evaluate the maternal outcome in women with very advanced maternal age (VAMA) at childbirth (>45 years) compared to advanced maternal age (35-39 and 40-44 years). METHODS: Retrospective cohort study using the Texas Public Use Data File, years 2013-2014. Maternal age was a three-level variable: 35-39 (referent), 40-44, and 45-59 years (VAMA). Adjusted risk ratios (aRRs) for the two older age groups for various obstetrical and nonobstetrical complications were calculated from log-binomial regression models...
July 17, 2018: Journal of Women's Health
Zahra Atarodi-Kashani, Nourossadat Kariman, Abbas Ebadi, Hamid Alavai Majd, Nahid Beladi-Moghadam, Omid Hesami
Background and aim: Epilepsy is a common neurological disorder in pregnancy, which is associated with increased maternal and fetal adverse outcomes. This study aimed to explore the reproductive healthcare needs of women with epilepsy before, during and after childbirth. Methods: This was a qualitative study using a content analysis method. The study population was marital women with epilepsy in reproductive age (15-45 years) referred to Imam Hossein Hospital, Tehran, Iran...
May 2018: Electronic Physician
Sarit Polsky, Mengdi Wu, Bruce W Bode, Stephanie N DuBose, Robin S Goland, David M Maahs, Nicole C Foster, Anne L Peters, Carol J Levy, Viral N Shah, Roy W Beck
BACKGROUND: Gestational tight glycemic control is critical for women with type 1 diabetes (T1D). Limited data exist on the adoption and retention of diabetes technologies among women in different parity strata. METHODS: We compared T1D management between T1D Exchange clinic registry participants (mean age 28 ± 9 years, 84% white non-Hispanic, and median T1D duration 13 years) who were pregnant at enrollment or year 1 follow-up ("recently pregnant" between 2010 and 2013, n = 214), ever (but not recently) pregnant (n = 1540), and never pregnant (n = 2586)...
August 2018: Diabetes Technology & Therapeutics
Nicola Kean, Jessica Turner, Christopher Flatley M ClinEpi, Sailesh Kumar
BACKGROUND: Pregnancies at the extremes of maternal age (< 20 and > 35) are associated with adverse obstetric and perinatal outcomes. There is limited evidence regarding the influence of maternal age on serious neonatal outcomes by mode of delivery. The aim of this study thus was to assess the relationship between maternal age and mode of delivery and its impact on a composite of serious neonatal outcomes. METHODS: This was a retrospective cohort study of low risk women birthing at term in Australia's largest maternity hospital over a 7-year period...
July 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
N Dayan, D B Fell, Y Guo, H Wang, M P Velez, K Spitzer, C A Laskin
STUDY QUESTION: Is there a synergistic risk of severe maternal morbidity (SMM) in overweight/obese women who conceived by IVF compared to normal-weight women without IVF? SUMMARY ANSWER: SMM was more common in IVF pregnancies, and among overweight/obese women, but we did not detect a synergistic effect of both factors. WHAT IS KNOWN ALREADY: While much is known about the impact of overweight and obesity on success rates after IVF, there is less data on maternal health outcomes...
July 3, 2018: Human Reproduction
Katherine Russell, Louise Gilbert, Denise Hébert, Amira Ali, Robin Sarah Lynne Taylor, Andrew Hendriks
INTERVENTION: Across Ontario, the Healthy Babies Healthy Children (HBHC) postpartum screening tool is routinely used to identify families with potential risk of negative development outcomes for children. RESEARCH QUESTION: To identify screening questions associated with subsequent high-risk in-depth assessment (IDA) in order to prioritize services. METHODS: Ottawa families who gave birth (2013-2016) consented to the postpartum HBHC Screen (N = 29,162)...
April 20, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide centre-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabour rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 weeks gestation, occurring over a 7-year period. These were women who delivered > 24 hours after membrane rupture, and had no signs of chorioamnionitis or advanced labour at admission...
July 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
M Smith, A Nicoll
BACKGROUND: Short foetal femur length (FL) is a normal variant but may also be a marker for disorders such as skeletal dysplasia, Trisomy 21 (T21), Turners syndrome, congenital infection (TORCH) and foetal growth restriction (FGR). AIM: Our aim was to review outcomes in our population following a diagnosis of isolated short FL (FL <5th centile) when detected at the time of mid trimester foetal anomaly scan (FAS). METHODS: All women within NHS Tayside who attended for routine mid trimester foetal anomaly scan at 18-21 weeks gestation (Range = 18+2 -21+3  weeks) between November 2011 and June 2016 were included...
July 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Sarah J Melov, Irene Tsang, Ralph Cohen, Nadia Badawi, Karen Walker, Soundappan S V Soundappan, Thushari I Alahakoon
BACKGROUND: Gastroschisis is a congenital anomaly of the fetal abdominal wall, usually to the right side of umbilical insertion. It is often detected by routine antenatal ultrasound. Significant maternal and pediatric resources are utilised in the care of women and infants with gastroschisis. Increasing rates of gastroschisis worldwide have led institutions to review local data and investigate outcomes. A collaborative project was developed to review local epidemiology and investigate antenatal and neonatal factors influencing hospital length of stay (LOS) and total parental nutrition (TPN) in infants born with gastroschisis...
June 11, 2018: BMC Pregnancy and Childbirth
Brandy A Wicklow, Elizabeth A C Sellers, Atul K Sharma, Kristine Kroeker, Nathan C Nickel, Wanda Philips-Beck, Garry X Shen
Importance: Type 2 diabetes is increasing worldwide, disproportionately affecting First Nations (FN) people. Identifying early-life determinants of type 2 diabetes is important to address the intergenerational burden of illness. Objective: To investigate the association of in utero exposure to gestational diabetes and type 2 diabetes, stratified by FN status, with the development of type 2 diabetes in offspring. Design, Setting, and Participants: This cohort study was derived from the linkage of a pediatric diabetes clinical database and a population-based research data repository in Manitoba, Canada...
June 11, 2018: JAMA Pediatrics
Carmen Messerlian, Paige L Williams, Jennifer B Ford, Jorge E Chavarro, Lidia Mínguez-Alarcón, Ramace Dadd, Joseph M Braun, Audrey J Gaskins, John D Meeker, Tamarra James-Todd, Yu-Han Chiu, Feiby L Nassan, Irene Souter, John Petrozza, Myra Keller, Thomas L Toth, Antonia M Calafat, Russ Hauser
Background: The Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and pregnancy outcomes. Methods: The EARTH Study recruits women 18 to 45 years and men 18 to 55 years seeking fertility evaluation and treatment at the Massachusetts General Hospital (MGH) Fertility Center, Boston, USA. Women and men are eligible to join either independently or as a couple...
February 2018: Human reproduction open
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