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Viral anterior uveitis

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https://www.readbyqxmd.com/read/30096015/review-for-disease-of-the-year-treatment-of-viral-anterior-uveitis-a-perspective
#1
Souska Zandi, Bahram Bodaghi, Justus G Garweg
PURPOSE: To define a clinically tailored therapeutic strategy for the treatment of viral anterior uveitis (VAU). METHODS: A PubMed search spanning the past 5 years was conducted using the MesH-terms "viral anterior uveitis" and "therapy." RESULTS: The herpes simplex virus (HSV), the varicella zoster virus (VZV), and the cytomegalovirus (CMV) are the predominant pathogens in VAU. Other viruses, including rubella, chikungunya, and zika, have been linked with distinct forms of the disease...
August 10, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/30075555/retinitis-associated-with-double-infection-of-epstein-barr-virus-and-varicella-zoster-virus-a-case-report
#2
Tomohito Sato, Riki Kitamura, Toshikatsu Kaburaki, Masaru Takeuchi
RATIONALE: Chronic uveitis with immunosuppressive agents could develop chronic herpetic retinitis with varicella-zoster virus (VZV) or herpes simplex virus (HSV). Ocular Epstein-Barr virus (EBV) infection develops uveitis and vitritis, but the clinical feature of EBV retinitis is not typical as a viral retinitis. EBV retinitis is rare, and only a few cases of EBV retinitis have been reported. Herein, we describe a case of retinitis with EBV and VZV which were the primary viruses verified by multiplex polymerase chain reaction (PCR)...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30018526/ocular-changes-in-metastatic-melanoma-patients-treated-with-mek-inhibitor-cobimetinib-and-braf-inhibitor-vemurafenib
#3
Ana Ursula Gavric, Janja Ocvirk, Polona Jaki Mekjavic
Background: Mitogen-activated protein kinase kinase (MEK) inhibitor cobimetinib and V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitor vemurafenib have significantly improved the prognosis of BRAF-mutated metastatic melanoma. Some ocular symptoms and signs were recently recognized to follow this treatment. The study was aimed to investigate ocular toxicity in patients with metastatic melanoma treated with cobimetinib in combination with vemurafenib. Patients and methods: In the prospective, observational study, patients with BRAF-mutated metastatic melanoma treated with cobimetinib in combination with vemurafenib at the Institute of Oncology Ljubljana were asked to participate...
June 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29993303/clinical-manifestations-and-pathogenesis-of-uveitis-in-ebola-virus-disease-survivors
#4
Steven Yeh, Jessica G Shantha, Brent Hayek, Ian Crozier, Justine R Smith
In the wake of the international Ebola virus disease (EVD) outbreak from 2014 to 2016, thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic sequelae including arthralgias, abdominal pain, psychosocial stressors, and risk of viral persistence in immune-privileged organs. Ophthalmic manifestations in EVD survivors include a spectrum of disease ranging from anterior uveitis to panuveitis, which confers a high risk of vision impairment and blindness, particularly given the access and resource limitations for ophthalmic subspecialty care in West Africa...
July 11, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29969370/virus-induced-anterior-uveitis-viau-in-immunocompromised-patients
#5
Alejandra de-la-Torre
PURPOSE: To describe the clinical characteristics, diagnosis, and treatment of VIAU in immunocompromised patients. METHODS: A critical review of literature was performed. RESULTS: Diagnosis and treatment of VIAU in immunocompromised patients may be a challenge due to atypical clinical-courses, severe presentations, and more frequent recurrences. A conclusive diagnosis can be made by aqueous-humour PCR-analysis. Visual prognosis depends on early diagnosis and prompt treatment...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29944680/different-composition-of-intraocular-immune-mediators-in-posner-schlossman-syndrome-and-fuchs-uveitis
#6
Dominika Pohlmann, Stephan Schlickeiser, Sylvia Metzner, Matthias Lenglinger, Sibylle Winterhalter, Uwe Pleyer
Posner-Schlossman-Syndrome (PSS) is clinically characterized by acute, recurrent, mild, unilateral uveitis anterior accompanied by elevated intraocular pressure (IOP). Fuchs´ Uveitis (FU) is a chronic, low-grade-inflammatory disorder, involving anterior uvea and vitreous. The clinical findings show remarkable similarities as well as differences. In our study, we determine the composition of immune mediators in aqueous humor of patients with PSS and FU and evaluate if immune mediators play a crucial role in specific viral intraocular inflammation and IOP rises...
2018: PloS One
https://www.readbyqxmd.com/read/29869892/differential-diagnosis-of-viral-induced-anterior-uveitis
#7
Lia Judice Relvas, Laure Caspers, Soon-Phaik Chee, Manfred Zierhut, François Willermain
Diagnosis of uveitis is often challenging, but can be easy in typical viral-induced anterior uveitis (VIAU). Associated symptoms and signs are an important source of information. Certain classical clinical features such as keratic precipitates (KPs) distribution, iris atrophy, elevated intraocular pressure (IOP), and unilaterality are commonly used to support the diagnosis of VIAU. However, many etiologies of anterior uveitis may to a certain extent mimic VIAU, especially the ones with unilateral granulomatous KPs and elevated IOP...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29780935/two-cases-of-cytomegalovirus-panuveitis-in-immunocompetent-patients
#8
Masato Sakai, Hiroshi Takase, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Susumu Ishida
Purpose: To report two cases of panuveitis in immunocompetent patients in which cytomegalovirus was involved. Observation: Case 1 was a 46-year-old man who had a history of recurrent anterior chamber inflammations in his left eye. After Nd:YAG laser posterior capsulotomy, he developed panuveitis with vitreous haze and periphlebitis. Polymerase chain reaction (PCR) examination revealed the presence of cytomegalovirus (CMV) DNA in the anterior chamber (AC). He responded well to a series of intravitreal injections of ganciclovir (GCV)...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29582812/changing-uveitis-patterns-in-south-india-comparison-between-two-decades
#9
COMPARATIVE STUDY
Jyotirmay Biswas, Ranju Kharel Sitaula, Priyansha Multani
Purpose: Changing pattern of uveitis in a subset of a population is an important ocular health indicator. Methods: A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test. Results: In 2013, 352 new uveitis cases were examined. Males 56%, females 44%; unilateral 30.4%; bilateral in 69.6%. A specific diagnosis achieved in 66.2%. Anterior uveitis was seen in 35.22%, intermediate uveitis in 30.11%, posterior uveitis in 25%, and panuveitis in 9...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29543540/immunopathology-of-virus-induced-anterior-uveitis
#10
REVIEW
Jolanda D F De Groot-Mijnes, Anita S Y Chan, Soon-Phaik Chee, Georges M G M Verjans
Herpes simplex virus, varicella zoster virus, human cytomegalovirus, and rubella virus are the most common causes of virus-induced anterior uveitis. They can present in a variety of entities not only with typical but also overlapping clinical characteristics. These viral infections are commonly associated with ocular infiltration of T cells and B/plasma cells, and expression of cytokines and chemokines typical of a proinflammatory immune response. The infections differ in that the herpes viruses cause an acute lytic infection and inflammation, whereas rubella virus is a chronic low-grade infection with slowly progressing immunopathological responses...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29474137/pcr-multiplex-for-cmv-detection-in-patients-with-anterior-uveitis
#11
Alexandra Martín Ramírez, Laura Cardeñoso Domingo, J Jacobo González Guijarro
PURPOSE: Describing the utility of Polymerase Chain Reaction for Cytomegalovirus (CMV-PCR) in the diagnosis of suspected viral anterior uveitis (AU). PATIENTS AND METHODS: We analyzed aqueous humor (AH) CMV-PCR positivity and treatment modifications in 47 eyes of 46 patients with viral uveitis and its correlation with high intraocular pressure (HIOP), uveitis clinical characteristics and time intervals from samples to uveitis diagnosis and to relapse. RESULTS: CMV-PCR positive results occurred in 13 eyes (27...
February 23, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29345511/clinical-characteristics-of-herpes-simplex-virus-associated-anterior-uveitis
#12
REVIEW
Barbara Wensing, Manabu Mochizuki, Joke H De Boer
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29070018/hemorrhagic-hypopyon-as-presenting-feature-of-intravascular-lymphoma-a-case-report
#13
Andrew Winegarner, Noriyasu Hashida, Shizuka Koh, Kohji Nishida
BACKGROUND: Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result. CASE PRESENTATION: We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia...
October 25, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29023181/review-for-disease-of-the-year-varicella-zoster-virus-induced-anterior-uveitis
#14
Ilknur Tugal-Tutkun, Luca Cimino, Yonca Aydin Akova
Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020537/challenges-of-diagnosing-viral-anterior-uveitis
#15
REVIEW
Fahriye Groen-Hakan, Kalpana Babu, Ilknur Tugal-Tutkun, Kessara Pathanapithoon, Joke H de Boer, Justine R Smith, Jolanda D F de Groot-Mijnes, Aniki Rothova
The viral causes of anterior uveitis (AU) emerged with the use of novel molecular diagnostic tests and serologic tests adapted for small volumes (Goldmann-Witmer Coefficient). The viral causes of AU may be underestimated, and some of the presumed idiopathic AU cases will probably be proven to be of viral origin in the coming years. So far, a viral origin of AU was suspected in patients who presented with unilateral hypertensive AU. It is not clear which clinical presentations should raise a suspicion of viral etiology...
October 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28666730/risk-factors-for-secondary-glaucoma-in-herpetic-anterior-uveitis
#16
Lisette Hoeksema, Nomdo M Jansonius, Leonoor I Los
PURPOSE: To determine the incidence of elevated intraocular pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), owing to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma. DESIGN: Retrospective observational cohort study. METHODS: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28619012/genetic-analysis-of-varicella-zoster-virus-in-the-aqueous-humor-in-uveitis-with-severe-hyphema
#17
Mayumi Hosogai, Yoko Nakatani, Kensuke Mimura, Shoji Kishi, Hideo Akiyama
BACKGROUND: Genetic variations have been identified in the genome of varicella-zoster virus (VZV) strains using vesicle fluid, varicella scabs and throat swab samples. We report a rare case of VZV-associated uveitis with severe hyphema, which was immediately diagnosed by polymerase chain reaction (PCR) using the aqueous humor, in which we were able to analyze the VZV genotype for the first time. CASE PRESENTATION: A 16-year-old Japanese boy was referred to our hospital with a 20-day history of unilateral anterior uveitis and 11-day history of hyphema...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28602016/long-term-results-of-cataract-surgery-in-patients-with-anterior-uveitis
#18
Ozgur Balta, Gulten Sungur, Mehmet Akif Acar, Mustafa Kosker, Mehmet Yakin, Firdevs Ornek
PURPOSE: This study was aimed to assess the long-term results of phacoemulsification and posterior chamber intraocular lens implantation in patients with anterior uveitis. METHODS: Patients with complicated cataract secondary to anterior uveitis who underwent phacoemulsification and posterior chamber intraocular lens implantation were included in this study. Long-term results and all complications were evaluated throughout the postoperative 4 years. RESULTS: A total of 55 eyes of 48 patients were identified in this study...
August 2018: International Ophthalmology
https://www.readbyqxmd.com/read/28240260/enhanced-cytomegalovirus-infection-in-human-trabecular-meshwork-cells-and-its-implication-in-glaucoma-pathogenesis
#19
Jin A Choi, Ju-Eun Kim, Seung-Jun Noh, Eun Kyoung Kim, Chan Kee Park, Soon-Young Paik
Cytomegalovirus (CMV) is one of the infectious causes of hypertensive anterior uveitis, which is characterized by recurrent episodes of elevated intraocular pressure (IOP) and mild anterior uveitis. Despite the potentially vision-threatening complications of this disease, the underlying mechanisms remain largely undefined. We aimed to investigate whether human trabecular meshwork (TM) cells, the key cell type that regulates IOP, could support CMV replication, as well as demonstrate the relevant pathological changes in TM...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115874/optic-neuritis-and-acute-anterior-uveitis-associated-with-influenza-a-infection-a-case-report
#20
Hayate Nakagawa, Hidetaka Noma, Osamu Kotake, Ryosuke Motohashi, Kanako Yasuda, Masahiko Shimura
BACKGROUND: A few reports have described ocular complications of influenza A infection, such as impaired ocular movement, parasympathetic ocular nerve, keratitis, macular lesion, and frosted branch angiitis. We encountered a rare case of acute anterior uveitis and optic neuritis associated with influenza A infection. CASE PRESENTATION: A 70-year-old man presented with symptoms of upper respiratory tract infection. A rapid diagnostic test showed a positive result for influenza A...
2017: International Medical Case Reports Journal
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