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Vladimir R Vukomanovic, Milovan Matovic, Mirjana Doknic, Vesna Ignjatovic, Ivana Simic Vukomanovic, Svetlana Djukic, Miodrag Peulic, Aleksandar Djukic
BACKGROUND: The aim of this study was to evaluate the behavioral uptake and ability to diagnose pituitary adenoma (PA) using tumor-seeking radiopharmaceuticals, and to provide a semiquantitative analysis of tracer uptake in the pituitary region. PATIENTS AND METHODS: The study included 33 (13 hormonally active and 20 nonfunctioning) patients with PA and 45 control participants without pituitary involvement. All patients (n=78) underwent single photon emission computed tomography (SPECT) imaging with technetium-99m-labeled EDDA-hydrazinonicotinyl-tyr-octreotide (Tc-HYNIC-TOC), Tc(V)-DMSA and technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI)...
October 16, 2018: Nuclear Medicine Communications
Silvia Migliari, Antonino Sammartano, Carla Cidda, Giorgio Baldari, Maura Scarlattei, Giulio Serreli, Caterina Ghetti, Silvia Pipitone, Giuseppe Lippi, Livia Ruffini
BACKGROUND AND AIM: Labeled leukocytes with 99mTc-HMPAO are routinely used for infection imaging. Although cell labeling with 99mTc-HMPAO represents an imaging probe to detect infection sites, the diagnostic efficiency of the probe is largely influenced by cell manipulation, multidisciplinary interventions (i.e., biologist, technicians) and available technology (i.e., SPECT, SPECT/CT). The aim of the study was to assess in vitro and in vivo accuracy of a comprehensive approach for quality assessment (QA) of all steps of the procedure...
October 8, 2018: Acta Bio-medica: Atenei Parmensis
Michelle A Erickson, W Sandy Liang, Elizabeth G Fernandez, Kristin M Bullock, Jarl A Thysell, William A Banks
Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the brain's response to a systemic inflammatory insult. Mouse strain is also an important factor that can contribute to pathophysiological responses to inflammatory stimuli. Therefore, we aimed to test whether BBB disruption and the associated cytokine profiles in response to LPS differed in male and female mice from two mouse strains most commonly used in blood-brain barrier studies: CD-1 and C57BL6/J (C57)...
2018: PloS One
Paula Fernández-Rodríguez, Juan José Martín-Marcuartu, Jose Manuel Jiménez-Hoyuela
We present a 44-year-old woman with scapular and pelvic muscle weakness, joint inflammation, and fever. Bone scintigraphy showed high uptake in proximal regions of upper and lower limbs, suspecting inflammatory myopathy and polyarticular damage. These features were the clue to request other complementary tests such as anti-aminoacyl-tRNA-synthetase antibodies and chest CT, which showed interstitial lung disease, defining an antisynthetase syndrome. Therefore, BS allows an earlier diagnosis of inflammatory muscle disease and to identify the optimal site for muscle biopsy...
October 15, 2018: Clinical Nuclear Medicine
Vanshika Gupta, Ritu Verma, Ethel Belho, Nikhil Seniaray
A 3-year-old boy presented with intermittent abdominal pain, melena, and anemia since 2 months. Upper gastrointestinal endoscopy did not reveal any significant abnormality. The child was then referred for Tc-pertechnetate scan to rule out the presence of ectopic functioning gastric mucosa. Tc-pertechnetate scan revealed abnormal tracer accumulation in the thoracic region, which persisted in the delayed images, suspicious for being ectopic gastric mucosa. Subsequently, ultrasound and contrast-enhanced CT (CECT) scans of the chest revealed a large multiseptate cystic lesion in the retrocardiac region, corresponding to the site of increased tracer uptake on Tc-pertechnetate scan...
October 15, 2018: Clinical Nuclear Medicine
Adriano Machado de Lacerda, Sergio Augusto Lopes de Souza, Bianca Gutfilen, Léa Mirian Barbosa da Fonseca, Flávia Paiva Proença Lobo Lopes, Elise Tonomura, Mário Vaisman, Patrícia de Fátima Dos Santos Teixeira
It has been suggested that technetium-99m (99mTc)-anti-tumour necrosis factor alpha (TNF-α) scintigraphy (SCI) may be a useful diagnostic tool in Graves' ophthalmopathy (GO). This study evaluated whether orbit total radioactivity uptake on SCI could be used to predict corticosteroid therapy (CorT) responses in active-GO patients. A longitudinal study of patients with active GO defined by Clinical Active Score (CAS) >3/7 was done. Clinical, laboratory and SCI evaluations were performed at baseline and 3 months after concluding intravenous CorT...
October 16, 2018: Clinical Physiology and Functional Imaging
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
October 4, 2018: International Journal of Surgery Case Reports
Federico Tomassini, Yves D'Asseler, Mariano C Giglio, Clarisse Lecluyse, Bieke Lambert, Mauricio Sainz-Barriga, Jo Van Dorpe, Anne Hoorens, Karen Geboes, Roberto I Troisi
BACKGROUND: Excessive increase of portal flow and pressure following extended hepatectomy have been associated to insufficient growth or function of the future liver remnant (FLR), with the risk of post-hepatectomy liver failure (PHLF). We prospectively assess the influence of liver hemodynamics on FLR regeneration and function in Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS). METHODS: Twenty-three patients underwent ALPPS; liver hemodynamics were assessed throughout the procedures...
October 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Leila Hasanzadeh, Reza Kazemi Oskuee, Kayvan Sadri, Esmail Nourmohammadi, Mohammad Mohajeri, Zahra Mardani, Alireza Hashemzadeh, Majid Darroudi
AIMS: The in vivo targeted diagnostic applications of biosynthetic Cerium oxide nanoparticles (CeO2 -NPs), prepared by applying chitosan as a stabilizer, was explored by evaluating the cytotoxicity through MTT assay on WEHI 164 cell line, Hemolytic activity of CeO2 -NPs and biodistribution in rats. MAIN METHODS: The CeO2 -NPs were characterized through the use of TGA/DTG, PXRD, FESEM, FTIR, and UV-Vis spectroscopy. The biodistribution of CeO2 -NPs were determined by directly labeled nanoparticles with Technetium-99 m (99mTc) radioisotope (99mTc-CeO2 -NPs)...
October 7, 2018: Life Sciences
Sebastian Hoberück, Enrico Michler, Danilo Seppelt, Jörg Kotzerke, Claudia Brogsitter
A 68-year-old woman who underwent a thyroidectomy for bilateral goiter 20 years ago was referred to our department. The examination revealed a newly occurred thyroid nodule in the right central lobe. Unexpectedly the Tc-pertechnetate scan revealed several extrathyroidal foci right-sided supraclavicular, beside a cold thyroid nodule in the right lower lobe. Consecutive surgery and histology confirmed the suspected diagnosis of follicular thyroid cancer with multiple bone metastases. Whole-body scintigraphy performed after the following radioiodine therapy indicated disseminated osseous metastases...
October 8, 2018: Clinical Nuclear Medicine
Lucia Leva, Roberta Matheoud, Gianmauro Sacchetti, Alessandro Carriero, Marco Brambilla
BACKGROUND: The aim of the study was to assess the agreement between the left ventricular ejection fraction (LVEF) values obtained with IQ-SPECT and those obtained with a conventional gamma camera equipped with low-energy high-resolution (LEHR), considered as the method of reference. METHODS: Gated-stress MPI using 99mTc-tetrofosmin was performed in 55 consecutive patients. The patients underwent two sequential acquisitions (Method A and B) performed on Symbia-IQ SPECT with different acquisition times and one (Method C) on a Ecam SPECT equipped with LEHR collimators...
October 8, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Yu Zhang, Jin-Wang Ding, Ling-Ying Yu, Ding-Cun Luo, Jian-Liang Sun, Zhi-Kai Lei, Zhi-Hua Wang
Primary hyperparathyroidism (PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple parathyroid lesions are difficult to diagnose, as pregnant women who insist upon continuing a pregnancy are not able to undergo 99mTc-sestamibi scintigraphy, so cases of PHPT are easily unobserved and often can have serious consequences for the patient and the fetus. Therefore, we reported a case of a 28-year-old woman mid-pregnancy with twins, who had hypercalcemia and was eventually diagnosed with twin pregnancy with PHPT due to a triple parathyroid adenoma, had good pregnancy outcomes after undergoing surgery in mid-pregnancy...
October 6, 2018: World Journal of Clinical Cases
Zejun Chen, Jingjing Fu, Qing Shao, Bin Zhou, Feng Wang
This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured...
October 2018: Medicine (Baltimore)
Bing Yan, Tong Fu, Yueming Liu, Wenbin Wei, Haojie Dai, Wei Fang, Feng Wang
Recent successes in monitoring and diagnosing a variety of tumors using Tc-PEG4-E[PEG4-c(RGDfK)]2 (Tc-3PRGD2) single-photon emission computed tomography (SPECT) imaging encouraged us to expand the use of this tracer. This case-control study aimed to evaluate the feasibility of Tc-3PRGD2 imaging for detecting choroidal melanoma (CM) and for monitoring tumor response to plaque brachytherapy (PB). Ten consecutive patients with CM who underwent Tc-3PRGD2 imaging before and 3 months after PB were reviewed. The tumor-to-occipital bone (T/O) and mirrored contralateral normal tissue-to-occipital bone (N/O) ratios were calculated by region of interest analysis at baseline and 3 months post-PB...
October 2018: Medicine (Baltimore)
Cristina Bolzati, Nicola Salvarese, Debora Carpanese, Roberta Seraglia, Laura Meléndez-Alafort, Antonio Rosato, Domenica Capasso, Michele Saviano, Annarita Del Gatto, Daniela Comegna, Laura Zaccaro
New integrin-selective molecules suitable for therapeutic or imaging purposes are currently of interest in development of effective personalized medical platforms. RGDechi is a bifunctional peptide selective for integrin αv β3 . Herein, RGDechi and three truncated derivatives functionalized with a cysteine (1-4) were synthesized and labeled with the [99m Tc][Tc(N)PNP43]-synthon ([PNP43 = (CH3 )2 P(CH2 )2 N(C2 H4 OCH3 )(CH2 )2 P(CH3 )2 ]) (99m Tc1-4) as a basis for selective integrin recognition. The pharmacological parameters of all radiolabeled peptides were assessed along with the pharmacokinetic profiles of the most promising 99m Tc1 and 99m Tc2 compounds both on healthy and melanoma-bearing mice...
October 17, 2018: Journal of Medicinal Chemistry
Agnieszka D Kolasińska-Ćwikła, Sonia J Konsek, John R Buscombe, Katarzyna Maciejkiewicz, Andrzej Cichocki, Katarzyna Roszkowska-Purska, Łukasz Sawicki, Michał Tenderenda, Jaroslaw B Cwikla
BACKGROUND: Neuroendocrine neoplasms of the pancreas (p-NEN) are common gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). The aim of this retrospective study was to review the of value of Somatostatin Receptor Scintigraphy (SRS) in initial detection of p-NEN, evaluation of tumour extent and as imaging follow-up after radical surgery in patients with confirmed well (NETG1) or moderate (NETG2) differentiated p-NEN based on pathological WHO 2017 classification. MATERIAL AND METHODS: Overall 281 patients with confirmed p-NEN were enrolled...
October 2, 2018: Nuclear Medicine Review. Central & Eastern Europe
Nikhil Seniaray, Ritu Verma, Ethel S Belho, Harsh Mahajan
We present the case of a 53-year-old man with left hydroureteronephrosis who underwent Tc-DTPA renography for functional assessment of bilateral kidneys. Tc-DTPA renography of the patient showed diffusely increased extrarenal Tc-DTPA uptake in the visualized lumbosacral vertebrae and in the pelvic bones, on the blood flow and functional phase of the renography, which was suggestive of disseminated skeletal disease. Subsequent MRI lumbosacral spine and F-FDG PET/CT revealed extensive skeletal metastases corresponding to the increased extrarenal Tc-DTPA uptake in the lumbosacral vertebrae and the pelvic bones from primary left lung mitotic lesion...
September 28, 2018: Clinical Nuclear Medicine
Yang Yang, Xinming Zhao, Yu Xing, Tianying Yu, Jingmian Zhang, Jianfang Wang
The present study aimed to label ZHER2:V2 with technetium-99m (99m Tc) using a simple method and to evaluate its clinical potential as a diagnostic probe for human epidermal growth factor receptor type 2 (HER2)-positive tumors. The ZHER2:V2 (Affibody molecule of ZHER2:2395-C, which is based on the ZHER2:342 binding sequence with C-terminal engineered cysteine) with C-terminal chelating sequence GGGC was designed and labeled with 99mTc. The 99mTc-ZHER2:V2 labeling efficiency was analyzed. The cellular uptake, retention and binding affinity, and the stability of the probe were examined in vitro ...
October 2018: Oncology Letters
Min Cai, Guisheng Feng, Guangwei Zhang
A 27-year-old woman, who has received a hydroxyapatite orbital implant in the right eye due to a trauma 6 years ago, was newly diagnosis with left breast invasive ductal carcinoma. Tc-MDP bone scan showed an increased radiotracer accumulation in the right orbit and SPECT/CT confirmed the focal accumulation at the site of the implant, without any sign of local malignant lesions or orbital infection. Radionuclide imaging could provide certain useful information in diagnosing or differential diagnosing orbital disease...
September 21, 2018: Clinical Nuclear Medicine
Tanvir Rizvi, Prem Batchala, Sugoto Mukherjee
Brain death (BD) is an irreversible cessation of functions of the entire brain, including the brainstem. The diagnosis of BD is made on clinical grounds and neurologic examination. In the United States, clinical criteria set by the American Academy of Neurology (AAN) emphasize 3 specific clinical findings to confirm BD, which include coma, absence of brainstem reflexes and apnea. Ancillary tests are needed when neurologic examination or apnea test cannot be performed. AAN recommended ancillary tests include electroencephalogram, which confirms electrical activity loss; catheter cerebral angiogram, which confirms loss of cerebral blood flow; as well as transcranial Doppler and nuclear scintigraphy...
October 2018: Seminars in Ultrasound, CT, and MR
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