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Hwan Lee, Christopher R Gault, Gang Cheng, Jagruti C Shah, Austin R Pantel
A 34-year-old man with end-stage renal failure status post rejection of a deceased donor kidney transplant presented with bone pain in the setting of elevated serum parathyroid hormone and calcium levels. A Tc-MIBI SPECT/CT was performed before planned subtotal parathyroidectomy. SPECT/CT imaging revealed a 1.9-cm anterior mediastinal lesion with radiotracer uptake on both the immediate and delayed images. Surgical pathology of the lesion showed a benign thymic cyst with no parathyroid component.
December 3, 2018: Clinical Nuclear Medicine
François Somme, Cyrille Blondet, Julien Matuszak, Céline Heimburger
We report a case of a 69-year-old woman with primary hyperoxaluria type I, who developed a severe hypercalcemia despite controlled secondary hyperparathyroidism. Bone scintigraphy showed diffuse increased uptake in axial and peripheral skeleton. F-FDG PET/CT showed countless striking hypermetabolic foci, interesting 2 types of lesions (joint calcifications and periosteal resorptions). Bone biopsy demonstrated inflammatory changes around many calcium oxalate crystals; hypercalcemia was then related to oxalate osteopathy...
December 3, 2018: Clinical Nuclear Medicine
Fuqiang Shao, Dan Zhou, Xiaoli Lan
False negative I accumulation in metastatic lesions of thyroid carcinoma could be due to various etiologies. Here we present a 33-year-old woman with a history of papillary thyroid cancer who had increased Tc pertechnetate activity in the mediastinal metastatic lymph nodes, which was not clearly seen on whole body I scan due to adjacent activity from lung metastases.
December 3, 2018: Clinical Nuclear Medicine
Qingqing Pan, Xin Zhang, Yaping Luo, Yanru Ma, Fang Li
A 50-year-old woman was found with a hypervascular abdominal mass in the right lower quadrant in contrast-enhanced CT. Somatostatin receptor scintigraphy with Tc-HYNIC-TOC showed positivity of the abdominal mass and detected additional lesion with moderate increased radioactivity in the right axilla. In F-FDG PET/CT, both of the lesions were FDG-avid. A hypermetabolic node in the right supraclavicular fossa was also noted. The histopathological examination of the abdominal mass after surgical resection revealed Castleman disease, a mixed hyaline vascular and plasma cell variant...
December 3, 2018: Clinical Nuclear Medicine
Damien Legallois, Pierre-Yves Marie, Philippe R Franken, Wassila Djaballah, Denis Agostini, Alain Manrique
BACKGROUND: This study aimed to determine whether the repeatability of dyssynchrony assessment using gated myocardial perfusion SPECT (GSPECT) allows the detection of synchrony reserve during low-dose dobutamine infusion. METHODS AND RESULTS: Sixty-one patients with ischemic cardiomyopathy and LV ejection fraction < 50% were prospectively included in 10 centers. Each patient underwent two consecutive rest GSPECT with 99mTc-labeled tracer (either tetrofosmin or sestamibi) to assess the repeatability of LV function and dyssynchrony parameters, followed by a GSECT acquisition during low-dose dobutamine infusion...
December 4, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Reem H El-Gebaly, Monira M Rageh, Islam K Maamoun
BACKGROUND: SPECT MPI (Single photon emission computed tomography myocardial perfusion imaging) is an essential tool for diagnosis of cardiovascular disease, but it also involves considerable exposure to ionizing radiation. OBJECTIVE: To determine the radioprotective potential of lipoic acid free and nano-capsule against 99mTc-MIBI-induced injury in cardiovascular tissue. METHODS: The radioprotective ability was assessed by blood count, histopathology and heart enzymes in different groups of mice...
November 29, 2018: Journal of X-ray Science and Technology
Gustavo J Daquarti, Alejandro Meretta, Mariana Corneli, Juan P Costabel, Mirta Diez, Osvaldo H Masoli
Transthyretin cardiac amyloidosis (ATTR) is a restrictive cardiomyopathy that leads to heart failure in considerable number of patients. Early diagnosis allows specific treatment options. However, ATTR diagnosis is complex and requires invasive procedures. The utility of 99mTc-phosphate tracers for non-invasive diagnosis is well-known but the experience in Argentina is insufficient. The aim of this work was to assess the utility of 99m Tc-phosphate tracers for the diagnosis of ATTR. A total of 46 scintigraphies for detection of cardiac amyloidosis performed between September 2016 and January 2018 were analyzed...
2018: Medicina
Silvia Ceccanti, Francesco Cozzi, Alice Cervellone, Augusto Zani, Denis A Cozzi
AIM: We sought to assess the magnitude of functional decline and the natural history of the operated kidney residual function after zero-ischemia nephron-sparing surgery (Z-NSS) in children with unilateral renal tumor (URT). PATIENTS AND METHODS: 50 children were treated for URT at our surgical unit between 1992 and 2016. Of these 12 who underwent Z-NSS were available for the current analysis. Operated kidney function was assessed by 99mTc-dimercapto-succinic acid (DMSA) renal scintigraphy...
November 7, 2018: Journal of Pediatric Surgery
Nicola Salvarese, Davide Carta, Cristina Marzano, Gabriele Gerardi, Laura Melendez-Alafort, Cristina Bolzati
[99mTc][TcN-DBODC(5) is the lead candidate of a class of cationic complexes proposed as myocardial imaging agents (MPIAs). However, phase I clinical studies showed that its clinical properties were comparable to those of the commercially available agents. Thus, modification of [99mTc]TcN-DBODC(5), directed to obtain an ideal myocardial imaging without interference from the adjacent organ activities, is desirable. This work describes the pharmacological and pharmacokinetic development of four new complexes of general formula [99mTc][Tc(N)(DASD)(PNPn)]+, [99mTc]TcN-DASD(n) (DASD=1,4-dioxa-8-azaspiro[4,5]decandithiocarbamate; PNPn=bisphosphinoamine), proposed as improved MPIAs...
November 29, 2018: Journal of Medicinal Chemistry
Gang Wang, Erming Wu, Yang Wang, Heyun Huang, Yanfang Zhou, Zhiming Chen
OBJECTIVE: We aimed to design and synthesize a new macromolecule for sentinel node detection to improve the imaging quality and avoid possible adverse effect. BACKGROUND: The imaging of sentinel lymph node has been an important field in the nuclear medicine. A lot of imaging agents have been developed, including Tc-sulfer colloid, Tc-labeled dextrans and the latest Tc-DTPA-mannosyl-dextran. With the technology advanced, the imaging ability of the agents has been better and better...
November 19, 2018: Nuclear Medicine Communications
Filipe Leal Portilho, Suyene Rocha Pinto, Aline Oliveira da Silva de Barros, Edward Helal-Neto, Sofia Nascimento Dos Santos, Emerson Soares Bernardes, Derya Ilem-Ozdemir, Makbule Asikoglu, Luciana Magalhães Rebelo Alencar, Clenilton Costa Dos Santos, Eduardo Ricci-Junior, Félix Sancenón, Ramón Martínez-Máñez, Ralph Santos-Oliveira
Breast cancer is women's most common type of cancer, with a global rate of over 522,000 deaths per year. One of the main problems related to breast cancer relies in the early detection, as the specialized treatment. In this direction was developed, characterized and tested in vivo a smart delivery system, based on radiolabelled magnetic core mesoporous silica doped with trastuzumab as intralesional nanodrug for breast cancer imaging and possible therapy. The results showed that nanoparticles had a size of 58...
November 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Harkamal Singh, Daniel J Wale, Ka Kit Wong, Milton D Gross, Benjamin L Viglianti
In addition to nuclear cardiac and breast imaging, Tc-sestamibi scintigraphy is often used to localize parathyroid adenomas. F- fluorodeoxyglucose (FDG) PET is heavily utilized in oncology, although its use in identifying parathyroid adenomas is limited. We describe a case of a 57-year-old woman who underwent parathyroid scintigraphy and F-FDG PET/CT in the same week due to hyperparathyroidism and an enlarging breast mass, respectively. A right paratracheal mediastinal mass that otherwise would be suspicious for nodal metastases by CT alone was correctly identified to be an ectopic parathyroid adenoma using a combination of the nuclear medicine studies performed...
November 27, 2018: Clinical Nuclear Medicine
Katarzyna Holcman, Wojciech Szot, Paweł Rubiś, Agata Leśniak-Sobelga, Marta Hlawaty, Sylwia Wiśniowska-Śmiałek, Barbara Małecka, Andrzej Ząbek, Krzysztof Boczar, Agnieszka Stępień, Piotr Podolec, Magdalena Kostkiewicz
Infective endocarditis (IE) is a life-threatening disease, establishing a diagnosis is often challenging. The aim of this prospective study was to evaluate and compare the diagnostic performance of the combined use of single photon emission tomography and computed tomography with technetium99m-hexamethylpropyleneamineoxime-labeled leukocytes (99mTc-HMPAO-SPECT/CT) with transthoracic echocardiography (TTE) in patients with suspected IE. We enrolled 40 consecutive patients (12 females, 28 males, mean age: 58...
October 31, 2018: International Journal of Cardiovascular Imaging
Kazuhiro Suzuki, Yoshiyuki Miyazawa
Bones are the most frequent sites in patients with progressive prostate cancer. Spinal column and pelvic bone are vulnerable for metastasis, and osteoblastic lesions are frequently observed. Imaging evaluation is performed using bone scintigrapy with 99mTc, CT or MRI. Extent of disease is categorized as EOD score, and it is still used for evaluation of bone metastasis in clinical trials. Clinical guidelines recommend the uses of bone modifying agents including zoledronic acid and denosumab for bone metastasis in patients with castration-resistant prostate cancer...
2018: Clinical Calcium
Marc R J Ten Broek, Erik T Te Beek, Roos E Stuurman-Wieringa
We report a case of a 49-year-old woman with a rare anomaly, intrathoracic renal ectopia. Her medical history includes a surgically corrected congenital diaphragmatic hernia, which can cause late presentations of diaphragmatic hernia in adult life. The Tc-MAG3 renogram demonstrated slower emptying of the dilated pelvis of the ectopic kidney than the normal kidney. The curve confirmed a delayed Tmax, followed by a distinct decline. These features are not indicative of a complete obstruction, but can result from partial obstruction, renal dysfunction with poor response to diuresis, pelvic dilatation (such as in our patient), or a combination...
October 27, 2018: Clinical Nuclear Medicine
Kun Tang, Wenwen Sun, Jie Lin, Ling Wang
Multiple intravascular papillary endothelial hyperplasia involved with bone is rare. In this study, we present the case of a 53-year-old woman having occasional chest pains located in the middle of the sternum and the left chest wall. Multiple intravascular papillary endothelial hyperplasia lesions with high metabolism distributed in the sternum, left ribs, 12th thoracic vertebra, and left ilium on bone scintigraphy as well as PET/CT, which were easily misdiagnosed as bone malignant tumors. Increased awareness of this benign lesion and its high metabolic findings will improve preoperative diagnosis and avoid misinterpretation that may lead to an unnecessary invasive treatment...
October 27, 2018: Clinical Nuclear Medicine
U Sambamoorthy, M P Venkataraju, A S Manjappa, M E Bhanoji Rao
BACKGROUND: Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer targeting. PEGylated liposomes decorated with folic acid have been investigated for several anticancer agents not only to extend plasma half-life but also for tumor targeting via folic acid receptors which over expressed on tumor cell surface...
October 24, 2018: Current Drug Delivery
Longlong Tian, Xuan Yi, Ziliang Dong, Jun Xu, Chao Liang, Yu Chao, Yaxing Wang, Kai Yang, Zhuang Liu
Tumor-associated macrophages (TAMs) are often related with poor prognosis after radiotherapy. Depleting TAMs may thus be a promising method to improve the radio-therapeutic efficacy. Herein, we report a biocompatible and biodegradable nanoplatform based on calcium bisphosphonate (CaBP-PEG) nanoparticles for chelator-free radiolabeling chemistry, effective in vivo depletion of TAMs, and imaging-guided enhanced cancer radioisotope therapy (RIT). It is found that CaBP-PEG nanoparticles prepared via a mineralization method with poly(ethylene glycol) (PEG) coating could be labeled with various radioisotopes upon simple mixing, including gamma-emitting 99m Tc for single-photon-emission computed tomography (SPECT) imaging, as well as beta-emitting 32 P as a therapeutic radioisotope for RIT...
November 27, 2018: ACS Nano
Matthew S Manganaro, John D Millet, Richard Kj Brown, Benjamin L Viglianti, Daniel J Wale, Ka Kit Wong
OBJECTIVE: Frostbite is a localized cold-thermal injury resulting from prolonged exposure of flesh to freezing and near freezing temperatures. The depth and extent of frostbite injuries are not easily assessed, from a clinical standpoint, at the time of injury making it challenging to plan appropriate management and treatment. METHODS: A review of the literature of management of cold-related injuries and retrospective case review of the imaging and clinical course of frostbite injury...
November 1, 2018: British Journal of Radiology
Meng-Ling Chen, Hung-Yi Su
A 59-year-old woman presented with fever for 2 weeks. The patient had end-stage renal disease and was undergoing dialysis therapy for 10 years. Plain radiographs revealed extensive calcification in the subcutaneous tissues of the shoulders, thighs, and hips. In this case, TC-MDP bone scan detected all sites of subcutaneous metastatic calcification in one sweep. Ga-citrate scintigraphy was also performed and showed similar uptake at the same locations as those revealed by the bone scan, suggesting the existence of an inflammatory process at the sites of metastatic calcification...
October 23, 2018: Clinical Nuclear Medicine
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