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organ AND protection

S Ibraev, M Alekberov, Zh Zharylkassyn, E Otarov, М Tilemisov
This study is aimed at studying the morbidity with temporary disability (MTD) of employee working in ore beneficiation at chrysotile production of JSC "Kostanay Minerals" . It was found that the incidence of MTD is higher among male male workers than in men in the control group, and the incidence of MTD in the compared professional groups decreases with an increase in work experience. This is possibly due to the fact that the organism of the trained workers is more stable due to the formation of protective adaptive mechanisms to the current production hazards...
October 2018: Georgian Medical News
S Safarova
The purpose of this study was to identify complex relationships between the mineral, organic component of bone and the risk of fractures under the influence of metabolic changes associated with type 2 diabetes. A cross-sectional study of patients diagnosed with T2DM (n=96) was conducted; control group, consisted of 82 individuals. All patients were studied calcitropic homons, serum bone remodeling markers and bone mineral density with (DXA). In the course of this study, there was a correlation between serum insulin levels, bone metabolism markers and bone mass density determined by lumbar DXA in patients with type 2 diabetes...
October 2018: Georgian Medical News
Lecticia Barbosa Jorge, Fernanda Oliveira Coelho, Talita Rojas Sanches, Denise M A C Malheiros, Leandro Ezaquiel de Souza, Fernando Dos Santos, Larissa de Sá Lima, Cristóforo Scavone, Maria Claudia Irigoyen, Makoto Kuro-O, Lucia Andrade
Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous Klotho-haploinsufficient mice and their wild-type littermates (CLP-Kl+/- and CLP-WT mice, respectively)...
December 5, 2018: American Journal of Physiology. Renal Physiology
Xiang-Juan Li, Hai-Tao Pan, Juan-Juan Chen, Yi-Bin Fu, Min Fang, Guo-Hua He, Tao Zhang, Hai-Gang Ding, Bin Yu, Yi Cheng, Ya-Jing Tan, Fa-Lin Zhao, Abraham N Morse, He-Feng Huang
PURPOSE: Damage to the uterosacral ligaments is an important contributor to uterine and vaginal prolapse. The aim of this study was to identify differentially expressed proteins in the uterosacral ligaments of women with and without pelvic organ prolapse and analyze their relationships to cellular mechanisms involved in the pathogenesis of pelvic organ prolapse. EXPERIMENTAL DESIGN: Uterosacral ligament connective tissue from four patients with pelvic organ prolapse and four control women underwent iTRAQ analysis followed by Ingenuity Pathway Analysis of differentially expressed proteins...
December 5, 2018: Proteomics. Clinical Applications
Stefanos Archontakis, Konstantinos Sideris, Konstantina Aggeli, Konstantinos Gatzoulis, Michael Demosthenous, Panagiotis Tolios, Vasilios Lozos, Nikolas Koumallos, Dimitrios Limperiadis, Dimitrios Tousoulis, Ioannis Kallikazaros, Skevos Sideris
INTRODUCTION: Cardiac perforation of the right ventricle associated with pacemaker or implantable cardioverter-defibrillator (ICD) leads' implantation is an uncommon, albeit potentially life-threatening, complication. The aim of this study is to further identify the optimal therapeutic strategy especially when lead dislocation has occurred outside the pericardial sac. METHODS AND RESULTS: The study population included 10 consecutive patients (6 female, mean age: 66...
December 5, 2018: Journal of Cardiovascular Electrophysiology
Tom Shlesinger, Yossi Loya
The reproductive patterns of coral communities with many of the same species can vary geographically (Shlesinger and Loya 1985), raising interesting questions of natural selection and ecology. Species of the colonial cnidarian genus Millepora have received the common name "fire corals" due to the painful sting inflicted to humans by the release of venom from their stinging cells. Despite their popular name and some similarities with scleractinian stony corals of the class Anthozoa, fire corals belong to a different class of organisms (i...
December 5, 2018: Ecology
Akari Murakami, Masashi Maekawa, Katsuhisa Kawai, Jun Nakayama, Nobukazu Araki, Kentaro Semba, Tomohiko Taguchi, Yoshiaki Kamei, Yasutsugu Takada, Shigeki Higashiyama
Rho GTPase Rac1 is a central regulator of F-actin organization and signal transduction to control plasma membrane dynamics and cell proliferation. Dysregulated Rac1 activity is often observed in various cancers including breast cancer, and is suggested to be critical for malignancy. Here, we showed that the ubiquitin E3 ligase complex Cullin-3 (CUL3)/KCTD10 is essential for epidermal growth factor (EGF)-induced/HER2-dependent Rac1 activation in HER2-positive breast cancer cells. EGF-induced dorsal membrane ruffle formation and cell proliferation that depends on both Rac1 and HER2 were suppressed in CUL3- or KCTD10-depleted cells...
December 4, 2018: Cancer Science
Elaine Hui-Chien Lee, Sherlyn Sheau-Chin Lim, Kah-Hay Yuen, Chong-Yew Lee
OBJECTIVES: This study aims to investigate the blood-brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect against amyloid-beta toxicity in a whole organism model. METHOD: Four curcumin analogues were synthesized. These analogues and curcumin were evaluated for their BBB permeability in the parallel artificial membrane permeability assay. The transgenic Caenorhabditis elegansGMC101 that expresses human Aβ1-42 was treated with the compounds to evaluate their ability to delay Aβ-induced paralysis...
December 4, 2018: Journal of Pharmacy and Pharmacology
Miriam Sanderson, Marc Chikhani, Esme Blyth, Sally Wood, Iain K Moppett, Tricia McKeever, Mark Jr Simmonds
Background: Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients with sepsis in Nottingham. Methods: Data were collected prospectively from adult patients with sepsis in Nottingham University Hospitals NHS Trust as part of an on-going quality improvement project between November 2011 and March 2014...
November 2018: Journal of the Intensive Care Society
Nisha Panth, Keshav Raj Paudel, Dal-Seong Gong, Min-Ho Oak
Morus alba (white mulberry) is native to the northern part of Korea and popularly used as a traditional medicine due to its numerous health benefits against human's disease. However, the possibility that M. alba may also affect the cardiovascular system remains unexplored. This study sought to investigate the vascular protective effects of the root bark extract of M. alba (MAE). Vascular reactivity was performed in organ baths using isolated rat thoracic aorta, while platelet derived growth factor (PDGF) induced proliferation and migration of vascular smooth muscle cells (VSMCs) were studied by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and wound healing assay, respectively...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Noah Kyame Asare-Donkor, Raymond Akanwi Adaagoam, Ray Bright Voegborlo, Anthony Apeke Adimado
This study evaluates the exposure of the Ghanaian population of the Kumasi Metropolis of Ghana to formaldehyde through the consumption of fish using 3-Methyl-2-Benzothiazoline Hydrazone method, with trichloroacetic acid as an extracting agent. A total of sixty (60) fish species comprising both local and imported fish were bought from cold stores and fish ponds were analysed. Formaldehyde was found in all the species analysed with concentration ranging from 0.174 to 3.710 μ gg-1 . However, the levels were still lower than 5 mg/kg, which is the maximum limit established by the Malaysian Food Act and Regulation for formaldehyde in fish...
2018: Journal of Toxicology
Jan Rossaint, Andreas Margraf, Alexander Zarbock
Platelets are most often recognized for their crucial role in the control of acute hemorrhage. However, current research has greatly expanded the appreciation of platelets beyond their contribution to primary hemostasis, indicating that platelets also actively participate in leukocyte recruitment and the regulation of the host defense in response to exogenous pathogens and sterile injury. Early recruitment of leukocytes, especially neutrophils, is the evolutionary stronghold of the innate immune response to successfully control exogenous infections...
2018: Frontiers in Immunology
Sidsel Pedersen, Virginia Sanders
INTRODUCTION: The gender landscape is changing. For professionals in health care, particularly diagnostic imaging (DI), we need better communication tools to obtain personal information from this gender diverse community. We need more specific information from patients because we are performing examinations in which radiation is involved. It is our professional duty to protect a patient's reproductive organs whenever possible, but we must know where those organs are located. In addition, we must determine if a patient could be pregnant or not...
December 2018: Journal of Medical Imaging and Radiation Sciences
Musa Marimani, Aijaz Ahmad, Adriano Duse
Tuberculosis (TB) infection caused by Mycobacterium tuberculosis (Mtb) is still a persistent global health problem, particularly in developing countries. The World Health Organization (WHO) reported a mortality rate of about 1.8 million worldwide due to TB complications in 2015. The Bacillus Calmette-Guérin (BCG) vaccine was introduced in 1921 and is still widely used to prevent TB development. This vaccine offers up to 80% protection against various forms of TB; however its efficacy against lung infection varies among different geographical settings...
December 2018: Tuberculosis
Tuhina Gupta, Monica LaGatta, Shelly Helms, Rebecca L Pavlicek, Simon O Owino, Kaori Sakamoto, Tamas Nagy, Stephen B Harvey, Mark Papania, Stephanie Ledden, Kevin T Schultz, Candace McCombs, Frederick D Quinn, Russell K Karls
Tuberculosis (TB) is currently the leading cause of death in humans by a single infectious agent, Mycobacterium tuberculosis. The Bacillus Calmette-Guérin (BCG) vaccine prevents pulmonary TB with variable efficacy, but can cause life-threatening systemic infection in HIV-infected infants. In this study, TBvac85, a derivative of Mycobacterium shottsii expressing M. tuberculosis Antigen 85B, was examined as a safer alternative to BCG. Intranasal vaccination of guinea pigs with TBvac85, a naturally temperature-restricted species, resulted in serum Ag85B-specific IgG antibodies...
December 2018: Tuberculosis
Frederik Federspiel, Mohammad Ali
The Yemen cholera outbreak has been driven by years of conflict and has now become the largest in epidemiologically recorded history with more than 1.2 million cases since the beginning of the outbreak in April, 2017. In this report we review and discuss the cholera management strategies applied by the major international humanitarian health organizations present in Yemen. We find the response by the organizations examined to have been more focused on case management than on outbreak prevention. Oral Cholera Vaccines (OCVs) were not delivered until nearly 16 months into the outbreak...
December 4, 2018: BMC Public Health
Won Jin Lee, Yeongchull Choi, Seulki Ko, Eun Shil Cha, Jaeyoung Kim, Young Min Kim, Kyoung Ae Kong, Songwon Seo, Ye Jin Bang, Yae Won Ha
BACKGROUND: Timely assessment of cancer risk from current radiation exposure among medical radiation workers can contribute to the development of strategies to prevent excessive occupational radiation exposure. The purpose of the present study is to estimate the lifetime risk of cancers induced by occupational radiation exposure among medical radiation workers. METHODS: Using estimated organ doses and the RadRAT risk assessment tool, the lifetime cancer risk was estimated among medical radiation workers who were enrolled in the Korean National Dose Registry from 1996 to 2011...
December 4, 2018: BMC Cancer
Li Li, Yulun Huang, Yuge Gao, Tengfei Shi, Yunyun Xu, Huini Li, Marko Hyytiäinen, Jorma Keski-Oja, Qiuying Jiang, Yizhou Hu, Zhimin Du
BACKGROUND: Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration of TMZ with other drugs, have failed in successful treatment of GBM. We have previously reported that Netrin-4 (NTN4), a laminin-like axon guidance protein, plays a protective role in GBM cell senescence upon TMZ-triggered DNA damage...
December 4, 2018: BMC Cancer
Dorota Kossowska, Kyungwon Kwak, Minhaeng Cho
Osmolytes are small organic compounds that can affect the stability of proteins in living cells. The mechanism of osmolytes' protective effects on protein structure and dynamics has not been fully explained, but in general, two possibilities have been suggested and examined: a direct interaction of osmolytes with proteins (water replacement hypothesis), and an indirect interaction (vitrification hypothesis). Here, to investigate these two possible mechanisms, we studied myoglobin-osmolyte systems using FTIR, UV-vis, CD, and femtosecond IR pump-probe spectroscopy...
December 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mattia Di Nunzio, Alessandra Bordoni, Federica Aureli, Francesco Cubadda, Andrea Gianotti
Although selenium is of great importance for the human body, in several world regions the intake of this essential trace element does not meet the dietary reference values. To achieve optimal intake, fortification of bread by using selenium-enriched flour has been put forward. Less is known on the potential effect of sourdough fermentation, which might be worth exploring as the biological effects of selenium strongly depend on its chemical form and sourdough fermentation is known to cause transformations of nutrients and phytochemicals, including the conversion of inorganic selenium into organic selenocompounds...
December 3, 2018: Nutrients
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