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Jessica Liang, Stephanie J Lee, Barry E Storer, Bronwen E Shaw, Eric J Chow, Mary E Flowers, Elizabeth F Krakow, Merav Bar, Karen L Syrjala, Rachel B Salit, Chareeni E Kurukulasuriya, Heather S L Jim
BACKGROUND: Hematopoietic cell transplant (HCT) can cause significant distress in patients and their informal caregivers. Despite advances in reduced intensity conditioning and supportive care, few recent studies have reported rates of clinically-significant post-traumatic stress disorder symptomatology (hereafter referred to as PTSD). Goals of the current study were to: 1) examine rates of PTSD and distress in patients and caregivers and 2) identify sociodemographic and clinical risk factors for PTSD...
August 8, 2018: Biology of Blood and Marrow Transplantation
Tyler Hyungtaek Rim, Hee Suk Kim, Jiyong Kwak, Jihei Sara Lee, Dong Wook Kim, Sung Soo Kim
Importance: Information on the incidence of central serous chorioretinopathy (CSC) in individuals who receive corticosteroids is scarce but clinically important because these agents are useful and widely used. Objective: To estimate the annual and 5-year incidence of CSC in South Korea in the overall population and in those who have used corticosteroid medications. Design, Setting, and Participants: A cohort study of a population-based random sample included East Asian adults for whom records are held in the Korean National Health Insurance Service database for calendar years 2011 through 2015...
August 9, 2018: JAMA Ophthalmology
Miguel Angel Ruiz Ibán, Rafael Lorente Moreno, Raquel Ruiz Díaz, Roselyn Álvarez Sciamanna, Andrea Paniagua Gonzalez, Alejandro Lorente Gómez, Jorge Díaz Heredia
PURPOSE: To evaluate the 2-year results of an absorbable subacromial spacer in patients with irreparable posterosuperior rotator cuff tears. METHODS: Prospective longitudinal study of a consecutive case series of 16 subjects with irreparable tears of the posterosuperior rotator cuff in which the InSpace® subacromial spacer was arthroscopically implanted. A full clinical evaluation that included the Constant test, Simple Shoulder Test (SST) and the QuickDash questionnaire was performed preoperatively and at 12 and 24 months follow-up...
August 10, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Frits M E Franssen, Dionne E Smid, Dorly J H Deeg, Martijn Huisman, Jan Poppelaars, Emiel F M Wouters, Martijn A Spruit
Chronic obstructive pulmonary disease (COPD) is associated with substantial health impact that may already become apparent in early disease. This study aims to examine the features of subjects with COPD in a Dutch population-based sample and compare their physical status, mental status, and social status to non-COPD subjects. This study made use of Longitudinal Aging Study Amsterdam (LASA) data. Demographics, clinical characteristics, self-reported diseases, post-bronchodilator spirometry, physical, mental, and social status were assessed...
August 10, 2018: NPJ Primary Care Respiratory Medicine
Samuele Cortese, Nicoletta Adamo, Cinzia Del Giovane, Christina Mohr-Jensen, Adrian J Hayes, Sara Carucci, Lauren Z Atkinson, Luca Tessari, Tobias Banaschewski, David Coghill, Chris Hollis, Emily Simonoff, Alessandro Zuddas, Corrado Barbui, Marianna Purgato, Hans-Christoph Steinhausen, Farhad Shokraneh, Jun Xia, Andrea Cipriani
BACKGROUND: The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in children, adolescents, and adults. METHODS: We did a literature search for published and unpublished double-blind randomised controlled trials comparing amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil with each other or placebo...
August 7, 2018: Lancet Psychiatry
Khemayanto Hidayat, Hui-Juan Li, Bi-Min Shi
The associations between anthropometric factors and non-Hodgkin's lymphoma (NHL) risk remain inconclusive. A meta-analysis was performed to clarify these associations. PubMed and Web of Science were searched for relevant prospective observational studies. A random-effects model was used to generate the summary relative risks (RRs) with 95% confidence intervals (CIs). A total of 22 prospective cohort studies, with over 20,000 NHL cases, were included in the present meta-analysis. The summary RRs of NHL risk were 1...
September 2018: Critical Reviews in Oncology/hematology
Lingmin Hu, Meiqun Jia, Jing Zhou, Hongxia Ma, Guangfu Jin, Ni Li, Dong Hang, Zhibin Hu
Chromosome 4q12 and 17q12 have been identified as two regions associated with susceptibility to cervical cancer in a genome-wide association study. To identify potential causal variants within these two regions, we conducted a case-control study including 1486 patients with cervical cancer and 1536 age-matched (±5 years) healthy controls. Based on RegulomeDB database, 12 potentially functional variants were selected and then genotyped by using Sequenom MassARRAY. Univariate and multivariate logistic regression models were used to evaluate the associations...
August 7, 2018: Gene
Alexandra Jana H Freeman, Cristina Gamboa, Jeanne A Darbinian, Ramey D Littell, Sandra Torrente
OBJECTIVE: To estimate the rate of human papillomavirus (HPV) vaccine completion by race and ethnicity. METHODS: In this retrospective cohort study, we analyzed females aged 11-26 years who initiated HPV vaccination from 2008 through 2012 in a community-based health care system in California. Vaccine completion was defined as having received at least three injections. Demographic data including age, race, ethnicity, and language preferences were obtained. Among Hispanic patients, acculturation was categorized as low or high using written and spoken Spanish vs English language as a proxy...
August 6, 2018: Obstetrics and Gynecology
Zhenbin Jiang, Meishun Cai, Bao Dong, Yu Yan, Bing Yang, Mi Wang, Yan Wang, Xin Li, Lichao Lian, Song Li, Li Zuo
Membranous nephropathy is typically classified as idiopathic and secondary, but nowadays the number of atypical membranous nephropathy (aMN) is increasing, many of which cannot determine its etiology in China. In this study, we compared the clinical and pathological characteristics of idiopathic membranous nephropathy (iMN) with aMN with unknown etiology from a single center in China.We retrospectively reviewed the clinical data of 577 patients with iMN and aMN at Peking University People's Hospital from January 2006 to December 2015 over a 10-year period, and analyzed their clinical and pathological characteristics...
August 2018: Medicine (Baltimore)
Mauri Witt, Daan B E van Wessel, Ruben H J de Kleine, Janneke L M Bruggink, Jan B F Hulscher, Henkjan J Verkade
OBJECTIVES: To determine the prognosis of patients with biliary atresia (BA) after two years of native liver survival (NLS) and to identify prognostic factors for continued NLS after two years of age. METHODS: We retrospectively analyzed perioperative, laboratory and outcome parameters of all BA patients in The Netherlands between January 1987-June 2015 with NLS of at least two years. We compared parameters between patients who continued to have their native liver (NLS+) to those who did not, either by transplant or death (NLS-)...
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
Anne Marie Sowerbutts, Simon Lal, Jana Sremanakova, Andrew Clamp, Chris Todd, Gordon C Jayson, Antje Teubner, Anne-Marie Raftery, Eileen J Sutton, Lisa Hardy, Sorrel Burden
BACKGROUND: People with advanced ovarian or gastrointestinal cancer may develop malignant bowel obstruction (MBO). They are able to tolerate limited, if any, oral or enteral (via a tube directly into the gut) nutrition. Parenteral nutrition (PN) is the provision of macronutrients, micronutrients, electrolytes and fluid infused as an intravenous solution and provides a method for these people to receive nutrients. There are clinical and ethical arguments for and against the administration of PN to people receiving palliative care...
August 10, 2018: Cochrane Database of Systematic Reviews
Amy L Byers, Li-Yung Lui, Eric Vittinghoff, Kenneth E Covinsky, Kristine E Ensrud, Brent Taylor, Kristine Yaffe
OBJECTIVES: To determine the association between cumulative burden of depressive symptoms and risk of nursing home (NH) placement over 2 decades. DESIGN: Prospective cohort study with data linked to Medicare claims files. SETTING: Clinic sites in Baltimore, Maryland; Minneapolis, Minnesota; and the Monongahela Valley near Pittsburgh, Pennsylvania. PARTICIPANTS: Initially community-dwelling women aged 65 and older (N=3,646)...
August 9, 2018: Journal of the American Geriatrics Society
Audree B Tadros, Hannah Y Wen, Monica Morrow
BACKGROUND/OBJECTIVE: Cancers classified as "special histologic subtypes" are felt to have a good prognosis. We used the 21-gene Oncotype DX Breast Recurrence Score® multigene assay to examine prognostic variation within special histologic subtypes. We also examined the Recurrence Score® (RS) distribution among the more common ductal (IDC) and lobular (ILC) cancers. METHODS: 610,350 tumor specimens examined in the Genomic Health clinical laboratory from 2/2004 to 8/2017 were included...
August 9, 2018: Annals of Surgical Oncology
Luís Silva Monteiro, Luís Antunes, Lúcio Lara Santos, Maria José Bento, Saman Warnakulasuriya
Background: Oral cancer represents a serious public health problem worldwide. Our aim was to analyse the survival probabilities and trends of patients presenting with lip, oral cavity and oropharynx cancers, who were residents in the north of Portugal. Methods: Using cancer-registry data, we conducted a population-based study of lip, oral cavity and oropharynx cancers diagnosed in the period 2000-2009, among residents in the north of Portugal. Net survival was estimated using the Pohar-Perme estimator...
2018: Ecancermedicalscience
Ana Mihailescu, Anca Labunet, Alexandrina Muntean, Andreea Kui, Radu Septimiu Campian
Background and aims: This survey evaluated the psycho-social impact of oral health on the quality of life in Romanian teenage and young adult orthodontic patients. Methods: Of the 300 standard questionnaires distributed in four dental offices, 125 questionnaires were returned. Each questionnaire contained 110 items, focusing on aspects like patients' satisfaction, self-confidence, school/work performances and aesthetic concern, in relation to oral health. The patients were 16-25 years of age and all were undergoing or had undergone orthodontic treatment in the previous two years...
July 2018: Clujul Medical (1957)
Paul D E Miller, Alice S Forster, Thushan I de Silva, Hayley Leonard, Chloe Anthias, Michaela Mayhew, Matthias Klammer, Susan Paskar, Erin Hurst, Karl Peggs, Alejandro Madrigal, John A Snowden
OBJECTIVES: Studies exploring vaccination rates among haematopoietic stem cell transplant (HSCT) recipients have focused on physician factors that limit uptake. Understanding the patient factors that determine vaccination intention is crucial to delivering a successful vaccination programme. Using a modified health belief model (mHBM), we conducted a cross-sectional survey with the objective of exploring the sociodemographic and psychological factors that determined autologous and allogeneic HSCT recipients' intention to receive the seasonal inactivated influenza vaccine (SIIV) during the 2015-2016 influenza season...
August 8, 2018: BMJ Open
Gill Mein, Robert Grant
BACKGROUND: To explore associations between pets, and specifically dog ownership and sleep, health, exercise and neighbourhood. METHODS: Cross sectional examination of 6575 participants of the Whitehall II study aged between 59 and 79 years. We used self-assessed measurement scales of the Short Form (SF36), General Health Questionnaire (GHQ), Control, Autonomy, Self-realisation and Pleasure (CASP), Centre for Epidemiologic Studies Depression Scale (CES-D), sleep, exercise, and perceptions of local neighbourhood...
August 9, 2018: BMC Geriatrics
D Mark Anderson, Daniel I Rees, Erdal Tekin
AIMS: The aim of this research was to determine the association between legalizing medical marijuana and workplace fatalities. DESIGN: Repeated cross-sectional data on workplace fatalities at the state-year level were analyzed using a multivariate Poisson regression. SETTING: To date, 29 states and the District of Columbia have legalized the use of marijuana for medicinal purposes. Although there is increasing concern that legalizing medical marijuana will make workplaces more dangerous, little is known about the relationship between medical marijuana laws (MMLs) and workplace fatalities...
August 6, 2018: International Journal on Drug Policy
Joshua K Swift, Jennifer L Callahan, Mick Cooper, Susannah R Parkin
Client preferences in psychotherapy reflect specific conditions and activities that clients desire in their treatment, with increasing evidence pointing to preference accommodation as facilitating psychotherapy outcomes. This updated meta-analysis establishes the magnitude of the effect of client preference accommodation in psychotherapy. Based on data from 53 studies and over 16,000 clients, preference accommodation was associated with fewer treatment dropouts (OR = 1.79) and more positive treatment outcomes (d = 0...
August 8, 2018: Journal of Clinical Psychology
Carmella Evans-Molina, Emily K Sims, Linda A DiMeglio, Heba M Ismail, Andrea K Steck, Jerry P Palmer, Jeffrey P Krischer, Susan Geyer, Ping Xu, Jay M Sosenko
BACKGROUND: The duration and patterns of β cell dysfunction during type 1 diabetes (T1D) development have not been fully defined. METHODS: Metabolic measures derived from oral glucose tolerance tests (OGTTs) were compared between autoantibody-positive (aAb+) individuals followed in the TrialNet Pathway to Prevention study who developed diabetes after 5 or more years or less than 5 years of longitudinal follow-up (Progressors≥5, n = 75; Progressors<5, n = 474) and 144 aAb-negative (aAb-) relatives...
August 9, 2018: JCI Insight
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