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Ruiguo Zhang, Feng Dong, Zhaowei Meng, Jian Tan
Heterotopic ossification is a rare phenomenon that refers to formation of bone outside the skeletal system. We present a 61-year-old woman who suffered from peritoneal cancer surgery 2 years ago, referred for Tc-MDP bone scan because of higher serum CA-125 level, which showed multiple intense tracer activities in her abdominal and pelvic region without other abnormalities. SPECT/CT revealed the activities were loaded in the intestine but not in the bone. A wait-and-see policy was adopted because of no abdominal discomfort...
August 13, 2018: Clinical Nuclear Medicine
Zhen-Kui Sun, Chen-Tian Shen, Zhong-Ling Qiu, Quan-Yong Luo
Extraskeletal osteosarcomas are uncommon entities in clinical practice, which account for 1% to 2% of all soft tissue sarcomas. We here reported a case of multiple extraskeletal osteosarcomas and nuclear medicine imaging findings of this disease in Tc-MDP bone scan as well as F-FDG PET/CT.
August 13, 2018: Clinical Nuclear Medicine
Stanley P Leong, Max Wu, Ying Lu, Donald M Torre, Anna von Bakonyi, Arianna M Ospina, James D Newsom, William S Luckett, Christopher W Soon, Kevin B Kim, Mohammed Kashani-Sabet
BACKGROUND: Preoperative imaging and intraoperative gamma probe (GP) localization is standard for identifying sentinel lymph nodes (SLNs) in melanoma patients. The aim of this prospective Institutional Review Board-approved study was to investigate whether an intraoperative portable gamma camera (PGC) improves SLN detection over the GP. METHODS: Lymphoscintigraphy and single photon emission computed tomography/computed tomography were performed after injection of 99mTc-Tilmanocept in melanoma patients (≥ 18 years, Breslow thickness ≥ 1...
August 13, 2018: Annals of Surgical Oncology
Ruifeng Wang, Xiaoyi Duan, Cong Shen, Dong Han, Junchao Ma, Wu Hulin, Xiaotong Xu, Tao Qin, Qiuju Fan, Zhaoguo Zhang, Weihua Shi, Youmin Guo
OBJECTIVE: To perform quantitative measurement based on the standardized uptake value (SUV) of Tc-99m methylene diphosphonate (MDP) in the normal pelvis using a single-photon emission tomography (SPECT)/computed tomography (CT) scanner. MATERIAL AND METHODS: This retrospective study was performed on 31 patients with cancer undergoing bone SPECT/CT scans with 99mTc-MDP. SUVmax and SUVmean of the normal pelvis were calculated based on the body weight. SUVmax and SUVmean of the bilateral anterior superior iliac spine, posterior superior iliac spine, facies auricularis ossis ilii, ischial tuberosity, and sacrum were also calculated...
July 31, 2018: Journal of X-ray Science and Technology
Anwin Joseph Kavanal, Deepa Singh, Ashwani Sood, Madan Parmar, Bhagwant Rai Mittal
Myocardial perfusion imaging (MPI) is one of the most commonly used nuclear medicine imaging modalities for coronary artery disease evaluation and risk stratification. The authors present incidental image findings in a patient who underwent MPI twice because of development of seizures just before the first SPECT-MPI acquisition. The projection images for first MPI done without medication (phenytoin) showed the retention of hepatic tracer activity. After a few days from restarting of phenytoin, the repeat MPI showed complete hepatic clearance of tracer...
September 2018: Clinical Nuclear Medicine
S Warner, P J McKiernan, J Hartley, E Ong, I D van Mourik, G Gupte, M Abdel-Hady, P Muiesan, M T P R Perera, D Mirza, K Sharif, D A Kelly, S V Beath
Hepatopulmonary syndrome (HPS) in stable cirrhotic patients can easily be overlooked. We report on the presenting symptoms, disease progression and outcomes post liver transplantation (LT) in children with HPS. SUBJECTS AND METHODS: 20patients were diagnosed with HPS between 1996-2016. Aetiologies: Biliary atresia n = 9, Alpha-1-antitrypsin deficiency n = 2, Cryptogenic liver disease n = 3, others n = 6. FINDINGS: HPS presentation: dyspnoea n = 17, cyanosis n = 8 and pneumonia n = 3...
July 31, 2018: Liver Transplantation
Laura Rozenblum-Beddok, Benjamin Verillaud, Frédéric Paycha, Pierre Vironneau, Mukedaisi Abulizi, Abdel Benada, Tumatarii Cross, Ghada El-Deeb, Nicolas Vodovar, Ilana Peretti, Philippe Herman, Laure Sarda-Mantel
Objective: Skull base osteomyelitis (SBO) is a rare but life-threatening disease observed in elderly diabetic patients, with high risk of recurrence and difficult therapeutic management. The diagnosis is ascertained from a set of clinical, biological, and imaging findings. CT and MRI allow initial diagnosis, but are not accurate to affirm healing at the end of therapy. 99mTc-HMPAO-Leucocyte Scintigraphy (LS) is highly sensitive and specific for the detection of infection. The aim of this study was to evaluate LS i) for initial diagnosis, and ii) to confirm healing at the end of antibiotherapy in SBO...
June 2018: Laryngoscope Investigative Otolaryngology
Muhammad Tauqeer Ahmed, Muhammad Yameen, Bushra Munir, Sadia Asim, Muhammad Usman, Syed Ali Raza Naqvi, Jawad Akhtar Hussain Gillani, Rashid Rasheed, Muhammad Adeel Shahzad
Bacterial infection is one of the vital sources of morbidity and mortality. The development of single photon emission computed tomography (SPECT) radiotracer agents using antibiotics, for targeting in-vivo bacteria, helps in antibiotic dose calibration, targeted infection therapy and reduction in mortality rate. The aim of this study was to appraised 99m Tc-labeling sulfadiazine as a radiopharmaceutical for bacillus infections imaging. Radiolabeling of sulfadiazine with technetium-99m was carried out by subsequent addition of 1...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Halil Komek, Edip Erdal Yilmaz, Bahri Cakabay, Serdar Altindag, Nilufer Ozdemir, Canan Can, Ferat Kepenek
OBJECTIVE: The aim of the present study was to compare the surgical results with contrast-enhanced [99mTc] MIBI SPECT/CT results by adding the simultaneous single phase contrast to the [99mTc] MIBI SPECT/CT examination. METHOD: Between November 2016 and January 2018, 24 (21 female, 3 male) patients who underwent an operation after preoperative contrast-enhanced [99mTc]MIBI SPECT/CT, and 49 asymptomatic patients (42 female, 7 male), who did not undergo surgery, were included in the study...
July 23, 2018: Annali Italiani di Chirurgia
Simona Censi, Valentina Bodanza, Jacopo Manso, Sara Gusella, Sara Watutantrige-Fernando, Elisabetta Cavedon, Susi Barollo, Loris Bertazza, Diego Cecchin, Caterina Mian
PURPOSE OF THE REPORT: Distinguishing between amiodarone-induced thyrotoxicosis (AIT) caused by excessive hormone synthesis (AIT-1) or by a destructive process (AIT-2) has important therapeutic implications, but is still difficult and debated. Tc-sestaMIBI thyroid scintigraphy (99m-STS) has been proposed as a tool for classifying the two forms. MATERIAL AND METHODS: 30 AIT patients (11 females and 19 males) who underwent 99m-STS were retrospectively assessed for the present study...
September 2018: Clinical Nuclear Medicine
Knut Liepe, Andreas Becker
The aim of this study was to assess the potential of 99m Tc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111 In-octreotide, 99m Tc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99m Tc-Hynic-TOC was used for assessing primary diagnosis ( n = 14) and during follow-up ( n = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed...
July 2018: World Journal of Nuclear Medicine
Maimoona Siddique
Ectopic thyroid is a rare/incidental imaging finding. When discovered, 90% of ectopic thyroid is found typically along the pathway of embryologic migration of thyroid tissue, whereas around 10% have been discovered in other anatomical locations including the mediastinum and the heart. Thyroid scintigraphy with Tc sodium pertechnetate (TcO4) is peculiar for thyroid tissue uptake. The current case, clinically euthyroid, had heterogeneous uptake in multinodular goiter with uptake in the ectopic thyroid tissue in right paratracheal location on functional imaging with TcO4...
September 2018: Clinical Nuclear Medicine
Eduardo Delgado-Oliver, Sergi Vidal-Sicart, Daniel Martínez, Mattia Squarcia, Mireia Mora, Felizia A Hanzu, Irene Halperin, David Fuster, Constantino Fondevila, Óscar Vidal-Perez
BACKGROUND: The optimal surgical management of papillary thyroid cancer (PTC) for T1-T2 tumors without pre or intrasurgical evidence of lymph node metastasis (cN0) remains controversial, since approximately 40% of patients have lymph node involvement (pN1) which becomes evident when a prophylactic lymphadenectomy (PL) is performed. The aim of this study was to investigate the feasibility of sentinel lymph node (SLN) identification with SPECT/CT lymphoscintigraphy imaging along with intraoperatory image techniques in early stages of PTC undergoing PL of central neck compartment (CNC)...
July 9, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Ryuto Otsuka, Yosuke Miyazaki, Narumi Kubo, Mio Kawahara, Jun Takaesu, Kazuki Fukuchi
Objectives: To appropriately use one-day myocardial perfusion imaging (MPI) with 99m Tc radiopharmaceuticals (i.e. to avoid shine-through artifacts), injection doses need to be optimized and dose ratios between the 1st and 2nd scans should be maintained at ≥ 3. However, the current state of practice in Japan is unclear. Thus, the aim of this study was to clarify the details of MPI protocols using 99m Tc radiopharmaceuticals in Japan. Methods: A nationwide survey was conducted in June and July 2016...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Jindian Li, Chenyu Peng, Zhide Guo, Changrong Shi, Rongqiang Zhuang, Xingfang Hong, Xiangyu Wang, Duo Xu, Pu Zhang, Deliang Zhang, Ting Liu, Xinhui Su, Xianzhong Zhang
The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125 I- or 131 I-pentixather) for single-photon-emission-computed-tomography (SPECT) imaging of CXCR4 expression in myocardial-infarction-reperfusion (MI/R) rat models. After SPECT-CT imaging with 125 I-pentixather at 4, 12, and 36 h and 3 and 7 days after MI/R, the models were validated by ex vivo autoradiography, TTC staining, and immunohistochemistry and in vivo echocardiography and classical 99m Tc-MIBI perfusion imaging...
July 26, 2018: Analytical Chemistry
Can Pang, Youben Fan, Huizheng Zhang, Haoyong Yu, Bomin Guo, Jie Kang, Xianzhao Deng, Yuqian Bao
RATIONALE: Parathyroid hormone PTH) levels are the main parameters to differentiate primary hyperparathyroidism (PHPT) from non-PTH-dependent hypercalcemia. We report a case of hypercalcemia with normal PTH levels due to a parathyroid adenoma. PATIENT CONCERNS: A 52-year-old female patient presented with 2-year history of documented sustained high-normal serum calcium and hypercalcemia (2.51-3.03 mmol/L) with normal serum intact PTH levels (21.95-40.15 pg/ mL)...
July 2018: Medicine (Baltimore)
Xiujuan Zheng, Wentao Wei, Qiu Huang, Shaoli Song, Gang Huang
The glomerular filtration rate (GFR) is a crucial index to measure renal function. In daily clinical practice, the GFR can be estimated using the Gates method, which requires the clinicians to define the region of interest (ROI) for the kidney and the corresponding background in dynamic renal scintigraphy. The manual placement of ROIs to estimate the GFR is subjective and labor-intensive, however, making it an undesirable and unreliable process. This work presents a fully automated ROI detection method to achieve accurate and robust GFR estimations...
June 11, 2018: IEEE Journal of Biomedical and Health Informatics
Xiaoqing Ni, Yunjuan Gu, Haoyong Yu, Shenqi Wang, Ying Chen, Xinlei Wang, Xinlu Yuan, Weiping Jia
Serum fatty acid-binding protein 4 (FABP4) has been linked to renal dysfunction. This study evaluated the association between serum FABP4 and the radioisotope glomerular filtration rate (rGFR) in type 2 diabetic patients (T2DM) with early diabetic nephropathy. Twenty healthy controls and 172 patients with T2DM were enrolled. Serum FABP4 and renal impairment biomarkers including urinary albumin-to-creatinine ratio (UACR), serum retinal-binding protein 4 (RBP4), urinary cystatin C-to-creatinine ratio (CysC/Cr), and neutrophil gelatinase-associated lipocalin-to-creatinine ratio (NGAL/Cr) were measured...
2018: BioMed Research International
Valentina Mancini, Giulio Mastria, Viviana Frantellizzi, Alessandro Viganò, Nikolaos Petsas, Saadi Sollaku, Martina Fanella, Carlo Di Bonaventura, Mauro Liberatore, Vittorio Di Piero
No abstract text is available yet for this article.
2018: European Neurology
Xuran Zhang, Qing Ruan, Xiaojiang Duan, Qianqian Gan, Xiaoqing Song, Sian Fang, Xiao Lin, Jin Du, Junbo Zhang
In this study, a d-glucosamine derivative with an isonitrile group (CN5DG) was synthesized and it was chosen to coordinate with 99m Tc for preparing 99m Tc-CN5DG. 99m Tc-CN5DG could be readily obtained with high radiochemical purity (>95%) and had great in vitro stability and metabolic stability in urine. The radiotracer demonstrated a positive response to the administration of glucose and insulin in S180 and A549 tumor cells in vitro, suggesting the mechanism of 99m Tc-CN5DG into tumor cells was related to glucose transporters...
July 19, 2018: Molecular Pharmaceutics
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