Ningfei Ji, Zhongqi Chen, Zhengxia Wang, Wei Sun, Qi Yuan, Xijie Zhang, Xinyu Jia, Jingjing Wu, Jingxian Jiang, Meijuan Song, Tingting Xu, Yanan Liu, Qiyun Ma, Zhixiao Sun, Yanmin Bao, Mingshun Zhang, Mao Huang
PURPOSE: The roles and mechanisms of long noncoding RNAs (lncRNAs) in T helper 2 (Th2) differentiation from allergic asthma are poorly understood. We aimed to explore a novel lncRNA, LincR-protein phosphatase 2 regulatory subunit B' gamma (PPP2R5C), in Th2 differentiation in a mouse model of asthma. METHODS: LincR-PPP2R5C from RNA-seq data of CD4+ T cells of asthma-like mice were validated and confirmed by quantitative reverse transcription polymerase chain reaction, northern blotting, nuclear and cytoplasmic separation, and fluorescence in situ hybridization (FISH)...
January 2024: Allergy, Asthma & Immunology Research