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https://www.readbyqxmd.com/read/28929933/the-extent-and-type-of-gambling-harms-for-concerned-significant-others-a-cross-sectional-population-study-in-finland
#1
Anne H Salonen, Hannu Alho, Sari Castrén
AIMS: This study investigates the proportion of concerned significant others (CSOs) of problem gamblers at population level and describes the extent and type of gambling harms for CSOs. METHODS: Cross-sectional random sample data ( n = 4515) were collected in 2015. The data were weighted based on age, gender and residence. CSOs were identified using a question including seven options. Gambling harms were inquired using structured questions. Descriptive statistics and Chi-Squared and Fischer's exact tests were used...
December 2016: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28929008/early-branching-euteleost-relationships-areas-of-congruence-between-concatenation-and-coalescent-model-inferences
#2
Matthew A Campbell, Michael E Alfaro, Max Belasco, J Andrés López
Phylogenetic inference based on evidence from DNA sequences has led to significant strides in the development of a stable and robustly supported framework for the vertebrate tree of life. To date, the bulk of those advances have relied on sequence data from a small number of genome regions that have proven unable to produce satisfactory answers to consistently recalcitrant phylogenetic questions. Here, we re-examine phylogenetic relationships among early-branching euteleostean fish lineages classically grouped in the Protacanthopterygii using DNA sequence data surrounding ultraconserved elements...
2017: PeerJ
https://www.readbyqxmd.com/read/28924497/phylogeographic-investigation-and-ecological-niche-modelling-of-the-endemic-frog-species-nanorana-pleskei-revealed-multiple-refugia-in-the-eastern-tibetan-plateau
#3
Bin Wang, Feng Xie, Jiannan Li, Gang Wang, Cheng Li, Jianping Jiang
The largest plateau Tibetan Plateau supplied an excellent opportunity to investigate the influence of the Pleistocene events on the high-elevation species. To test for the alternative hypotheses of Pleistocene glacial refugia, we used partial sequences of two mitochondrial genes and one nuclear gene to examine the phylogeographic patterns of the endemic frog species Nanorana pleskei across its known range in the eastern Tibetan Plateau, and conducted species distribution modelling (SDM) to explore changes of its distribution range through current and paleo periods...
2017: PeerJ
https://www.readbyqxmd.com/read/28923104/phase-1-study-of-intravenous-administration-of-the-chimeric-adenovirus-enadenotucirev-in-patients-undergoing-primary-tumor-resection
#4
Rocio Garcia-Carbonero, Ramon Salazar, Ignacio Duran, Ignacio Osman-Garcia, Luis Paz-Ares, Juan M Bozada, Valentina Boni, Christine Blanc, Len Seymour, John Beadle, Simon Alvis, Brian Champion, Emiliano Calvo, Kerry Fisher
BACKGROUND: Enadenotucirev (formerly ColoAd1) is a tumor-selective chimeric adenovirus with demonstrated preclinical activity. This phase 1 Mechanism of Action study assessed intravenous (IV) delivery of enadenotucirev in patients with resectable colorectal cancer (CRC), non-small-cell lung cancer (NSCLC), urothelial cell cancer (UCC), and renal cell cancer (RCC) with a comparator intratumoral (IT) dosed CRC patient cohort. METHODS: Seventeen patients scheduled for primary tumor resection were enrolled...
September 19, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28922595/a-new-order-parameter-based-method-for-characterizing-radiation-damage-in-amorphous-materials
#5
Nikolaos Galanakis, Karl Patrick Travis
We present a new method of characterizing damage arising from α-recoil cascades in amorphous materials including glasses. The approach taken is topological, yielding information of atom connectivity and utilizing complete sets of orthogonal functions (spherical harmonics and Hermite functions) to compute order parameters. The utility of our new approach is demonstrated by first applying it to models of radiation damaged crystalline zircon, enabling validation against the standard defect counting method (Wigner-Seitz)...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28922357/analysis-of-nuclear-and-organellar-genomes-of-plasmodium-knowlesi-in-humans-reveals-ancient-population-structure-and-recent-recombination-among-host-specific-subpopulations
#6
Ernest Diez Benavente, Paola Florez de Sessions, Robert W Moon, Anthony A Holder, Michael J Blackman, Cally Roper, Christopher J Drakeley, Arnab Pain, Colin J Sutherland, Martin L Hibberd, Susana Campino, Taane G Clark
The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing. Parasites infecting humans originate from genetically distinct subpopulations associated with the long-tailed (Macaca fascicularis (Mf)) or pig-tailed macaques (Macaca nemestrina (Mn)). We used a new high-quality reference genome to re-evaluate previously described subpopulations among human and macaque isolates from Malaysian-Borneo and Peninsular-Malaysia. Nuclear genomes were dimorphic, as expected, but new evidence of chromosomal-segment exchanges between subpopulations was found...
September 18, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28919488/mast-cells-derived-from-human-induced-pluripotent-stem-cells-are-useful-for-allergen-tests
#7
Akira Igarashi, Yasuhiro Ebihara, Tomoaki Kumagai, Hiroyuki Hirai, Kinya Nagata, Kohichiro Tsuji
BACKGROUND: Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Only a few human cultured cell lines are easily applicable to the passive IgE sensitization assay. However, the use of human induced pluripotent stem cells (iPSCs) to generate human mast cells (MCs) has not yet been reported...
September 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28919399/a-numerical-model-suggests-the-interplay-between-nuclear-plasticity-and-stiffness-during-a-perfusion-assay
#8
Solenne Deveraux, Rachele Allena, Denis Aubry
Cell deformability is a necessary condition for a cell to be able to migrate, an ability that is vital both for healthy and diseased organisms. The nucleus being the largest and stiffest organelle, it often is a barrier to cell migration. It is thus essential to characterize its mechanical behaviour. First, we numerically investigate the visco-elasto-plastic properties of the isolated nucleus during a compression test. This simulation highlights the impact of the mechanical behaviour of the nuclear lamina and the nucleoplasm on the overall plasticity...
September 14, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28916520/rubrocerebellar-feedback-loop-isolates-the-interposed-nucleus-as-an-independent-processor-of-corollary-discharge-information-in-mice
#9
Christy S Beitzel, Brenda D Houck, Samantha M Lewis, Abigail L Person
Understanding cerebellar contributions to motor coordination requires deeper insight into how the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence downstream motor pathways. The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes...
September 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28915791/segmentation-and-classification-of-two-channel-c-elegans-nucleus-labeled-fluorescence-images
#10
Mengdi Zhao, Jie An, Haiwen Li, Jiazhi Zhang, Shang-Tong Li, Xue-Mei Li, Meng-Qiu Dong, Heng Mao, Louis Tao
BACKGROUND: Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research, and this calls for an automatic image processing method that is suitable for both normal and abnormal structures. RESULTS: Our image processing method consists of nuclear segmentation, feature extraction and classification...
September 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28914236/the-kr%C3%A3-mmel-germany-childhood-leukaemia-cluster-a-review-and-update
#11
Bernd Grosche, Peter Kaatsch, Birger G J Heinzow, Heinz-Erich Wichmann
The debate surrounding possible adverse health effects from the civil use of nuclear power under normal operating conditions has been on-going since its introduction. It was particularly intensified by the detection of three leukaemia clusters near nuclear installations, i.e. near the reprocessing plants in Sellafield and Dounreay, UK, and near the Krümmel nuclear power plant, Germany, the last of which commenced between 1990 and 1991 and was first described in 1992; it continued until 2003, and an elevated risk up to 2005 has been reported in the literature...
September 15, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28913338/clinical-validation-of-a-pixon-based-reconstruction-method-allowing-a-twofold-reduction-in-planar-images-time-of-111in-pentetreotide-somatostatin-receptor-scintigraphy
#12
Philippe Thuillier, David Bourhis, Philippe Robin, Nathalie Keromnes, Ulrike Schick, Pierre-Yves Le Roux, Véronique Kerlan, Philippe Chaumet-Riffaud, Pierre-Yves Salaün, Ronan Abgral
OBJECTIVE: The objective of this study was to evaluate the diagnostic efficacy of Pixon-based reconstruction method on planar somatostatin receptor scintigraphy (SRS). METHODS: All patients with neuroendocrine tumors (NETs) disease who were referred for SRS to our department during 1-year period from January to December 2015 were consecutively included. Three nuclear physicians independently reviewed all the data sets of images which included conventional images (CI; 15 min/view) and processed images (PI) obtained by reconstructing the first 450 s extracted data using Oncoflash(®) software package...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#13
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28904767/genetic-differentiation-and-inferred-dynamics-of-a-hybrid-zone-between-northern-spotted-owls-strix-occidentalis-caurina-and-california-spotted-owls-s-%C3%A2-o-%C3%A2-occidentalis-in-northern-california
#14
Mark P Miller, Thomas D Mullins, Eric D Forsman, Susan M Haig
Genetic differentiation among Spotted Owl (Strix occidentalis) subspecies has been established in prior studies. These investigations also provided evidence for introgression and hybridization among taxa but were limited by a lack of samples from geographic regions where subspecies came into close contact. We analyzed new sets of samples from Northern Spotted Owls (NSO: S. o. caurina) and California Spotted Owls (CSO: S. o. occidentalis) in northern California using mitochondrial DNA sequences (mtDNA) and 10 nuclear microsatellite loci to obtain a clearer depiction of genetic differentiation and hybridization in the region...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28902997/coupled-cluster-in-real-space-i-cc2-ground-state-energies-using-multi-resolution-analysis
#15
Jakob Siegfried Kottmann, Florian Andreas Bischoff
A framework to calculate approximate coupled-cluster CC2 ground-state correlation energies in a multiresolution basis is derived and implemented into the MADNESS library. The CC2 working equations are rederived in first quantization which makes them suitable for real-space methods. The first-quantized equations can be interpreted diagrammatically using the usual diagrams from second quantization with adjusted interpretation rules. Singularities arising form the nuclear and electronic potentials are regularized by explicitly taking the nuclear and electronic cusps into account...
September 13, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28902358/serp1-is-a-novel-marker-of-poor-prognosis-in-pancreatic-ductal-adenocarcinoma-patients-via-anti-apoptosis-and-regulating-srprb-nf-%C3%AE%C2%BAb-axis
#16
Qiang Ma, Xiuxiu Wu, Jing Wu, Zhiyong Liang, Tonghua Liu
Stress associated endoplasmic reticulum protein 1 (SERP1), can cause accumulation of unfolded proteins in ER stress. However, studies on the role of SERP1 in pancreatic ductal adenocarcinoma (PDAC) are still incomplete. The present study aimed at identifying whether SERP1 acts as a potential novel prognostic marker of PDAC, and analyzed its possible mechanism. GEO database analysis showed SERP1 was significantly upregulated in PDAC tissues, and strongly associated with advanced clinical stage of PDAC patients from TCGA database...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28900542/mitochondrial-dna-haplotypes-induce-differential-patterns-of-dna-methylation-that-result-in-differential-chromosomal-gene-expression-patterns
#17
William T Lee, Xin Sun, Te-Sha Tsai, Jacqueline L Johnson, Jodee A Gould, Daniel J Garama, Daniel J Gough, Matthew McKenzie, Ian A Trounce, Justin C St John
Mitochondrial DNA copy number is strictly regulated during development as naive cells differentiate into mature cells to ensure that specific cell types have sufficient copies of mitochondrial DNA to perform their specialised functions. Mitochondrial DNA haplotypes are defined as specific regions of mitochondrial DNA that cluster with other mitochondrial sequences to show the phylogenetic origins of maternal lineages. Mitochondrial DNA haplotypes are associated with a range of phenotypes and disease. To understand how mitochondrial DNA haplotypes induce these characteristics, we used four embryonic stem cell lines that have the same set of chromosomes but possess different mitochondrial DNA haplotypes...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28899858/redd1-induction-regulates-the-skeletal-muscle-gene-expression-signature-following-acute-aerobic-exercise
#18
Bradley S Gordon, Jennifer L Steiner, Michael L Rossetti, Shuxi Qiao, Leif W Ellisen, Subramaniam S Govindarajan, Alexey M Eroshkin, Dave L Williamson, Paul M Coen
The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through changes in gene expression. However, the transducers that mediate altered gene expression signatures have not been completely elucidated. Regulated in Development and DNA Damage 1 (REDD1) is a stress-induced protein whose expression is transiently increased in skeletal muscle following acute aerobic exercise. However, the role of this induction remains unclear. Because REDD1 altered gene expression in other model systems, we sought to determine whether REDD1 induction following acute exercise altered the gene expression signature in muscle...
September 12, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28898675/a-dna-crosslinker-collects-mitotic-chromosomes
#19
Mingxuan Sun, Rebecca Heald
Incorporating each set of daughter chromosomes into a single nucleus at the end of mitosis is essential for genome stability. In a recent Cell paper, Samwer et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome coalescence, preventing nuclear membranes from enwrapping individual chromosomes to form micronuclei.
September 11, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28898238/glucosamine-stimulates-pheromone-independent-dimorphic-transition-in-cryptococcus-neoformans-by-promoting-crz1-nuclear-translocation
#20
Xinping Xu, Jianfeng Lin, Youbao Zhao, Elyssa Kirkman, Yee-Seul So, Yong-Sun Bahn, Xiaorong Lin
Morphotype switch is a cellular response to external and internal cues. The Cryptococcus neoformans species complex can undergo morphological transitions between the yeast and the hypha form, and such morphological changes profoundly affect cryptococcal interaction with various hosts. Filamentation in Cryptococcus was historically considered a mating response towards pheromone. Recent studies indicate the existence of pheromone-independent signaling pathways but their identity or the effectors remain unknown...
September 2017: PLoS Genetics
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