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Yoko Edahiro, Jun Ando, Toshifumi Suzuki, Yuki Fukumura, Azuchi Masuda, Shiori Sakayori, Jun Takeda, Yojiro Maruyama, Shintaro Makino, Atsuo Itakura, Norio Komatsu
Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis, mainly occur in older patients, but have also been reported in younger patients. A "second peak" occurs in female patients in their thirties, particularly in ET; thus, the management of pregnancy is often discussed. We herein present the case of a 33-year-old woman with a high platelet count and multiple placental infarcts during delivery who was subsequently diagnosed with ET...
August 10, 2018: Internal Medicine
Lakshmy Ayyar, Fidaa Shaib, Kalpalatha Guntupalli
Sleep-disordered breathing (SDB) in pregnancy can present as snoring and/or obstructive sleep apnea (OSA), and the prevalence is increasing due to the increase in maternal obesity. Pregnant women often present with fatigue and daytime sleepiness rather than the classic symptoms. Habitual snoring, older age, chronic hypertension, and high prepregnancy body mass index are reliable indicators of increased risk for SDB and should trigger further testing. The gold standard for diagnosis of OSA is an overnight laboratory polysomnography...
September 2018: Sleep Medicine Clinics
Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Stacey A Missmer, Hafsatou Diop
OBJECTIVE: To quantify the effect of medical and obstetrical factors on the odds of cesarean delivery, comparing assisted reproductive technology (ART)-treated women and women with subfertility not treated with ART versus fertile women. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Singleton deliveries to primiparous women; with the source of this data being the Massachusetts vital and hospital records linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data (2004-2010)...
August 2018: Fertility and Sterility
Wen Zhang, Shuangzheng Jia, Yang Xiang, Junjun Yang, Congwei Jia, Jinhua Leng
BACKGROUND: Synchronous endometriosis has been poorly studied in women with endometrioid borderline ovarian tumors (EBOTs). The aims of this study were to compare the clinicopathological features and prognosis of EBOTs with or without endometriosis. RESULTS: Of 52 patients diagnosed with EBOTs, no death was observed and only one case had successful pregnancy during the follow-up period. Older, menopausal EBOT patients, EBOT patients with small tumors and relatively low CA125 level probably had better progression-free survival (PFS) outcomes...
August 11, 2018: Journal of Ovarian Research
Dael Jarvie, Sherif Hanafy Mahmoud
PURPOSE: Levetiracetam (LEV) is a broad spectrum antiepileptic drug (AED) that has a more favorable side effect profile compared to older AEDs. Therapeutic drug monitoring (TDM) of LEV is generally unnecessary given its linear and predictable dose-serum concentration relationship, lack of drug-drug interactions, and broad therapeutic window. However, there is growing evidence showing that alteration of LEV pharmacokinetics (PK) may occur in special populations calling for the need for TDM...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Diane Korb, Catherine Deneux-Tharaux, Aurélien Seco, François Goffinet, Thomas Schmitz
OBJECTIVE: To evaluate the association between the planned mode of delivery and severe acute maternal morbidity in women with twin pregnancies. METHODS: In this planned secondary analysis of the JUmeaux MODe d'Accouchement cohort, a national prospective population-based study of twin deliveries conducted from February 2014 to March 2015 in 176 hospitals performing more than 1,500 annual deliveries in France, we included women with twin pregnancies at 24 weeks of gestation or greater with two live fetuses...
August 6, 2018: Obstetrics and Gynecology
Jamie Stanhiser, Anne Z Steiner
Psychosocial aspects of fertility, infertility, and assisted reproductive technology (ART) can significantly impact patients' sense of self-identity and personal agency, mental well-being, sexual and marital relationships, reproductive efficiency, compliance with treatment, and pregnancy outcomes. Research is needed to understand how stress, anxiety, depression, mood disorders, and psychotropic medications impact fertility and infertility treatment. The psychosocial implications of ART on our society include a shift toward older maternal age at conception, the complexities of third-party reproduction, and consideration for the psychological and socioeconomic barriers to receiving care...
September 2018: Obstetrics and Gynecology Clinics of North America
Alex Y Wang, Nadom Safi, Fathalla Ali, Kei Lui, Zhuoyang Li, Mark P Umstad, Elizabeth A Sullivan
BACKGROUND: While their incidence is on the rise, twin pregnancies are associated with risks to the mothers and their babies. This study aims to investigate the likelihood of adverse neonatal outcomes of twins following assisted reproductive technology (ART) compared to non-ART twins. METHODS: A retrospective population study using the Australian National Perinatal Data Collections (NPDC) which included 19,662 twins of ≥20 weeks gestational age or ≥ 400 g birthweight in Australia...
August 8, 2018: BMC Pregnancy and Childbirth
Juliane Dias Aldrighi, Marilene Loewen Wall, Silvana Regina Rossi Kissula Souza
OBJECTIVE: To describe the experience of pregnant women at an advanced age. METHOD: This is a qualitative and descriptive study, which was conducted with 21 pregnant women aged 35 years older or over undergoing high-risk prenatal care, from December 2015 to April 2016. The data were collected by means of semi-structured interviews. The thematic analysis of the data followed the six steps proposed by Creswell. RESULTS: Six thematic categories have appeared: Ambivalence: from fear to happiness; The (un)planning and the divine; Family (re)organization: from support to non-acceptance; Maturity as a facilitator for motherhood; Advanced age and risk perception; The biological age of the body hindering pregnancy...
August 2, 2018: Revista Gaúcha de Enfermagem
K M Tote, V T Raziano, K M Wall, S Cordes, I Ofotokun, L B Haddad
OBJECTIVE(S): Effective contraceptive method use is important for HIV-positive women to meet fertility goals, prevent unintended pregnancy, and reduce risk of vertical HIV transmission. Our objective was to evaluate factors associated with HIV-positive women's contraceptive method use at last coitus defined as more effective (Tier 1 and 2 methods (T1/2)) versus less effective (Tier 3 or No method (T3/None)) by the US Medical Eligibility Criteria for contraception use. STUDY DESIGN: HIV-positive women, recruited from an HIV clinic in Atlanta, Georgia between 2013-2014, completed a survey of demographic, clinical, and reproductive health characteristics surrounding contraception...
July 31, 2018: Contraception
Mohammed Bashir, Manar E Abdel-Rahman, Mahmoud Aboulfotouh, Fatin Eltaher, Khalid Omar, Isaac Babarinsa, Kwabena Appiah-Sakyi, Tarek Sharaf, Eman Azzam, Mohammad Abukhalil, Malika Boumedjane, Wigdan Yousif, Warda Ahmed, Sadaf Khan, Justin C Konje, Abdul-Badi Abou-Samra
BACKGROUND: Diabetes first detected during pregnancy is currently divided into gestational diabetes mellitus (GDM) and diabetes mellitus (DM)- most of which are type 2 DM (T2DM). This study aims to define the prevalence and outcomes of diabetes first detected in pregnancy based on 75-gram oral glucose tolerance test (OGTT)using the recent WHO/IADPSG guidelines in a high-risk population. METHODS: This is a retrospective study that included all patients who underwent a 75 g (OGTT) between Jan 2016 and Apr 2016 and excluded patients with known pre-conception diabetes...
2018: PloS One
Yasaman Kavousi, Ziad Al Adas, Efstathios Karamanos, Nicole Kennedy, Loay S Kabbani, Judith C Lin
BACKGROUND: Risk factors for chronic venous disease (CVD) have been widely reported in population health management. However, predisposing factors associated with patients treated for advanced stages of CVD have yet to be established. We examined the demographics and risk factors associated with advanced clinical presentation of CVD for patients referred for vein ablation. METHODS: Retrospective analysis of our institutional Vascular Quality Initiative Varicose Vein Registry included endovenous laser treatment and radiofrequency ablation procedures at our tertiary institution, community hospital, and outpatient vein clinic between January 2015 and December 2016...
July 28, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Kelly M Babchishin, Michael C Seto, Seena Fazel, Niklas Långström
Although prior research suggests associations between parental characteristics and later sexual offending in offspring, possible links between early pregnancy-related factors and sexual offending remain unclear. Early risk markers unique to sexual offending, however, may be more prominent among sexual offenders with atypical sexual interests, such as individuals involved with child sexual exploitation material (CSEM; also referred to as child pornography). We examined the prospective association between parental and pregnancy-related risk markers and a behavioral indicator of pedophilic interest, CSEM offending...
July 31, 2018: Journal of Sex Research
Simon Timpka, Abigail Fraser, Tommy Schyman, Jennifer J Stuart, Bjørn Olav Åsvold, Ingrid Mogren, Paul W Franks, Janet W Rich-Edwards
Women with a history of hypertensive disorders of pregnancy (HDP; preeclampsia and gestational hypertension) or delivering low birth weight offspring (LBW; < 2500 g) have twice the risk of cardiovascular disease (CVD). We aimed to study the extent to which history of these pregnancy complications improves CVD risk prediction above and beyond conventional predictors. Parous women attended standardized clinical visits in Sweden. Data were linked to registries of deliveries and CVD. Participants were followed for a first CVD event within 10 years from age 50 (n = 7552) and/or 60 years (n = 5360) and the predictive value of each pregnancy complication above and beyond conventional predictors was investigated...
July 30, 2018: European Journal of Epidemiology
Sadequa Shahrook, Erika Ota, Nobutsugu Hanada, Kimi Sawada, Rintaro Mori
To study supplementation effect of vitamin K (VK) alone or combined with other nutrients administered to pregnant women, we searched Cochrane Pregnancy and Childbirth Group's Trials Register (till 22 January 2016, updated on 28 February 2018) including other resources. Two review authors independently assessed randomised or quasi-randomised controlled trials for inclusion, data extraction, accuracy, and risk of bias. We included older trials from high-income countries (six; 21,493 women-newborns), judged mostly as high or unclear bias risk...
July 30, 2018: Scientific Reports
Ashraf Soliman, Husam Salama, Hilal Al Rifai, Vincenzo De Sanctis, Sawsan Al-Obaidly, Mai Al Qubasi, Tawa Olukade
AIMS OF THE STUDY: We describe the impact of different forms of dysglycemia on maternal and neonatal health. This research is a part of the PEARL-Peristat Maternal and newborn registry, funded by Qatar National Research Fund (QNRF) Doha, Qatar. METHODS: A population-based retrospective data analysis of 12,255 women with singleton pregnancies screened during the year 2016-2017, of which 3,027 women were identified with gestation diabetes mellitus (GDM) during pregnancy and 233 were diabetic before pregnancy...
May 23, 2018: Acta Bio-medica: Atenei Parmensis
Kwamena Sekyi Dickson, Kenneth Setorwu Adde, Bright Opoku Ahinkorah
Background: Despite the variances in abortion laws accounting for differences in incidence of abortion among African countries, it appears there is absence of literature on other factors that may also account for the differences in incidence of abortion. Specifically, there is paucity of information on how socio-demographic factors account for the disparities in prevalence of pregnancy termination among women of reproductive age in sub-Saharan Africa. In view of this, this paper examined how socio-demographic factors influence pregnancy termination among women in reproductive age in Mozambique and Ghana...
2018: Archives of Public Health, Archives Belges de Santé Publique
Mehmet Musa Aslan, Adem Atici
Background and Objective: Cardiovascular deaths usually occur in older pregnancies and arrhythmia is the third most common cause. Our study aimed to determine whether the risk of arrhythmia increases in pregnancy with advanced age. Methods: In total, 280 pregnant women, of whom 98 were of advanced age and 182 were under 35 years of age were included in the study. The risk of arrhythmia was evaluated by calculating the electrocardiographic P-wave duration, QT interval, T peak-to-end interval, and the Tp-e/QT ratio...
May 2018: Pakistan Journal of Medical Sciences Quarterly
Jacinda M Nicklas, Chloe A Zera, Ellen W Seely
OBJECTIVE: Women with gestational diabetes (GDM) have a 7-12-fold increased risk for developing type 2 diabetes later in life. Postpartum weight retention is highly predictive for future obesity, and further increases risk for type 2 diabetes. We sought to identify predictors of losing at least 75% of gestational weight gain by very early postpartum in women with recent GDM. METHODS: We recruited women with GDM during pregnancy or just after delivery. Prepregnancy weight was self-reported at recruitment; gestational weight gain, mode of delivery, and insulin use were extracted from medical records...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
Sharon Ng, Izzuddin M Aris, Mya Thway Tint, Peter D Gluckman, Keith M Godfrey, Lynette Pei-Chi Shek, Fabian Yap, Kok Hian Tan, Ngee Lek, Oon Hoe Teoh, Yiong Huak Chan, Mary Foong-Fong Chong, Yung Seng Lee, Yap-Seng Chong, Michael S Kramer, Shiao-Yng Chan
Background: Self-reported maternal active smoking has been associated with reduced offspring birth length and shorter stature in early and late childhood. Objective: To use circulating cotinine as an objective biomarker to investigate the association between smoking and environmental tobacco smoke (ETS) exposure in pregnancy, and longitudinal measures of offspring length/height from birth to 60 months. Methods: In 969 maternal-offspring dyads from the GUSTO cohort, maternal plasma cotinine at 26-28 weeks' gestation was measured by LC/MS/MS and categorized into 4 groups: Group 1: cotinine <0...
July 19, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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