Mohamad El Amki, Chaim Glück, Nadine Binder, William Middleham, Matthias T Wyss, Tobias Weiss, Hanna Meister, Andreas Luft, Michael Weller, Bruno Weber, Susanne Wegener
Despite successful clot retrieval in large vessel occlusion stroke, ∼50% of patients have an unfavorable clinical outcome. The mechanisms underlying this functional reperfusion failure remain unknown, and therapeutic options are lacking. In the thrombin-model of middle cerebral artery (MCA) stroke in mice, we show that, despite successful thrombolytic recanalization of the proximal MCA, cortical blood flow does not fully recover. Using in vivo two-photon imaging, we demonstrate that this is due to microvascular obstruction of ∼20%-30% of capillaries in the infarct core and penumbra by neutrophils adhering to distal capillary segments...
October 13, 2020: Cell Reports