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Diagnostic histopathology

Do Hoon Kim, Gwang Ha Kim, Chang Min Cho, Chang Hwan Park, Soo-Young Na, Tae Hyeon Kim, Yu Kyung Cho, Ji Hyun Kim, Dong-Wan Seo
BACKGROUND: Endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) may facilitate tissue acquisition for a definitive diagnosis of gastrointestinal subepithelial tumors (SETs). This study aimed to determine the diagnostic yield of EUS-FNB using a novel 20-gauge ProCore needle with a coiled sheath in tissue sampling of gastrointestinal SETs. METHODS: Between July 2016 and February 2017, 39 patients with gastrointestinal SETs were prospectively recruited from six university hospitals in Korea...
October 19, 2018: BMC Gastroenterology
C Borghi, U Indraccolo, G Scutiero, P Iannone, R Martinello, P Greco, F Greco, L Nappi
OBJECTIVE: Endometrial cancer (EC) is a complex gynecological neoplasm with several clinical, histopathological and genetic features. Different hormonal, metabolic and biochemical axes are involved in pathogenesis. Obesity is a well-known risk factor for this disease and the role of local and systemic effects of adipose tissue, especially in the promotion of subclinical chronic inflammation, is an important issue. Indeed, inflammation is related to the pathogenesis of different tumors, including EC...
October 2018: European Review for Medical and Pharmacological Sciences
Jian Wang, Wei Cheng, Shaoji Zhang, Yousheng Li, Jieshou Li
OBJECTIVES: Intestinal tuberculosis (ITB) remains prevalent and a big health hazard in China. The aim of this study was to retrospectively analyze its clinico-pathological features. METHODS: Retrospective study of 85 consecutive ITB patients in two tertiary hospitals in East China. Relevant clinical, laboratory examination, radiological, endoscopic and histopathological features of ITB were recorded. RESULTS: The mean age was 37.3±16.0 years; 56 patients (65...
October 18, 2018: Tropical Medicine & International Health: TM & IH
Ivanka Temelkova, Michael Tronnier, Ivan Terziev, Uwe Wollina, Ilia Lozev, Mohamad Goldust, Georgi Tchernev
BACKGROUND: Kaposi's sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi's sarcoma: classical, endemic, AIDS-associated, and iatrogenic. CASE REPORT: A 90-year-old male is presented with multiple plaques- and tumour-shaped brown-violet formations located on an erythematous-livid base in the area of both feet and both shanks...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Sami Akbulut, Felat Ciftci, Abuzer Dirican
Gastrointestinal stromal tumors (GISTs) are the most common non-epithelial (mesenchymal) tumors of the gastrointestinal tract. Although GISTs appear as solid and well-circumscribed lesions in most patients, they may also appear as solid- cystic (mixed) or pure cystic lesions due to reasons like intra-tumor hemorrhage and necrosis in a very small percentage of patients. Hence, cystic GISTs mostly lead to a diagnostic dilemma. In this paper we aimed to report a case of pure cystic giant GIST that was drained percutaneously twice after being misdiagnosed as a mesenteric cyst...
2018: Annali Italiani di Chirurgia
Aymen Mouelhi, Hana Rmili, Jaouher Ben Ali, Mounir Sayadi, Raoudha Doghri, Karima Mrad
BACKGROUND AND OBJECTIVE: This paper presents an improved scheme able to perform accurate segmentation and classification of cancer nuclei in immunohistochemical (IHC) breast tissue images in order to provide quantitative evaluation of estrogen or progesterone (ER/PR) receptor status that will assist pathologists in cancer diagnostic process. METHODS: The proposed segmentation method is based on adaptive local thresholding and an enhanced morphological procedure, which are applied to extract all stained nuclei regions and to split overlapping nuclei...
October 2018: Computer Methods and Programs in Biomedicine
Tomasz Madej, Joanna Flak-Nurzyńska, Ewa Dutkiewicz, Anna Ciechomska, Jerzy Kowalczyk, Andrzej Paweł Wieczorek
INTRODUCTION: The diagnostic process of bone tumors, including malignant ones, is based on conventional radiological methods, such as radiography and computed tomography, and with precise assessment of local advancement in magnetic resonance imaging. Ultrasonography is not included in the diagnostic algorithms as a tool suitable to detect this type of pathology. More and more frequent usage of musculoskeletal ultrasound in children as the first imaging method or, in some cases, as the only diagnostic method, makes it necessary to be familiar with sonographic presentation of bone tumors to suggest this diagnosis early enough and, after its verification, start treatment without a significant delay...
2018: Journal of Ultrasonography
Marielena Gutt-Will, Michael Murek, Christa Schwarz, Ekkehard Hewer, Sonja Vulcu, Jürgen Beck, Andreas Raabe, Philippe Schucht
BACKGROUND: In contrast to isocitrate dehydrogenase (IDH) mutation analysis, which is homogenous within a given tumor, diagnostic errors in histological analysis following the 2016 World Health Organization (WHO) classification could be due to small samples because of histological heterogeneity. OBJECTIVE: To assess whether the sample size sent to histopathology influences the tumor grading in IDH wild-type gliomas. METHODS: Histologically diagnosed WHO grade, sample volume, and preoperative tumor volume data of 111 patients aged who received resection of IDHwt gliomas between January 2007 and December 2015 at our hospital were evaluated...
October 17, 2018: Neurosurgery
Jerome B Taxy, Harry M Goldin, Sara Dickie, Thomas Cibull
The ulcerated papules of cutaneous leishmaniasis represent an unusual form of granulomatous dermatitis caused by Leishmania species, a protozoan transmitted by sandfly bites. As the disease is not native to North America, clinical suspicion is partially based on a compatible travel history and may result in a biopsy. The key role of standard morphology is the identification of Leishmania organisms, supplemented by Giemsa and/or CD1a immunostaining. Histologically, the organism may be confused with Histoplasma species, which is resolved by staining with methenamine silver or PAS...
October 16, 2018: American Journal of Surgical Pathology
Sudhanshu Abhishek, Uma Nahar Saikia, Amod Gupta, Reema Bansal, Vishali Gupta, Nirbhai Singh, Suman Laal, Indu Verma
Background: Intraocular tuberculosis (IOTB), an extrapulmonary manifestation of tuberculosis of the eye, has unique and varied clinical presentations with poorly understood pathogenesis. As it is a significant cause of inflammation and visual morbidity, particularly in TB endemic countries, it is essential to study the pathogenesis of IOTB. Clinical and histopathologic studies suggest the presence of Mycobacterium tuberculosis in retinal pigment epithelium (RPE) cells. Methods: A human retinal pigment epithelium (ARPE-19) cell line was infected with a virulent strain of M...
2018: Frontiers in Cellular and Infection Microbiology
Daniel Paramythiotis, Petros Bangeas, Anestis Karakatsanis, Alexandros Iliadis, Georgia Karayannopoulou, Antonios Michalopoulos
BACKGROUND: A mesenteric chylous cyst is defined as a cyst occurring in the mesentery of the gastrointestinal tract anywhere from the duodenum to the rectum and is diagnosed most often during the fifth decade of life. CASE PRESENTATION: In our case report, we describe a case of 38-year-old Greek woman who presented at our Emergency Department complaining of abdominal pain without any other symptoms. Her medical and family histories were clear and she had never had any abdominal interventions...
October 17, 2018: Journal of Medical Case Reports
Ur Metser, Rosanna Chan, Patrick Veit-Haibach, Sangeet Ghai, Noam Tau
OBJECTIVE: The purpose of this study is to investigate the diagnostic value of various MRI sequences used for whole-body (WB) 18 F-fluorocholine (FCH) PET/MRI staging of patients with high-risk prostate cancer (PCa). SUBJECTS AND METHODS: This analysis is based on data from a prospective study that included 58 patients with untreated high-risk PCa who underwent integrated WB FCH PET/MRI (n = 10) or FCH PET/CT and WB MRI (n = 48). Metastatic sites were recorded. The standard of reference was histopathologic findings or clinical and imaging follow-up, or both...
October 17, 2018: AJR. American Journal of Roentgenology
Joachim Dissemond
The diagnosis of pyoderma gangraenosum was previously made as a diagnosis of exclusion. For this reason repeated attempts have been made in recent years to develop new diagnostic scores, whereby the typical clinical and anamnestic aspects were usually taken into account and the relevant differential diagnoses were excluded. With the PARACELSUS score an evaluated diagnostic score was presented for the first time. The main diagnostic criteria of this score are a rapidly progressing disease, the assessment of relevant differential diagnoses and reddish-violaceous wound borders...
October 16, 2018: Zeitschrift Für Rheumatologie
Ingmar Blümcke, Roland Coras, Annika K Wefers, David Capper, Eleonora Aronica, Albert Becker, Mrinalini Honavar, Thomas J Stone, Thomas S Jacques, Hajime Miyata, Angelika Mühlebner, Jose Pimentel, Figen Söylemezoğlu, Maria Thom
Low-grade epilepsy-associated brain tumours (LEAT) are the second most common cause for drug-resistant, focal epilepsy, i.e. ganglioglioma (GG) and dysembryoplastic neuroepithelial tumours (DNT). However, molecular pathogenesis, risk factors for malignant progression, and their frequent association with drug-resistant focal seizures remain poorly understood. This contrasts recent progress in understanding the molecular-genetic basis and targeted treatment options in diffuse gliomas. The Neuropathology Task Force of the International League against Epilepsy examined available literature to identify common obstacles in diagnosis and research of LEAT...
October 16, 2018: Neuropathology and Applied Neurobiology
Ahmet Sami Yazar, Seher Erdoğan, Ceyhan Şahin, Şirin Güven
Yazar AS, Erdoğan S, Şahin C, Güven Ş. Reliability of ultrasonography and the Alvarado scoring system in acute appendicitis. Turk J Pediatr 2018; 60: 173-179. In this study, we aimed to evaluate the diagnostic performance of ultrasonography, the Alvarado score, mean platelet volume and C-reactive protein in the diagnosis of acute appendicitis. Patients admitted to the pediatric emergency department with abdominal pain who were operated on with a preliminary diagnosis of acute appendicitis were evaluated...
2018: Turkish Journal of Pediatrics
Mélanie Pagès, Kristian W Pajtler, Stéphanie Puget, David Castel, Nathalie Boddaert, Arnault Tauziède-Espariat, Stéphanie Picot, Debily Marie-Anne, Marcel Kool, David Capper, Christian Sainte-Rose, Fabrice Chrétien, Stefan M Pfister, Torsten Pietsch, Jacques Grill, Pascale Varlet, Felipe Andreiuolo
Ependymoma with RELA fusion has been defined as a novel entity of the revised WHO 2016 classification of tumours of the central nervous system (CNS), characterised by fusion transcripts of the RELA gene and consequent pathological activation of the NFkB pathway. These tumours represent the majority of supratentorial ependymomas in children. The validation of diagnostic tools to identify this clinically relevant ependymoma entity is essential. Here, we have used interphase fluorescent in situ hybridisation (FISH) for C11orf95 and RELA, immunohistochemistry (IHC) for p65-RelA and the recently developed DNA-methylation based classification besides conventional histopathology and compared the precision of the methods in 40 supratentorial paediatric brain tumours diagnosed as ependymomas in the past years...
October 16, 2018: Brain Pathology
Jingqiao Zhang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Jiao Deng, Zhendong Liang, Xia Zhang, Ji Feng, Hao Lin, Xingshun Qi
IgG4-related sclerosing cholangitis is a rare autoimmune liver disease. Biliary tract imaging, serum IgG4 concentration, and histopathological examination are the major diagnostic criteria for IgG4-related sclerosing cholangitis. In this paper, we report a male patient with yellowish skin, in whom classical liver-protection drugs were initially given, but the efficacy was poor. After that, IgG4-related sclerosing cholangitis was diagnosed, and he achieved a good response to steroid therapy.
September 2018: Clinical and Experimental Hepatology
Ayesha Saba, Rozilla Sadia Khan, Humera Ismail
Growing teratoma syndrome (GTS) is a rare complication of ovarian germ cell tumours and occurs in young age group. It is characterized by clinical or radiological increase in tumour size during or after chemotherapy, with normalization of tumour marker levels. Histopathological tissue growth post chemotherapy is a mature teratoma without any malignant component. Mainstay of treatment is surgical excision of the disease to prevent progression of tumour as mature teratomas are resistant to both chemotherapy and radiotherapy...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Matthew A Weiss, Marie-Christine Aubry, Benjamin R Pflederer
BACKGROUND IgG4-related disease (IgG4-RD) is a systemic inflammatory condition with a myriad of presentations related to the pattern of organ involvement. Diagnostic workup for IgG4-RD requires a high index of suspicion, and further workup often includes the results of serological testing for elevated levels of IgG4. Correlation of presentation, past medical history, and histopathologic analysis are required to make a diagnosis. CASE REPORT In this case, incidental discovery of non-infectious aortitis and pulmonary mass lesions were the specific signs that led to the consideration of IgG4-RD...
October 16, 2018: American Journal of Case Reports
Oriol Yélamos, Ralph P Braun, Konstantinos Liopyris, Zachary J Wolner, Katrin Kerl, Pedram Gerami, Ashfaq A Marghoob
Dermoscopy is increasingly used by clinicians (dermatologists, family physicians, podiatrists, doctors of osteopathic medicine, etc.) to inform clinical management decisions. Dermoscopic findings and/or images provided to pathologists offer an important insight into the clinician's diagnostic and management thought process. However, with limited dermoscopic training in dermatopathology, dermoscopic descriptions and images provided in the requisition form will provide little value to pathologists. Since most dermoscopic structures have direct histopathological correlates, dermoscopy can act as an excellent communication bridge between the clinician and the pathologist...
October 12, 2018: Journal of the American Academy of Dermatology
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