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Metastatic osteosarcoma

Steven Georges, Lidia Rodriguez Calleja, Camille Jacques, Melanie Lavaud, Brice Moukengue, Fernando Lecanda, Thibaut Quillard, Marta Tellez Gabriel, Pierre-François Cartron, Marc Baud'huin, François Lamoureux, Dominique Heymann, Benjamin Ory
The metastatic dissemination is a complex multistep process by which tumor cells from a primary site enter into the systemic circulation to finally spread at distant sites. Even if this mechanism is rare at the tumor level, it remains the major cause of Osteosarcoma-patients' relapse and mortality. MicroRNAs (miRNAs) have recently been described as novel epigenetics' genes' expression regulators actively implicated in cancer progression and dissemination. The understanding of their implication in the metastatic spreading could help clinicians to improve the outcome of osteosarcoma...
November 6, 2018: Oncotarget
Shuli Fan, Xiang Gao, Peng Chen, Xu Li
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents, and metastatic OS is the major cause of OS-related death. Carboxypeptidase E (CPE) is demonstrated to be highly expressed in some cancer types, and its N-terminal truncated form, CPE-ΔN, is implicated in tumor metastasis and poor prognosis. In this study, we investigated the effect of CPE-ΔN on cell migration, invasion and epithelial-mesenchymal transition (EMT) of OS cells, and illustrated the molecular mechanisms. We first constructed CPE-ΔN overexpressing human OS cell lines (143B and U2OS cells), and found that ectopic CPE-ΔN expression in OS cells enhanced cellular migratory and invasiveness abilities, and promoted EMT process...
December 3, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Jahnabi Roy, Payam Dibaeinia, Timothy M Fan, Saurabh Sinha, Aditi Das
Osteosarcoma (OS) is the most common form of primary bone cancer in humans. The early detection and subsequent control of metastasis has been challenging in OS. Lipids are important constituents of cells that maintaining structural integrity that can be converted into lipid signaling molecules and are reprogrammed in cancerous states. Herein, we investigate the global lipidomic differences in metastatic (143B) and non-metastatic (HOS) human OS cells as compared to normal fetal osteoblast cells (FOB) using lipidomics...
November 30, 2018: Journal of Lipid Research
Hao Yao, Bo Wang, Lili Wen, Qinglin Jin, Hongbo Li, Gang Huang, Junqiang Yin, Changye Zou, Xianbiao Xie, Jingnan Shen
BACKGROUND: The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences. METHODS: From Jaunary 2000 to February 2015, 28 patients with non-metastatic proximal fibular osteosarcoma and 214 patients with non-metastatic proximal tibial osteosarcoma underwent surgery were identified in our center. All clinical data were analyzed retrospectively...
November 29, 2018: BMC Cancer
Dolly Patricia Pardo Mora, Karina Basso Santiago, Bruno José Conti, Eliza de Oliveira Cardoso, Fernanda Lopes Conte, Lucas Pires Garcia Oliveira, Marjorie de Assis Golim, Jaime Fabian Cruz Uribe, Rafael María Gutiérrez, Mauricio Rey Buitrago, Milena Popova, Boryana Trusheva, Vassya Bankova, Orlando Torres García, José Maurício Sforcin
Osteosarcoma (OSA) is a type of bone cancer showing an aggressive biological behavior with metastatic progression. Because propolis potential for the development of new antitumoral drugs has been indicated, we evaluated the chemical composition of Colombian propolis samples and the mechanisms involved in their cytotoxic effects on OSA cells. The chemical composition was analyzed by GC-MS and the DPPH free radical scavenging activity was measured. Cluster and principal components analysis were used to establish an association with their inhibitory concentration 50% (IC50 )...
November 28, 2018: Phytotherapy Research: PTR
Dominique Heymann
No abstract text is available yet for this article.
November 23, 2018: Lancet Oncology
Florence Duffaud, Olivier Mir, Pascaline Boudou-Rouquette, Sophie Piperno-Neumann, Nicolas Penel, Emanuelle Bompas, Corinne Delcambre, Elsa Kalbacher, Antoine Italiano, Olivier Collard, Christine Chevreau, Esma Saada, Nicolas Isambert, Jessy Delaye, Camille Schiffler, Corinne Bouvier, Vincent Vidal, Sylvie Chabaud, Jean-Yves Blay
BACKGROUND: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. In this Article, we report the results of the osteosarcoma cohort. METHODS: In this non-comparative, double-blind, placebo-controlled, phase 2 trial, patients aged 10 years or older with histologically confirmed osteosarcoma whose disease had progressed after treatment with one to two previous lines of chemotherapy for metastatic disease and an Eastern Cooperative Oncology Group performance status of 0 or 1 were enrolled...
November 23, 2018: Lancet Oncology
Anita K Luu, Courtney R Schott, Robert Jones, Andrew C Poon, Brandon Golding, Roa'a Hamed, Benjamin Deheshi, Anthony Mutsaers, Geoffrey A Wood, Alicia M Viloria-Petit
BACKGROUND: Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression. The role of Hippo signalling effectors TAZ and YAP has never been addressed in canine OSA. Further, the cooperative role of TGFβ and Hippo signalling has yet to be explored in osteosarcoma. To address these gaps, this study investigated the prognostic value of TAZ and YAP alone and in combination with pSmad2 (a marker of active TGFβ signalling), as well as the involvement of a TGFβ-Hippo signalling crosstalk in tumourigenic properties of OSA cells in vitro...
November 26, 2018: BMC Veterinary Research
Qiyuan Bao, Yuhui Shen, Weibin Zhang
No abstract text is available yet for this article.
November 19, 2018: Annals of Surgical Oncology
Bin Liu, Liang Xu, E-Nuo Dai, Jia-Xin Tian, Jian-Min Li
Osteosarcoma (OS) is the most common primary malignancy of skeleton with higher mortality rates among children and young adults worldwide, whereas effective and secure therapies have also been sought by researches with ongoing efforts. The purpose of this study was to investigate the impact of MDA19 on OS and explore its potential mechanism. Cell Counting Kit-8 (CCK8) and colony formation assay were employed to evaluate the potential effect of MDA19 on U2OS and MG-63 cells proliferation. Moreover, transwell migration and invasion assay were performed to assess the influence of MDA19 on U2OS and MG-63 cells migration and invasion...
November 15, 2018: Bioscience Reports
Jamie T Caracciolo, Evita Henderson-Jackson, Odion Binitie
Synovial sarcoma typically presents as periarticular soft tissue mass in adolescent and young adult patients. Very rarely, soft tissue sarcomas may arise primarily within bone posing a significant diagnostic challenge as primary osseous malignancies such as osteosarcoma and metastatic disease are much more common. While tissue sampling with immunohistochemical and genetic testing are required for definitive diagnosis, radiologists and orthopedic oncologists should consider alternate etiologies when typical imaging features of more common bone tumors are not identified...
February 2019: Radiology case reports
Zhigang Nie, Hao Peng
Only few systematic and comprehensive studies have focused on osteosarcoma in children and adolescents. In the present study, 3,085 patients with osteosarcoma were identified in the Surveillance, Epidemiology and End Results Program database. The patients were <25 years of age and diagnosed between 1973 to 2012. A retrospective study was performed to investigate the factors associated with tumor incidence, metastasis, treatment and survival. The results indicated that the incidence of osteosarcoma was higher in male patients compared with female patients...
November 2018: Oncology Letters
Angela Shaw, Miriam Morrell, Annikka Weissferdt, Andrea Hayes-Jordan, Douglas Harrison
Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission...
2018: Case Reports in Oncological Medicine
Rui Li, Yanlong Shi, Shiwei Zhao, Tingting Shi, Guichun Zhang
Osteosarcoma is a common primary bone malignancy, and distant metastasis limited the cure estimate during last decades. Detailed investigation of osteosarcoma metastasis is valuable for improving therapeutic strategy. Our study indicated increased integrin-β1 expression and NF-kB signaling activation in metastatic osteosarcoma tissues. Gain-of-function assays showed that integrin-β1 knockdown significantly inhibited osteosarcoma growth and metastasis, whereas exogenous reintroducing of integrin-β1 restored cell proliferation and metastasis in vitro and in vivo...
November 3, 2018: International Journal of Biological Macromolecules
Jie Wang, Di Wang, Xiaohui Niu, Zhijie Wang, Cheng-Li Song, Zhen Huang, Ke-Neng Chen, Jianchun Duan, Hua Bai, Jiachen Xu, Jun Zhao, Yu Wang, Minglei Zhuo, X Sunney Xie, Xiaozheng Kang, Yanhua Tian, Liangliang Cai, Jie-Fei Han, Tongtong An, Yu Sun, Shugeng Gao, Jun Zhao, Jianming Ying, Luhua Wang, Jie He
Osteosarcoma (OS) is the most common primary bone malignancy, and the lung is the most frequent site of metastasis. The limited understanding of the tumoral heterogeneity and evolutionary process of genomic alterations in pulmonary metastatic osteosarcoma impedes development of novel therapeutic strategies. Here we systematically illustrate the genomic disparities between primary tumors (PT) and corresponding pulmonary metastatic tumors (MT) by multiregional whole-exome and whole-genome sequencing in 86 tumor regions from 10 OS patients...
November 2, 2018: Cancer Research
Kritika Krishnamurthy, Sarah Alghamdi, Jyotsna Kochiyil, George F Bruney, Robert J Poppiti
Osteosarcoma is the most common primary malignant neoplasm of the bone with over 60% of the cases occurring in patients 10-20 years old. Osteosarcoma rarely occurs in patients older than 40 years of age, most commonly in bones affected by preexisting conditions such as Paget's disease, prior irradiated bone or osteogenesis imperfecta. Osteosarcoma presenting with pleural metastases is very rare. Herein we describe a case of metastatic osteosarcoma presenting with pleural effusion due to underlying pleural metastases in a 55 year old woman...
2018: Respiratory Medicine Case Reports
Huensuk Kim, Seungyeul Yoo, Ruoji Zhou, An Xu, Jeffrey M Bernitz, Ye Yuan, Andreia M Gomes, Michael G Daniel, Jie Su, Elizabeth G Demicco, Jun Zhu, Kateri A Moore, Dung-Fang Lee, Ihor R Lemischka, Christoph Schaniel
Osteosarcoma (OS), the most common primary bone tumor, is highly metastatic with high chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells (iPSCs) generated from Li-Fraumeni syndrome (LFS) patients, we investigate an oncogenic role of secreted frizzled-related protein 2 (SFRP2) in p53 mutation-associated OS development. Interestingly, we find that high SFRP2 expression in OS patient samples correlates with poor survival. Systems-level analyses identified that expression of SFRP2 increases during LFS OS development and can induce angiogenesis...
November 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Courtney R Schott, Latasha Ludwig, Anthony J Mutsaers, Robert A Foster, Geoffrey A Wood
Dogs diagnosed with appendicular osteosarcoma typically succumb to metastatic disease within a year of diagnosis. The current standard of care for curative intent, amputation followed by adjuvant chemotherapy, increases survival time but chemoresistance is a major contributor to mortality. Unfortunately, the mechanisms driving the progression of metastatic disease and the development of chemoresistance are unknown. One theory is that autophagy may contribute to chemoresistance by providing neoplastic cells with a mechanism to survive chemotherapy treatment...
2018: PloS One
Ghasem Farjanikish, Omid Dezfoulian, Hossein Mohammadi
A four-year-old male Persian cat was referred with three weeks history of progressive lameness due to a rigid osseous mass with 3.50×2.50×2.00 cm in dimensions in his left arm. In the histopathological evaluation of bone biopsy, two distinct populations of cells including multinucleated giant cells and oval cells which embedded in a fibro-osseous stroma and surrounded by lamellar bone trabeculae were observed. At necropsy, multiple metastatic nodules with different sizes unveiled in the liver and spleen. Microscopically, those tumor cells which already described in the bone lesion were also infiltrated to the liver and spleen...
2018: Veterinary Research Forum
Jason L Hornick
Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The following guidelines are helpful when approaching the diagnosis of a pleomorphic sarcoma. (1) Be aware of the relative incidence of the various sarcoma types: several pleomorphic sarcomas are relatively common (e.g., dedifferentiated liposarcoma and undifferentiated pleomorphic sarcoma), whereas others are exceptionally rare. (2) Pay attention to anatomic location: some pleomorphic sarcomas have a predilection for somatic soft tissues, especially the thigh (e...
October 11, 2018: Annals of Diagnostic Pathology
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