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Sebaceous Glands

B F Thomazini, C A Lamas, M A H Dolder
Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treatment. The treatment for the average patient is carried out during two to ten months. This study was designed to investigate liver structure, hepatic enzyme levels and the stress oxidative parameter after isotretinoin treatment during a similar period and using the dosages of 1 mg/kg and another one of 10 mg/kg in young male Wistar rats. We have analyzed the blood serum biochemical levels to determine hepatic function and lipid peroxidation, hepatic tissue levels of hepatic enzymes, histology and ultrastructure...
December 17, 2018: Histology and Histopathology
Swathi Kaliki, Sasi Pyda, Nupur Goel, Tarjani Vivek Dave, Milind N Naik, Dilip K Mishra
PURPOSE: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors. METHODS: This is a retrospective study of 120 cases and 429 frozen section slides. RESULTS: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. All cases with these malignant eyelid tumors underwent wide surgical excisional biopsy under frozen section control of surgical margins...
December 8, 2018: International Ophthalmology
James W Bush, Alejandro A Gru, Mark R Wick
Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. SOX10 staining was seen in the majority of sweat gland tumors with the exception of syringoma and microcystic adnexal carcinoma...
December 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Hadla Hariri, Mazen Kurban, Christiane Al-Haddad, Akl C Fahed, Sarin Poladian, Athar Kahlil, Oussama Abbas, Mariam Arabi, Fadi Bitar, Georges Nemer
BACKGROUND: Cutaneous malformations are at times associated with some forms of congenital heart defects. Many a times subtle cutaneous phenotypes maybe overlooked as their significance on the lives of individuals is minimal. Lebanon represents an area of high consanguinity, where the rates can go beyond 70% in some districts. For the past 6 years, we have been studying several genodermatoses in Lebanon including those with cardiac malformations. OBJECTIVES: The main aim of this study is to document the genetic basis of a familial case of Axenfeld-Rieger Syndrome (ARS) with a mild cutaneous phenotype represented histologically with degeneration/ absence of hair follicles and incomplete formation of sebaceous and eccrine glands, in addition to the cardiac and ocular phenotypes...
November 10, 2018: Journal of Dermatological Science
Yaolin Song, Ana C Boncompagni, Sang-Seok Kim, Heather R Gochnauer, Yuhang Zhang, Gabriela G Loots, Dianqing Wu, Yulin Li, Mingang Xu, Sarah E Millar
Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Plantar skin retains all of the mechanistic components needed for hair follicle development, as genetic deletion of Dkk2 permits formation of fully functional plantar hair follicles that give rise to external hair, contain sebaceous glands and a stem cell compartment, and undergo regenerative growth...
November 29, 2018: Cell Reports
Chen Heng, Tan Wei, Tu Yingbing, Liu Hanzhong
Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. The differences between the two cases are as follows: First, the mass in the first case had a mixed echo pattern on ultrasound, whereas that in the second case had a hypoechoic pattern...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Chong Won Choi, Yejin Kim, Ji Eun Kim, Eun Young Seo, Christos C Zouboulis, Jae Seung Kang, Sang Woong Youn, Jin Ho Chung
A relationship between acne and free fatty acids (FFAs) has been suggested recently. However, the effects of FFAs on sebaceous glands are still largely unknown. At the same time, the role of FFAs during chronic inflammation is well established. Considering that FFAs are also a major component of sebum, it is likely that changes in FFA affect both the synthesis of sebum and the inflammatory response in sebaceous glands. In this study, we examined a hypothesis that FFAs increase the production of sebum and induce inflammation in the sebaceous glands...
December 2, 2018: Experimental Dermatology
T Brément, C Cossec, C Roux, A C Knol, B Dréno, A Khammari, P Bourdeau, V Bruet
Adipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and systemic inflammatory conditions. We aimed to evaluate the expression of three adipokines (i.e...
November 28, 2018: Journal of Comparative Pathology
Tze Hau Lam, Davide Verzotto, Purbita Brahma, Amanda Hui Qi Ng, Ping Hu, Dan Schnell, Jay Tiesman, Rong Kong, Thi My Uyen Ton, Jianjun Li, May Ong, Yang Lu, David Swaile, Ping Liu, Jiquan Liu, Niranjan Nagarajan
BACKGROUND: Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely studied in adults, little is known for teenagers and pre-pubescent children who have distinct sweat composition from immature apocrine and sebaceous glands, but are arguably more susceptible to the social and psychological impact of malodor. RESULTS: We integrated information from whole microbiome analysis of multiple skin sites (underarm, neck, and head) and multiple time points (1 h and 8 h after bath), analyzing 180 samples in total to perform the largest metagenome-wide association study to date on malodor...
November 29, 2018: Microbiome
Jörg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Rémi Longuespée, Sören-Oliver Deininger, Rita Casadonte
PURPOSE: To present matrix-assisted laser desorption/ionization (MALDI) imaging as a powerful method to highlight various tissue compartments. EXPERIMENTAL DESIGN: Formalin-fixed paraffin-embedded (FFPE) tissue of a uterine cervix, a pancreas, a duodenum, a teratoma, and a breast cancer tissue microarray (TMA) are analyzed by MALDI imaging and by immunohistochemistry (IHC). Peptide images are visualized and analyzed using FlexImaging and SCiLS Lab software. Different histological compartments are compared by hierarchical cluster analysis...
November 24, 2018: Proteomics. Clinical Applications
Malcolm Maden, Jason O Brant
Members of the Acomys genus, known as spiny mice, are unique among mammals in being perfectly capable of regenerating large areas of skin that have been removed. During this regenerative process hairs, sebaceous glands, erector pili muscles, adipocytes and the panniculus carnosus all regenerate and the dermis does not scar. We review here the processes that the epidermis and the individual components of the dermis undergo in the regeneration process of the spiny mouse, the molecules that have been identified as potentially being important in regeneration and relate this to what has been proposed as playing a role in studies from the lab mouse, Mus musculus...
November 20, 2018: Experimental Dermatology
Hiroyasu Matsuoka, Hirochika Matsubara, Aya Sugimura, Tsuyoshi Uchida, Tomofumi Ichihara, Hiroyuki Nakajima
INTRODUCTION: A perforating mediastinal mature teratoma can cause severe inflammation and adhesion; therefore, open surgery is usually performed. Asymptomatic perforation involving a teratoma is very rare. Complete thoracoscopic surgery is often difficult because of inflammation associated with perforation and the frequently large size of a mediastinal mature teratoma. We report a rare case of an asymptomatic perforating mediastinal mature teratoma successfully treated with complete thoracoscopic surgery...
November 2, 2018: International Journal of Surgery Case Reports
Li Zhengguang, Huang Jie, Zhang Yong, Cao Jiaojiao, Wang Xingqi, Chu Xiaoqin
OBJECTIVE: The purpose of this study was to research the mechanism of percutaneous penetration of Ibuprofen (IBU) nanoemulsion. METHOD: Transdermal penetration mechanism of IBU nanoemulsion was investigated by using Fourier transform infra-red spectral analysis (FTIR), differential scanning calorimeter thermogram (DSC), and activation energy (Ea) measurement. The in vivo skin penetration test of rats was carried out using Rhodamine B nanoemulsion to simulate the process of drug penetration into the skin, and the frozen section of the skin was observed by confocal laser scanning microscopy (CLSM)...
November 16, 2018: Drug Development and Industrial Pharmacy
Kazutoshi Kumagai, Saaya Yokoshiki, Kazuto Kobayashi, Yoshifumi Saijo
High-frequency ultrasound has realized high-resolution observation of deep part of the dermis in vivo. The size of sebaceous glands was evaluated by three-dimensional ultrasound microscopy with the ultrasonic frequency of 120 MHz. The viscoelasticity of the same regions was measured by well-established biomechanical equipment. There was no significant difference between the size of sebaceous glands in cheek and forearm. The skin's ability to recover to its initial position after deformation was significantly higher in forearm than in cheek...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Anne-France de Bengy, Nico Forraz, Louis Danoux, Nicolas Berthelemy, Sébastien Cadau, Olivier Degoul, Valérie Andre, Sabine Pain, Colin McGuckin
OBJECTIVES: Sebaceous glands maintain skin homeostasis by producing sebum. Low production can induce hair loss and fragile skin. Overproduction provokes seborrhoea and may lead to acne and inflammatory events. To better study sebaceous gland maintenance, sebocyte maturation, lipid production and ageing or inflammatory processes, we developed innovative 3D ex vivo models for human sebaceous glands. MATERIALS AND METHODS: Culture conditions and analytical methods optimized on sebocyte monolayers were validated on extracted sebaceous glands and allowed the development of two 3D models: (a) "air-liquid" interface and (b) human fibronectin-coated "sandwich" method...
November 6, 2018: Cell Proliferation
Jawad El-Azhari, Mohammed Boui
Sebaceous naevus (sebaceous hamartoma) is a congenital lesion mainly localized to the scalp, whose clinical and histologic diagnosis is generally easy. In the vast majority of cases, it is diagnosed at birth, but it can sometimes go unnoticed and give the impression to occur later. This lesion may be complicated by benign tumors or more rare malignancies. We report the case of a 45-year old patient, who had been followed-up for Biermer's anemia (treated with monthly HYDROXOCOBALAMINE injection) and ophiasic alopecia for 15 years, presenting with a 10-year history of bilateral and symmetric pigmented plaques gradually increasing in size...
2018: Pan African Medical Journal
John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E Kennedy, Nicholas E Gott, Louise A Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct...
2018: PloS One
Angel Fernandez-Flores, David S Cassarino
INTRODUCTION: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was demonstrated that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Our purpose in this study is to examine for the presence of Merkel cells in extraocular sebaceous carcinomas. MATERIALS AND METHODS: Nineteen cases of extraocular sebaceous carcinoma were retrospectively studied with cytokeratin (CK) 20...
October 25, 2018: Journal of Cutaneous Pathology
JiaYang Sun, YunFeng Zhang, XianJi Song, Jiajing Zhu, QingSan Zhu
Radioactive dermatitis is caused by the exposure of skin and mucous membranes to radiation fields. The pathogenesis of radioactive dermatitis is complex and difficult to cure. Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) may serve as a promising candidate for the therapy of cutaneous wounds. The aim of this study was to investigate whether a WJ-MSC-derived conditioned medium (MSC-CM) could be used to treat radiation-induced skin wounds in rats using a radiation-induced cutaneous injury model. The present study was designed to examine MSC-CM therapy in the recovery of radiation-induced skin wounds in vitro and in vivo...
October 23, 2018: Cell Transplantation
Chao Qi, Luming Xu, Yan Deng, Guobin Wang, Zheng Wang, Lin Wang
Full-thickness skin injury affects millions of people worldwide each year. It often leads to scar formation and loss of skin appendages even after clinical treatment. The majority of wound dressings currently used cannot achieve scarless skin regeneration with complete recovery of appendages such as hair follicles and sebaceous glands. Functional regeneration of these skin appendages is a great challenge. However, we achieved this goal by the successful development and utilization of a photo-crosslinkable sericin hydrogel (SMH) as a new type of wound dressing for repairing full-thickness skin injury...
November 1, 2018: Biomaterials Science
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