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Sebaceous Glands

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https://www.readbyqxmd.com/read/30088446/molecular-interactions-of-different-steroids-contributing-to-sebum-production-review
#1
Marisa Cabeza, Lucero Bautista, Marisol Guadalupe Bravo, Yvonne Heuze
Considerable progress has been made in learning about the physiology and biochemistry of the sebaceous glands and several of the diseases that affect this component of the skin. Of these diseases, acne has particular importance. Although it is associated with adolescence, because of the hormonal changes that take place in this stage, when it is severe it can cause depression. Moreover, in a considerable proportion of acne sufferers both adolescent and adult, it can produce tumors and deformation of the sebaceous glands...
August 7, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/30085961/a-new-histologic-pattern-in-6-biopsies-from-early-frontal-fibrosing-alopecia
#2
Mariya Miteva, Samar Sabiq
Frontal fibrosing alopecia (FFA) is an irreversible scarring alopecia with unknown etiology and no cure. The goal is to establish the diagnosis in the early stage, before developing a hairless band of atrophy involving the frontal, temporal scalp and sideburns. Pathology is rarely needed once the disease is clinically apparent. The classic histologic features include follicular dropout with the absence or atrophy of the sebaceous glands and lichenoid lymphohistiocytic infiltrate with concentric layered fibrosis at the upper follicular level...
August 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/30066947/mutation-and-expression-of-abca12-in-keratosis-pilaris-and-nevus-comedonicus
#3
Fen Liu, Yao Yang, Yan Zheng, Yan-Hua Liang, Kang Zeng
Keratosis pilaris (KP) and nevus comedonicus (NC) are congenital keratinized dermatoses; however, the exact etiology of these two diseases is unclear. The objective of the present study was to identify the disease‑causing genes and their association with functional alterations in the development of KP and NC. Peripheral blood samples of one KP family, two NC families and 100 unrelated healthy controls were collected. The genomic sequences of 147 genes associated with 143 genetic skin diseases were initially analyzed from the KP proband using a custom‑designed GeneChip...
July 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30065281/influence-of-the-sebaceous-gland-density-on-the-stratum-corneum-lipidome
#4
Matteo Ludovici, Nina Kozul, Stefano Materazzi, Roberta Risoluti, Mauro Picardo, Emanuela Camera
The skin surface lipids (SSL) result from the blending of sebaceous and epidermal lipids, which derive from the sebaceous gland (SG) secretion and the permeability barrier of the stratum corneum (SC), respectively. In humans, the composition of the SSL is distinctive of the anatomical distribution of the SG. Thus, the abundance of sebum biomarkers is consistent with the density of the SG. Limited evidence on the influence that the SG exerts on the SC lipidome is available. We explored the differential amounts of sebaceous and epidermal lipids in areas at different SG density with lipidomics approaches...
July 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30055201/preservation-of-sebaceous-glands-and-ppar%C3%AE-expression-in-central-centrifugal-cicatricial-alopecia
#5
Yemisi Dina, Walaa Borhan, Gulsun Erdag, Ginette A Okoye, Rajni Sharma, Powell Perng, Crystal Aguh
No abstract text is available yet for this article.
July 25, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30053505/anti-ageing-skin-effects-of-korean-bamboo-salt-on-skh1-hairless-mice
#6
Xin Zhao, Yongcai Qi, Ruokun Yi, Kun-Young Park
Bamboo salt is generated by baking bamboo and sea salt and is used as a traditional food or medicine. The aim of this study was to investigate the anti-ageing skin effects of Korean bamboo salt and to compare the antioxidant, anti-ageing and anti-inflammatory effects of various salts, including purified salt, solar salt, bath solar salt, Masada solar salt, 1-time baked bamboo salt (1× bamboo salt), and 9-times baked bamboo salt (9× bamboo salt). Based on the content of mineral elements, pH, OH groups and redox potential amperometric analysis, the 9× bamboo salt showed the most antioxidant components and characteristics compared to the other salts...
July 24, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/30045980/neutrophils-cause-obstruction-of-eyelid-sebaceous-glands-in-inflammatory-eye-disease-in-mice
#7
Nancy J Reyes, Chen Yu, Rose Mathew, Carolina M Kunnen, Joan Kalnitsky, Rachel L Redfern, Andrea Leonardi, Victor L Perez, Amanda S MacLeod, Preeya K Gupta, Daniel R Saban
Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. Although chronic eyelid inflammation, such as allergic eye disease, is an associated risk factor for obstructive MG dysfunction, it is not clear whether inflammatory processes contribute to the pathophysiology of MG obstruction. We show that polymorphonuclear neutrophils (PMNs) promoted MG obstruction in a chronic inflammatory model of allergic eye disease in mice...
July 25, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30033522/inactivation-of-autophagy-leads-to-changes-in-sebaceous-gland-morphology-and-function
#8
Heidemarie Rossiter, Gerald Stübiger, Marion Gröger, Ulrich König, Florian Gruber, Supawadee Sukseree, Veronika Mlitz, Maria Buchberger, Olga Oskolkova, Valery Bochkov, Leopold Eckhart, Erwin Tschachler
We have reported recently that inactivation of the essential autophagy related gene 7 (Atg7) in keratinocytes has little or no impact on morphology and function of the epidermal barrier in experimental animals. When these mice aged, mutant males, (Atg7 ΔKC), developed an oily coat. Since the keratin 14 promoter driven cre/LoxP system inactivates floxed Atg7 in all keratin 14 (K14) expressing cells, including sebocytes, we investigated whether the oily hair phenotype was the consequence of changes in function of the skin sebaceous glands...
July 22, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/30027508/isolation-and-characterization-of-cutaneous-epithelial-stem-cells
#9
Stephanie R Gillespie, David M Owens
The outer layer of mammalian skin is a multilayered epithelium that perpetually renews multiple differentiated lineages. During homeostasis, the maintenance of skin epithelial turnover is ensured by regionalized populations of stem cells that largely remain dedicated to distinct epithelial lineages including squamous, follicular, sebaceous, Merkel, and sweat glands. Cutting edge developments in this field have focused on: (1) stem cell activation cues derived from a number of extrinsic sources including neurons, dermal fibroblasts and adipocyte, and immune cells; and (2) characterization of epithelial stem cell homeostasis via hierarchical versus stochastic paradigms...
July 20, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30027448/clinicopathological-features-of-considerable-reduction-in-androgen-receptor-expression-in-sebaceous-gland-carcinoma-of-the-eyelid
#10
Tatsuya Yunoki, Akio Miyakoshi, Mitsuya Otsuka, Atsushi Hayashi
PURPOSE: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. METHODS: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. RESULTS: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups...
July 19, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/30009192/tissue-engineering-of-skin-and-regenerative-medicine-for-wound-care
#11
REVIEW
Steven T Boyce, Andrea L Lalley
Engineering of biologic skin substitutes has progressed over time from individual applications of skin cells, or biopolymer scaffolds, to combinations of cells and scaffolds for treatment, healing, and closure of acute and chronic skin wounds. Skin substitutes may be categorized into three groups: acellular scaffolds, temporary substitutes containing allogeneic skin cells, and permanent substitutes containing autologous skin cells. Combined use of acellular dermal substitutes with permanent skin substitutes containing autologous cells has been shown to provide definitive wound closure in burns involving greater than 90% of the total body surface area...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29998103/cutaneous-adnexal-cysts-revisited-what-we-know-and-what-we-think-we-know
#12
REVIEW
Gürkan Kaya, Jean-Hilaire Saurat
Cutaneous cysts have been classified by dermatopathologists in many different ways. Here, we propose a novel classification of cutaneous adnexal cysts according to their origin in the folliculosebaceous unit and the sweat glands. By examining the lining of the cystic structure, its origin can be easily identified. Epidermal cysts have an epithelial wall containing a granular layer with lamellar keratinization, indicating an infundibular origin. Tricholemmal cysts have an undulating epithelial wall with no granular layer and a compact keratinization, showing an isthmic origin...
April 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29996607/-establishment-of-standardized-diagnosis-and-treatment-of-eyelid-sebaceous-carcinoma-in-china
#13
D M Li
Eyelid sebaceous carcinoma is a malignant tumor originating from Meibomian glands, Zeis glands, and other glands surrounding hair follicles. It is the second most common eyelid malignancy, following basal cell carcinoma, in China. Considering its diversified clinical manifestations and strong tendency for recurrence and metastasis, standardized cancer staging, surgical excision with frozen section control, and postsurgical follow-up has been internationally adopted with the aim to considerably reduce the risk of recurrence and metastasis...
July 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29972220/overexpression-of-androgen-oestrogen-and-progesterone-receptors-in-skin-lesions-of-becker-s-naevus
#14
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan
Becker's naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder. Immunohistochemistry showed that epidermal expression of androgen receptors, oestrogen receptors (α, β) and progesterone receptors was higher in skin lesions of Becker's naevus than in perilesional and control skin. Androgen receptor overexpression was observed in pilosebaceous glands, while oestrogen and progesterone receptor overexpression was seen in hair follicles, but not in sebaceous glands in skin lesions compared with perilesional skin...
June 8, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29969769/is-human-sebum-the-source-of-skin-follicular-ultraviolet-induced-red-fluorescence-a-cellular-to-histological-study
#15
De-Tian Xu, Jian-Na Yan, Wei Liu, Xiao-Xiao Hou, Yan Zheng, Wei-Wei Jiang, Qiang Ju, Christos C Zouboulis, Xiu-Li Wang
BACKGROUND: The ultraviolet-induced red fluorescence (UVRF) from human skin follicles was suggested to be a result of Propionibacterium acnes and was used for the monitoring of acne. More recent studies suggested that the UVRF may be more related to sebum rather than to microorganisms. OBJECTIVE: To clarify whether human sebum or follicular microorganisms are the source of UVRF. METHODS: We examined the fluorescence of human-derived SZ95 sebocytes, human sebaceous glands, sebum extracted from the sebaceous glands, and bacteria isolated from human hair follicles under ultraviolet light...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29968898/untreated-submandibular-megalith-for-over-60-years
#16
Khalid A Ahmed, Alia K Alfadhel, Bayan J Mohammed
Intra-parenchymal sialolithiasis and subsequent fibrosis of the submandibular salivary glands is a rare disorder. The resulting swelling, pain, and infection derives affected patients to seek treatment. We present the case of an 85-years-old Saudi male patient who suffered from repeated swelling and infection in the left submandibular region which was misdiagnosed and treated for over 60 years as dental infection, infected skin sebaceous gland or lipoma. The presented case represents the largest intra-glandular submandibular stone with the longest duration ever reported in the medical literature...
July 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29964224/ala-pdt-suppressing-the-cell-growth-by-akt-erk-mtor-p70-s6k-pathway-in-human-sz95-sebocytes-in-vitro
#17
Wenjie Liu, Qianqian Wang, Jiang Tuo, Yufeng Chang, Jiayi Ying, Min Jiang, Christos C Zouboulis, Leihong Xiang
BACKGROUND: Topical 5-aminolevulinic acid mediated photodynamic therapy (PDT) is known to be an effective method in treating acne vulgaris and other sebaceous gland-related diseases. The therapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate the upstream of mammalian target of rapamycin (mTOR) signaling cascade after ALA-PDT on cell growth of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of 5-ALA PDT...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29963441/sebaceous-cyst-in-the-oral-cavity
#18
Matias Garcia Blanco, Sebastian Ariel Puia
Sebaceous glands are reported to be normally located in the oral region in the vermilion of the upper lip and on the buccal mucosa. They are small yellowish bodies located immediately beneath the mucosa, and although numerous pathologies of these tissues have been described, very few clinical reports have been made. Pathologies such as ectopic location, hyperplasia, adenomas, carcinomas, and cysts have been described. If an excretory duct suffers a dilatation which does not regress of its own accord, it may originate a cyst...
January 2018: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29951567/hair-follicle-stem-cell-isolation-and-expansion
#19
Mindy Call, Ewa Anna Meyer, Winston W Kao, Friedrich E Kruse, Ursula Schlötzer-Schrehardt
Stem cells are widely used for numerous clinical applications including limbal stem cell deficiency. Stem cell derived from the bulge region of the hair follicle have the ability to differentiate into a variety of cell types including interfollicular epidermis, hair follicle structures, sebaceous glands and corneal epithelial cells when provided the appropriate cues. Hair follicle stem cells are being studied as a valuable source of autologous stem cells to treat disease. The protocol described below details the isolation and expansion of these cells for eventual clinical application...
May 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29947022/skin-structure-in-newborn-marsupials-with-focus-on-cutaneous-gas-exchange
#20
Kirsten Ferner
A morphological and morphometric study of the skin of a variety of newborn marsupials (Dasyurus viverrinus, Monodelphis domestica, Trichosurus vulpecula, Isoodon obesulus, Perameles nasuta, Phascolarctos cinereus, Potorous tridactylus, Petrogale penicillata, Thylogale thetidi, Macropus dorsalis) and of a monotreme hatchling (Ornithorhynchus anatinus) was undertaken to assess the possibility of cutaneous gas exchange. Additionally, the lungs of some of these species were investigated to assess its structural degree at birth...
June 26, 2018: Journal of Anatomy
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