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https://www.readbyqxmd.com/read/30105973/intranasal-delivery-of-a-formulation-containing-stage-specific-recombinant-proteins-of-fasciola-hepatica-cathepsin-l5-and-cathepsin-b2-triggers-an-anti-fecundity-effect-and-an-adjuvant-mediated-reduction-in-fluke-burden-in-sheep
#1
Luke J Norbury, Katarzyna Basałaj, Anna Zawistowska-Deniziak, Alicja Sielicka, Przemysław Wilkowski, Agnieszka Wesołowska, Peter M Smooker, Halina Wędrychowicz
Fasciola hepatica infection continues to be a major problem in the agriculture sector, particularly in sheep and cattle. Cathepsin L and B proteases are major components of the excretory/secretory material of the parasite, and their roles in several important aspects of parasite invasion and survival has led to their use as targets in rational vaccine design. Previous studies in rats demonstrated that the use of stage-specific antigens, cathepsin B2 and cathepsin L5, as part of a multivalent vaccine, was able to confer significant protection against challenge...
July 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/30104094/a-comparison-of-induced-effects-on-urinary-calcium-by-thiazides-and-different-dietary-salt-doses-implications-in-clinical-practice
#2
María Martínez García, Pablo Trincado Aznar, Leticia Pérez Fernández, Isabel Azcona Monreal, María Elena López Alaminos, Javier Acha Pérez, Ramón Albero Gamboa
INTRODUCTION: Both dietary restriction of sodium chloride (NaCl) and treatment with thiazides have been used in hypercalciuric patients. OBJECTIVES: To calculate regular salt intake and investigate the correlation between natriuresis and urinary calcium with usual diet (B) and after changing the amount of NaCl intake and administration of thiazides. MATERIAL AND METHODS: Nineteen healthy young individuals had their diet replaced by 2l of Nutrison® Low Sodium (500mg sodium/day) daily for two days...
August 10, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/30089434/investigation-of-a-novel-gradient-degradable-ureteral-stent-in-a-beagle-dog-model
#3
Lu Jin, Lei Yao, Yan Zhou, Guangcheng Dai, Wenfang Zhang, Boxin Xue
Ureteral stents are widely used in the department of urology, while the stent could result in many stent-associated complications, such as encrustation, a forgotten stent and patient discomfort. Thus, we developed a novel gradient degradable ureteral stent, which could degrade gradient in vivo, and assessed its effectiveness of the drainage, degradation and biocompatibility in a beagle dog model. In the present study, the degradation time and cytotoxicity were investigated in vitro. And the beagle dogs were inserted with a degradable stent or a biostable stent, and blood studies, liver function tests, renal function tests, urine studies, X-ray, excretory urograms and computerized tomography were performed at immediately, two weeks, four weeks and six weeks postoperative...
August 8, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/30077796/neural-and-endocrine-regulation-of-osmoregulatory-organs-in-tick-recent-discoveries-and-implications
#4
REVIEW
Donghun Kim, Ladislav Šimo, Marie Vancová, Joshua Urban, Yoonseong Park
Ticks can survive in harsh and fluctuating vegetated environments for long durations between blood feedings with highly developed osmoregulatory mechanisms. Like the unique life history of hematophagous ticks, osmoregulatory organs and their regulatory mechanisms are significantly different from those in the closely related insect taxa. Over the last ten years, research has uncovered several neuropeptidergic innervations of the primary osmoregulatory organ, the salivary glands: myoinhibitory peptide (MIP), SIFamide, and elevenin...
August 2, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/30073616/discontinuation-of-renal-replacement-therapy-in-critically-ill-patients-with-severe-acute-kidney-injury-predictive-factors-of-renal-function-recovery
#5
REVIEW
Helmut Schiffl
INTRODUCTION: Severe acute kidney injury (AKI-D) is common in critically ill patients and contributes substantially to short- and long-term morbidity and mortality. Acute renal replacement therapy (RRT) is an increasingly widely utilized life-sustaining support strategy for AKI-D patients, providing a bridge to renal recovery in many survivors of AKI. However, key aspects (when and how) of this therapy's appropriate cessation remain unclear. Today, wide variation in clinical practice exists regarding the indication for and the timing of RTT discontinuation, likely due to the poor current evidence base...
August 2, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30061894/the-serine-threonine-protein-phosphatase-1-from-haemonchus-contortus-is-actively-involved-in-suppressive-regulatory-roles-on-immune-functions-of-goat-peripheral-blood-mononuclear-cells
#6
Muhammad Ehsan, WenJuan Wang, Javaid Ali Gadahi, Muhammad Waqqas Hasan, MingMin Lu, YuJian Wang, XinChao Liu, Muhammad Haseeb, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li
Serine/threonine-protein phosphatases (STPs), as integral constituents of parasitic excretory/secretory proteins, are assumed to be released during the host-parasite interactions. However, knowledge about these phosphatases and their immunoregulatory and immune protective efficiencies with host peripheral blood mononuclear cells (PBMCs) is scant. In this study, an open reading frame of STP from Haemonchus contortus designated as HcSTP-1 was amplified and cloned using reverse-transcription-polymerase chain reaction (RT-PCR) method...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30056980/the-somatic-proteins-of-toxocara-canis-larvae-and-excretory-secretory-products-revealed-by-proteomics
#7
Márcia B da Silva, Juan R Urrego A, Yisela Oviedo, Philip J Cooper, Luis G C Pacheco, Carina S Pinheiro, Fátima Ferreira, Peter Briza, Neuza M Alcantara-Neves
Toxocariasis is a widespread helminth infection of dogs and cats, caused by Toxocara canis and Toxocara cati larvae, respectively. Toxocara spp. can cause zoonotic infections in humans by invading tissues and organs causing pathology. Toxocara spp. larvae release excretory-secretory molecules (TES) into the body of their host that are fundamental to the host-parasite interaction and could be used as targets for novel diagnostics and vaccines. In the present study, we identified 646 T. canis proteins from TES and larval extract using 1D-SDS PAGE followed by mass spectrometry...
August 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/30056671/relationship-between-saliva-and-blood-cortisol-in-handled-cows
#8
Melody Dzviti, Lizwell Mapfumo, Voster Muchenje
Objective: The objective of the study was to determine the relationship between plasma and salivary cortisol concentrations in beef cattle that were subjected to handling prior to sampling. Methods: Twenty-one Nguni cows of three age categories; 5-7yrs (n= 7), 8-10yrs (n=6) and 11-13yrs (n=8) were handled for five consecutive weeks. In the pen, a human avoidance test was performed and cattle responses to restraint in the chute and crush were observed. In addition, faecal samples were collected and analysed for glucocorticoid metabolites, and rectal temperature readings were taken...
July 26, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/30040720/urine-based-biomarkers-for-alzheimer-s-disease-identified-through-coupling-computational-and-experimental-methods
#9
Fang Yao, Xiaoyu Hong, Shuiming Li, Yan Zhang, Qing Zhao, Wei Du, Yong Wang, Jiazuan Ni
Alzheimer's disease (AD) is a chronic neurodegenerative disorder contributing to nearly 70% of dementia cases. However, no diagnostic protein biomarkers are available in urine. In this study, we combined computational and experimental methods to identify urinary biomarkers for AD. First, by analyzing brain tissue-based gene expression data of AD, 2,754 differentially expressed genes were identified, 559 of which were predicted to encode urine-excretory proteins that might act as candidate protein biomarkers of AD...
July 18, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/30033092/significant-apoptosis-rather-autophagy-predominates-in-astrocytes-caused-by-toxocara-canis-larval-excretory-secretory-antigens
#10
Chia-Mei Chou, Chia-Kwung Fan
BACKGROUND/PURPOSE: Toxocariasis is a worldwide parasitic zoonosis and mainly caused by Toxocara canis. Humans can be infected by accidental ingestion of T. canis embryonated ova through contacting with contaminated food, water, or encapsulated larvae in paratenic hosts' viscera or meat. Since humans are the paratenic host of T. canis, the wandering and neuroinvasive larvae can cause mechanical tissue damage and the excretory-secretory antigens (TcES Ag) might induce neuroinflammatory responses in the brain...
July 11, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/30019233/-diagnostics-and-treatment-of-lacrimal-duct-diseases-a-structured-patient-centred-care-concept
#11
REVIEW
J Heichel, H-G Struck, A Glien
BACKGROUND: The cardinal symptom of lacrimal stenosis is epiphora and a subjective high level of discomfort due to continuous dacryorrhea. OBJECTIVE: The aim of the current paper is to present a structured review of common diagnostic and therapeutic strategies for lacrimal stenosis. MATERIALS AND METHODS: The most important diagnostic and therapeutic approaches are analysed using the existing literature and by reporting the authors' own experiences...
July 17, 2018: HNO
https://www.readbyqxmd.com/read/30006888/effects-of-lead-and-lead-melatonin-exposure-on-protein-and-gene-expression-of-metal-transporters-proteins-and-the-copper-zinc-ratio-in-rats
#12
Karla J Soto-Arredondo, Juvencio Robles, Erik Díaz-Cervantes, Carolina Ruiz-Ramírez, Marco A García-Revilla, Katarzyna Wrobel, Kazimierz Wrobel, Mauricio Díaz-Muñoz, Isabel Méndez, Alberto Flores, Francisco Javier Acevedo-Aguilar, Minerva Martínez-Alfaro
Human lead (Pb) exposure induces many adverse health effects, including some related to lead accumulation in organs. Although lead bio-distribution in the body has been described, the molecular mechanism underlying distribution and excretion is not well understood. The transport of essential and toxic metals is principally mediated by proteins. How lead affects the expression of metal transporter proteins in the principal metal excretory organs, i.e., the liver and kidney, is unknown. Considering that co-administration of melatonin and lead reduces the toxic effects of lead and lead levels in the blood in vivo, we examined how lead and co-administration of lead and melatonin affect the gene and protein expression of metal transporter proteins (ZIP8, ZIP14, CTR1 and DMT1) in these organs...
July 13, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30006035/genome-wide-analysis-of-excretory-secretory-proteins-in-trypanosoma-brucei-brucei-insights-into-functional-characteristics-and-identification-of-potential-targets-by-immunoinformatics-approach
#13
Gowdham Manivel, Arun Meyyazhagan, Ruban Durairaj D, Shanmughavel Piramanayagam
Trypanosoma brucei brucei (T.b.brucei) is an extra-cellular parasite that causes Animal African Trypanosomiasis (AAT) disease in animals. Till day, this disease is more difficult to treat and control due to lack of efficient vaccines and early diagnosis of the parasite infection. T.b.brucei Excretory/Secretory (ES) proteins were involved in pathogenesis and key for understanding the host-parasite interactions. Functions of T.b.brucei's ES proteins were poorly investigated and experimental identification is expensive and time-consuming...
July 10, 2018: Genomics
https://www.readbyqxmd.com/read/30004810/role-of-the-heart-in-blood-pressure-lowering-during-chronic-baroreflex-activation-insight-from-an-in-silico-analysis
#14
John S Clemmer, William Andrew Pruett, Robert L Hester, Radu Iliescu, Thomas E Lohmeier
Electrical stimulation of the baroreflex chronically suppresses sympathetic activity and arterial pressure and is currently being evaluated for the treatment of resistant hypertension. The antihypertensive effects of baroreflex activation are often attributed to renal sympathoinhibition. However, baroreflex activation also decreases heart rate, and robust blood pressure lowering occurs even after renal denervation. Because controlling renal sympathetic nerve activity and cardiac autonomic activity cannot be achieved experimentally, we used an established mathematical model of human physiology (HumMod) to provide mechanistic insight into their relative and combined contributions to the cardiovascular responses during baroreflex activation...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29997362/gut-microbiota-and-cardiovascular-uremic-toxicities
#15
REVIEW
Manuel T Velasquez, Patricia Centron, Ian Barrows, Rama Dwivedi, Dominic S Raj
Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD or increased mortality rates in CKD patients. In CKD the loss of urinary excretory function results in the retention of various substances referred to as "uremic retention solutes". Many of these molecules have been found to exert toxicity on virtually all organ systems of the human body, leading to the clinical syndrome of uremia...
July 11, 2018: Toxins
https://www.readbyqxmd.com/read/29996630/opisthorchis-felineus-and-metorchis-bilis-metacercariae-in-cyprinid-fish-leuciscus-idus-in-nura-sarysu-river-kazakhstan
#16
Vladimir S Kiyan, Aitbay K Bulashev, Aleksey V Katokhin
Aim of the present study was to provide presence of opisthorchiid metacercariae in cyprinid fish Leuciscus idus in Nura-Sarysu river, Kazakhstan. Infection rate of the ides by the metacercariae was 42%. The metacercariae, similar morphologically to those of the liver flukes, were found: elliptical in shape, 0.19-0.25×0.15-0.22 mm, oral and ventral suckers nearly equal size, and excretory bladder O-shape with black content, occupying posterior part of the body. The metacercariae were divided into 2 groups with differences in size and thickness of cyst wall...
June 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29990477/assessment-of-fasciola-hepatica-glutathione-s-transferase-as-an-antigen-for-serodiagnosis-of-human-chronic-fascioliasis
#17
Vasti Aguayo, Bianca Valdes, Ana M Espino
Due to the unsatisfactory performance of parasitological diagnosis of human fascioliasis; the use of immunodiagnosis based on the detection of anti-Fasciola antibodies is traditionally used as a diagnostic alternative using total or purified parasite excretory-secretory products (ESPs). Glutathione S-transferase (GST) protein, one of the F. hepatica ESP components, possesses well-known roles in the detoxification of xenobiotic and endogenously derived toxins within the host bile environment. GST has shown to be a good target for vaccine or drug development against fascioliasis...
October 2018: Acta Tropica
https://www.readbyqxmd.com/read/29988351/molecular-cloning-and-characterization-of-the-endothelin-3-gene-in-black-bone-sheep
#18
Hesham Y A Darwish, Yuanyuan Zhang, Kai Cui, Zu Yang, Deping Han, Xianggui Dong, Huaming Mao, Weidong Deng, Xuemei Deng
Background: Black bone sheep was first discovered in Yunnan province of China in 1970, with unique black pigmentation on the body and internal organs. Endothelin 3 ( EDN3 ) has been known as a key gene causing hyperpigmentation in black bone chicken, the Silky fowl. Methods: In this study, EDN3 was employed as a candidate gene for regulating black color pigmentation. First, EDN3 was cloned from sheep to obtain the full-length cDNA by using the rapid amplification of cDNA ends (RACE)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29987358/association-of-qualitative-and-quantitative-imaging-features-on-multiphasic-multidetector-ct-with-tumor-grade-in-clear-cell-renal-cell-carcinoma
#19
Heidi Coy, Jonathan R Young, Michael L Douek, Alan Pantuck, Matthew S Brown, James Sayre, Steven S Raman
PURPOSE: The purpose of the study was to determine if enhancement features and qualitative imaging features on multiphasic multidetector computed tomography (MDCT) were associated with tumor grade in patients with clear cell renal cell carcinoma (ccRCC). METHODS: In this retrospective, IRB approved, HIPAA-compliant, institutional review board-approved study with waiver of informed consent, 127 consecutive patients with 89 low grade (LG) and 43 high grade (HG) ccRCCs underwent preoperative four-phase MDCT in unenhanced (UN), corticomedullary (CM), nephrographic (NP), and excretory (EX) phases...
July 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29975779/physiological-processes-and-gross-energy-budget-of-the-submerged-longline-cultured-pacific-oyster-crassostrea-gigas-in-a-temperate-bay-of-korea
#20
Young-Jae Lee, Eunah Han, Michael J Wilberg, Won Chan Lee, Kwang-Sik Choi, Chang-Keun Kang
Physiological processes and gross energy budget of the longline-cultured Pacific oyster Crassostrea gigas were investigated in Geoje-Hansan Bay, Korea during two entire culturing periods. Based on physiological measurements of food consumption, feces production, ammonium excretion, and respiration from July 2008 to February 2009 and from July 2013 to February 2014, scope for growth appeared to be positive during most of the culturing period, except for one period with extremely high temperatures (up to 25°C)...
2018: PloS One
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