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Igfpb-2

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https://www.readbyqxmd.com/read/18463107/homozygous-and-heterozygous-expression-of-a-novel-mutation-of-the-acid-labile-subunit
#1
H A van Duyvenvoorde, M J E Kempers, Th B Twickler, J van Doorn, W J Gerver, C Noordam, M Losekoot, M Karperien, J M Wit, A R M M Hermus
CONTEXT: Acid-labile subunit (ALS) deficiency due to homozygous inactivation of the ALS gene (IGFALS) is associated with moderate short stature, and in few cases pubertal delay. The clinical expression of heterozygosity is unknown. OBJECTIVE: To investigate the clinical, laboratory, and radiological features of homozygous and heterozygous carriers of a novel mutation in the ALS gene in comparison with non-carriers. SUBJECTS: Three short Kurdish brothers and their relatives...
August 2008: European Journal of Endocrinology
https://www.readbyqxmd.com/read/18420611/growth-hormone-receptor-insulin-like-growth-factor-igf-1-and-igf-binding-protein-2-expression-in-the-reproductive-tissues-of-early-postpartum-dairy-cows
#2
M L Rhoads, J P Meyer, S J Kolath, W R Lamberson, M C Lucy
The growth hormone/insulin-like growth factor (IGF) system plays a critical endocrine role controlling nutrient metabolism in dairy cattle. In liver, growth hormone receptor (GHR) and IGF-1 are dynamically regulated by lactation and energy balance. Less is known about the regulation of GHR, IGF-1, and IGF-binding protein mRNA in reproductive tissues (uterus, ovarian follicle, and corpus luteum). The objective was to determine expression patterns for GHR, IGF-1, and IGF-binding protein (IGFBP)-2 mRNA in the liver, uterus, dominant follicle, and corpus luteum in Holstein cows (n = 21) sampled at 3 times during early lactation...
May 2008: Journal of Dairy Science
https://www.readbyqxmd.com/read/1717246/the-ovarian-expression-of-the-antigonadotropic-insulin-like-growth-factor-binding-protein-2-is-theca-interstitial-cell-selective-evidence-for-hormonal-regulation
#3
E Ricciarelli, E R Hernandez, A Hurwitz, E Kokia, R G Rosenfeld, J Schwander, E Y Adashi
To begin the process of identification and charactization of rat ovarian insulin-like growth factor binding proteins, we have undertaken to explore the ovarian expression, cellular localization, and hormonal regulation of the insulin-like growth factor binding protein-2 (IGFBP-2) gene for which an antigonadotropic potential has recently been demonstrated. To this end, a solution hybridization/RNase protection assay was employed wherein total ovarian RNA (20 micrograms) from immature (21-23 days old) female rats was hybridized with a [32P]-labeled IGFBP-2 riboprobe...
October 1991: Endocrinology
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