Xiaowei Hu, Jeongok G Logan, Younghoon Kwon, Joao A C Lima, David R Jacobs, Daniel Duprez, Lyndia Brumback, Kent D Taylor, Peter Durda, W Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P Tracy, Thomas W Blackwell, George Papanicolaou, Gary F Mitchell, Stephen S Rich, Jerome I Rotter, David J Van Den Berg, Julio A Chirinos, Timothy M Hughes, Francine E Garrett-Bakelman, Ani Manichaikul
Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link between epigenetics (DNA methylation) and AS/PH, we examined the relationship of eight measures of AS/PH with CpG sites and co-methylated regions using multi-ancestry participants from Trans-Omics for Precision Medicine (TOPMed) Multi-Ethnic Study of Atherosclerosis (MESA) with sample sizes ranging from 438 to 874...
October 17, 2023: Scientific Reports